ViralRegulatesPeptidesReceptorReplicationRecombinant ProteinInhibitsGenomeSerotypesIndependentlyMetabolismGenePathwaysInfectionsPotentIntracellularEvidenceRevealsHumanMutantSubunitComplexAminoRegulationCellVaccineTranscriptionCellsDomainCancerTissueControlDomainsExpressionMajorTargetDevelopmentCurrent
Viral11
- Adenovirus (Ad) vectors are among the most commonly used viral vectors in gene therapy clinical trials because they have the following advantages. (hindawi.com)
- It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
- E2 is expressed throughout the differentiation-dependent virus life cycle and is functionally regulated by association with multiple viral and cellular proteins. (microbiologyresearch.org)
- Here, we show for the first time to our knowledge that HPV16 E2 directly associates with the major capsid protein L1, independently of other viral or cellular proteins. (microbiologyresearch.org)
- Upon co-expression in keratinocytes, L1 reduces nucleolar association of E2 protein, and when co-expressed with E1 and E2, L1 is partially recruited to viral replication factories. (microbiologyresearch.org)
- This pathway is hijacked for viral entry, regulation of endocytosis, suppression of premature apoptosis, viral protein expression, and replication. (bvsalud.org)
- A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. (leibniz-liv.de)
- Evidence that the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments. (leibniz-liv.de)
- Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers. (leibniz-liv.de)
- Recombinant Human IFN-beta Protein Binding Activity Recombinant Human IFN‑ beta (Catalog # 8499-IF) exhibits anti-viral activity in HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. (bio-techne.com)
- The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have antioncogenic properties. (docksci.com)
Regulates2
- The PI3K/Akt signalling pathway is a crucial signalling cascade that regulates transcription, protein translation, cell growth, proliferation, cell survival, and metabolism. (bvsalud.org)
- Apoptosis-inducing factor (AIF), named for its involvement in cell death pathways, is a mitochondrial protein that regulates metabolic homeostasis. (biomedcentral.com)
Peptides1
- The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
Receptor3
- On the other hand, Ad vectors also have a number of disadvantages, including their low transduction efficiency in cells lacking coxsackievirus-adenovirus receptor (CAR) and their induction of innate immune responses. (hindawi.com)
- During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the endosomal receptor Niemann-Pick C1 (NPC1) protein. (bvsalud.org)
- 7 VSIG4 can suppress T cell proliferation and promote Foxp3 + regulatory T cell (Tregs) differentiation by binding an unidentified receptor on T cells [ 9 ]. (thno.org)
Replication2
- The human papillomavirus (HPV) E2 protein is a multifunctional protein essential for the control of virus gene expression, genome replication and persistence. (microbiologyresearch.org)
- Adipocyte commitment of 3T3-L1 cells is required to support human adenovirus 36 productive replication concurrent with altered lipid and glucose metabolism. (leibniz-liv.de)
Recombinant Protein1
- Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (bio-techne.com)
Inhibits1
- We have previously shown that the adenovirus (Ad) E4orf4 protein inhibits DDR signaling, but the mechanisms were not identified. (grandlacs-med-journal.com)
Genome1
- The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
Serotypes1
- For example, the common cold is caused by a wide variety of respiratory viruses, most commonly rhinovirus, but also coronaviruses, adenoviruses, and other virus serotypes [ 13 ]. (breathinglabs.com)
Independently1
- Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein. (leibniz-liv.de)
Metabolism1
- This study aims to investigate the molecular mechanism of Adenovirus type 36 (Ad36) in adipocyte differentiation and glucolipid metabolism. (biomedcentral.com)
Gene2
- The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. (microbiologyresearch.org)
- The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
Pathways1
Infections1
- KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. (leibniz-liv.de)
Potent2
- Conserved E1B-55K SUMOylation in different human adenovirus species is a potent regulator of intracellular localization. (leibniz-liv.de)
- However, inclusion of protein antigens fromStreptococcus pneumoniaecombined with potent adjuvants and a suitable delivery system are expected to both extend protection to serotype strains not represented in the formulation and stimulate a broader immune response, thus more effective in young children, elderly, and immunocompromised populations. (univ-nantes.fr)
Intracellular1
Evidence1
- Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. (microbiologyresearch.org)
Reveals1
- Crystal structure of the N-terminal domain of the effector protein SidI of Legionella pneumophila reveals a glucosyl transferase domain. (resist-cluster.de)
Human6
- A novel interaction between the human papillomavirus type 16 E2 and E1^E4 proteins leads to stabilization of E2. (microbiologyresearch.org)
- Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. (microbiologyresearch.org)
- Animal Models in Human Adenovirus Research. (leibniz-liv.de)
- Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes. (leibniz-liv.de)
- Mature human IFN-beta shares 47% and 46% amino acid sequence identity with the mouse and rat proteins, respectively. (bio-techne.com)
- Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. (docksci.com)
Mutant2
- A) HeLa cells were either mock infected or infected with the Ad mutant lacking the whole E4 region or expressing E4orf4 as the only E4 ORF. (grandlacs-med-journal.com)
- Immunofluorescence study suggested that the mutant protein was retained in the endoplasmic reticulum. (embl.de)
Subunit1
- Protein phosphatase 2A (PP2A) is an enzymatic complex containing three subunits: a catalytic subunit, a scaffolding subunit, and one of several regulatory subunits responsible for dictating substrate specificity of the enzyme (42). (grandlacs-med-journal.com)
Complex1
- This phenotype is associated with interaction of E2 with the Mitotic Checkpoint Complex (MCC) proteins Cdc20, MAD2 and BUBR1. (docksci.com)
Amino2
- The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. (embl.de)
- The complement control protein (CCP) modules (also known as short consensus repeats) are defined by a consensus sequence within a stretch of about 60 amino acid residues. (embl.de)
Regulation1
- Protein-Protein Interactions Facilitate E4orf6-Dependent Regulation of E1B-55K SUMOylation in HAdV-C5 Infection. (leibniz-liv.de)
Cell3
- The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro. (leibniz-liv.de)
- Cell transformation by the Adenovirus oncogenes E1 and E4. (leibniz-liv.de)
- Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. (medindex.am)
Vaccine1
- Several vaccine technology infection, rodents and small animal models that mimic hu- platforms targeting the MERS-CoV spike protein were dis- man disease hallmarks would be useful in initial screening cussed. (cdc.gov)
Transcription2
- this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
- However, the binding rate of the transcription factor PPARγ to its target genes Acc, Adipoq, Lpin1 and Glut4 was enhanced, and thus increased the protein expression of P-FoxO1, PPARγ2, ACC, LPIN1, GLUT4 and ADIPOQ. (biomedcentral.com)
Cells1
- Immunoblot analysis was used to determine relative protein quantities within cells. (biomedcentral.com)
Domain4
- The sushi domain is also known as the complement controle protein (CCP) module or the short consensus repeat (SCR). (embl.de)
- Taxonomic distribution of proteins containing CCP domain. (embl.de)
- The complete taxonomic breakdown of all proteins with CCP domain is also avaliable . (embl.de)
- Click on the protein counts, or double click on taxonomic names to display all proteins containing CCP domain in the selected taxonomic class. (embl.de)
Cancer1
- This work pinpoints E2 as a key protein in the initiation of HPV-induced cervical cancer and identifies the SAC as a target for oncogenic pathogens. (docksci.com)
Tissue1
- Genomic and phylogenetic analysis of two guinea pig adenovirus strains recovered from archival lung tissue. (leibniz-liv.de)
Control1
- Three-dimensional structure of a complement control protein module in solution. (embl.de)
Domains4
- There are 156860 CCP domains in 32570 proteins in SMART's nrdb database. (embl.de)
- Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. (embl.de)
- Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. (embl.de)
- There are 417572 IG domains in 173507 proteins in SMART's nrdb database. (embl.de)
Expression1
- The mRNA and protein expression levels of PPARγ and downstream target genes were detected by RT-PCR and Western blot, respectively. (biomedcentral.com)
Major2
- The papillomavirus major capsid protein L1. (microbiologyresearch.org)
- This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
Target1
- A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
Development1
- The VSIG4-Fc fusion protein protects against the development of experimental autoimmune arthritis, uveoretinitis, and hepatitis [ 10 ]. (thno.org)
Current1
- Treatment for MSUD represents an unmet need because the current treatment with life-long low-protein diet is challenging to maintain, and despite treatment the risk of acute decompensations and neuropsychiatric symptoms remains. (nature.com)