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  • aPKC
  • Diminished IRS-1/PI 3-kinase-dependent aPKC activation is observed in muscle and adipose tissue during insulin resistance and type 2 diabetes ( 6 ) but remains intact in liver. (diabetesjournals.org)
  • Signaling
  • Our preliminary experiments showed that diacylglycerol (DAG) signaling promotes Treg differentiation. (upenn.edu)
  • Here, we review the emerging evidence that TRP channels, especially TRPCs, are critical regulators of microdomain signaling in the heart to control pathological hypertrophy in coordination with signaling through effectors such as calcineurin and NFAT (nuclear factor of activated T cells). (ahajournals.org)
  • Changes in BCR signaling following class switch are thought to result from differences in binding of signaling regulators by IgM and IgG, and evidence indicates that recruitment of the cell surface coreceptor CD22 may be a key difference between IgM and IgG B cells ( 14 , 15 ). (jimmunol.org)
  • Description: State-of-the-art genetic and molecular methods will be used to identify and clone genes that encode regulators of nerve cell signaling in C. elegans. (bio.net)
  • Significance: Much of our research focuses on a G protein signaling network that is a major regulator of nerve cell signaling in C. elegans. (bio.net)
  • RIC-8 (Synembryn): A Novel Regulator of Gqa Signaling in the C. elegans Nervous System. (bio.net)
  • vascular
  • Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. (springer.com)
  • TET2 is an mTORC1-dependent master regulator of vascular smooth muscle plasticity. (yale.edu)
  • cell
  • Calcium and diacylglycerol are critical second messengers that together effect mast cell degranulation after allergen cross-linking of immunoglobulin (Ig)E-bound FcepsilonRI. (duke.edu)
  • availability
  • In particular, we propose that PKCε warrants further investigation, not merely as a treatment for insulin resistance as previously supposed, but also as a positive regulator of insulin availability. (diabetesjournals.org)
  • results
  • Although the ten DGK isozymes are highly similar to each other, our current results have encouraged us to identify and develop specific inhibitors/activators against every DGK isozyme that can be effective regulators and drugs against a wide variety of physiological events and diseases. (frontiersin.org)