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Transcription FactorsChromatinTranscription, GeneticPromoter Regions, GeneticDNA-Binding ProteinsGene Expression RegulationMolecular Sequence DataBase SequenceSp1 Transcription FactorBinding SitesTranscriptional ActivationTrans-ActivatorsProtein BindingRepressor ProteinsNuclear ProteinsChromatin ImmunoprecipitationChromatin Assembly and DisassemblyRNA, MessengerBasic Helix-Loop-Helix Transcription FactorsPaired Box Transcription FactorsCell LineHomeodomain ProteinsGene Expression Regulation, DevelopmentalDNASignal TransductionTranscription Factor AP-1Amino Acid SequenceForkhead Transcription FactorsMutationCell NucleusPAX2 Transcription FactorHistonesCell DifferentiationBasic-Leucine Zipper Transcription FactorsTransfectionTranscription Factor AP-2HeLa CellsGenes, ReporterKruppel-Like Transcription FactorsCells, CulturedTranscription Factors, TFIIReverse Transcriptase Polymerase Chain ReactionYY1 Transcription FactorSTAT3 Transcription FactorTranscription Initiation SiteEnhancer Elements, GeneticElectrophoretic Mobility Shift AssayTranscription Factor TFIIDGATA4 Transcription FactorGene Expression ProfilingNFATC Transcription FactorsRNA Polymerase IIZinc FingersNF-kappa BActivating Transcription Factor 3Regulatory Sequences, Nucleic AcidSp3 Transcription FactorRecombinant Fusion ProteinsGene Expression Regulation, FungalProtein Structure, TertiaryCloning, MolecularPlasmidsGene ExpressionActivating Transcription Factor 2Saccharomyces cerevisiae ProteinsNucleosomesTranscription Factor TFIIBSaccharomyces cerevisiaeE2F1 Transcription FactorCell Line, TumorBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPhosphorylationModels, BiologicalGATA1 Transcription FactorGATA3 Transcription FactorMEF2 Transcription FactorsPAX7 Transcription FactorGATA2 Transcription FactorLuciferasesOligonucleotide Array Sequence AnalysisTCF Transcription FactorsMicrophthalmia-Associated Transcription FactorGATA Transcription FactorsDrosophila ProteinsSequence Homology, Amino AcidGene Expression Regulation, PlantMice, KnockoutAcetylationBlotting, WesternModels, GeneticSTAT1 Transcription FactorGene Expression Regulation, BacterialActivating Transcription FactorsTranscription Factor RelAE2F Transcription FactorsDown-RegulationPhenotypeHelix-Loop-Helix MotifsProto-Oncogene ProteinsMice, Transgenic
ProteinProteinsRoleCellExpressionMYODDifferentiationMyoblastGenesExpressionRegulatesCellsStructureStronglyCancer
Protein3
  • Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. (wikipedia.org)
  • The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
Proteins2
  • Through the HTH motif, they share limited sequence similarity and structural similarity to prokaryotic transcription factors, such as lambda phage proteins that alter the expression of genes in prokaryotes. (wikipedia.org)
  • CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular growth and differentiation, metabolism, and inflammation [ 18 ]. (biomedcentral.com)
Role2
  • Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
  • It may function as a transcriptional regulator and play a role in hematopoiesis. (avivasysbio.com)
Cell2
  • These findings demonstrate that C/EBPβ is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2. (biomedcentral.com)
  • As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
Expression1
  • Persistent expression of C/EBPβ upregulates Pax7, inhibits MyoD, and blocks myogenic differentiation. (biomedcentral.com)
MYOD13
  • Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer that expresses myogenic master regulatory factor MYOD but fails to differentiate. (nih.gov)
  • Here, we show that the zinc finger transcription factor CASZ1 up-regulates MYOD signature genes and induces skeletal muscle differentiation in normal myoblasts and ERMS. (nih.gov)
  • Furthermore, we have successfully predicted and validated that the transcription factor myogenic differentiation (MYOD) binds to the MEG3 core promoter though utilizing chromatin immunoprecipitation (CHIP) and luciferase reporter assays. (bvsalud.org)
  • The results indicated that MYOD acts as a transcription factor of MEG3 to promote MEG3 transcription. (bvsalud.org)
  • It is concluded that MYOD acts as a transcription factor to induce MEG3 expression. (bvsalud.org)
  • The bHLH transcription factor MyoD is a master regulator of myogenic differentiation, and its sustained expression in fibroblasts suffices to differentiate them into muscle cells. (bvsalud.org)
  • The oscillatory expression of MyoD is driven by the oscillatory expression of the bHLH transcription factor Hes1 that periodically represses MyoD. (bvsalud.org)
  • Here, we examined the time-dependent expression patterns of multiple biomarkers associated with satellite cell fate, including the transcription factor paired box 7 (Pax7), myoblast determination protein (MyoD), myogenin, and insulin-like growth factor (IGF-1), using immunohistochemistry, western blotting, and quantitative real-time PCR in contused skeletal muscle. (bvsalud.org)
  • Morphometrically, the data obtained from the numbers of Pax7 + , MyoD + , and myogenin + cells were highly correlated with the wound age. (bvsalud.org)
  • Pax7, MyoD, myogenin, and IGF-1 expression patterns were upregulated after injury at both the mRNA and protein levels. (bvsalud.org)
  • Pax7, MyoD, and myogenin protein expression levels confirmed the results of the morphometrical analysis. (bvsalud.org)
  • Expression of the myogenic regulatory factors required to promote differentiation, MYOD and MYOG, was downregulated in the absence of JARID2, even though decreases in the methylation of histone H3 lysine 27 (H3K27 me3 ) were observed on both promoters. (biomedcentral.com)
  • Skeletal muscle differentiation is controlled by four highly related basic helix-loop-helix proteins known as the myogenic regulatory factors (MRFs), which include MYF5, MYOD, MYOG and MYF6. (biomedcentral.com)
Differentiation4
  • The methylation status of CpG islands and surrounding regions (CpG island shores) is an important factor in regulating chromatin structure and gene expression during development and differentiation (Deaton and Bird 2011 ). (springer.com)
  • Differential Contributions of mSWI/SNF Chromatin Remodeler Sub-Families to Myoblast Differentiation. (umassmed.edu)
  • Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. (umassmed.edu)
  • The Sox6 transcription factor is a key regulator of fast-twitch muscle fiber differentiation in the zebrafish, a role similar to that ascribed to its murine ortholog. (biomedcentral.com)
Myoblast1
  • Differential requirements for different subfamilies of the mammalian SWI/SNF chromatin remodeling enzymes in myoblast cell cycle progression and expression of the Pax7 regulator. (umassmed.edu)
Genes6
  • ChIP-seq, ATAC-seq and RNA-seq experiments reveal that CASZ1 directly up-regulates skeletal muscle genes and represses non-muscle genes through affecting regional epigenetic modifications, chromatin accessibility and super-enhancer establishment. (nih.gov)
  • Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. (wikipedia.org)
  • Through the HTH motif, they share limited sequence similarity and structural similarity to prokaryotic transcription factors, such as lambda phage proteins that alter the expression of genes in prokaryotes. (wikipedia.org)
  • 13. Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma. (nih.gov)
  • HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
  • In this study, we present CLIP-GENE, a web service that selects gene markers by utilizing differentially expressed genes, mouse transcription factor (TF) network, and single nucleotide variant information. (biomedcentral.com)
Expression5
  • 14. Brg1 Controls the Expression of Pax7 to Promote Viability and Proliferation of Mouse Primary Myoblasts. (nih.gov)
  • As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
  • The transcription factor Sox6 has been implicated in regulating muscle fiber type-specific gene expression in mammals. (biomedcentral.com)
  • In zebrafish, loss of function of the transcription factor Prdm1a results in a slow to fast-twitch fiber type transformation presaged by ectopic expression of sox6 in slow-twitch progenitors. (biomedcentral.com)
  • This leads to disassembly of the destruction complex releasing free β-catenin in the cytoplasm, which later translocates to the nucleus and activates gene expression in concert with the T cell factor (TCF) and lymphoid enhancer-binding factor (LEF) families of transcription factors. (biomedcentral.com)
Regulates1
  • 4. The BAF (BRG1/BRM-Associated Factor) chromatin-remodeling complex exhibits ethanol sensitivity in fetal neural progenitor cells and regulates transcription at the miR-9-2 encoding gene locus. (nih.gov)
Cells2
  • 11. The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. (nih.gov)
  • Recent advances in adipogenesis had provided insights into understanding of the complex cues for influencing the cytoarchitecture, epigenomic remodeling, signaling pathways and transcription regulators on gene actions for both white and brown adipogenic progression from mesenchymal stem cells to matured committed adipocytes. (scirp.org)
Structure1
  • Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML. (umassmed.edu)
Strongly2
  • The induction of lineage-specific gene programs are strongly influenced by alterations in local chromatin architecture. (mdpi.com)
  • DNA methylation is strongly affected by environmental factors, including diet (Bacalini et al. (springer.com)
Cancer1
  • 20. Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer. (nih.gov)