GlandCarcinomaTranscriptional regulatorsGeneGenesTumorCarcinomasAdenomasAnaplasticTumorsProteinsRegulatesFollicular epithelialPathwaysReceptorCarcinogenesisRegulateSubtypeNeed thyroid hormonePAX8CancerRegulationHuman ThyroidProteinFamily of transcription factorsStrong regulatorPatientsMechanismsPrognosticMolecularHypothalamicHormonesNeuronsDifferentiateHypothyroidismMetabolismExpressionSynthesisVEGFDevelopment
Gland8
- The PAX8 gene is also associated congenital hypothyroidism due to thyroid dysgenesis because of its role in growth and development of the thyroid gland. (wikipedia.org)
- It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. (novusbio.com)
- Expressed in the excretory system, thyroid gland and Wilms tumors. (abeomics.com)
- The focus of my research program is the thyroid with a focus on the role of gland development and the actions of its hormones. (bu.edu)
- To accomplish these goals we have built a unique program in thyroid gland development from endoderm in order to derive new therapies for hypothyroidism. (bu.edu)
- Congenital hypothyroidism, which occurs in 1 in less than 3,000 births ( 3 ), and other thyroid gland disorders are associated with defects in the maturation and function of many tissues and organ systems. (jci.org)
- Homozygotes for a targeted mutation have profoundly abnormal lungs and ventral forebrain defects, lack thyroids, pituitary gland, and tracheoesophageal septation, and die at birth from respiratory failure. (jax.org)
- and dysfunction of the thyroid gland (a butterfly-shaped tissue in the lower neck), which can result in many symptoms including weight gain and fatigue. (medlineplus.gov)
Carcinoma11
- A fusion protein, PAX8-PPAR-γ, is implicated in some follicular thyroid carcinomas and follicular-variant papillary thyroid carcinoma. (wikipedia.org)
- Lin X, Zhang J, Zhao RH, Zhang WJ, Wu JF, Xue G. APOE Is a Prognostic Biomarker and Correlates with Immune Infiltrates in Papillary Thyroid Carcinoma. (jcancer.org)
- However, the clinical value of APOE in papillary thyroid carcinoma (PTC) remains to be determined. (jcancer.org)
- Thyroid Papillary Carcinoma (PTC) is the most common subtype of thyroid cancer, accounting for about 80% and its incidence and mortality rate have increased significantly in recent years [ 1 , 2 ]. (jcancer.org)
- This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. (novusbio.com)
- Anaplastic thyroid carcinoma (ATC) is an extremely malignant type of endocrine cancer frequently accompanied by extrathyroidal extension or metastasis through mechanisms that remain elusive. (biomedcentral.com)
- CREB3L1 knockdown dramatically attenuated invasion of ATC cells, whereas overexpression of CREB3L1 facilitated the invasion of papillary thyroid carcinoma (PTC) cells. (biomedcentral.com)
- Anaplastic thyroid carcinoma (ATC) is a rare but extremely malignant thyroid - cancer subtype. (biomedcentral.com)
- Lin X, Wu JF, Wang DM, Zhang J, Zhang WJ, Xue G. The correlation and role analysis of KCNK2/4/5/15 in Human Papillary Thyroid Carcinoma microenvironment. (jcancer.org)
- However, the expression pattern and prognostic value of KCNK factors in papillary thyroid carcinoma have not been reported. (jcancer.org)
- Is new American Thyroid Association risk classification for hereditary medullary thyroid carcinoma applicable to Chinese patients? (cdc.gov)
Transcriptional regulators5
- Pit-1 is a member of the POU domain containing proteins, a group of transcriptional regulators with a critical role in cell differentiation and proliferation. (ajol.info)
- The nuclear hormone receptor family comprises a group of structurally related transcriptional regulators that mediate the actions of diverse ligands, including steroid hormones, thyroid hormone, vitamin D, and retinoids. (duke.edu)
- Among the identified transcriptional regulators inactivated in lung adenocarcinoma vs . normal lung, NKX2-1 was linked to a large number of silenced enhancers. (prolekarniky.cz)
- Among the activated transcriptional regulators identified, CENPA, FOXM1, and MYBL2 were linked to numerous cancer-specific enhancers. (prolekarniky.cz)
- Identification and characterization of key transcriptional regulators and associated enhancers in lung adenocarcinoma provides important insights into the deregulation of lung adenocarcinoma epigenomes, highlighting novel potential targets for clinical intervention. (prolekarniky.cz)
Gene14
- This gene is a member of the paired box (PAX) family of transcription factors. (wikipedia.org)
- Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. (wikipedia.org)
- It was shown that this group of proteins control the transcription of the growth hormone (GH), the prolactin (PRL), the thyroid-stimulating hormone β-subunit (TSH-β), the GHRH receptor genes and the Pit-1 gene itself. (ajol.info)
- This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. (bioseek.eu)
- Specifically we were amongst the first to begin to differentiate how thyroid hormone is able to stimulate both positive and negative gene regulation. (bu.edu)
- Transforming growth factor-beta(1) regulation of surfactant protein B gene expression is mediated by protein kinase-dependent intracellular translocation of thyroid transcription factor-1 and hepatocyte nuclear factor 3. (ucsf.edu)
- It occurs more frequently in male smokers, and the epidermal growth factor receptor ( EGFR ) gene is often mutation‑free. (spandidos-publications.com)
- First identified as a tissue-specific regulator of the transcription of the cytochrome P450 steroid hydroxylases, considerably broader roles for SF-1 were revealed by genetic studies in mice lacking SF-1 due to targeted gene disruption. (duke.edu)
- And the LEF / TCF family transcription factor, along with other proteins, binds to DNA and inhibits gene expression. (researchsquare.com)
- The hub genes of PIM were discovered, and their associated gene regulatory network was built to determine the master regulators involved in the pathogenesis of primary SGC. (genominfo.org)
- Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
- Mutations of the gene encoding fibroblast growth factor 8 have been found in a small minority of patients with autosomal dominant Kallmann syndrome. (medscape.com)
- Mutations of the DAX1 gene, which encodes a nuclear transcription factor, lead to X-linked idiopathic hypogonadotropic hypogonadism associated with adrenal hypoplasia congenita (AHC). (medscape.com)
- A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. (bvsalud.org)
Genes15
- This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. (wikipedia.org)
- PAX8 and other transcription factors play a role in binding to DNA and regulating the genes that drive thyroid hormone synthesis (Tg, TPO, Slc5a5 and Tshr). (wikipedia.org)
- As a master regulator, it is possible that it regulates expression of genes other than thyroid-specific. (wikipedia.org)
- Some studies have suggested that the renal PAX genes act as pro-survival factors and allow tumor cells to resist apoptosis. (wikipedia.org)
- This study implied that KCNK2, KCNK4, KCNK5 and KCNK15 are potential targets of precision therapy for patients with thyroid cancer and these genes are new biomarkers for the therapeutic target for thyroid cancer. (jcancer.org)
- PAX-8 is a transcription factor in the paired box (PAX) family, who functions as important regulators in early development, especially in thyroid follicular cells and thyroid specific genes. (cloverbiosciences.com)
- Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant protein A (SP-A) genes. (ucsf.edu)
- The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. (embl.de)
- These response elements position the receptors, and the complexes recruited by them, close to the genes of which transcription is affected. (embl.de)
- Thyroid hormone acts through the intracellular thyroid hormone receptor (TR), which belongs to the nuclear receptor family and acts as a ligand-regulated transcription factor ( 4 , 5 ), eliciting cellular responses by binding to and regulating the expression of target genes. (jci.org)
- Knockdown experiments of FOXM1 and MYBL2 suggest that these factors regulate genes involved in controlling cell cycle progression and cell division. (prolekarniky.cz)
- PGC-1α is a transcriptional coactivator that binds to and activates transcription factors that regulate the genes involved in energy metabolism. (mrsupps.com)
- We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. (genominfo.org)
- This study illustrated several hub genes and their master regulators that might be appropriate targets for the therapeutic aims of primary SGC. (genominfo.org)
- La expansión de repeticiones del trinucleótido CAG en los genes que codifican Ataxinas se asocia con las ATAXIAS ESPINOCEREBELOSAS (AEC). (bvsalud.org)
Tumor6
- Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. (novusbio.com)
- It is estimated that there are 53,990 new cases of thyroid cancer in the US in 2018, and thyroid cancer was the fifth most common malignant tumor in American women [ 2 ]. (jcancer.org)
- Due to these properties and its increased expression in response to intratumoral hypoxia, HIF-1 is considered a significant regulator of tumor biology. (scite.ai)
- SWI/SNF‑related, matrix‑associated, actin‑dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)‑deficient non‑small cell lung cancer (dNSCLC) is a rare malignant tumor that originates in the lungs. (spandidos-publications.com)
- In thyroid cancer cell lines, PATZ1 functioned as a tumor suppressor regardless of p53 status. (oncotarget.com)
- Our study demonstrates that PATZ1 knockdown enhances malignant phenotype both in thyroid follicular epithelial cells and thyroid cancer cells, suggesting that PATZ1 functions as a tumor suppressor in thyroid follicular epithelial cells and is involved in the dedifferentiation of thyroid cancer. (oncotarget.com)
Carcinomas3
- The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. (novusbio.com)
- Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. (novusbio.com)
- Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. (novusbio.com)
Adenomas1
- Mutations in PAX-8 could lead to thyroid follicular carcinoams, atypical thyroid adenomas, and thyroid dysgenesis. (cloverbiosciences.com)
Anaplastic2
- Anaplastic thyroid cancer (ATC) is the most aggressive form of human thyroid cancer, lacking any effective treatment. (scite.ai)
- More than 95% of thyroid cancers are derived from thyroid follicular epithelial cells and are classified into differentiated thyroid cancer (DTC), including papillary and follicular thyroid cancer (PTC and FTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC). (oncotarget.com)
Tumors3
- Over 90% of thyroid tumors arise from follicular thyroid cells. (wikipedia.org)
- Due to the continuous improvement of modern diagnostic methods and other factors, thyroid cancer (TC) has become one of the common malignant tumors [ 1 ]. (jcancer.org)
- In China's 2018 cancer report, it was mentioned that thyroid cancer ranked fourth in female tumors in 2014. (jcancer.org)
Proteins6
- It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. (nih.gov)
- Background and objectives: sterol regulator element binding proteins (srebps) are a family of transcription factors that involve in the biogenesis of cholesterol, fatty acids, and triglyceride. (icbcongress.com)
- Assays showed that multiple proteins can bind to this sequence and that one of these is the transcription regulator delta-EF1 (dEF1). (usda.gov)
- Electromobility shift assays showed that the transcription regulator delta-EF1 (dEF1) is one of the proteins that recognize the E box region. (usda.gov)
- Our work has uncovered a unique role for nuclear receptor co-regulatory proteins termed nuclear corepressors in thyroid hormone signaling and determining hormone sensitivity. (bu.edu)
- GTPase activating proteins: critical regulators of intracellular signaling. (ucsf.edu)
Regulates3
- Significance: This study explains how TRPC1 regulates receptor expression and migration in thyroid cancer cells. (scite.ai)
- It has been a long-standing challenge to decipher the mechanisms by which thyroid hormone regulates such a wide range of cellular processes in so many different tissues. (jci.org)
- The coordinated and differential actions of TH signalling are mediated by the binding of the active form of TH (3,3,5-triiodo- l -thyronine, T3) to its receptors-the thyroid hormone receptors alpha and beta (TRα1-3 and TRβ1-3)-through which it regulates downstream signalling pathways and transcription factors [ 8 ] . (encyclopedia.pub)
Follicular epithelial1
- Single - cell RNA-sequencing analysis revealed that CREB3L1 expression gradually increased during the neoplastic progression of a thyroid follicular epithelial cell to an ATC cell, accompanied by the activation of the extracellular matrix (ECM) signaling. (biomedcentral.com)
Pathways4
- Some whole-genome sequencing studies have shown that PAX8 also targets BRCA1 (carcinogenesis), MAPK pathways (thyroid malignancies), and Ccnb1 and Ccnb2 (cell-cycle processes). (wikipedia.org)
- Signaling pathways that are activated by intrinsic or extrinsic stimulation converge on the transcriptional factors and regulate phenotypic changes of cancer cells [ 9 ]. (biomedcentral.com)
- In addition to our work on thyroid hormone action we have also had a long standing interest in the intersection of the regulation of biomarkers of thyroid hormone action including the regulation of the hypothalamic pituitary thyroid axis by thyroid hormone and other metabolic pathways. (bu.edu)
- Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
Receptor13
- Cotransfection assays were done, using expression vectors for thyroid receptor (TR) or chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1) to increase the levels of these hormone receptors in the cells containing the CAV promoter driving expression of EGFP. (usda.gov)
- This tested for transcription regulation by these members of the nuclear receptor family that also recognize a consensus ERE. (usda.gov)
- Cotransfection assays, using expression vectors for thyroid receptor (TR) or chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1) and the CAV promoter driving expression of EGFP, were used to test for transcription regulation by these members of the nuclear receptor family that also recognize a consensus ERE. (usda.gov)
- Additionally, we explore thyroid hormone action and nuclear receptor signaling as a model system. (bu.edu)
- Studies in this area allowed us to be able to characterize the interaction of the thyroid hormone receptor with its cofactors which are necessary for genomic regulation. (bu.edu)
- We were pioneers in the use of knock-out mouse models to validate the role of thyroid hormone receptor co-factors, specifically nuclear corepressors, in thyroid hormone signaling. (bu.edu)
- Furthermore these studies have allowed us to better understand the specificity of coregulator interactions with the thyroid hormone receptor and their role in disease. (bu.edu)
- Here, we describe a previously unknown population of parvalbuminergic neurons in the anterior hypothalamus that requires thyroid hormone receptor signaling for proper development. (jci.org)
- Furthermore, the findings may be beneficial for treatment of the recently identified patients that have a mutation in thyroid hormone receptor α1. (jci.org)
- Thyroid hormone is a well-known regulator of metabolic and cardiovascular functions, and signaling through thyroid receptors has differential effects on cells depending on the receptor isoform that they express. (jci.org)
- Natural regulators of brown and beige fat include external conditions like cold temperatures, and exercise, as well as internal mechanisms like thyroid hormones, beta-adrenergic hormones, retinoids, PPARγ and PPARα agonists, and the liver X receptor. (mrsupps.com)
- Analysis of AP2S1, a calcium-sensing receptor regulator, in familial and sporadic isolated hypoparathyroidism. (cdc.gov)
- [ 4 ] Of note, anosmin may enhance fibroblast growth factor signaling through the fibroblast growth factor receptor 1. (medscape.com)
Carcinogenesis1
- This study was designed to examine the involvement of PATZ1 in carcinogenesis and dedifferentiation of thyroid cancer. (oncotarget.com)
Regulate2
- For example, Natural Society says coconut oil has long been used to threat underactive thyroids, due to the presence of fatty acids called MCTs that help regulate metabolism. (thyroidproadvice.com)
- SREBP-2 is a member of a family of transcription factors that regulate glucose metabolism, fatty acid synthesis, and cholesterol metabolism. (thyroidproadvice.com)
Subtype1
- Notably, CENPA, FOXM1, and MYBL2 are also key regulators of cancer-specific enhancers in breast adenocarcinoma of the basal subtype, but they are associated with distinct sets of activated enhancers. (prolekarniky.cz)
Need thyroid hormone1
- The clinic treads the medical routewhich is seeing your doctor to determine if you need thyroid hormone therapy. (thyroidproadvice.com)
PAX81
- PAX8 (and PAX2) is one of the important regulators of urogenital system morphogenesis. (wikipedia.org)
Cancer22
- Transcription factor Prospero homeobox 1 (PROX1) as a potential angiogenic regulator of follicular thyroid cancer dissemination. (waw.pl)
- This revealed that CREB3L1 was specifically up regulated in ATC tissues and negatively associated with overall survival of patients with thyroid cancer. (biomedcentral.com)
- Several collagen subtypes are closely associated with thyroid cancer occurrence and development. (biomedcentral.com)
- In this study, we used the data from databases such as ONCOMINE, GEPIA, Kaplan-Meier Plotter, and cBioPortal to perform bioinformatics analysis of KCNK factors in patients with thyroid cancer. (jcancer.org)
- We found that the mRNA expression of KCNK1, KCNK5, KCNK6, KCNK7, and KCNK15 were significantly higher in thyroid cancer tissues than that in normal tissues, while KCNK2, KCNK4, KCNK9, KCNK16 and KCNK17 mRNA levels were decreased compared to normal tissues. (jcancer.org)
- Survival analysis using the Kaplan-Meier Plotter database revealed that KCNK2/3/4/5/12/15 were associated with overall survival (OS) in patients with thyroid cancer. (jcancer.org)
- Among them, papillary thyroid cancer (PTC) is the most common pathological type, accounting for about 80% of the total number of thyroid cancers [ 3 ]. (jcancer.org)
- Although thyroid cancer, including PTC, has the advantages of high diagnostic detection rate, good therapeutic effect, and high survival rate [ 4 ]. (jcancer.org)
- However, once distant metastasis of PTC occurs, it will seriously affect the survival time of patients, and some researchers have reported that the five year survival rate drops to about 54.1% for patients with thyroid cancer due to distant metastasis [ 5 - 7 ]. (jcancer.org)
- Therefore, early detection of lymph node metastases and the study of the molecular mechanism of thyroid cancer lymph node metastasis are of great significance for the choice of surgical approach, clinical treatment and prognosis of thyroid cancer patients. (jcancer.org)
- The relationship between ion channels and ion channels has become a new focus of attention with the development of thyroid cancer research. (jcancer.org)
- We have previously shown S1P to induce migration of follicular ML-1 thyroid cancer cells. (scite.ai)
- In conclusion, we have identified S1P as a non-hypoxic regulator of HIF-1 activity in thyroid cancer cells, studied the signaling involved in S1P-induced HIF-1α expression and shown S1P-induced migration to be mediated by HIF-1. (scite.ai)
- SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)- deficient non-small cell lung cancer (SMARCA4-dNSCLC) is an uncommon yet notable malignancy originating within the lung. (spandidos-publications.com)
- 3. Malhotra J, Malvezzi M, Negri E, La Vecchia C, Boffetta P. Risk factors for lung cancer worldwide. (prolekarniky.cz)
- These data indicate that APE1/Ref-1 is a key regulator of survivin and a potentially viable target in prostate cancer. (oncotarget.com)
- In addition, Wnt/β-catenin has emerged as a critical regulator of cancer stem cells (CSCs), which is considered one of the root causes of cancer recurrence and metastasis because of their heterogeneity and plasticity ( 13 ). (frontiersin.org)
- Immunohistochemistry on clinical specimens indicated nuclear PATZ1 expression in all normal thyroid glands and adenomatous goiter, while nuclear PATZ1 expression decreased along with the dedifferentiation of thyroid cancer. (oncotarget.com)
- When PATZ1 was silenced in differentiated thyroid cancer (DTC) cell lines (TPC-1 and FTC-133), proliferation, cellular motility, and expression of uPA and MMPs were significantly increased. (oncotarget.com)
- Thyroid cancer is the most common endocrine malignancy worldwide [ 1 ]. (oncotarget.com)
- In contrast, ATC is one of the most aggressive cancers in humans with a median survival rate of 3-9 months and is responsible for 14-39% of thyroid cancer-related deaths regardless of the multimodal treatments, although it accounts for less than 2% of all thyroid cancers [ 2 , 3 ]. (oncotarget.com)
- Cancer Prev Res (Phila), factor 1. (who.int)
Regulation4
- Finally, the results of ROC curves, immunohistochemical staining, immune cell infiltration and kinase / miRNA / transcription factor regulation showed that KCNK2, KCNK4, KCNK5 and KCNK15 levels could be used as biomarkers for PTC diagnosis. (jcancer.org)
- My laboratory has a long-standing interest in how thyroid hormone mediates its effects in context of genomic regulation. (bu.edu)
- Regulation of Thyroid Hormone Levels by Hypothalamic Thyrotropin-Releasing Hormone Neurons. (bu.edu)
- The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
Human Thyroid1
- Human Thyroid stained with Thyroglobulin Ab (2H11 + 6E1). (novusbio.com)
Protein5
- Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
- The cAMP responsive element binding protein 3 (CREB3) family members locate in the endoplasmic reticulum (ER) membrane and act as transcription factors when cleaved by S1P and S2P proteases. (biomedcentral.com)
- VEGF transcription leads to Ras frame in a Ras-guanine state curvature ligand( GEF) NOX2 protein. (erik-mill.de)
- The Ki‑67 positivity index was 75%, and the thyroid transcription factor‑1, NapsinA, p40, nuclear protein in testis, CD34, Sal‑like protein 4, SRY‑box transcription factor 2 and synaptophysin were negative. (spandidos-publications.com)
- Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein that is essential in activating oncogenic transcription factors. (oncotarget.com)
Family of transcription factors1
- PAX-8 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. (bioseek.eu)
Strong regulator2
- Nuclear corepressor SMRT acts as a strong regulator of both ß-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells. (bu.edu)
- In this way, iodothyronines were gradually converted from a sensing molecule into a strong regulator of both metabolism and development. (encyclopedia.pub)
Patients1
- Patients with AD have been reported to present changes in the homeostasis of thyroid hormones. (bvsalud.org)
Mechanisms1
- Although some mechanisms have been clarified, including growth factors, ionizing radiation, iodine intake, gender and genetic factors, these factors have not yet specifically clarified the mechanisms of PTC occurrence and cannot be used as specific targets for clinical treatment for PTC. (jcancer.org)
Prognostic1
- Recent data indicates that serum level of sphingosine-1-phosphate (S1P) is a prognostic factor for COVID-2 severity. (scite.ai)
Molecular2
- To accomplish this we began a complete collaboration with the Kotton laboratory at Boston University and have successfully developed the molecular paradigm to develop thyroid follicular cells from ESCs or IPSCs across multiple species. (bu.edu)
- One of these basic elements, iodine, provided the key material for the evolution of thyroid hormone (TH) signalling-a universal and crucial molecular pathway for the evolution of life on earth. (encyclopedia.pub)
Hypothalamic1
- Thus, the data identify what we believe to be a novel hypothalamic cell population potentially important for understanding hypertension and indicate developmental hypothyroidism as an epigenetic risk factor for cardiovascular disorders. (jci.org)
Hormones1
- The production of hor- mones that are very important to the development of the central nervous system, such as thyroid hormones, is affected by DS. (bvsalud.org)
Neurons1
- provide evidence that thyroid hormone receptors are essential for the formation of a population of parvalbuminergic neurons in the anterior hypothalamus, linking, for the first time, impaired thyroid hormone signaling during development to cellular deficits in the hypothalamus. (jci.org)
Differentiate1
- Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms. (novusbio.com)
Hypothyroidism1
- The main way to diagnose hypothyroidism is a blood test called the thyroid stimulating hormone test . (thyroidproadvice.com)
Metabolism2
- Thyroid hormone is well known for its profound direct effects on cardiovascular function and metabolism. (jci.org)
- Thyroid hormone (TH) signalling is a universally conserved pathway with pleiotropic actions that is able to control the development, metabolism, and homeostasis of organisms. (encyclopedia.pub)
Expression3
- Pit-1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals. (ajol.info)
- These studies allowed us to demonstrate that the tissue-specific expression of co-factors determines a set hormone sensitivity. (bu.edu)
- Thyroid hormone receptors have separate expression patterns and divergent functional roles during foetal and adult life that are dependent on their liganded states [ 7 ] [ 9 ] . (encyclopedia.pub)
Synthesis1
- On the other hand, S1P activated translational regulators eIF-4E and p70S6K, which are known to control HIF-1α synthesis. (scite.ai)
VEGF2
- Results: TRPC1 functions as a major regulator of S1P and VEGF receptors via a calcium-dependent mechanism. (scite.ai)
- VEGF uncouples its truncated cell through phase with thyroid muscle transcription factors VEGFR, enough used on inner Lo-like diseases. (erik-mill.de)
Development2
- Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. (embl.de)
- Scholars@Duke publication: Steroidogenic factor 1 plays multiple roles in endocrine development and function. (duke.edu)