Regulator proteins proto oncogene proteins c myc. Medical search. Frequent questions

NCMV proteins and their oncogenic effects on cell mechanisms. (surgicalneurologyint.com)
In this regard, the emerging molecular diversity of brain tumor suptypes (e.g. in glioma and medulloblastoma) highlights the link between oncogenic pathways and the tumor repertoire of coagulation system regulators (coagulome). (rmmj.org.il)
For more than a decade, numerous studies have suggested that the c-Myc oncogenic protein is likely to broadly influence the composition of the transcriptome. (elsevierpure.com)
The oncogenic activity of Myc family proteins is initiated when their transcriptional regulation is disrupted by events such as gene amplification and gene translocation, which typically lead to elevated cellular Myc levels. (silverchair.com)

In a number of studies, it has been shown that while only a select number of cells are actually infected with the virus, numerous viral proteins are released into the cancer and stromal cells in the microenvironment and these viral proteins are known to affect tumor behavior and aggressiveness. (surgicalneurologyint.com)
Rather, only a few cells need to be infected, with the release of viral proteins from the viruses, which occupy most if not all of the tumor cells, including stromal cells. (surgicalneurologyint.com)
We also showed that MMTV encodes several different regulatory and accessory proteins that contribute to viral replication and tumorigenesis, including superantigen (Sag), Rem, signal peptide (SP), and Rem-CT. (utexas.edu)
However, we showed that viral DNA insertions of the MMTV variant (TBLV), which has a modified enhancer, increased the expression of different proto-oncogenes (c- Myc or Rorc ) to induce T-cell lymphomas. (utexas.edu)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Considering multiple signaling pathways converge on MYC it is not surprising that overexpression is frequently observed in multiple tumor types where elevated MYC levels are associated with malignant transformation and tumor proliferation [ 5 ]. (oncotarget.com)
Protein-coding genes dysregulated by 3 h TCPOBOP exposure were strongly enriched in KEGG pathways of xenobiotic and drug metabolism, with stronger and more extensive gene responses observed in female than male liver. (nih.gov)
p53 is a master gene regulator controlling diverse cellular pathways, by either activating or repressing downstream genes. (bioinf.org)
Stable monoubiquitinated form of wild type p53, accumulates in the cytoplasm and interacts with BAK or BAX proteins in mitochondria to induce apoptosis Thus Kevetrin activates both transcription dependent and transcription independent pathways to promote apoptosis. (shu.edu)
Additionally, scientists have found that this relationship is an important part of a number of complex cellular signaling cascade pathways, including Ras, β-catenin, myc, Rb, and many more. (shu.edu)

Changes in epigenetic regulation, transcription, RNA stability, protein translation, and post-translational control can be detected in cancer. (edu.vn)

The p53 protein itself functions as a transcription factor. (edu.vn)
Myc is a transcription factor that is aberrantly activated in Burkett's Lymphoma, a cancer of the lymph system. (edu.vn)
In this study, we identified zinc finger transcription factor 148 ( ZNF148 , also called Zfp148 and ZBP-89) as a direct target of MYC. (nature.com)
The MYC proto-oncogene is a transcription factor essential in stem/progenitor cell maintenance and differentiation [ 11 ]. (nature.com)
The p53 protein is a transcription factor that normally inhibits cell growth and stimulates cell death in response to myriad stressors, including DNA damage (induced by either UV or chemical agents such as hydrogen peroxide), oxidative stress, and deregulated oncogene expression [6-10]. (bioinf.org)
The role of the regulatory T cell transcription factor Foxp3 in shaping the transcriptosomes of natural and induced regulatory T cells was analyzed using mice expressing a mutant FOXP3-EGFP fusion protein (Foxp3deltaEGFP). (gsea-msigdb.org)

The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
Overexpression of the oncogene can lead to uncontrolled cell growth. (edu.vn)
Overexpression of myc transforms normal B cells into cancerous cells that continue to grow uncontrollably. (edu.vn)
The overexpression of c-Myc predisposes cells to apoptosis under nutrient or growth factor deprivation conditions, although the critical sets of genes involved remain elusive. (elsevierpure.com)
Mnt overexpression suppressed cell cycle entry and cell proliferation, suggesting that the ratio of Mnt-Max to c-Myc-Max is critical for cell cycle entry. (silverchair.com)

Myc has been demonstrated also to be a potent inducer of apoptosis when expressed in the absence of serum or growth factors. (sigmaaldrich.com)
Apoptosis may serve also as a protective mechanism to prevent tumorigenicity elicited by deregulated Myc expression. (sigmaaldrich.com)
Conclusions These findings ascertained an conversation between p53, c-myc, p21, p27, Bcl-2, PI3K/Akt pathway, and CF-induced apoptosis in MSTO-211H and HCT-116 cells, suggesting that CF acts as an important regulator of cell growth in human malignancy cell lines. (bioinf.org)
Apoptosis and cell proliferation are linked by cell-cycle regulators and apoptotic stimuli that affect both processes. (bioinf.org)
AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. (biomedcentral.com)

Myc therefore is an important positive regulator of cell growth and proliferation. (sigmaaldrich.com)
The MAPK pathway activates JUN, FOS and MYC, plus the JAK STAT pathway activates VEGF and each encourage proliferation and angiogenesis. (dubinhibitors.com)
ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. (nature.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
Two proteins involved intimately in regulating cell proliferation are Akt and the tumor suppressor p53 (p53). (bioinf.org)
Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival. (oncotarget.com)
These results demonstrate that Mnt-Myc antagonism plays a fundamental role in regulating cell cycle entry and proliferation. (silverchair.com)

This is because oncogenes can alter transcriptional activity, stability, or protein translation of another gene that directly or indirectly controls cell growth. (edu.vn)
The protein of Myc modulator 1 (Mm-1) has been reported to repress the transcriptional activity of the proto-oncogene c-Myc in humans. (scielo.org)

Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. (sigmaaldrich.com)

Perturbation of mitochondrial function using a number of conventional and novel inhibitors resulted in the decreased expression of MYC mRNA. (oncotarget.com)
This decrease in MYC mRNA occurred concomitantly with an increase in the levels of tumor-suppressive miRNAs such as members of the let-7 family and miR-34a-5p . (oncotarget.com)
We also identified let-7 -dependent downregulation of the MYC mRNA chaperone, CRD-BP (coding region determinant-binding protein) as an additional control following mitochondria damage. (oncotarget.com)
JUN mRNA was decreased and, as JUN transcription is autoregulated by JUN protein,and JUN heterodimerizes with Meq. (dubinhibitors.com)
We propose that even though total JUN protein was enhanced in CD30hi lymphocytes, it is actually not out there for auto transactivation, an substitute chance is as JUN protein is stabilized by submit translational interactions with Meq, the JUN mRNA might not basically reflect the total JUN protein levels. (dubinhibitors.com)
At last, the mRNA and protein expression of NFAT2, Egr2, FasL, COX-2 and c-myc in carcinoma and adjacent tissues was investigated. (researchsquare.com)
We identified the virally encoded protein, Rem (regulator of MMTV mRNA export and expression). (utexas.edu)
Results from zebrafish embryos injected with murine Stat3 mRNA and stat3 morpholino suggest that Ambra1b could indirectly regulate this protein through CUL4-DDB1 interaction. (biomedcentral.com)

In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
After the degradation of damaged proteins and lipids, amino acids and fatty acids are released into the cytoplasm and recycled for new biosynthesis of cellular components or energy production [ 4 ]. (hindawi.com)
The function of this cellular pathway and Rem-CT protein have yet to be determined. (utexas.edu)
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (childrensmercy.org)

A large number of E-box containing genes have been identified underlying the important role of MYC as a master regulator of gene expression [ 2 ]. (oncotarget.com)
Numerous genes have been identified as proto-oncogenes. (cancerquest.org)

In contrast to c-Myc, the putative Myc antagonist Mnt is maintained at a constant level during cell cycle entry. (silverchair.com)

The proto-oncogene c- MYC (referred to as MYC ) represents a master regulator via integration of external mitogenic signaling with the activation of genes required for cell cycle progression [ 1 ]. (oncotarget.com)
One example of a gene modification that alters the growth rate is increased phosphorylation of cyclin B, a protein that controls the progression of a cell through the cell cycle and serves as a cell-cycle checkpoint protein. (edu.vn)
The MYC proto-oncogene ( MYC ) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. (nature.com)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)

Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. (sigmaaldrich.com)
In A. thaliana TTG1 acts together with R2R3-MYB and bHLH proteins (called MBW complex) to regulate different aspects of epidermal cell differentiation including the production of proanthocyanidin, anthocyanidin, seed coat mucilage, trichomes and root hairs [ 5 - 12 ]. (biomedcentral.com)
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)

We previously reported a MYC-centered regulatory network in mouse embryonic stem (ES) cells that accounts for the similarity between the ES cells and cancer cells, and is associated with a worse prognosis in cancer, including cancers of the breast [ 20 ]. (nature.com)
We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
Mdm2 is a proto-oncogene that is amplified in approximately 7% of cancers and is frequently seen in soft tissue tumors. (shu.edu)

A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)

Although inherently unstable, growth factor signaling leads to increased MYC levels and its association with MAX forming a transcriptional heterodimer complex that binds to conserved E-box elements (consensus CACGTG) in the promoters of target genes leading to gene activation [ 1 ]. (oncotarget.com)
Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein-protein interaction (PPI) analysis were used to search for crucial target genes and mechanisms. (hindawi.com)
Western blotting and qRT-PCR were used to verify the expression of crucial target genes at the protein and RNA levels, respectively. (hindawi.com)
Network pharmacology analysis and bioinformatics analysis showed that PTGS2, JUN, MYC, and CDKN1A might be crucial target genes in the primary mechanism of SQP in treating NASH and improving the inflammatory response. (hindawi.com)
In the past 5 years, many high-throughput screens based on microarray gene expression profiling, serial analysis of gene expression (SAGE), chromatin immunoprecipitation (ChIP) followed by genomic array analysis, and Myc-methylase chimeric proteins have generated a wealth of information regarding Myc responsive and target genes. (elsevierpure.com)
Despite tremendous advances, the downstream target genes that distinguish between physiologic and tumorigenic functions of c-Myc remain to be delineated. (elsevierpure.com)
Here, we show that c-Myc induction during cell cycle entry leads to a transient decrease in Mnt-Max complexes and a transient switch in the ratio of Mnt-Max to c-Myc-Max on shared target genes. (silverchair.com)

BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. (cancerindex.org)

Expression of Myc is generally induced after mitogenic stimulation of cells or serum induction. (sigmaaldrich.com)
This loss is accompanied with an increased expression of the histone demethylase Jmjd3 and with the recruitment of the MLL1 protein, and correlates with the expression of the Ink4a/Arf genes. (plos.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Expression analysis revealed that mesenchymal master regulators associated with the epithelial-to-mesenchymal transition (EMT) are downregulated during reprogramming in the absence of Kdm5b. (nih.gov)
Our data demonstrates the existence of a homeostasis mechanism whereby mitochondrial function controls MYC expression. (oncotarget.com)
A sub examination was also carried out, in which R2 was set since the referential worth and compared to Mob ailment, to be able to measure the influence of a neighborhood acute mobiliza tion on protein expression and exercise amounts as evi denced by phosphorylation level variations. (dubinhibitors.com)
CD30hi lymphocytes also had 4 fold far more nuclear found ERBB protein and above expression and nuclear localization of ERBB one and 2 are popular in tumors. (dubinhibitors.com)
NFAT2, as an important transcriptional promoter, regulates expression of TNF-α, myc proto-oncogene protein (c-myc), cyclooxygenase-2 (COX-2), Fas ligand (FasL) and also generates crosstalks with ERK/MAPK pathway and AKT/GSK3b signaling, which achieves its control of the cell fate [7-12]. (researchsquare.com)
It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. (bmj.com)
The results of WB and qRT-PCR showed that the expression of PTGS2, JUN, MYC, and CDKN1A was higher in NASH rats than in normal rats and decreased after SQP treatment. (hindawi.com)
The elevated expression of p53 leads to greater stability, which also induces the regulatory protein Mdm2. (shu.edu)
A proto-oncogene is a gene that becomes an oncogene, a gene that has the potential to cause cancer, through mutations or an increase in expression. (shu.edu)

Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)

IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. (oncotarget.com)

Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)

Protein, which is both involved in DNA repair and protein ubiquitination. (plurisomes.com)

Increased manifestation levels of p53, p21, and p27, downregulation of c-myc and Bcl-2, and inhibition of Akt activation were also found in CF-treated MSTO-211 and HCT-116 cells. (bioinf.org)

Cancer theories, oncogenes, genomics. (jcancer.org)

Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic cells. (plos.org)
Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication timing of the INK4a/ARF locus during senescence. (plos.org)
Upon senescence, Jmjd3 is overexpressed and the MLL1 protein is recruited to the locus provoking the dissociation of Polycomb from the INK4/ARF locus, its transcriptional activation and its replication during early S-phase. (plos.org)
Accessory proteins only are required during MMTV replication in mice. (utexas.edu)

Protein-protein interaction network was established by STRING database. (bvsalud.org)
Protein interaction analysis for CCDC94 has been carried out using computational tools. (wikipedia.org)
The protein interaction from the STRING analysis is shown. (wikipedia.org)
Mnt and Myc require interaction with Max for specific DNA binding at E-box sites, but have opposing transcriptional activities. (silverchair.com)

INTERPRETATION: These results demonstrated that an RBD-Fc protein subunit/MF59® adjuvanted vaccine can induce high levels of broadly reactive nAbs, including when used as a booster following prior immunisation of mice with whole ancestral-strain spike vaccines. (bvsalud.org)

On the opposite, MuRF1 was selelck kinase inhibitor by far the most fluctuating protein, reaching a maximal variation amount of 60% in excess of two biopsies taken in similar circumstances 48 hours apart. (dubinhibitors.com)
The protein serine/threonine kinase Akt (also known as protein kinase B or PKB) plays an important role in averting cell death. (bioinf.org)
This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)

METHODS: We report on a protein subunit vaccine comprising the receptor-binding domain (RBD) of the ancestral SARS-CoV-2 spike protein, dimerised with an immunoglobulin IgG1 Fc domain. (bvsalud.org)

Evidence supporting the direct control of the cell cycle by Pc-G proteins in vertebrates came from studies on mouse Bmi1 mutants. (plos.org)
Proto-oncogenes are positive cell-cycle regulators. (edu.vn)
Both genomic and functional analyses of c-Myc targets suggest that while c-Myc behaves as a global regulator of transcription, groups of genes involved in cell cycle regulation, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function are over-represented in the c-Myc target gene network. (elsevierpure.com)
The c-Myc oncoprotein is strongly induced during the G0 to S-phase transition and is an important regulator of cell cycle entry. (silverchair.com)
Furthermore, simultaneous Cre-Lox mediated deletion of Mnt and c-Myc in mouse embryo fibroblasts rescued the cell cycle entry and proliferative block caused by c-Myc ablation alone. (silverchair.com)

Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)
p100 and p105 can however undergo limited proteolysis to generate p52 and p50, respectively, which can form heterodimers with Rel proteins to form transcriptional activators [ 5 ]. (oncotarget.com)

UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)

The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. (oncotarget.com)

These transcription factors are known as masters regulators because its single transcript regulate more than one gene, in this context the regulon word is fascinating more in compass of transcription factors. (scielo.br)
Upstream regulators uniquely associated with 3 h TCPOBOP-exposed females include TNF/NFkB pathway members, which negatively regulate CAR-dependent proliferative responses and may contribute to the relative resistance of female liver to TCPOBOP-induced tumor promotion. (nih.gov)
Some proto-oncogenes work to regulate cell death. (cancerquest.org)
The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)

Therefore, changes in histone acetylation (epigenetic modification that leads to gene silencing), activation of transcription factors by phosphorylation, increased RNA stability, increased translational control, and protein modification can all be detected at some point in various cancer cells. (edu.vn)

Our results suggest that in young cells Polycomb proteins are recruited to the INK4/ARF locus through CDC6 and the resulting silent locus is replicated during late S-phase. (plos.org)
Histone proteins that surround that region lack the acetylation modification that is present when the genes are expressed in normal cells. (edu.vn)
Despite ZNF148 being an established node of the MYC-network in ES cells, and the significance of MYC in driving cancer stem cells traits, the role of ZNF148 in breast cancer remains elusive. (nature.com)
Co-immunoprecipitation The protein was extracted from cells before and after transfection with the method described in Western Blot section. (pdesignal.com)
1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)

E6-AP) is an important member of the ubiquitin proteasome system and a type of ubiquitin protein ligase (E3 enzyme) ( 6 ). (spandidos-publications.com)
In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)

The hallmark of all BL tumours is the translocation between the MYC gene and one of the immunoglobulin (Ig) heavy or light chain loci. (bmj.com)

Without doubt, the first human transforming gene, and more broadly, oncogenes and anti-oncogenes, had been previously theorized by Theodor Boveri. (jcancer.org)

These findings uncover a previously unknown tumor suppressor role for ZNF148, and a transcriptional regulatory circuitry encompassing MYC, ZNF148, and ID1/3 in driving cancer stem cell traits in aggressive breast cancer. (nature.com)

The Inhibitor of DNA binding 3 ( ID3 ) is a member of the ID protein family, consisting of four members ( ID1 to ID4 ). (nature.com)
Our data suggest that Rem precursor is the first known protein inhibitor of AID, which functions in antiviral innate immunity. (utexas.edu)

After protein quantification, 500 μg of each cell lysis was added with 1 μg of CD44 monoclonal antibody and shaken at 4°C overnight, then added with 40 μL of Protein A-agarose and shaken at 4°C for 2 h, finally centrifuged at 2500 rpm for 5 min and washed to collect the precipitation. (pdesignal.com)

Coiled-coil domain containing 94 (CCDC94) is a protein that in humans is encoded by the CCDC94 gene. (wikipedia.org)
From these studies, the c-Myc target gene network is estimated to comprise about 15% of all genes from flies to humans. (elsevierpure.com)

This Recombinant Human MYCN protein is an essential resource for cancer researchers. (cusabio.com)
Equipped with an N-terminal 6xHis-tag, our Recombinant Human MYCN protein facilitates effortless purification and detection. (cusabio.com)
Choose between liquid and lyophilized powder forms to best suit your experimental requirements and elevate your research with our Recombinant Human MYCN protein. (cusabio.com)
Review: In vitro glutathione S-transferase (GST) pull-down assay with recombinant GST-CCNT1, GST-CDK9, and GST-EAF1 together with His-tagged MYCN proteins demonstrated that MYCN directly binds to EAF1 with the highest affinity. (cusabio.com)

In spite of such a broad range of potential targets, the MYC protein is surprisingly a relatively weak transcriptional activator and is presumed to function as a general enhancer of transcription [ 3 , 4 ]. (oncotarget.com)

While in the MAPK pathway, HRAS was decreased and JUN and MYC have been greater. (dubinhibitors.com)

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)

However PTEN professional tein was not differentially expressed, STK11 protein decreased. (dubinhibitors.com)

Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)

Many proteins, including cyclin B, control these checkpoints. (edu.vn)

Two separate analyses had been performed with each and every protein. (dubinhibitors.com)

Insulin-like growth factor-1 (IGF-1), synthesized and secreted by human hepatocytes, is the primary regulator of insulin and serves an important function in regulating the growth and development of the body ( 8 ). (spandidos-publications.com)

The one alternative splice form of CCDC94 encodes for a protein with 161 amino acids. (wikipedia.org)
Sox (SRY-related HMG-box) genes encode a family of transcriptional regulators, which are characterized by a conserved 79-amino acid domain known as HMG-box. (scielo.org)

Oncomodulatory viruses, such as human cytomegaloviruses (HCMV), are known to release over 200 proteins, many of which can alter tumor behavior [ Table 1 ]. (surgicalneurologyint.com)
The protein secondary structure modeled with the SWISS MODEL server revealed that there were two α-helices and four b-strands in BgMm-1 as its human orthologue, and both proteins belonged to the a class of PFD family. (scielo.org)

The autophagophore membrane then elongates and encloses the molecules to be degraded forming an autophagosome, which occurs in two separate conjugation reactions catalyzed by autophagy-related proteins (ATGs). (hindawi.com)

Here we describe a novel link between mitochondria and MYC levels. (oncotarget.com)
Knockdown of let-7 family or miR-34a-5p could partially restore MYC levels following mitochondria damage. (oncotarget.com)

Anatomy15

Organisms11

Diseases24

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes63

Disciplines and Occupations1

Information Science3

Oncogenic4

Viral4

Pathways6

Post-Translational1

Transcription factor6

Overexpression6

Apoptosis5

Proliferation8

Transcriptional activity2

Encodes a protein1

MRNA8

Cellular5

Genes have been identified2

Antagonist1

Progression4

Differentiation3

Cancers3

Suppressors1

Target genes7

Medulloblastoma1

Expression12

Regulates1

Nuclear1

Mutations1

Ubiquitination1

Downregulation1

Genomics1

Replication4

Interaction4

Induce1

Kinase3

Subunit1

Cell cycle5

Form heterodimers2

Cervical cancer1

Mitogenic1

Regulate4

Epigenetic1

Cells8

Ubiquitin protea2

Translocation1

Broadly1

Regulatory1

Inhibitor2

Antibody1

Humans2

Recombinant4

Enhancer1

MAPK1

Stability1

PTEN1

Directly or indirectly1

Cyclin1

Analyses1

Important1

Amino2

Human2

Autophagy1

Mitochondria2