• Camptothecin (CPT) analogues and derivatives serve as a novel class of effective anticancer agents that exert their action against DNA topoisomerase I. This paper presents procedures for the rapid, high frequency regeneration of a camptothecin producing plant, Ophiorrhiza prostrata D. Don from leaf and internode explants via shoot organogenesis. (ejbiotechnology.info)
  • Influence of basal vitamins, growth regulators, and explants on in vitro organogenesis from synthetic seeds of Citrus jambhiri Lush. (myresearchjournals.com)
  • These explants were inoculated separately in tissue culture bottles containing MS[4] medium fortified with various combinations and concentrations of different growth regulators viz. (rroij.com)
  • AtRBR1 plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate maintenance during organogenesis and gametogenesis. (nih.gov)
  • Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. (upf.edu)
  • The high-mobility group (HMG) domain is a DNA-binding motif that is shared abundant non-histone components of chromatin and by specific regulators of transcription and cell differentiation. (embl.de)
  • An understanding of the role of plant growth regulators in shoot branching offers a new pathway to produce multiple stem buds in a palm through in vitro culture. (cgiar.org)
  • Knowing the specific balance between the growth regulators is necessary to establish in vitro shoot cultures, callus induction and shoot regeneration and, hence, to propagate disease-free true to type grape cultivars in a short time. (oeno-one.eu)
  • Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
  • Optimizing the concentration of growth regulators is crucial for the efficient micropropagation of a grape cultivar. (oeno-one.eu)
  • Protocols for enhancing callus culturing, organogenesis and micropropagation of these tentatively threatened wild plants were developed and optimized in this research work. (alquds.edu)
  • Therefore, further studies on organogenesis and hardening were carried out by using leaf derived calli. (rroij.com)
  • A similar protein in mice is an essential regulator of the vertebrate head organizer. (wikipedia.org)
  • Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. (ugent.be)
  • Influence of growth regulators and length of cuttings on the propagation potential of Piper pedicellatum C. DC. (myresearchjournals.com)
  • Embryoids transformed into complete plantlets when transferred to growth regulator free half-strength MS medium. (tubitak.gov.tr)
  • This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. (thermofisher.com)
  • The maximum frequency of shoot regeneration (53.33%) was achieved on the medium supplemented with 1.5 mg L -1 BAP and 0.5 mg L -1 NAA, and the regenerated shoots successfully formed roots on growth regulator-free half strength MS medium. (oeno-one.eu)
  • Finally, we suggest the half strength MS medium that is free from growth regulators for the root formation of the regenerated shoots. (oeno-one.eu)
  • microRNAs (miRNAs) are important regulators in plant growth and development. (biomedcentral.com)
  • using MS-media with specific plant growth regulators were successfully applied. (alquds.edu)
  • The latter can now be treated with certain plant growth regulators (PGR) and so-called elicitors in order to produce secondary metabolites. (brainstorming.com)
  • Effects of antioxidant vitamins on molecular regulators involved in lung hypoplasia induced by nitrofen. (medscape.com)
  • TALT advancement is normally unbiased of organogenesis regulators We following driven the molecular requirements for TALT advancement. (phytid.org)
  • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. (nature.com)
  • It is also key in development of renal and urogenital systems and is required for normal organogenesis. (wikipedia.org)
  • Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. (thermofisher.com)
  • On the other hand, we discovered deposition of mononuclear cells at D10 in both BALB/c and C57BL/6 mice, indicating that the TALT advancement was initiated between D10 and D5, which the various genetics of both strains didn't impact TALT organogenesis (Fig. 1 D and Fig. S1). (phytid.org)
  • Receptor Activator of NF-kB Ligand (RANKL), its receptor RANK and the natural antagonist osteoprotegerin (OPG) are essential regulators of bone resorption. (oncotarget.com)
  • Using genetic mouse-models, we and others identified the RANKL/RANK system as a key regulator of sex hormone, BRCA1 -mutation, and oncogene-driven breast cancer and we proposed that RANKL/RANK might be involved in the initiation of breast tumors. (oncotarget.com)
  • Although more research is needed to confirm the best method to produce coconut clones, based on the literature, for direct shoot organogenesis, it is expected that a treatment of thidiazuron only (for embryo) or in combination with picloram (for immature inflorescence) in Eeuwens Y3 medium would produce the best likelihood of success. (cgiar.org)
  • The establishment of a system for robustly growing normal mouse embryos ex utero from pre-gastrulation to advanced organogenesis represents a valuable tool for investigating embryogenesis, as it eliminates the uterine barrier and allows researchers to mechanistically interrogate post-implantation morphogenesis and artificial embryogenesis in mammals. (nature.com)
  • Organogenesis and somatic embryogenesis in tomato ( Lycopersicon esculentum Mill. (scialert.net)
  • Regeneration occurred as a result of somatic embryogenesis and organogenesis. (edu.pl)
  • Introduction: In recent years, the application of nanoparticles has been used successfully in plant tissue culture, which has a tremendous impact on the removal of microbial contamination of the explant through the use of these materials and also the positive role of these materials in callus formation, organogenesis, somatic embryogenesis, somaclonal variation and production of secondary metabolites. (ac.ir)
  • Cross-stage comparisons will identify candidate cell-intrinsic regulators of the embryonic-to-adult pluripotency transition and will reveal changes in the PSC lineage repertoire during embryogenesis. (nih.gov)
  • TDZ-induced direct shoot organogenesis and somatic embryogenesis on cotyledonary node explants of lentil (Lens culinaris Medik. (notulaebiologicae.ro)
  • Sub-culturing of cotyledon somatic embryos in MS liquid medium without growth regulators was performed to obtain well developed shoots with roots. (vegetosindia.org)
  • Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. (novusbio.com)
  • DESCRIPTION (provided by applicant): Regulation of Hoxa1 Gene Expression in Mouse Embryonic Stem Cells The homeobox (Hox) family of transcription factors comprises important regulators of embryonic patterning and organogenesis. (hhs.gov)
  • In this work, we present preliminary data that suggests a role for the retinoic acid receptor beta 2 (RARb2) as a negative regulator of Hoxa1 gene expression in mouse Embryonic Stem (ES) cells. (hhs.gov)
  • 2014). Ror2 is best characterized as a positive regulator of a PNU 282987 non-canonical Wnt signaling pathway functioning in mouse embryonic fibroblast (MEF) migration (Nishita et al. (bioskinrevive.com)
  • Our published data suggest that cycling, piwi-1+ embryonic PSCs give rise to adult PSCs as organogenesis begins. (nih.gov)
  • Although pre- and peri-implantation mouse embryos are routinely cultured in vitro 1 , 2 , approaches for the robust culture of post-implantation embryos from egg cylinder stages until advanced organogenesis remain to be established. (nature.com)
  • Fig. 1: Ex utero culture system for growing mouse late-gastrulating embryos until advanced organogenesis. (nature.com)
  • New, D. A. T. Whole-embryo culture and the study of mammalian embryos during organogenesis. (nature.com)
  • Further, these preconception PFC exposures impaired pancreatic organogenesis, decreasing insulin-producing islet area in the resulting embryos. (nih.gov)
  • Cdk1 in fly embryos act in waves to synchronize multiple divisions and is widely known as the master regulator of cell cycle (Deneke et al. (biologists.com)
  • Covering topics from cell-fate determination, genome-wide identification of developmental regulator, to environmental impact on organ development, this symposium will attract a broad audience with interests on organogenesis, signal transduction, stem cell biology, cancer biology, and fetal-environment interaction. (nih.gov)
  • cDNAs reported here code for potential rice homologues of housekeeping molecules, regulators of gene expression, and signal transduction molecules. (iisc.ac.in)
  • The experiment was conducted in the Tissue Culture Laboratory of the Department of Crop Botany, Bangladesh Agricultural University, Mymensingh, Bangladesh for micropropagation of tomato to evaluate the effect of variety and plant growth regulators in MS medium on shoot induction from virus infected calli of tomato plants. (scialert.net)
  • Callus derived shoots were induced on MS medium supplemented with different concentrations and combinations of plant growth regulators (PGRs). (scialert.net)
  • In this study, different plant growth regulators were used for callus induction in lemon grass. (ac.ir)
  • Remarkably, auxin appears to be the only growth regulator that is actively transported throughout the entire plant body to create complex variations in concentration patterns and flow directions over time. (boku.ac.at)
  • PIN proteins represent a plant-specific family of membrane proteins that mediate directional transport of the plant growth regulator auxin, thereby affecting a multitude of developmental processes and growth responses. (boku.ac.at)
  • A key role in the control of auxin transport has been attributed to the localization of PIN proteins, since regulators of PIN localization and intracellular trafficking were found to influence plant development in general and directionality of auxin transport in particular. (boku.ac.at)
  • The plant growth regulators (PGRs) combination and concentrations tested could not stimulate organogenesis after three subcultivations of the callus cultures on the same PGRs-amended solid medium and when cultivated in the liquid but, formation of morphogenic callus was observed. (notulaebiologicae.ro)
  • Effects of plant growth regulators on cell growth and alkaloids production by cell cultures of Lycopodiella inundata. (notulaebiologicae.ro)
  • The Reproductive Developmental Biology Group uses organogenesis of the gonads, reproductive tracts, and external genitalia as a model to delineate the basic process of organ formation and the potential implication of the impacts of environment on reproductive organ formation in fetuses and fertility in adulthood. (nih.gov)
  • Keywords: C. elegans CAM-1 Ror kinase neuronal polarity Introduction Wnts belong to a conserved family of secreted glycoproteins that are important for a wide range of developmental processes that includes cell-fate specification directed cell GRK7 motility organogenesis and stem cell renewal (Komiya and Habas 2008). (bioskinrevive.com)
  • Identification, Structural and Functional Characterization of Dormancy Regulator Genes in Apricot (Prunus armeniaca L. (frontiersin.org)
  • EZH2-repressed genes were enriched for transcriptional regulators of noncardiomyocyte expression programs such as Pax6, Isl1, and Six1. (nih.gov)
  • Fig. 3: Extending the mouse embryo ex utero culture system from pre-gastrulation to advanced organogenesis. (nature.com)
  • We have discovered novel epigenetic mechanisms regulating hematopoietic development and eye development , and we are currently carrying out the first large-scale forward-genetic screen in a vertebrate for tissue-specific epigenetic regulators using a novel transgenic reporter. (nih.gov)
  • This highly successful ongoing screen has resulted in the identification of a large number of new vertebrate epigenetic regulators, which we are now in the process of further characterizing and studying. (nih.gov)
  • Epigenetic marks are crucial for organogenesis, but their role in heart development is poorly understood. (nih.gov)
  • A significant array of genetic evidence during the past years has identified SnRK1 as a key regulator of cellular metabolism during starvation and nutrient acquisition. (plantae.org)
  • This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. (novusbio.com)
  • In mammals, receptor activator of NF-κB ligand (Rankl) is a regulator of osteoclast formation and activation: its misexpression causes osteoclast stimulation and osteoporotic bone loss. (biologists.com)
  • Transcription factor that is involved in regulation of organogenesis. (nih.gov)
  • 13. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. (nih.gov)
  • CDNA libraries were constructed from rice panicles at the stage of branching and flower primordia specification or from panicles undergoing floral organogenesis. (iisc.ac.in)
  • This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. (novusbio.com)
  • Numerous positive and negative regulators of Wnt signaling have been identified and the observation that deregulated Wnt signaling can lead PNU 282987 to cancer (Logan and Nusse 2004) underscores the need for a precise control of molecules that regulate Wnt function. (bioskinrevive.com)
  • B) In some chromatin remodeling mutants auxin-induced lateral root formation is impaired, which correlates with deficiencies in the expression of some core cell cycle regulators. (boku.ac.at)