Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Convertase10
C3 convertase (C4bC2b, formerly C4b2a) belongs to family of serine proteases and is necessary in innate immunity as a part of the complement system which eventuate in opsonisation of particles, release of inflammatory peptides, C5 convertase formation and cell lysis. (wikipedia.org)
The smaller fragment called C3a serves to increase vascular permeability and promote extravasation of phagocytes, while the larger C3b fragment can be used as an opsonin or bind to either type of C3 convertase to form the trimolecular C5 convertase to activate C5 for the membrane attack complex. (wikipedia.org)
Cleavage of complement C3 by a free floating convertase, thrombin, plasmin or even a bacterial enzyme leads to formation of C3a and C3b fragments. (wikipedia.org)
Since C3 convertases cleave C3 to produce C3b which can then form an additional C3 convertase through the alternative pathway, this is a potential mechanism of signal amplification in the complement cascade resulting in the deposition of large numbers of C3b molecules on the surface of activating particles, enabling opsonisation and acute local inflammation. (wikipedia.org)
Properdin (Factor P) is the only known positive regulator of complement activation that stabilizes the alternative C3 convertase (C3bBb). (wikipedia.org)
Decay-accelerating factor (DAF) is another negative regulator of C3 convertase. (wikipedia.org)
It is a membrane protein and regulates also C5 convertase of the classical and alternative pathway. (wikipedia.org)
DAF acts on C2b and Bb and dissociates them rapidly from C4b and C3b - thereby preventing the assembly of the C3 convertase. (wikipedia.org)
C4 binding protein (C4BP) interferes with the assembly of the membrane-bound C3 convertase of the classical pathway. (wikipedia.org)
It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. (cusabio.com)
Proteolytic2
In the classical pathway, this is by sequential proteolytic activation of proteins within the C1 complex (C1q, C1r, C1s) in response to binding to CRP or immunoglobulin, and in the lectin pathway it is driven by mannose binding lectin and its associated serine proteases (MASPs, particularly MASP2 but also MASP1). (wikipedia.org)
Brock J.H., Ortega F., Pineiro A., Bactericidal and haemolytic activity of complement in bovine colostrum and serum: effect of proteolytic enzymes and ethylene glycol tetraacetic acid (EGTA), Ann. (vetres.org)
Membrane-bound2
The overexpression of membrane-bound complement regulatory proteins (mCRPs) on tumour cells helps them survive complement attacks by suppressing antibody-mediated complement-dependent cytotoxicity (CDC). (bvsalud.org)
Normal primary human alveolar type II epithelial cells (AECs) exposed to exogenous complement 3a or 5a, and primary AECs purified from IPF lungs demonstrated decreased membrane-bound DAF expression with concurrent increase in the endoplasmic reticulum (ER) stress protein, ATF6. (bvsalud.org)
Cleavage1
After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B. The Factor B (a zymogen) is cleaved by a plasma serine protease Factor D releasing a small fragment called Ba and generating a larger fragment called Bb that remains attached to C3b. (wikipedia.org)
Receptor1
The role of complement and its receptor in the elimination of immune complexes. (akjournals.com)
CD594
The consequently upregulated CD55/CD59 expression suppresses the complement system and cytokine secretion required for CD8+ T cell activation. (bvsalud.org)
CD55/CD59-neutralizing antibody treatment or mutation of the LINC00973 promoter activates the complement and CD8+ T cells, inhibiting tumor growth. (bvsalud.org)
These findings underscore the critical role of EGFR/Wnt/ß-catenin-upregulated CD55/CD59 expression in inhibiting the complement and CD8+ T cell activation for tumor immune evasion and immune checkpoint blockade resistance and identify a potential combination therapy to overcome these effects. (bvsalud.org)
Bjorge L., Jensen T.S., Kristoffersen E.K., Ulstein M., Matre R., Identification of the complement regulatory protein CD59 in human colostrum and milk, Am. J. Reprod. (vetres.org)
Peptides1
Damereau B., Biological activities of complement-derived peptides, Rev. Physiol. (vetres.org)
C3bBb1
El factor H del complemento inhibe también la asociación de C3b con el FACTOR B DEL COMPLEMENTO para formar la proenzima C3bB, y promueve la disociación de Bb del complejo C3bBb (CONVERTASA C3 DE LA VÍA ALTERNATIVA DEL COMPLEMENTO). (bvsalud.org)
Pathways1
This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators. (akjournals.com)
Increased loss of extracellular cleaved DAF fragments was detected in normal human AECs exposed to complement 3a or 5a, and in lungs of IPF patients. (bvsalud.org)
Serum2
It interacts also with anticoagulant protein S and with serum amyloid P component. (cusabio.com)
We previously constructed an in vitro model comprising cancer cell lines expressing α-gal and serum containing natural antibodies against α-gal and complement. (bvsalud.org)
Bind1
AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
Activation4
C3b, the larger fragment, becomes covalently attached to the microbial surface or to the antibody molecules through the thioester domain at the site of complement activation. (wikipedia.org)
The complement system is a critical immune component, yet its role in tumor immune evasion and CD8+ T cell activation is not clearly defined. (bvsalud.org)
Cooper N.R., Morrison D.C., Binding and activation of the first component of human complement by the lipid A region of lipopolysaccharides, J. Immunol. (vetres.org)
Immune1
Complement deficiency and immune complex disease. (akjournals.com)
Promotes1
Membrane-associated sialic acid promotes high-affinity binding of β1H to C3b without influencing the affinity of B for C3b. (wikipedia.org)
System2
Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. (akjournals.com)
The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. (akjournals.com)
Factor2
Se une al COMPLEMENTO C3B y hace que iC3b (complemento 3b inactivado) sea susceptible al desdoblamiento por el FACTOR I DEL COMPLEMENTO. (bvsalud.org)
CD55 or decay accelerating factor (DAF), a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored protein, confers a protective threshold against complement dysregulation which is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF). (bvsalud.org)
Complex2
HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Human1
Complement-dependent clearance of apoptotic cells by human macrophages. (akjournals.com)
Domain1
It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
Levels1
CD55 protein levels were negatively correlated with miR-132-3p expression in colon cancer tissues. (bvsalud.org)
Family1
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)