Regulator of cell cycle cell division cycle cell cycle. Medical search. Frequent questions

Together, these results show a strong preventive efficacy of silibinin against photocarcinogenesis, which involves the inhibition of DNA synthesis, cell proliferation, and cell cycle progression and an induction of apoptosis. (nih.gov)
Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation]. (nih.gov)
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. (cas.cz)
Efficacious and safe intramyocardial delivery of modified mRNA encoding cell cycle regulators as a gene therapy for cardiac regeneration through resident cardiomyocyte proliferation. (ca.gov)
These results establish that PU.1 mediates chromosome looping and functions as a master regulator of HSC proliferation. (elsevierpure.com)
A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. (nih.gov)
The cell cycle is the process of accurate self-reproduction and proliferation of a cell. (intechopen.com)
Misregulation of the cell cycle may result in malignant cell proliferation, tumorigenesis or cell death. (intechopen.com)
Cytokinins promote cell division and increase cell expansion during the proliferation and expansion stages of leaf cell development, respectively. (answerlib.org)
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow. (haematologica.org)
During the natural developmental process of Drosophila, the developing eye shows a remarkable, tight coordination between cell proliferation and the steps for cell specialisation. (europa.eu)
We show here that PML knockdown (KD) in MDA-MB-231, but not MCF7, breast cancer cells, prolonged stem-cell-like survival, and increased cell proliferation and migration, which is in line with gene-enrichment results from their RNA sequencing analysis. (bvsalud.org)
Through physical interaction or modification of diverse protein clients, PML-NBs regulate a multitude of - often antithetical- biological processes such as antiviral and stress response, inhibition of cell proliferation and autophagy, and promotion of apoptosis or senescence. (bvsalud.org)
Functional loss of p16 may lead to uncontrolled cell proliferation 3,4 . (bvsalud.org)
Present study was designed to determine the impact of cadmium on cell proliferation, cell cycle and apoptosis, and to investigate the possible involvement of p53 and MAPKs signaling pathways in J774A.1 murine macrophages. (cdc.gov)
Cd inhibited cell proliferation via cell cycle arrest and induced apoptosis in a dose-dependent manner. (cdc.gov)
Inhibition of ERK suppressed DNA synthesis and had an additive effect with Cd-inhibited proliferation suggesting that Cd-induced ERK activity is not responsible for the G2/M arrest and subsequent inhibition of cell proliferation. (cdc.gov)
In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)

These proteins are also catalysts for a process called apoptosis , or "programmed cell death. (breastcancerconqueror.com)
If it cannot be repaired, P53 will signal for the cell to undergo apoptosis, or cancer cell death. (breastcancerconqueror.com)
Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)
The first project focuses on E2F1, a regulator of genes important for cell cycle progression and apoptosis. (mdanderson.org)
The effects of CMTM4 on cellular apoptosis and cell cycle progression were analysed by flow cytometry, and cell cycle hallmarks were detected by western blotting and RT-PCR. (biomedcentral.com)
Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
Effect of cadmium on P53 and mitogen-activated protein kinases in a murine macrophage cell line: relation to apoptosis. (cdc.gov)
It is immunotoxic in vivo and induces apoptosis in many cultured cells. (cdc.gov)
Results suggested that p53 is not involved in Cd-induced cell cycle arrest and apoptosis in J774A.1 cells. (cdc.gov)

Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. (kegg.jp)
CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. (kegg.jp)
Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome replication and partitioning to daughter cells. (ebi.ac.uk)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
In that position, it regulates cell cycle progression. (univmiami.net)
SRA737 is a potent, highly selective, orally bioavailable small molecule inhibitor of Checkpoint kinase 1 (Chk1), a key regulator of cell cycle progression and the DNA Damage Response (DDR). (salesandmarketingnetwork.com)
A report published Physica Energetics calls P53 the "master regulator of cell cycle progression. (breastcancerconqueror.com)
Therefore, understanding how the division of the cells, i.e. the cell cycle, is coordinated with their responses to the external clues is key to understanding the causes of the formation and progression of tumours as well as the pathology of degenerative disorders, which will ultimately help develop new therapeutic strategies to these diseases. (europa.eu)
Correspondingly, most cancer signaling pathways seem to converge on one or more TFs, termed "master regulators" (MRs) [ 4 ], which direct tumor development, progression, and metastasis through hierarchical control of gene expression patterns. (aging-us.com)
Essential for DNA repair in response to any endogenous or environmental assaults thereby allowing smooth progression of the cell cycle. (incozen.com)
CDK inhibitors interfere with multiplication of cancer cells thereby playing a major role in attenuating progression of tumors. (incozen.com)
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
Immunohistochemical identification of molecular genetic events in the progression of preneoplastic lesions to spindle cell squamous-cell carcinoma enables early detection of lesions with the potential for malignant progression, thus permitting timely intervention 1,2 . (bvsalud.org)

The latest advances in the field of spinal cord development and its regeneration following damage were discussed at a recent EMBO workshop 'Spinal cord development and regeneration' in Sitges, Spain (October, 2014), highlighting the use of direct visualization of cellular processes, genome-wide molecular techniques and the development of methods for directed stem cell differentiation and regeneration. (biologists.com)
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)
Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
The Draviam lab aims to understand the molecular principles that govern cell division and the consequence of its failure when cells transition between states during differentiation. (qmul.ac.uk)
Together with MSD, the project aims to focus on developing AI methods to track iPSC (induced Pluripotent Stem Cells) differentiation to neural precursors, astrocytes and neurons. (qmul.ac.uk)
During the process of differentiation, quiescence and senescence are two cell dormancy states with distinct cell fates and transcriptomic statuses. (qmul.ac.uk)
APA naturally occurs during development and cellular differentiation, with around 70% of human genes displaying APA in particular tissues and cell types. (stanford.edu)
Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
Here, we utilized microarrayed patterns to provide a controlled biochemical and biomechanical microenvironment for mouse liver progenitor cell differentiation. (elifesciences.org)
We investigated the impact of downstream signaling, showing that peripheral biliary differentiation is dependent not only on Notch and TGFβ but also E-cadherin, myosin-mediated cell contractility, and ERK. (elifesciences.org)
Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
These reflect the differentiation between the immature B-cell of chronic lymphocytic leukemia and the plasma cell of multiple myeloma. (medscape.com)

A cells cycle is positively regulated promoting progress through the stages via the interaction of two classes of proteins found in the cytoplasm. (jove.com)
2007). The Biarsenical Dye Lumioâ ¢ Exhibits a Reduced Ability to Specifically Detect Tetracysteine-Containing Proteins Within Live Cells. (wikipedia.org)
I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
The mechanism, which is based on the synthesis and degradation of three ''master regulator'' proteins (CtrA, GcrA, and DnaA), is converted into a quantitative model, in order to study the temporal dynamics of these and other cell cycle proteins. (ebi.ac.uk)
Since many of the proteins involved in regulating the cell cycle of C. crescentus are conserved among many genera of a-proteobacteria, the proposed mechanism may be applicable to other species of importance in agriculture and medicine. (ebi.ac.uk)
Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
P53 produces proteins that repair damaged cells. (breastcancerconqueror.com)
Cell-type-specific interacting proteins collaborate to regulate the timing of Cyclin B protein expression in male meiotic prophase. (stanford.edu)
Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
One of the critical factors for the control of the protein levels during the cell cycle is the Anaphase Promoting Complex/Cyclosome (APC/C). This complex recognises proteins with specific signatures (or degrons) and targets them for degradation via the protein destruction machinery called the proteasome. (europa.eu)
Moreover, they can bind to proteins and nanoparticles through the biotin-streptavidin interaction and mediate their delivery to cells. (bvsalud.org)
Furthermore, two streptavidin-conjugated model proteins, alkaline phosphatase and horseradish peroxidase can be delivered into the cell cytoplasm in their enzymatically active form. (bvsalud.org)
The field of research of bacterial serine/threonine phosphorylation is fairly new, and while the advance of phosphoproteomics allowed to detect an increasing number of proteins that are phosphorylated in bacteria, biosensors able to report phosphorylation in single bacterial cells are still lacking, compared to the vast array of phosphorylation biosensors designed for eukaryotic cells. (fems-microbiology.org)
To tackle this, I constructed different fluorescent hybrid proteins able to report StkP activity in single pneumococcal cells, or interacting specifically with its phosphorylated substrates. (fems-microbiology.org)

When B levels drop, the cell exits mitosis and divides. (jove.com)
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. (antikoerper-online.de)
Cytokinesis begins after chromosome separation in mitosis and ends when the cell divides. (jove.com)

At the cellular level, several processes are highly controlled, including the establishment and maintenance of apico-basal polarity, the control of the cell cycle and cell cycle exit, and the acquisition of cell subtype identities. (biologists.com)
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)

The results of GO analysis showed that the downregulated genes were significantly enriched in matrix adhesion and angiogenesis and upregulated differential genes were significantly enriched in cell adhesion and vascular development. (hindawi.com)
Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism, signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. (biomedcentral.com)
14 , 15 HIF-1 and HIF-2 mediate adaptive responses to hypoxia by inducing the transcription of genes associated with erythropoiesis, glycolytic metabolism, cell survival and angiogenesis. (haematologica.org)
The majority of cell cycle regulators, including APC/C, as well as the genes regulating cells' responses to external cues, are very similar between Drosophila and mammals, although the genetic circuit in Drosophila is relatively simple and less complex compared to mammals. (europa.eu)
Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. (aging-us.com)

For instance, during G1, when one type of cyclin, named D, is synthesized and binds to a CDK, the cell transitions into S phase, as another cyclin, E, peaks and forms a complex with CDK to promote DNA replication. (jove.com)
Positive regulators include two protein groups that allow cells to pass through regulatory checkpoints: cyclins and cyclin-dependent kinases (CDKs). (jove.com)
Generally, levels of a given cyclin are low during most of the cell cycle but abruptly increase at the checkpoint they most contribute to (G 1 cyclins are an exception, as they are required throughout the cell cycle). (jove.com)
Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. (kegg.jp)
1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
Enables cyclin-dependent protein serine/threonine kinase regulator activity. (nih.gov)
Previous work showed that the cell cycle regulator Cyclin B (CycB) is subject to translational repression in immature spermatocytes, mediated by the RNA-binding protein Rbp4 and its partner Fest. (stanford.edu)
Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. (bvsalud.org)
Overexpression of cyclin D1 protein, an important cell-cycle regulator, has been observed in hairy cell leukemia and may play a role in the molecular pathogenesis of the disease. (medscape.com)

Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. (kegg.jp)
Prezygotic transcripts included multiple regulators that are most likely involved in developmental processes that take place long after fertilization, such as components of ErbB, hedgehog, notch, retinoid, TGFb, VEGF and Wnt signaling pathways, as well as transcripts involved in the development of nervous system. (biomedcentral.com)
Most of the identified module pairs cover cooperative pathways and components essential to the cell cycle. (biomedcentral.com)
Several pathways involved in cell cycle and DNA repair were affected upon NV651 treatment. (lu.se)

Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)

Methods: fifteen histological specimens of spindle cell squamous cell carcinoma of the lower lip were obtained from the Department of Oral Pathology, Bahia Federal University. (bvsalud.org)
The mitotic kinase monopolar spindle 1 (Mps1) is a key regulator of the Spindle assembly checkpoint, which ensures the correct chromosome segregation. (lu.se)

Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. (springer.com)
Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
Restoration of CMTM4 significantly suppressed 786-O cell growth by inducing G2/M cell cycle arrest and p21 upregulation, and cell migration was also inhibited. (biomedcentral.com)
Cd at 20 microM markedly increased cells in G2/M and hypodiploid sub-G1 phases of the cell cycle suggesting cycle arrest and cell death. (cdc.gov)

Cytokinin positively regulates cell division and also serves a key role in establishing organization within shoot stem cell centers. (answerlib.org)
CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)

2015. Versatility of global transcriptional regulators in alpha-Proteobacteria: from essential cell cycle control to ancillary functions. (csun.edu)
TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii. (pluginlabs-hautsdefrance.fr)

SRA141 is a potent, selective, orally bioavailable small molecule inhibitor of Cell division cycle 7 kinase (Cdc7). (salesandmarketingnetwork.com)
Description: RET is a receptor kinase for GDNF (glial cell-line derived neurotrophic factor) family ligands (GFLs). (morulaivf.com)
Description: Bruton's tyrosine kinase or BTK, is an enzyme that plays a role in the functionality and maturation of B cells. (morulaivf.com)
This kinase is acknowledged as a central regulator of pneumococcal cell division and cell wall synthesis, but it is still not understood when and in which order StkP phosphorylates its substrates in the course of the cell cycle. (fems-microbiology.org)

A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation. (ebi.ac.uk)
To develop a data-driven model of cell cycle regulation, we used contiguous, dynamic measurements over two time scales (minutes and hours) calculated from static multiparametric cytometry data. (ebi.ac.uk)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
During meiosis, germ cell and stage-specific components impose additional layers of regulation on the core cell cycle machinery to set up an extended G2 period termed meiotic prophase. (stanford.edu)
The hypoxic regulation of CXCL12 was examined in multiple myeloma plasma cell lines using polymerase chain reaction and western blotting. (haematologica.org)
My thesis work was on the understanding of the regulation of the morphogenesis and cell division by serine/threonine phosphorylation in the human pathogen Streptococcus pneumoniae . (fems-microbiology.org)
Despite their importance for immunity against sexually transmitted infections (STIs), the composition of female reproductive tract (FRT) memory T cell populations in response to changes within the local tissue environment under the regulation of the menstrual cycle remains poorly defined. (cdc.gov)
[ 7 ] Similarly, in 2001, Priolo and Laganà reclassified the ectodermal dysplasias into 2 main functional groups: (1) defects in developmental regulation/epithelial-mesenchymal interaction and (2) defects in cytoskeleton maintenance and cell stability. (medscape.com)
[ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)
Hancock, 2004), and cell volume regulation (Garner and technique known as magnetic relaxation dispersion (MRD). (lu.se)

Caulobacter's obligate cell cycle is controlled by oscillating master regulators that control different genetic modules in space and time. (csun.edu)

Piller also worked with the John Curtin School of Medical Research, where she became a visiting fellow with their Division of Biochemistry and Molecular Biology. (wikipedia.org)
Joyce M. Slingerland, director of the Braman Family Breast Cancer Institute at Sylvester at the University of Miami Miller School of Medicine, led a team of researchers in collaboration with David Helfman, professor of cell biology and anatomy at Sylvester. (univmiami.net)
Although widespread, the role of APA in the biology of cells, tissues, and organisms has been controversial. (stanford.edu)
6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)

In fact, it can lose its restraining action on cell growth and bind to other molecules to promote cell motility, one of the first steps in the spread of cancer. (univmiami.net)
Indeed, PML displayed tumor cell pro-survival and pro-migratory functions via inhibition of migration suppressing molecules or promotion of transforming growth factor beta (TGF-ß) mediated Epithelial-Mesenchymal Transition (EMT) that may promote cancer cell dissemination. (bvsalud.org)

Cyclins can be categorized as G 1 , G 1 /S, S, or M cyclins based on the cell cycle phase or transition they are most involved in. (jove.com)
Cell cycle regulators that bind to cyclins and participate in the cell division process. (incozen.com)

and syncytial blastoderm mitotic cell cycle. (nih.gov)
Treatment with the novel cyclophilin inhibitor NV651, presented a potent antiproliferative effect in HCC cell lines via cell cycle perturbations arresting cells in the mitotic phase. (lu.se)
Targeting the cell cycle has been proposed as a therapeutic strategy in cancer treatment with special interest in the mitotic phase. (lu.se)
We could confirm the increased polyploidy upon Mps1 inhibition in neuroblastoma cell lines and PDX model, leading to mitotic catastrophe activating the caspase-dependent mitochondrial apoptotic pathway. (lu.se)

REG4, an important regulator of gastro-intestinal carcinogenesis, was highly expressed in KRAS mutant lung adenocarcinoma with low expression of TTF-1 (KC subtype). (cancerindex.org)
Other markers, such as retinoblastoma and p53, may be related with early steps of carcinogenesis in oral cavity squamous cell carcinoma. (bvsalud.org)

When this complex forms the CDK can phosphorylate a target protein which alters it's function and initiates the cell to advance to the next phase. (jove.com)

For some time, researchers have known that the protein p27 is an important inhibitor of the cell division that spreads cancer. (univmiami.net)
The growth inhibitor p27 is a key regulator of cell division and motility, and resides in the nucleus. (univmiami.net)
Accordingly, pre-treatment with 350 nM LSD1 inhibitor for 3 days followed by exposure to serial dilutions of ruxolitinib led to synergistic growth inhibition in non-DS-AMKL and ML-DS cell lines (Supplementary Fig. 4 ), as well as in all ML-DS patient samples (Fig. 1A ). (nature.com)
Cycloheximide, an inhibitor of protein synthesis, did not alter Cd-induced cytotoxicity indicating that J774A.1 cell death by Cd is independent of de novo protein synthesis including p53. (cdc.gov)

Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)

Only by further elucidating the control mechanisms of bacterial cell division can we advance the development of new antimicrobial compounds. (csun.edu)
While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
These results are consistent with previous studies and demonstrate that our methodology is effective for studying cooperative mechanisms in the cell cycle. (biomedcentral.com)
[ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)

Motile swarmer cells can not undergo DNA replication until they differentiate into stationary stalked cells. (csun.edu)
Stalked cells are competent for DNA replication and cell division. (csun.edu)
p)ppGpp modulates cell size and the initiation of DNA replication in Caulobacter crescentus in response to a block in lipid biosynthesis. (csun.edu)
2012. The Caulobacter crescentus ctrA P1 promoter is essential for the coordination of cell cycle events that prevent the overinitiation of DNA replication. (csun.edu)
In this chapter, we mainly discuss the coordination regulations between DNA replication initiation and other cell cycle events that ensure genomic integrity. (intechopen.com)
DNA replication occurs once and only once per cell cycle mainly regulated by DNA replication initiation factors in eukaryotic cells. (intechopen.com)
Cdc7 is a key regulator of DNA replication and is involved in the DDR network, making it a compelling emerging target for the potential treatment of a broad range of tumor types. (salesandmarketingnetwork.com)

Internal regulatory checkpoints ensure that a cell's size, energy reserves, and DNA quality and completeness are sufficient to advance through the cell cycle. (jove.com)
At these checkpoints, positive and negative regulators promote or inhibit a cell's continuation through the cell cycle. (jove.com)
However, when p27 localization is shifted out into the cell's cytoplasm, it takes on a different role, promoting cell motility and tumor spread. (univmiami.net)

Downstream targets of CDKs include transcription factor E2F and its regulator Rb. (kegg.jp)
Although several regulators that control this mechanism have been identified, we demonstrate that the transcription factor PU.1 acts upstream of these regulators. (elsevierpure.com)
PU.1 prevented excessive HSC division and exhaustion by controlling the transcription of multiple cell-cycle regulators. (elsevierpure.com)
12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
Intensive study has demonstrated interactions with host-cell signal transduction and possibly eukaryotic transcription. (cdc.gov)

An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)
NV556 treatment in an in vitro 3D human liver Extracellular Matrix (ECM) cultured with a TGFβ1-activated human hepatic stellate cell line led to decreased collagen production. (lu.se)

From published experimental evidence, we propose a molecular mechanism for control of the cell division cycle in Caulobacter crescentus. (ebi.ac.uk)
When this happens, this essential genetic mechanism simply stops protecting you from cell overgrowth. (breastcancerconqueror.com)
An intrinsic mechanism that through the secretion of a specific molecule called Wingless by the neighbouring cells, instruct the receiving cells to keep their proliferative state. (europa.eu)
Combining what I had been studying in PhD and Postdoc, I am currently investigating at MMSB the molecular mechanism of antibiotics escape in Streptococcus pneumoniae with a focus on the role of serine/threonine phosphorylation regarding antibiotic stress, and more generally how this bacterium grows and divides. (fems-microbiology.org)

The right balance between these two fates of cells is essential not only for forming proper shapes of organs and tissues but also for maintaining their functions throughout the life of the organisms. (europa.eu)
Alternatively, all the cells may become specialised and stop producing new cells, which accelerates the degeneration of tissues or the ageing process. (europa.eu)
Primary clear cell renal cell carcinoma (ccRCC) and the paired adjacent non-tumour tissues were then collected to examine the expression of CMTM4 by western blotting, immunohistochemistry, and quantitative RT-PCR. (biomedcentral.com)
Western blotting then confirmed that CMTM4 was dramatically reduced in 86.9 % (53/61) of ccRCC tissues compared with the paired adjacent non-tumour tissues, as well as in the 786-O and A498 ccRCC cell lines. (biomedcentral.com)
Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. (pluginlabs-hautsdefrance.fr)
Cyclophilin overexpression is a common event in fibrotic tissues playing a key role in different stages of the fibrotic process, including inflammation, hepatocyte death, and activation of the hepatic stellate cells leading to increased collagen production. (lu.se)

Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. (haematologica.org)
Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
This hypothesis has not been confirmed by other reports, although a French study that evaluated occupational exposure to pesticides and lymphoid neoplasms among men appears to support the hypothesis that occupational pesticide exposures may not only be involved in hairy cell leukemia, Hodgkin lymphoma, and multiple myeloma, but also may play a role in non-Hodgkin lymphoma. (medscape.com)

Immuno-oncology has gained high visibility over the last decade with agents priming the hosts immune cells to target tumors. (incozen.com)
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and accounts for approximately 60% to 70% of all renal tumors [ 1 ]. (hindawi.com)
Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)
Recently, new DNA scanning techniques using whole-exome sequencing identified 5 missense somatic clonal mutations, including a heterozygous mutation in BRAF that results in the BRAF V600E variant protein, which is oncogenic for other tumors as well, was identified in all hairy cell leukemia patients and may be responsible for the pathogenesis, diagnosis, and targeted therapy of hairy cell leukemia. (medscape.com)

The model accounts for important details of the physiology, biochemistry, and genetics of cell cycle control in stalked C. crescentus cell. (ebi.ac.uk)

We demonstrate that streptavidin-conjugated gold nanoparticles can be transported into NIH3T3 fibroblast and HeLa cancer cell lines. (bvsalud.org)

In a number of animal species, MZT roughly coincides with the mid-blastula transition (MBT) [ 20 ] when cells become motile and divide asynchronously. (biomedcentral.com)

The ccRCC cell lines A498 and 786-O and the normal renal tubular epithelial cell line HK-2 were also tested for CMTM4 expression by western blotting. (biomedcentral.com)

In males mutant for rbp4 or lut, spermatocytes enter and exit meiotic division 6-8 hours earlier than in wild-type. (stanford.edu)

This protein is a molecular chaperone with specific function in cell signal transduction. (nih.gov)

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. (nih.gov)
2) Therefore, the proper control of protein levels is crucial for the cell cycle. (ukessays.com)
Accumulating evidence suggests that the APC/C is involved in the control of the balance between cell division and specialisation, however, the knowledge about how the APC/C accomplishes such a task remains scarce. (europa.eu)
In turn, the plant produces GA, which seems to combat the improper growth signals and re-establishes cell-cycle control. (nature.com)
As an outcome of the two-part signalling and/or cell-cycle control. (who.int)

How do cytokinins regulate the cell cycle? (answerlib.org)
Cytokinins were discovered during the 1950s because of their ability to induce plant cell division (1). (answerlib.org)

Activating mutations upstream may also underlie some epigenetic or within the ERK1/2 cascade are events that change cell signalling. (who.int)

This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)

Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)

The meeting, organized by Elisa Martí (IBMB-CSIC, Barcelona, Spain), Jonas Muhr (Karolinska Institutet, Stockholm, Sweden) and Kate Storey (University of Dundee, UK), brought together international researchers interested in spinal cord development and those who are developing strategies to restore the function of the spinal cord in pathological situations using regeneration of the damaged tissue, including controlled cell replacement. (biologists.com)

abstract = "To provide a lifelong supply of blood cells, hematopoietic stem cells (HSCs) need to carefully balance both self-renewing cell divisions and quiescence. (elsevierpure.com)

The progenitor cells of the developing liver can differentiate toward both hepatocyte and biliary cell fates. (elifesciences.org)

For example, neurons tend to express mRNAs with long 3'UTRs due to preferential processing at PASs more distal than other PASs used in other cell types. (stanford.edu)

10) Therefore, it is important to evaluate its role in the cell cycle and its dysregulation. (ukessays.com)

These results provide a global view of the cell cycle and the method can be used to discover the dynamic coordination properties of functional components in other cellular processes. (biomedcentral.com)

Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University ( www.upol.cz ) and the Institute of Experimental Botany of the Czech Academy of Sciences ( www.ueb.cas.cz ). (cas.cz)
Laboratory of Growth Regulators guarantees the teaching for biological study programs. (cas.cz)
P53 is similar to the BCRA gene in that, when it is working properly, it actually protects against the excessive growth of cancer cells. (breastcancerconqueror.com)
By stimulating cell division , they regulate shoot meristem size, leaf primordia number, and leaf and shoot growth. (answerlib.org)
Is cytokinin a growth regulator? (answerlib.org)
Which hormone is known as growth regulator? (answerlib.org)
Our HCC signature covered well-established liver cancer hallmarks, and network analyses revealed coordinated interaction between several MRs. One novel MR, SEC14L2 , exerted an anti-proliferative effect in HCC cells and strongly suppressed tumor growth in a mouse model. (aging-us.com)
Cell Counting Kit-8 (CCK-8) and viable cell counting assays were used to delineate the growth curves of 786-O cells after CMTM4 overexpression or knockdown. (biomedcentral.com)
In line with these results, tumor xenografts of MDA-MB-231 PML-KD cells had enhanced aggressive properties, including higher microvessel density, faster local growth, and higher metastatic ability, with a preference for lung. (bvsalud.org)
Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)

Efficacy of modRNA delivery of cell cycle regulators on improving ejection fraction in mice with acute myocardial infarction (MI). (ca.gov)
Evaluate safety parameters for modRNA delivery of cell cycle regulators in mice and rats. (ca.gov)

Anatomy27

Organisms18

Diseases2

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes85

Disciplines and Occupations1

Information Science4

Health Care2

Proliferation21

Apoptosis12

Progression15

Differentiation13

Proteins15

Mitosis3

Polarity2

Genes5

Cyclin9

Pathways4

Expression in Multiple Myeloma2

Spindle2

Arrest4

Regulates2

Transcriptional2

Kinase4

Regulation10

Master regulators1

Biology4

Molecules2

Cyclins2

Mitotic4

Carcinogenesis2

Phase1

Inhibitor4

Pathway1

Mechanisms4

Replication7

Cell's3

Transcription5

Vitro3

Mechanism4

Tissues6

Multiple Myeloma4

Tumors4

Biochemistry1

HeLa1

Motile1

Epithelial cell1

Meiotic division1

Signal transduction1

Control5

Cytokinins2

Upstream1

Genetic1

Genetics1

Regeneration1

Abstract1

Fates1

Neurons1

Important1

Processes1

Growth10

Mice2