• AML has a characteristic dependency on chromatin and transcriptional regulators, which has been discussed in many reviews. (frontiersin.org)
  • Hepatic gluconeogenesis is controlled in part by the concerted actions of transcriptional regulators. (e-enm.org)
  • More recent reports suggest that PRMTs can affect transcription by direct modification of transcriptional regulators. (e-enm.org)
  • Interestingly, recent reports suggest that PRMTs function as regulators of fuel metabolism through interaction with a number of transcriptional regulators in the pathway. (e-enm.org)
  • Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. (wikipedia.org)
  • To date, the different types of regulators involved in polyene macrolide biosynthesis have been categorized as follows: (1) Streptomyces antibiotic regulatory protein (SARP) family regulator, such as ActII-orf4, which regulates actinorhodin biosynthesis, and CcaR, which regulates clavulanic biosynthesis. (biomedcentral.com)
  • Thus, Ankrd11 is a crucial epigenetic regulator of neural development that regulates histone acetylation and gene expression, thereby providing a likely explanation for its association with cognitive dysfunction and ASD. (springeropen.com)
  • Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection. (uthscsa.edu)
  • The multivalent chromatin regulator BRPF1 (bromodomainand plant homeodomain-linked (PHD) zinc finger-containing protein 1) recognizes different epigenetic marks and activates three histone acetyltransferases, so it is both a reader and a co-writer of the epigenetic language. (canada.ca)
  • More specifically, the volatile chemicals released by the damaged plants enhanced histone acetylation and the response of defense gene regulators, such as the ethylene response factor genes " ERF8 " and " ERF104 ," together with a specific set of histone acetyltransferase enzymes (HAC1, HAC5, and HAM1). (earth.com)
  • Fasting signals are relayed by various intracellular enzymes, such as kinases, phosphatases, acetyltransferases, and deacetylases, which affect the transcriptional activity of transcription factors and transcriptional coactivators for gluconeogenic genes. (e-enm.org)
  • 14733) putative transcriptional regulator%2C AsnC family CP001857 CDS Arcpr_0015 complement(14711. (go.jp)
  • The genomic island harbours genes for the restriction-modification system commonly found on SCC elements, a putative transposon with IS6 family element similar to IS431mec, a putative transcriptional regulator and accessory genes, which have been found frequently on plasmids. (muni.cz)
  • These chromatin modifiers are important regulators of development and deregulated in cancer. (edu.au)
  • The hexosamine biosynthetic pathway (HBP) and its end product uridine diphosphate N-acetyl glucosamine (UDP-GlcNAc) are important regulators of cell signaling that favor tumor promotion. (biomedcentral.com)
  • More recently, Tim has completed a drug discovery project, developing acetyltransferase inhibitors and a new class of anti-cancer therapeutics. (edu.au)
  • Importantly, strains lacking subunits of the NuA4 H4 histone acetyltransferase complex, orthologous to a complex previously shown in Drosophila to be associated with a similar gene dosage compensation mechanism, did not show an increase in H4 acetylation. (biomedcentral.com)
  • The KAT5 (Tip60/Esa1) histone acetyltransferase is part of NuA4, a large multifunctional complex highly conserved from yeast to mammals that targets lysines on H4 and H2A (X/Z) tails for acetylation. (uthscsa.edu)
  • Histone acetyltransferase 1 (HAT1) has been reported to be essential for mammalian development and genome stability, and involved in multiple organ aging. (bvsalud.org)
  • In this study, we found that the previously identified PWWP-EPCR-ARID-TRB (PEAT) complex components interact with both the ubiquitin-specific protease UBP5 and the redundant histone acetyltransferases HAM1 and HAM2 (HAM1/2) to form a larger version of PEAT complex in Arabidopsis thaliana. (bvsalud.org)
  • Finally, the Ankrd11 knockdown-mediated decrease in precursor proliferation was rescued by inhibiting histone acetyltransferase activity or expressing HDAC3. (springeropen.com)
  • Thus, the deacetylase activity of HDAC3 is a powerful negative regulator of fear memory formation in multiple subregions of the fear circuit. (mysciencework.com)
  • Targeting ∼7000 genes with this methodology, we discovered SAGA complex members Tada2b and Taf5l as key regulators of HSC lineage commitment. (biorxiv.org)
  • We have previously reported multiple genes encoding negative regulators of laboratory resistance to echinocandins or sorbose that are scattered across Ch5 [ 9 ]. (biomedcentral.com)
  • These cells express the master regulator transcription factor (TFs) Foxp3. (encyclopedia.pub)
  • Finally, we examine the conservation of 135 USA300 TFs amongst 11 other S. aureus strains, identifying a key group of regulators that display a high degree of conservation, including many that have previously been demonstrated to play a role in virulence gene regulation. (biomedcentral.com)
  • GNA1/GNPNAT1 (glucosamine-6-phosphate N-acetyltransferase) then converts glucosamine-6P (which can also be made by glucosamine entering the cell) into GlcNAc-6P (N-acetylglucosamine-6-Phosphate), also utilizing acetyl-CoA that is made from fatty acid metabolism. (biomedcentral.com)
  • In the next step, the enzyme glucosamine-phosphate N-acetyltransferase (GNPNAT) catalyzes Ac-CoA and glucosamine-6-phosphate to generate N-acetylglucosamine-6-phosphate (GlcNAc-6P) and CoA. (biomedcentral.com)
  • In this study, using domain structure and amino acid alignment and phylogenetic tree construction, rimR 2, which located in the rimocidin biosynthetic gene cluster, was first found and identified as a larger ATP-binding regulators of the LuxR family (LAL) subfamily regulator. (biomedcentral.com)
  • HDACs are known to be powerful negative regulators of memory formation, but it is not clear whether this function depends on HDAC enzymatic activity per se. (mysciencework.com)
  • We will also take a Systems Biology approach to model the stochastic establishment of drug tolerance, and how this random process depends on epigenetic regulators. (findaphd.com)
  • NAT10 (N-acetyltransferase 10) has been reported to promote transcription of RNA polymerase I and is a critical regulator of p53 homeostasis. (confex.com)
  • A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
  • Predicted to be part of histone acetyltransferase complex and transcription regulator complex. (zfin.org)
  • The dynamics of the expression of the main flowering regulators was consistent with previous reports: notably, the expression of FLOWERING LOCUS C ( FLC ) decreased over the course of the time series while expression of LEAFY ( LFY ) increased. (biomedcentral.com)
  • The Thomas lab has a long-term interest in understanding the epigenetic regulation of embryonic development and in particular has characterised the function of histone acetyltransferases. (edu.au)
  • Ankrd11 is a potential transcriptional regulator that is implicated in cognitive dysfunction and ASD, but has no known function in the brain. (springeropen.com)
  • Dr. Jacobs described Vaccinia viruses deficient in E3L, a regulator of the cellular antiviral response and noted their potential for the production of improved vaccines. (cdc.gov)
  • A LAL regulator RimR2 was identified as a positive specific-pathway regulator of rimocidin biosynthesis in M527. (biomedcentral.com)
  • Unlike sequence-specific transcription factors, epigenetic regulators do not necessarily bind DNA at consensus sequences, but still achieve reproducible target binding in a manner that is cell and maturation-type specific. (frontiersin.org)