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Transcription FactorsMEF2 Transcription FactorsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceTranscriptional ActivationBinding SitesTrans-ActivatorsMyogenic Regulatory FactorsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerProtein BindingNuclear ProteinsTranscription Factor AP-1Repressor ProteinsCell LineGene Expression Regulation, DevelopmentalForkhead Transcription FactorsHomeodomain ProteinsSignal TransductionAmino Acid SequenceDNABasic-Leucine Zipper Transcription FactorsMutationTranscription Factor AP-2Cell NucleusCell DifferentiationTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIGenes, ReporterChromatin ImmunoprecipitationGATA4 Transcription FactorHeLa CellsCells, CulturedYY1 Transcription FactorSTAT3 Transcription FactorTranscription Factor TFIIDNFATC Transcription FactorsActivating Transcription Factor 3Reverse Transcriptase Polymerase Chain ReactionElectrophoretic Mobility Shift AssaySp3 Transcription FactorNF-kappa BEnhancer Elements, GeneticTranscription Initiation SiteZinc FingersPaired Box Transcription FactorsActivating Transcription Factor 2Transcription Factor TFIIBRegulatory Sequences, Nucleic AcidGene Expression ProfilingE2F1 Transcription FactorRecombinant Fusion ProteinsCloning, MolecularRNA Polymerase IIPlasmidsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGene ExpressionGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsLuciferasesProtein Structure, TertiaryMicrophthalmia-Associated Transcription FactorMADS Domain ProteinsPhosphorylationSTAT1 Transcription FactorActivating Transcription FactorsCell Line, TumorHelix-Loop-Helix MotifsTranscription Factor RelAE2F Transcription FactorsChromatinOligonucleotide Array Sequence AnalysisSaccharomyces cerevisiaeModels, BiologicalSequence Homology, Amino AcidSaccharomyces cerevisiae ProteinsGene Expression Regulation, PlantMice, KnockoutCyclic AMP Response Element-Binding ProteinGATA6 Transcription FactorActivating Transcription Factor 4Transcription Factor 7-Like 1 ProteinActivating Transcription Factor 1Blotting, WesternProto-Oncogene ProteinsTranscription Factor TFIIIAProto-Oncogene Proteins c-junMice, TransgenicDown-RegulationDrosophila Proteins
Preferentially bindsRibosylation factorNeuronMitochondrialEmbryonic developmentGeneProteinsTargetsIsoformsPathwayProteinInsightsSitesActivityResponseExpressionGrowth
Preferentially binds1
  • CP190 is an essential transcription factor and preferentially binds to housekeeping gene promoters and insulators through interactions with architectural proteins, including Su(Hw) and dCTCF. (bvsalud.org)
Ribosylation factor2
Neuron1
  • Each type of neuron in the mammalian CNS has a distinctive dendritic arbor that is typically extensively branched, and that instructs the specific function of the neuron in part by ensuring that the proper synaptic connections are formed ( Elston, 2000 ). (jneurosci.org)
Mitochondrial1
Embryonic development2
  • Arc is critical as a ubiquitous signaling factor in early embryonic development and is required for growth and patterning during gastrulation. (wikipedia.org)
  • Regulation of gene expression plays a central role in embryonic development. (biomedcentral.com)
Gene2
  • Despite the expression of multiple Rho GDP/GTP exchange factors (GEFs) in the nervous system, the Kalrn gene, which encodes multiple isoforms of Kalirin, plays an essential, non-redundant role. (biomedcentral.com)
  • The overall results provide a systematic view of gene regulation in the human, which will be refined as additional mammalian genomes become available. (gsea-msigdb.org)
Proteins5
  • these multidomain guanine nucleotide exchange factors (GEFs) contain additional domains known to interact with phosphatidylinositides as well as with a number of different proteins. (biomedcentral.com)
  • CUX1 isoforms are transcription factors, whereas CASP are Golgi proteins that share with CUX1 the N-terminal region but not the DNA binding motifs [ 2 ]. (nature.com)
  • The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
  • A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
  • Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. (elifesciences.org)
Targets1
Isoforms1
  • p200 CUX1 acts as a transcriptional repressor, whereas short CUX1 isoforms can activate or suppress transcription [ 1 , 3 ]. (nature.com)
Pathway1
  • The Arc transcript is dependent upon activation of the mitogen-activated protein kinase or MAP kinase (MAPK) cascade, a pathway important for regulation of cell growth and survival. (wikipedia.org)
Protein7
  • ARC mRNA is localized to activated synaptic sites in an NMDA receptor-dependent manner, where the newly translated protein is believed to play a critical role in learning and memory-related molecular processes. (wikipedia.org)
  • Arc protein is widely considered to be important in neurobiology because of its activity regulation, localization, and utility as a marker for plastic changes in the brain. (wikipedia.org)
  • Dysfunction in the production of Arc protein has been implicated as an important factor in understanding various neurological conditions, including amnesia, Alzheimer's disease, Autism spectrum disorders, and Fragile X syndrome. (wikipedia.org)
  • and a synaptic activity response element (SARE) sequence at ~7 kb upstream that contains binding sites for cyclic AMP response element-binding protein (CREB), myocyte enhancer factor 2 (MEF2), and SRF. (wikipedia.org)
  • The mRNA (and aggregate protein) is carried along microtubules radiating out from the nucleus by kinesin (specifically KIF5) and likely translocated into dendritic spines by the actin-based motor protein myosin-Va. Arc has been shown to be associated with polyribosomes at synaptic sites, and is translated in isolated synaptoneurosomal fractions in vitro indicating that the protein is likely locally translated in vivo. (wikipedia.org)
  • Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW , Kim TK , Greenberg ME , Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. (neurotree.org)
  • Overall, our results indicate that CP60 has an important but redundant function in transcriptional regulation as a partner of the CP190 protein. (bvsalud.org)
Insights1
  • New Molecular Insights into the Excitation-Transcription Coupling. (neurotree.org)
Sites3
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. (neurotree.org)
  • Genes having at least one occurrence of the highly conserved motif M129 RRAGTTGT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb]. (gsea-msigdb.org)
  • The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs. (gsea-msigdb.org)
Activity2
  • An Intrinsic Transcriptional Program Underlying Synaptic Scaling during Activity Suppression. (neurotree.org)
  • Widespread transcription at neuronal activity-regulated enhancers. (neurotree.org)
Response1
  • see serum response factor) at ~1.5 kb upstream of the initiation site. (wikipedia.org)
Expression1
  • Glia-derived tumor necrosis factor acts through its neuronal receptor to maintain calcium channel expression after injury. (bvsalud.org)
Growth1
  • Molecular alterations involved in adult gliomas have been identified and mainly affect tyrosine kinase receptors with amplification and/or mutation of the epidermal growth factor receptor (EGFR) and its associated signaling pathways. (bvsalud.org)