Regulation of virulence gene expression gene expression regulation bacterial. Medical search. Frequent questions

QS is a process of bacterial cell-cell communication that controls virulence and biofilm formation in many bacterial species. (wadsworth.org)
Knockout mutants of rna01 and a double knockout mutant of rna01 and hfq, both had decreased biofilm formation and hemolytic activity, attenuation for virulence in Galleria mellonella, altered stress susceptibility, and an altered outer membrane protein profile. (bvsalud.org)
This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. (absin-reagent.com)
Subramani (2019) said that Quorum sensing (QS) is a process of intercellular signaling or cell-cell communication and a vital regulatory mechanism for coordinating biofilm formation including common activities and physiological processes such as symbiosis, formation of spores or fruiting bodies, antibiotics synthesis, genetic competence, apoptosis, and virulence in many bacterial species using extracellular QS signaling molecules, which is often referred to as autoinducers. (learnlifescience.com)
It is a second messenger that modulates a variety of bacterial growth phenotypes including biofilm formation. (learnlifescience.com)
Other virulence mechanisms including biofilm formation and QS-regulated acute virulence factors are AmpR-regulated. (psu.edu)
The data demonstrates that AmpR functions as a global regulator in P. aeruginosa and is a positive regulator of acute virulence while negatively regulating biofilm formation, a chronic infection phenotype. (psu.edu)
Research on pathogenic E. coli will focus on examining the association between acid tolerance in STEC and virulence potential, curli expression, biofilm formation, and persistence. (usda.gov)

100 types on the basis of immunogenic differences in their surface M proteins and polymorphisms in the emm gene ( 1 ). (cdc.gov)
In addition to the PrfA regulon, the Clp stress proteins have an impact on Listeria virulence. (ed.ac.uk)
In this sense, we aim to characterize the behaviour of different promoters of genes involved in biofilm regulation under different conditions and to search for possible new DNAbinding proteins associated with their promoter regions. (usp.br)
I enjoyed working with yeast RNA mechanisms and the involved proteins, but I was also very happy to collaborate with groups working on other organisms and mechanisms, such as bacterial mechanisms of virulence. (cosminribo.eu)
Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST. (psl.eu)
CBP and p300 are two highly similar proteins that play critical roles as "super-organizers" of transcription of genes. (atlasofscience.org)
BioID screen for bacterial virulence proteins: new tools for… The discovery of penicillin in the 1920s revolutionized our ability to treat bacterial infection. (atlasofscience.org)
These thermosensors are part of a regulatory network, such as the production of heat shock proteins mediated by sigma factor 32 (RpoH) in Escherichia coli or the transcriptional repressor of heat-shock genes HrcA in Bacillus subtilis (Hecker et al. (springer.com)
We will use omic technologies to analyze a large variety of strains of each of the pathogens to identify genes and proteins necessary for pathogens to survive stresses encountered in food environments and cause human illness. (usda.gov)
The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
Launch For all microorganisms well-timed and temporal legislation of gene appearance and its own translation to proteins level is essential for cell proliferation. (immune-source.com)
The observed inhibition of fibronectin binding was confirmed by a reduction in the expression of genes encoding two major fibronectin-binding streptococcal surface proteins, Sof and SfbI. (microbiologyresearch.org)

Fermentable carbon sources seem to have a particular role in virulence gene regulation. (ed.ac.uk)
Finally, we examine the conservation of 135 USA300 TFs amongst 11 other S. aureus strains, identifying a key group of regulators that display a high degree of conservation, including many that have previously been demonstrated to play a role in virulence gene regulation. (biomedcentral.com)

Research in the Paczkowski laboratory focuses on the mechanisms of regulation of quorum sensing (QS) in Gram-negative bacteria, such as Pseudomonas aeruginosa , Vibrio cholerae , Aeromonas hydrophila , and Chromobacterium violaceum . (wadsworth.org)
Although CSS systems regulate bacterial processes as crucial as stress response, iron scavenging and virulence, the exact mechanisms that drive CSS are still not completely understood. (vu.nl)
The research in the Division of Microbiology & Parasitology comprises a wide range of topics including: bacterial motility and flagellar biogenesis, mechanisms of entry of bacteria into mammalian cells, bacterial toxin export and multi-drug efflux, regulation of gene expression during host-pathogen interaction, transmission, cell-cycle dynamics and virulence mechanisms in malaria parasites, host modulation by parasitic organisms and dynamics of parasitic worm infection in human populations. (cam.ac.uk)
SPI-2 virulence is induced upon entry into macrophages, but the mechanisms of SPI-2 gene control in vivo remain unclear, particularly with regard to negative regulators that control the contextual activation of SPI-2. (mcmaster.ca)
I am a scientist working at the Pasteur Institute and interested in the molecular mechanisms that shape gene expression. (cosminribo.eu)
Bacterial pathogenesis is triggered by complex molecular mechanisms that sense bacterial density within an infected host and induce the expression of toxins for overriding the immune response. (cipsm.de)
Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (nature.com)
Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. (nature.com)
Understanding the mechanisms of resistance acquisition by the bacterial strains is therefore essential to prevent and overcome resistance. (openmicrobiologyjournal.com)
Streptococcal pathogens continue to evade concerted efforts to decipher clear-cut virulence mechanisms, although numerous genes have been implicated in pathogenesis. (cdc.gov)

Microscopic analysis of cell and colony structure indicates that CmrRST promotes the formation of elongated bacteria arranged in bundled chains, which may contribute to bacterial migration on surfaces. (nih.gov)
QS allows bacteria to synchronously alter gene expression patterns that underpin collective behaviors. (wadsworth.org)
Learning how bacteria correctly interpret these blends of AIs and elicit appropriate gene expression responses is essential to understand how bacteria communicate, and, more globally, to understand how all organisms decode environmental stimuli. (wadsworth.org)
We use a combination of bacterial genetics, biochemistry, structural biology, and chemical biology to understand how bacteria respond appropriately to signals in a complex environment. (wadsworth.org)
DNA supercoiling and environmental regulation of gene expression in pathogenic bacteria. (microbiologyresearch.org)
As in all pathogenic bacteria, virulence of the facultative intracellular Listeria species is a multifactorial trait. (ed.ac.uk)
An important factor of bacterial virulence is the formation of biofilms which are aggregates of microorganisms incorporated into an extracellular matrix that protects bacteria from hostile environments. (usp.br)
Bacterial regulatory small RNAs (sRNAs) play important roles in gene regulation and are frequently connected to the expression of virulence factors in diverse bacteria. (bvsalud.org)
The bacteria experienced restricted levels of iron, magnesium, and phosphate in both host cell types, as shown by up-regulation of the sitABCD system, the mgtA gene, and genes of the phoBR regulon. (strath.ac.uk)
Given the high number of virulence factors present in these bacteria, and the niche-specific role many of them play during different stages of the infectious process, gene expression must be finely tuned in order to efficiently coordinate their expression, and also continue to preserve energy pools. (biomedcentral.com)
N-(β-ketocaproyl)-L-Homoserine lactone is a component of quorum regulatory sensing which is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. (absin-reagent.com)
Most c-di-GMP-dependent signaling pathways control the ability of bacteria to interact with abiotic surfaces or with other bacterial and eukaryotic cells (Romling et al, 2013). (learnlifescience.com)
ppGpp is an intracellular sensor that, in response to different types of stress, coordinates the rearrangement of the gene expression pattern of bacteria to promote adaptation and survival to new environmental conditions. (ibecbarcelona.eu)
Consequently, bacteria have developed different systems to sense changes in environmental conditions such as temperature and induce an adaptation of metabolism and gene expression. (springer.com)
Bacteria with variant cagY alleles that reduced T4SS function showed comparable reduction in binding to a5ß1 integrin, although CagY was still expressed on the bacterial surface. (pacb.com)
The aim of this review is to provide a new perspective on the possible ways by which resistance is acquired by the bacterial strains within the patient, with a special emphasis on the adaptive response of the infecting bacteria to the administered antibiotic. (openmicrobiologyjournal.com)
We observed CsrS-dependent regulation of 72 of the 73 genes whose expression changed in response to elevated extracellular Mg(2+) in wild-type bacteria, a result that identifies CsrS as the principal, if not exclusive, sensor for extracellular Mg(2+) in GAS. (lu.se)

This down-regulation of virulence factors leads to increased susceptibility of the deletion strain to phagocytosis, reduced adherence to human keratinocytes. (wikipedia.org)
The analysis of virulence gene expression in vivo, i.e. in infected host cells, indicates that yet uncharacterized bacterial factors other than PrfA, and possibly also host factors, modulate the expression of the PrfA regulon. (ed.ac.uk)
It is quite resistant to antimicrobials and has several virulence factors that contribute to its high pathogenicity. (usp.br)
Most of this regulation is carried out directly by transcription factors that modulate the activity of promoters aimed at expressing virulence factors. (usp.br)
S. aureus has a vast array of virulence determinants whose expression is modulated by an intricate regulatory network, where transcriptional factors (TFs) are the primary elements. (biomedcentral.com)
This organism produces a diverse array of virulence factors, including toxins, adhesins, colonization and biofilm factors. (biomedcentral.com)
In this context, DNA-binding transcription factors (TFs) play an important regulatory role by either repressing or activating genes in response to environmental and physiological conditions. (biomedcentral.com)
2023. Editorial: Role of Transcription Factors and Sigma Factors in Bacterial Stress. (openwetware.org)
Comparative genomics of DNA-binding transcription factors in archaeal and bacterial organisms. (openwetware.org)
In Escherichia coli, ppGpp regulates the expression of cellular factors that are important during urinary tract infections. (ibecbarcelona.eu)
Our data further support the role of ppGpp participating in the coordinated regulation of the expression of bacterial factors required during infection. (ibecbarcelona.eu)
In addition to regulating ampC, P. aeruginosa AmpR regulates the sigma factor AlgT/U and production of some quorum sensing (QS)-regulated virulence factors. (psu.edu)
Further, we show differential regulation of other transcriptional regulators and sigma factors by AmpR, accounting for the extensive AmpR regulon. (psu.edu)
Unraveling this complex regulatory circuit will provide a better understanding of the bacterial response to antibiotics and how the organism coordinately regulates a myriad of virulence factors in response to antibiotic exposure. (psu.edu)
Genomic analysis of pasteurella atlantica provides insight on its virulence factors and phylogeny and highlights the potential of reverse vaccinology in aquaculture. (uib.no)
To explore a possible role of an E. faecalis gelatinase (encoded by gelE), which belongs to a family of Zn-metalloproteases that have been shown to be virulence factors in other organisms, in enterococcal infections, an insertion mutant was constructed in OG1RF and tested in the mouse peritonitis model. (uth.edu)
Sequence analysis of the gelE flanking regions revealed three genes (fsrA, fsrB and fsrC) upstream of gelE that show homology to the genes in a locus (agr) that globally regulates the expression of virulence factors in Staphylococcus aureus and one open reading frame (sprE) with homology to bacterial serine protease downstream of gelE. (uth.edu)
Bacterial ribonucleotide reductases (RNRs) play a significant role in the formation of dNTPs and their expression is normally regulated with the transcription factors NrdR and Hair. (immune-source.com)

The RNA chaperone Hfq promotes the association of small RNAs (sRNAs) with cognate mRNAs, controlling the expression of bacterial phenotype. (bvsalud.org)
ydgT mutants displayed a biphasic virulence phenotype during in vivo competitive infections that consisted of an early "gain-of-virulence" dependent on SPI-2 activation, followed by attenuation later in infection indicating that proper contextual regulation of SPI-2 by YdgT is necessary for full virulence during systemic colonization. (mcmaster.ca)

In MarS deletion strains expression of mga and several Mga-activated genes is reduced. (wikipedia.org)
Among these strains is a highly virulent subclone of serotype M1T1 that has exhibited unusual epidemiologic features and virulence, unlike all other streptococcal strains. (cdc.gov)
The T3SS imposes a significant cost on the bacterium, and strains which have lost the plasmid and/or genes encoding the T3SS grow faster than wild-type strains in the laboratory, and fail to bind the indicator dye Congo Red (CR). (ox.ac.uk)
Actinobacillus pleuropneumoniae hfq mutants strains are attenuated for virulence in pigs, impaired in the ability to form biofilms, and more susceptible to stress, but knowledge of the extent of sRNA involvement is limited. (bvsalud.org)
Additionally, exploring the regulatory differences between CA-MRSA and other MRSA strains may aid our understanding of the increase in virulence observed amongst community-associated isolates. (biomedcentral.com)
Even though diverse strains of S. aureus have been extensively studied, and subjected to genome sequencing, the function of a large proportion of their genes remains unidentified. (biomedcentral.com)
Sub-objective 4.1: Analysis of ExPEC isolated from chickens and humans: biofilm assays, virulence gene profiles, antimicrobial resistance profiles, whole genome comparison of ExPEC strains isolated from chicken and human infections. (usda.gov)
We will examine poultry and swine as reservoirs for food-borne infections linked to ExPEC and STEC, respectively, and characterize isolated strains to determine their virulence. (usda.gov)

Genomic characterization predicted specific genomic islands highly associated with virulence, transcriptional regulation, and DNA restriction-modification systems. (frontiersin.org)
Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)

Our findings indicate that C. difficile employs phase variation of the CmrRST signal transduction system to generate phenotypic heterogeneity during infection, with concomitant effects on bacterial physiology and pathogenesis. (nih.gov)
Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. (absin-reagent.com)
Here, we identified and characterized YdgT as a negative modulator of the SPI-2 pathogenicity island and established that this negative regulation is central to systemic pathogenesis because ydgT mutants overexpressing typhoid virulence genes were ultimately attenuated during infection. (mcmaster.ca)
I also have a strong background in bacterial pathogenesis of both Animal and Plant Hosts. (ncl.ac.uk)

For example, in chronic skin wounds, Pseudomonas aeruginosa virulence is activated by Gram-positive organisms, such as Staphylococcus aureus . (asmblog.org)
The expression of retS over time was also evaluated by western blot when co-cultivated with Staphylococcus aureus and Candida albicans in artificial sputum media and we noticed that there was no change in the expression of this gene when compared to the axenically cultured PAO1. (usp.br)
2023. The gene regulatory network of Staphylococcus aureus ST239-SCCmecIII strain Bmb9393 and assessment of genes associated with the biofilm in diverse backgrounds. (openwetware.org)

Whereas host genetic susceptibility plays a key role in modulating disease manifestation, variations in bacterial virulence properties contribute to infection severity. (cdc.gov)
Dissection of the global gene expression profile of the bacterium in its intracellular niche is essential to fully understand the biology of Shigella infection. (strath.ac.uk)
This theme seems to be common in bacterial infection, because the Ipa-Mxi-Spa-like type III secretion systems were also down-regulated during mammalian cell infection by Salmonella enterica serovar Typhimurium and Escherichia coli O157. (strath.ac.uk)
Here, we characterize the role of this alarmone in the regulation of the hlyCABD(II) operon of the UPEC isolate J96, encoding the toxin alpha-hemolysin that induces cytotoxicity during infection of bladder epithelial cells. (ibecbarcelona.eu)
Corre M, Boehm V, Besic V, Kurowska A, Viry A, Mohammad A, Sénamaud-Beaufort C, Thomas-Chollier M et Lebreton A. ‡ 2023 Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection. (psl.eu)
Revue) Organelle targeting during bacterial infection : Insights from Listeria . (psl.eu)
The major H. pylori virulence factor that determines whether infection causes disease or asymptomatic colonization is the type IV secretion system (T4SS), a sort of molecular syringe that injects bacterial products into gastric epithelial cells and alters host cell physiology. (pacb.com)
Urinary tract infections (UTIs) are a common bacterial infection with symptoms that include urinary frequency, urgency to void, dysuria and abdominal pain. (ncl.ac.uk)
At present it is assumed that the relationship between an individual's susceptibility and bacterial virulence determines the balance between tolerance of invading pathogens and the mounting of an immune response, which in turn dictates the course of infection and subsequent recurrence. (ncl.ac.uk)

Cloned structural genes for the osmotically regulated binding-protein-dependent glycine betaine transport system (ProU) of Escherichia coli K-12. (microbiologyresearch.org)
The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside. (uib.no)

During my career I have gained valuable experience working with a range of bacterial pathogens. (ncl.ac.uk)

The bacterial plant pathogen Pseudomonas syringae causes economically important diseases of a wide variety of plant species and is used as a model organism to understand the molecular basis of plant disease. (ox.ac.uk)

We have determined the complete gene expression profiles for S. flexneri infecting human epithelial HeLa cells and human macrophage-like U937 cells. (strath.ac.uk)

Using QS as a model will allow us to understand long-standing questions in the field related to signal recognition preferences in single species and multi-species environments and the regulation of the interrelated signaling cascade that exists to coordinate behavior. (wadsworth.org)
This system is present in most archaeal species and approxi-mately half of all bacterial species. (pjmonline.org)
Structure of Co-expression Networks of Bifidobacterium species in Response to Human Milk Oligosaccharides. (openwetware.org)
tracrRNA-mediated crRNA maturation is conserved among different bacterial species. (nature.com)
A significant number of bacterial species encode multiple copies of the filament building block - flagellin. (ncl.ac.uk)
We have studied how bacterial species such as the pathogen Salmonella enterica maintain a discrete number of flagellar per cell during cell growth and division. (ncl.ac.uk)
We complement our study on flagellar abundance with research to understanding how a filament is assembled from multiple flagellins, a trait maintained by many bacterial species. (ncl.ac.uk)

Epigenetic analysis revealed a specific N 6 -methyl adenine (m 6 A) methylating pattern including methylation of alginate, flagellar and quorum sensing associated genes. (frontiersin.org)

Salmonella typhimurium proP gene encodes a transport system for the osmo- protectant glycine betaine. (microbiologyresearch.org)
Osmoregulation of gene expression in Salmonella typhimurium: proU encodes an osmotically-induced glycine betaine transport system. (microbiologyresearch.org)
Comparison with the gene expression of intracellular Salmonella serovar Typhimurium, which resides within the Salmonella-containing vacuole, indicated that S. flexneri is exposed to oxidative stress in U937 cells. (strath.ac.uk)

The sRNA was shown to interact with the 5'UTR of the mga transcript (the multiple virulence gene regulator gene) and was renamed MarS for mag-activating regulatory sRNA. (wikipedia.org)
CsrRS (or CovRS) is a two-component system implicated in the control of multiple virulence determinants in the important human pathogen, group A Streptococcus (GAS). (lu.se)

The plasmid encodes a Type III secretion system (T3SS) on a 30 kb pathogenicity island (PAI), and is maintained in a bacterial population through a series of toxin:antitoxin (TA) systems which mediate post-segregational killing (PSK). (ox.ac.uk)

To search for sRNAs in A. pleuropneumoniae, we developed a strategy for the computational analysis of the bacterial genome by using four algorithms with different approaches, followed by experimental validation. (bvsalud.org)
AmpR, a member of the core genome, also regulates genes in the regions of genome plasticity that are acquired by horizontal gene transfer. (psu.edu)
Natural competence is a mode of horizontal gene transfer, which is based on the ability of a bacterium to take up free DNA from the environment and recombine it with the bacterial genome resulting in natural transformation. (biomedcentral.com)

We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family. (cipsm.de)
To our knowledge, this study is the first to characterize global gene regulation by a GAS two-component system in response to a specific environmental stimulus. (lu.se)

In Enterobacteriaceae, the transcriptional regulator AmpR, a member of the LysR family, regulates the expression of a chromosomal β-lactamase AmpC. (psu.edu)

The clue to pathogenicity might be in specially tuned gene regulation together with a set of adhesin genes and increased thermo- and starvation tolerance. (boku.ac.at)

Revue) A trip in the "New Microbiology" with the bacterial pathogen Listeria monocytogenes . (psl.eu)

These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats. (jci.org)
Some asd RNA are associated with genes, such as asd, that are suggestive of a cis-regulatory function. (wikipedia.org)
The latter group has several potential mRNA targets, many of which are involved with virulence, stress resistance, or metabolism, and connect the sRNAs in a complex gene regulatory network. (bvsalud.org)
As virulence determinant production is very tightly regulated in S. aureus , a thorough understanding of its regulatory network is necessary to fully comprehend the pathogenic processes of this bacterium. (biomedcentral.com)
Homology-based reconstruction of regulatory networks for bacterial and archaeal genomes. (openwetware.org)
Gene regulatory network inference and gene module regulating virulence in Fusarium oxysporum. (openwetware.org)

mvaT is a major regulator, exerting negative control in many genes described. (usp.br)
This gene encodes a protein that is the master regulator of transformation and a homolog of Sxy, which was first described in Haemophilus influenzae [ 7 ],[ 8 ]. (biomedcentral.com)
22 ]. The transcriptional regulator QstR, which might require a cofactor for its full activity (indicated by the triangle), positively regulates the comEA gene potentially by binding to a QstR-specific binding motif (indicated by the dashed box and so far unidentified). (biomedcentral.com)

My expertise utilise bacterial genetics to study fundamental aspects of the bacterial life cycle and host-microbe interactions. (ncl.ac.uk)
My laboratory uses, bacterial genetics, protein biochemistry, structural biology, bioinformatics and microscopic techniques to validate our genetic findings. (ncl.ac.uk)

To study the functions of these genes, gene disruption mutants of fsr and sprE were constructed. (uth.edu)
Testing the virulence of fsr and sprE mutants in the mouse peritonitis model showed that these mutants had significant delays in lethality compared to OG1RF, suggesting that sprE and fsr genes contribute to the virulence of E. faecalis OG1RF in this model. (uth.edu)

Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. (jci.org)
Fluorescent secreted bacterial effectors reveal active intravacuolar proliferation of Listeria monocytogenes in epithelial cells. (psl.eu)
Moreover in comparison to NrdR deletion cells overexpressing NrdR demonstrated significantly reduced adherence to individual epithelial cells reflecting reduced bacterial Fesoterodine fumarate (Toviaz) virulence. (immune-source.com)

The flagellar filament is a major antigen recognized by hosts during bacterial infections. (ncl.ac.uk)
Pelvic inflammatory disease (PID) is a female upper genital tract inflammatory disorder that arises after sexually transmitted bacterial infections (STI). (microbialcell.com)
To explore a possible role for these antigens in enterococcal infections, the genes encoding these three antigens were disrupted in Enterococcus faecalis OG1RF. (uth.edu)
Acquisition of resistance is one of the major causes of failure in therapy of bacterial infections. (openmicrobiologyjournal.com)

A comparison of the TF repertoire of S. aureus against 1209 sequenced bacterial genomes was carried out allowing us to identify a core set of orthologous TFs for the Staphylococacceae , and also allowing us to assign potential functions to previously uncharacterized TFs. (biomedcentral.com)
We have evaluated the orthologous distribution of these elements in other sequenced bacterial genomes using the repertoire of TFs identified in USA300, and identified a core set of regulators for both the Firmicutes phylum, and the Staphylococacceae group. (biomedcentral.com)
However, this analysis requires accurate reference genomes to identify the specific genes from which RNA reads originate. (osti.gov)
Sample-specific meta-genomic assembled genomes (MAGs) were used as reference genomes to accurately identify the origin of RNA reads, and transcript ratios of genes with opposite transcription responses were compared to eliminate biases related to differences in organismal abundance, an approach hereafter named the "diametric ratio" method. (osti.gov)

Bacterial small RNAs (sRNAs) are known regulators in many physiological processes. (learnlifescience.com)
Revue) Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk. (psl.eu)

Coordination of transcriptional and translational regulations in human cells infected by Listeria monocytogenes . (psl.eu)
Revue) RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression. (psl.eu)

First described to modulate metabolic adaptive responses, ppGpp modulates the expression of genes belonging to very diverse functional categories. (ibecbarcelona.eu)
An RNA-binding protein secreted by a bacterial pathogen modulates RIG-I signaling. (psl.eu)

Current antibiotics work by interfering with bacterial growth, which is a fine game plan… until it stops working. (wadsworth.org)

Within the research in Molecular Biology, one important field along the years has been the analyses on how prokaryotes regulate the expression of their genes and what the consequences of these activities are. (ibecbarcelona.eu)
Moreover, we present strong evidence that Mg(2+) signals through CsrS to regulate an extensive and previously undefined repertoire of GAS genes. (lu.se)

Essentially nothing is known about the signal transduction pathways involved in the observed differential expression of virulence genes. (ed.ac.uk)
Transcriptome analysis demonstrates that the AmpR regulon is much more extensive than previously thought, with the deletion of ampR influencing the differential expression of over 500 genes. (psu.edu)

Differential gene expression analysis indicated that this isolate formed excessive biofilm by reducing flagellar formation (7.4 to 1,624.1 folds) and overproducing extracellular matrix components including CdrA (4.4 folds), alginate (5.2 to 29.1 folds) and Pel (4.8-5.5 folds). (frontiersin.org)
Our in-depth knowledge of flagellar assembly and its regulation allow us to investigate the interaction of the host innate immune system during UTIs. (ncl.ac.uk)

Second, in Streptococcus mutans, there is a strong promoter immediately downstream of the transcription terminator that follows the asd RNA, and this promoter precedes the downstream gene. (wikipedia.org)
Nucleotide sequence of the asd gene of Streptococcus mutans. (wikipedia.org)

Right here we profile bacterial destiny under circumstances of overexpression and deletion of NrdR in appearance causes a substantial decrease in bacterial development and fitness also at normal temperature ranges and causes lethality at raised temperature ranges. (immune-source.com)
In parallel research on complementary appearance of downregulated important genes and demonstrated partial rescue from the fitness defect due to NrdR overexpression. (immune-source.com)
Deletion of downregulated nonessential genes and upon NrdR overexpression led to diminished bacterial development and fitness recommending an additional function for NrdR in regulating various other genes. (immune-source.com)

We report on the preparation of a new type of immunotoxin via in vitro ligation of the αHer2 antigen binding fragment (Fab) of the clinically-validated antibody trastuzumab to the plant toxin gelonin, employing catalysis by the bacterial enzyme sortase A (SrtA). (cipsm.de)
Virulence is controlled by a set of transcriptional regulators that directly bind to DNA promoter regions of toxin-encoding genes. (cipsm.de)

These outcomes suggest that raised appearance of NrdR is actually a suitable methods to retard bacterial development and virulence as its raised expression decreases bacterial fitness and impairs web host cell adhesion. (immune-source.com)

Revue) Regulation of cold-inducible RNA-binding protein (CIRBP) in response to cellular stresses. (psl.eu)
This altered gene expression also correlated directly with protein levels, bacterial capacity for DNA uptake, and natural transformability. (biomedcentral.com)
Sjöberg A., Trouw L., McGrath F., Hack E. C. and Blom A. M. (2006) Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. (lu.se)

For this, the upstream regions of the gacA, gacS, ladS, retS, rsmA, rsmZ and PA1611 genes were cloned separately into a miniTn7 vector and inserted into the PAO1 chromosome. (usp.br)
We then evaluated the growth and activity of the upstream regions by lux expression under different carbon sources and iron deprivation. (usp.br)
In our findings, mvaT has a negative influence on regulating rsmA, since its inactivation leads to a higher expression of the upstream region of rsmA. (usp.br)
In our study, we hypothesized that both have a role in the activation of the upstream region of the retS in LB media and MOPS glucose since their mutation led to higher expression of the upstream region. (usp.br)
Para isso, as regiões upstream dos genes gacA, gacS, ladS, retS, rsmA, rsmZ e PA1611 foram clonadas separadamente em um vetor repórter miniTn7 e inseridas no cromossomo de PAO1. (usp.br)
We identified previously unrecognized putative CRP-S sites upstream of both genes. (biomedcentral.com)

The effect of Mg(2+) on regulation of global gene expression was evaluated using genomic microarrays in an M-type 3 strain of GAS and in an isogenic csrS mutant. (lu.se)

The expression of the bacterial genes involved in the different steps of the infectious process--invasion, intracellular multiplication and spreading--is temporally and spatially controlled, thus ensuring the presence of the respective gene products at the right moment and place. (ed.ac.uk)
The key S. flexneri virulence genes, ipa-mxi-spa and icsA, were drastically downregulated during intracellular growth. (strath.ac.uk)

Comparative assessment of Vibrio virulence in marine fish larvae. (uib.no)

However, interpretation of the lack of an effect on virulence is complicated by the overproduction of the serine protease in the gelE deletion mutant. (uth.edu)

Here we found that these recombination events produce parallel changes in specific binding to a5ß1 integrin, a host cell receptor that is essential for T4SS-dependent translocation of bacterial effectors. (pacb.com)

accordingly, the fittest members of this diverse bacterial community are selected to survive and invade host tissue. (cdc.gov)

Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences. (ox.ac.uk)
The proinflammatory cytokines TNF-α and IL-6 in lumpfish (Cyclopterus lumpus L.) -identification, molecular characterization, phylogeny and gene expression analyses. (uib.no)
Interleukin-1 ligands and receptors in lumpfish (Cyclopterus lumpus L.): molecular characterization, phylogeny, gene expression and transcriptome analyses. (uib.no)
Molecular cloning of MDA5, phylogenetic analysis of RIG-I-like receptors (RLRs) and differential gene expression of RLRs, interferons and proinflammatory cytokines after in vitro challenge with IPNV, ISAV and SAV in the salmonid cell line TO. (uib.no)
The flagellum is a unique molecular machine driving bacterial movement through liquid environments. (ncl.ac.uk)

However, the lack of MarS increased bacterial dissemination and tolerance towards oxidative stress. (wikipedia.org)

The physiological conditions experienced by a microbial community can thus be inferred using meta-transcriptomic sequencing by comparing transcription levels of specifically chosen genes. (osti.gov)

These systems are composed of an outer membrane receptor that senses the inducing signal, an extracytoplasmic function sigma factor (σECF) that targets the cytosolic response by modifying gene expression and a cytoplasmic membrane anti-sigma factor that keeps the σECF in an inactive state in the absence of the signal and transduces its presence from the outer membrane to the cytosol. (vu.nl)

2023. Comparative genomics sheds light on transcription factor-mediated regulation in the extreme acidophilic Acidithiobacillia representatives. (openwetware.org)
Studies in both commensal and UPEC isolates demonstrate that no UPEC specific factor is strictly required for the ppGpp-mediated regulation described. (ibecbarcelona.eu)
Our study reveals a novel pathway of small guide RNA maturation and the first example of a host factor (RNase III) required for bacterial RNA-mediated immunity against invaders. (nature.com)

Changing of external physical parameters such as high temperature or osmotic stress elicit immediate activation of signaling pathways leading to changes of enzyme activities and also large scale changes of gene expression patterns. (boku.ac.at)
In previous work we investigated Stress and starvation responses such as autophagy and their contribution to virulence. (boku.ac.at)

So far, one network which is involved in the regulation of listerial virulence, the PrfA regulon, has been characterized rather well. (ed.ac.uk)

Nesse sentido, objetivamos caracterizar o comportamento de diferentes promotores de genes envolvidos na regulação de biofilme de P. aeruginosa sob diferentes condições e buscar possíveis novas proteínas de ligação ao DNA associadas às suas regiões promotoras. (usp.br)
In the recent past, the presence and function of a ROSE-like RNA-thermometer located in the 5′UTR of the rhamnosyltransferase genes rhlAB has been reported in wild type P. aeruginosa . (springer.com)
For this purpose, the non-pathogenic production host P. putida KT2440 containing the rhlAB genes with the native P. aeruginosa 5′-UTR region was used. (springer.com)

He also mentions that microorganisms produce a wide variety of QS signaling molecules that can be self-recognized in a concentration-dependent manner and subsequently induce or suppress the expression of QS-controlled genes. (learnlifescience.com)

Discussion Differentially expressed genes inC. jejuniNCTC 11168 and itsluxSmutant InVibriospp, AI-2 functions as an extracellular signalling molecule. (hsdpathway.com)

Anatomy17

Organisms35

Diseases10

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes99

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science8

Health Care3

Biofilm formation8

Proteins12

Role in virulence gene regulation2

Mechanisms10

Bacteria17

Factors18

Phenotype2

Strains8

Transcriptional regulation2

Pathogenesis4

Staphylococcus3

Infection9

Escherichia2

Pathogens1

Pseudomonas1

Infecting human epit1

Species7

Quorum1

Salmonella3

Multiple virulence2

Type III secre1

Genome3

Characterize2

Regulates the expression1

Pathogenicity1

Microbiology1

Regulatory6

Regulator3

Genetics2

Mutants2

Epithelial3

Infections4

Genomes4

RNAs2

Listeria2

Modulates2

Antibiotics1

Regulate2

Differential expression2

Flagellar2

Streptococcus2

Overexpression3

Toxin2

Decreases1

Protein3

Upstream6

Genomic1

Intracellular2

Vibrio1

Deletion1

Effectors1

Diverse bacterial1

Molecular5

Tolerance1

Physiological1

Outer membrane1

Factor3

Stress2

Regulon1

Aeruginosa3

Induce1

Extracellular1