• It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. (cancerindex.org)
  • It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). (cancerindex.org)
  • The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells. (stanford.edu)
  • Repressor proteins are coded for by regulatory genes. (proteopedia.org)
  • Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
  • There were 3954 correlations and a total of 15 correlations for differentially expressed proteins (DEPs) and differentially expressed genes (DEGs) from proteomics and transcriptomics. (hindawi.com)
  • The proteins involved in homologous recombination have to work around other processes that go on inside the nucleus, such as the transcription of DNA in genes into RNA molecules. (elifesciences.org)
  • Signals from the environment or from other cells activate proteins called transcription factors. (medlineplus.gov)
  • These proteins bind to regulatory regions of a gene and increase or decrease the level of transcription. (medlineplus.gov)
  • L genes encode viral capsid proteins. (medscape.com)
  • Disruption of E1 and E2 allows for dysregulated downstream genes and the expression of E6 and E7 proteins, which are selectively maintained in virally induced tumors. (medscape.com)
  • E7 forms complexes with pRb and functionally inactivates pRb and related proteins, such as EF2, which leads to transcription growth-related proteins. (medscape.com)
  • Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
  • Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
  • Ribosome-mediated attenuation is a gene expression mechanism in which a transcriptional termination signal is regulated by translation. (wikipedia.org)
  • Here we show that in Saccharomyces cerevisiae a single DSB causes transcriptional inhibition of proximal genes independently of Tel1/ATM and Mec1/ATR. (elifesciences.org)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • The dynamics of poly(A) tail length play a significant role in regulating post-transcriptional gene expression by regulating the stability, translation, and decay of messenger RNAs. (bvsalud.org)
  • Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)
  • We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
  • We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
  • Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
  • Run-on analysis showed transcriptional attenuation in the normal rat myc gene, similar to the situation in mice and humans. (lu.se)
  • In the first part we consider basic facts about the expression and activity of these transcription factors: the organization of the encoding genes and their promoters, the second messenger cascades converging on their regulatory promoter sites, the control of their transcription, the binding to dimeric partners and to specific DNA sequences, their trans-activation potential, and their posttranslational modifications. (nih.gov)
  • Gene regulation in the human genome is controlled by distal enhancers that activate specific nearby promoters 1 . (nature.com)
  • However, the degree to which human enhancers and promoters are intrinsically compatible has not yet been systematically measured, and how their activities combine to control RNA expression remains unclear. (nature.com)
  • Promoters of housekeeping genes contain built-in activating motifs for factors such as GABPA and YY1, which decrease the responsiveness of promoters to distal enhancers. (nature.com)
  • Promoters of variably expressed genes lack these motifs and show stronger responsiveness to enhancers. (nature.com)
  • When located at gene promoters, DNA methylation is usually association with repression of gene expression. (nationaljewish.org)
  • From DNA to RNA: the structure and function of the gene, promoters and terminators. (manchester.ac.uk)
  • Various hybrid or combination promoters have been constructed from the CaMV 35S promoter which led to improved expression of transgenes: double 35S promoters (10), a hybrid containing the core 19S promoter from CaMV and the 35S upstream enhancers (11), and combination of CaMV 35S with mannopine synthase elements (12), or with Adh1 - and ocs- promoter elements for expression in monocotyledons (13). (i-sis.org.uk)
  • It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. (nih.gov)
  • In 10 of 14 tumors investigated the breakpoints on the myc carrying chromosome were clustered in a 1.5 kb region 5' of the intact gene, proximal to the myc promoters. (lu.se)
  • This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. (cancerindex.org)
  • This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
  • Together, this systematic assessment of enhancer-promoter compatibility suggests a multiplicative model tuned by enhancer and promoter class to control gene transcription in the human genome. (nature.com)
  • Fig. 4: Promoter classes correspond to enhancer responsive versus ubiquitously expressed genes. (nature.com)
  • Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). (nih.gov)
  • Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription. (nih.gov)
  • Binding of Fis to the cbpA regulatory region prevents the action of a strong σ70-dependent promoter found within the coding region of a neighbouring gene, yccE. (bham.ac.uk)
  • Furthermore, the regulation of cbpA was also found to be dependent on the interplay between the strong σ70-dependent promoter and a weak but convergent σ32-dependent promoter. (bham.ac.uk)
  • In addition, we found that ZNF513 binds to the SOS1 promoter and plays an important positive role in regulating the expression of SOS1 . (nature.com)
  • The CaMV promoter is a sequence of about 350 basepairs upstream of the 35S transcript (-343 to +8, with Cap site at +1), about 250 basepairs of which overlap with the 3' end of gene Vl, the last of the six large open reading frames. (i-sis.org.uk)
  • These studies show that the loss of up to 40 amino acids from the 3' end of gene Vl (which overlaps with the 35S promoter) had no effect on pathogenesis whereas further truncation into a putative zinc finger region was fatal to the virus. (i-sis.org.uk)
  • To understand this mechanism, we need to know which transcription factor (TFs) would bind to which promoter, thus regulate their target gene expression. (usda.gov)
  • This was related to an increased DNMT3a protein association with a discreet region of the Nr3c1 (GR gene) promoter, shown here to undergo increased DNA methylation after FSS. (karger.com)
  • DNA constructs were cloned into a pGL3 promoter vector for luciferase gene reporter assays. (cdc.gov)
  • Methods for analysis of gene expression: microarray, hybridisation, promoter analyses. (lu.se)
  • These dCas9-activator fusions targeted to the promoter region of endogenous genes can then modulate gene expression 7 - 11 . (cdc.gov)
  • Genetic alterations in the tuberous sclerosis complex (TSC) genes, key mediators of protein synthesis, are strongly associated with autism spectrum disorders. (sfari.org)
  • Genetic analysis found a 3-bp deletion in the covR gene of the HH/LC variant. (cdc.gov)
  • The National Human Genome Research Institute provides a definition of gene regulation in their Talking Glossary of Genetic Terms. (medlineplus.gov)
  • The Genetic Science Learning Center at the University of Utah offers an explanation of gene expression as it relates to disease risk . (medlineplus.gov)
  • Genetic variants with gene regulatory effects are associated with diisocyanate -induced asthma. (cdc.gov)
  • These results demonstrate that many DA-associated genetic variants likely act by modulating gene regulation. (cdc.gov)
  • Gene technology: basic and applied molecular genetic methods. (lu.se)
  • These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)
  • Genetic testing for mutations in the VHL gene is performed at many laboratories throughout the United States and the world. (medscape.com)
  • In this study, differentially expressed genes (DEGs) under drought and flooding conditions were investigated using Illumina RNA-Seq transcriptome profiling. (frontiersin.org)
  • By integrating two datasets (GSE77459 and GSE92681) in the GEO database using the sva and limma packages of R, differentially expressed genes (DEGs) of pulpitis were identified. (researchsquare.com)
  • Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). (researchsquare.com)
  • A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. (researchsquare.com)
  • In addition, important genes related to osmoregulation, such as ion transport and carbonic anhydrase, were also detected in the correlation analysis for same trend DEPs_DEGs. (hindawi.com)
  • Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)
  • To provide a general introduction to the molecular basis of genetics, how genes are maintained from one generation to the next and how their expression is regulated in various systems. (manchester.ac.uk)
  • Students will understand the basis of genome maintenance and gene expression, and appreciate the concept of mutation at the level of the genotype and how this manifests at the phenotypic level. (manchester.ac.uk)
  • Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease. (nih.gov)
  • Gene Tests ( www.genetests.org ) cites 48 different laboratories in the United States that can test for the VHL gene mutation. (medscape.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Gene mutations: missense versus nonsense mutations, insertions, deletions and frameshifts. (manchester.ac.uk)
  • Here, based on a family pedigree with 26 members, including nine patients with HGF, we identified double heterozygous pathogenic mutations in the ZNF513 (c.C748T, p.R250W) and KIF3C (c.G1229A, p.R410H) genes within the GINGF3 locus related to HGF. (nature.com)
  • Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)
  • Chromosomal abnormalities, HLA phenotypes, and polymorphisms of various genes have been associated with acne. (springer.com)
  • These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
  • Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
  • Genes are contained in chromosomes in the cell nucleus and mitochondria. (msdmanuals.com)
  • The 23rd pair, the sex chromosomes (X and Y), determines a person's sex as well as containing other functional genes. (msdmanuals.com)
  • Genes are arranged linearly along the DNA of chromosomes. (msdmanuals.com)
  • Each gene has a specific location (locus), which is typically the same on each of the 2 homologous chromosomes. (msdmanuals.com)
  • Some genes occur in multiple copies that may be next to each other or in different locations in the same or different chromosomes. (msdmanuals.com)
  • This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)
  • The Jardetzky Laboratory is studying the structures and mechanisms of macromolecular complexes important in viral pathogenesis, allergic hypersensitivities and the regulation of cellular growth and differentiation, with an interest in uncovering novel conceptual approaches to intervening in disease processes. (stanford.edu)
  • Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway. (nih.gov)
  • DMRs show continuous gain or loss of methylation during differentiation, and the overall change in DNA methylation correlates inversely with gene expression at key loci. (lu.se)
  • We also found an unexpectedly dynamic pattern of transcript isoform regulation, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells. (lu.se)
  • the smaller Y chromosome carries genes that initiate male sex differentiation, as well as a few other genes. (msdmanuals.com)
  • The factor determining this depends on the function of the downstream genes (e.g. the operon encoding enzymes involved in the synthesis of histidine contains a series of histidine codons is the control region). (wikipedia.org)
  • The lac repressor, and the group of genes it controls, which is called an operon , were the first such gene regulatory system to be discovered. (proteopedia.org)
  • GBS production of β-h/c is encoded by the genes of the cyl operon ( 5 , 6 ) and is associated with direct lysis of a variety of eukaryotic cell types ( 7 - 9 ), inflammatory activation ( 10 - 12 ), and virulence in animal models ( 10 , 13 , 14 ). (cdc.gov)
  • This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)
  • This study provides a comprehensive genome-wide resource for the functional exploration of molecular, cellular, and epigenetic regulation at the top of the hematopoietic hierarchy. (lu.se)
  • More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)
  • Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)
  • Translation promotes transcription elongation and regulates transcription termination. (wikipedia.org)
  • These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses. (nih.gov)
  • Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro. (nih.gov)
  • Deadenylation is a major process that regulates gene expression by shaping the length of mRNA poly(A) tails. (bvsalud.org)
  • The role of the control region is to modulate whether transcription remains coupled to translation depending on the cellular state (e.g. a low availability of histidine slows translation leading to uncoupling, while high availability of histidine permits efficient translation and maintains coupling). (wikipedia.org)
  • Three types of epigenetic modification that regulate gene expression in mammalian cells. (nationaljewish.org)
  • In mammalian cells, inhibiting the transcription of genes around a double-strand DNA break depends on a signaling pathway that is activated whenever DNA damage is detected. (elifesciences.org)
  • Transforming growth factor-beta (TGF-beta) signaling in naive T cells induces expression of the transcription factor Foxp3, a 'master' regulator of regulatory T cells (T(reg) cells). (nih.gov)
  • The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. (cancerindex.org)
  • Bacteria depend on transcription-translation coupling for genome integrity, termination of transcription and control of mRNA stability. (wikipedia.org)
  • Consequently, artificial disruption of transcription-translation coupling impairs the fitness of bacteria. (wikipedia.org)
  • Question: The Process By Which Genotype Becomes Expressed As Phenotype Is Translation Transcription Gene Expression O Gene Regulation Question 57 In Bacteria, What Name Is Given To A Cluster Of Genes With Related Functions, Along With Their DNA Control Sequences? (prowritershub.com)
  • This module provides an up to date understanding of how fundamental research in bacterial cell biology helps to elucidate central biological questions such as the control and regulation of cell division and of gene expression in bacteria. (ncl.ac.uk)
  • The objective being to give an overview of the methods used in the discovery of molecular mechanisms used by model bacteria and the application of this in understanding the basic processes involved in bacterial growth and development in terms of regulation and biological function. (ncl.ac.uk)
  • Each repressor targets a specific co-regulated group of genes by recognizing a specific sequence of DNA, called the operator in bacteria . (proteopedia.org)
  • The Khan Academy has an educational unit on gene regulation , including videos about gene regulation in bacteria and eukaryotes. (medlineplus.gov)
  • After transcription, one or more microRNAs bind to cis-regulatory sites, usually in the 3' UTR of the mRNA, and repress protein translation 4 . (nationaljewish.org)
  • Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). (cshlpress.com)
  • Ranking of DA-associated SNPs based on their likelihood to affect gene regulatory mechanisms in the lung yielded 21 prioritized SNPs. (cdc.gov)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Raw and processed data for ExP STARR-seq, motif ExP STARR-seq, HS-STARR-seq and K562 PRO-seq can be found at the NCBI's Gene Expression Omnibus under accession number GSE184426 . (nature.com)
  • By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)
  • Without coupling, genome integrity is compromised as stalled transcription complexes interfere with DNA replication and induce DNA breaks. (wikipedia.org)
  • All HPV subtypes contain early (E) genes and late (L) genes, which are essential to viral integration and replication. (medscape.com)
  • E genes are responsible for episomal replication. (medscape.com)
  • E1 protein has helicase activity for replication, and E2 encodes DNA-binding protein for regulation of transcription. (medscape.com)
  • Unlike Escherichia coli, in Bacillus subtilis transcription significantly outpaces translation, and coupling consequently does not occur. (wikipedia.org)
  • The expression of photosynthesis and chlorophyll synthesis related genes were significantly reduced under both types of stresses, which limit the metabolic processes and thus help prolong survival under extreme conditions. (frontiersin.org)
  • Functional studies demonstrated that the ZNF513 p.R250W and KIF3C p.R410H variants significantly increased the expression of ZNF513 and KIF3C in vitro and in vivo. (nature.com)
  • However, a significant increase only in GLUT3 surface expression was identified 30 min after excitation, with this high surface expression remaining significantly above control levels in many neurons for up to 4 h. (jneurosci.org)
  • BRSV infection significantly increased transcription of five genes in bovine respiratory tract cells in vitro and ex vivo. (cdc.gov)
  • The signature of our top screening hits is significantly correlated with gene expression data from clinical melanoma samples. (cdc.gov)
  • Transcription-translation coupling is a mechanism of gene expression regulation in which synthesis of an mRNA (transcription) is affected by its concurrent decoding (translation). (wikipedia.org)
  • When coupled by transcription factor NusG, the ribosome binds newly synthesized mRNA and prevents formation of secondary structures that inhibit transcription. (wikipedia.org)
  • The attenuator functions via a set of mRNA sequence elements that coordinate the status of translation to a transcription termination signal: A short open reading frame encoding a "leader peptide" A transcription pause sequence A "control region" A transcription termination signal Once the start of the leader open reading frame has been transcribed, RNA polymerase pauses due to folding of the nascent mRNA. (wikipedia.org)
  • The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. (cancerindex.org)
  • Gera R, Mokbel L, Jiang WG, Mokbel K mRNA Expression of Cancer Genomics Proteomics. (cancerindex.org)
  • Our objective was to determine if CDK2AP1 mRNA expression levels were consistent with tumour-suppressive functions in breast cancer. (cancerindex.org)
  • To our knowledge, this is the first study in the literature to examine the mRNA expression of CDK2AP1 in human breast cancer over a long-term follow-up period. (cancerindex.org)
  • FSS also caused a time-dependent increase in the expression of miR-124a, a microRNA known to reduce GR mRNA expression, which was inversely correlated with a reduction in GR mRNA levels 30 min after FSS. (karger.com)
  • Acute stress results in decreased GR mRNA expression specifically in the dentate gyrus. (karger.com)
  • Gene regulation can occur at any point during gene expression, but most commonly occurs at the level of transcription (when the information in a gene's DNA is passed to mRNA). (medlineplus.gov)
  • Functional states of the sodium channel (closed, open, and inactivated) and their structure help to understand the cardiac regulation processes. (bvsalud.org)
  • A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
  • Current work is directed towards the structure and mechanism of RSC, and the specificity of RSC for genes engaged in transcription. (stanford.edu)
  • In contrast to some previously described early genes, most of the novel genes are not induced in cortex by apomorphine, indicating specificity of induction. (jneurosci.org)
  • For example, complex regulation of expression of the nucleoid-associated protein cbpA was found to be dependent not only on sigma factor specificity, but also on binding of the transcription factor Fis upstream of the cbpA start codon. (bham.ac.uk)
  • that is, they inhibit the transcription of messenger RNA from their target genes. (proteopedia.org)
  • For amino acid biosynthesis operons, these allow the gene expression machinery to sense the abundance of the amino acid produced by the encoded enzymes, and adjust the level of downstream gene expression accordingly: transcription occurring only if the amino acid abundance is low and the demand for the enzymes is therefore high. (wikipedia.org)
  • Transcriptome and chromatin immunoprecipitation analysis revealed c-Myc as a new and direct downstream target of XBP1 for regulation of NK cell proliferation. (cancerindex.org)
  • In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
  • Lack of coupling produces premature transcription termination, likely due to increased binding of termination factor Rho. (wikipedia.org)
  • This allows communication between RNA polymerase, the multisubunit enzyme that catalyzes transcription, and the ribosome, which catalyzes translation. (wikipedia.org)
  • Formation of an expressome complex also aids transcription elongation by the trailing ribosome opposing back-tracking of RNA polymerase. (wikipedia.org)
  • The lactose ("lac") repressor controls the expression of bacterial enzymes involved in the metabolism of of the sugar lactose. (proteopedia.org)
  • However, cell wall synthesis related genes were up-regulated under drought stress and down-regulated under flooding stress. (frontiersin.org)
  • The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA's influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. (cshlpress.com)
  • In addition, they discovered a set of genes that exhibit an unusually high increase in the efficiency of protein synthesis in the mutant mice. (sfari.org)
  • This suggests a mechanism by which the regulation of protein synthesis can produce a defined program of gene expression at the RNA level. (sfari.org)
  • This gene encodes a member of the synaptotagmin protein family. (nih.gov)
  • however, only two disease-causing genes, SOS1 and REST , inducing HGF have been identified at two loci, GINGF1 and GINGF5, respectively. (nature.com)
  • 16 Among these loci, "son of sevenless homologue 1" ( SOS1 , OMIM 182530) and "RE1 silencing transcription factor" ( REST , OMIM 600571), which are HGF-related pathogenic genes, have been identified as associated with GINGF1 and GINGF5, respectively. (nature.com)
  • Interestingly, FLU-exposed biofilms showed no significant changes in gene expression over the course of the experiment. (who.int)
  • In the luciferase assay 4 of the 21 SNPs exhibited allele-dependent changes in gene expression. (cdc.gov)
  • Gene regulation in developmental biology and the cell cycle. (lu.se)
  • Degradation of prokaryotic mRNAs is accelerated by loss of coupled translation due to increased availability of target sites of RNase E. It has also been suggested that coupling of transcription with translation is an important mechanism of preventing formation of deleterious R-loops. (wikipedia.org)
  • The changes in expression of genes involved in regulating the flux of cell wall precursors and starch/sugar content can serve as an adaptive mechanism for soybean survival under stress conditions. (frontiersin.org)
  • who also correctly proposed the general mechanism of regulation by the lac repressor. (proteopedia.org)
  • Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
  • Strategies for gene therapy and production of medicines via genetically-modified organisms (expression vectors and viral vectors). (lu.se)
  • However, it is difficult to capture the complexity of transcript isoform variance using these libraries, and large cDNA sequences are often difficult to clone into size-limited viral expression vectors. (cdc.gov)
  • Foreign gene sequences could be inserted into deletion mutants, which may alter the infectious characteristics of the virus. (i-sis.org.uk)
  • Cis-acting DNA sequences which can increase transcription of genes. (bvsalud.org)
  • Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization. (crossref.org)
  • However, the complete B region allows a more general constitutive expression than expected from the combinations of subdomains. (i-sis.org.uk)
  • Humans have about 20,000 to 23,000 genes depending on how a gene is defined. (msdmanuals.com)
  • Finally, the transcription terminator sequence is transcribed. (wikipedia.org)
  • The genes that occupy the same locus on each chromosome of a pair (one inherited from the mother and one from the father) are called alleles. (msdmanuals.com)
  • These translocations most commonly involve the TFE3 gene on locus Xp11.2 and less commonly involve the TFEB gene on locus 6p21. (medscape.com)
  • Presence of cagPAI genes and characterization of vacA s, i and m regions in Helicobacter pylori isolated from Alaskans and their association with clinical pathologies. (cdc.gov)
  • The genes involved in the translocation were determined in one case (Meyer et al. (atlasgeneticsoncology.org)
  • This translocation seems to create nonfunctional fusion genes. (atlasgeneticsoncology.org)
  • Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)
  • In this paper we describe the effect of the translocation on myc transcription in the RIC system. (lu.se)
  • Molecular Biology introduces you to the structure and function of molecules, including DNA and RNA, which allow genes to be expressed and be maintained from one generation to the next. (manchester.ac.uk)
  • Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
  • We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)
  • ZNF513 , a transcription factor, binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts. (nature.com)
  • There were no significant associations between CDK2AP1 expression and estrogen receptor status, tumour grade and tumour type. (cancerindex.org)
  • Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. (karger.com)
  • Some of the induced genes, such as CREM, CHOP, and MAP kinase phosphatase-1, may be components of a homeostatic response to excessive stimulation. (jneurosci.org)
  • An Arabidopsis full-length enhanced yeast one hybrid (eY1H) transcription factor (TF) resource comprised of 645 or 91% of TFs expressed in the root stele and 75% of root-expressed TFs is presented. (usda.gov)
  • However, 19 genes contained codons under positive selection. (bvsalud.org)
  • We also identified 34 taxon-specific codon aversion motifs from 49 plastid genes. (bvsalud.org)
  • Deciphering the regulation of poly(A) tail shortening requires both transcriptome-wide approaches and more targeted methodologies, allowing deep analyses of specific mRNAs. (bvsalud.org)
  • Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)
  • Transcription occurs from a nonintegrated, circular minichromosome in the nucleus of the plant cell, and virion DNA is synthesised in the cytoplasm by reverse transcription of the 35S RNA transcript (4, 5). (i-sis.org.uk)
  • Proteomics is a new science direction that explores biological activity related to protein expression [ 28 ]. (hindawi.com)
  • While transcription-translation coupling is likely prevalent across prokaryotic organisms, not all species are dependent on it. (wikipedia.org)
  • This programmed arrest of transcription gives time for translation of the leader peptide to commence, and transcription to resume once coupled to translation. (wikipedia.org)
  • Whether transcription is coupled to translation determines whether this stops transcription. (wikipedia.org)