Regulation of striated muscle contraction. Medical search. Frequent questions

The regulation of vertebrate striated muscle contraction involves a number of different molecules, including the thin-filament accessory proteins tropomyosin and troponin that provide Ca(2+)-dependent regulation by controlling access to myosin binding sites on actin. (egelmanlab.org)
These observations help to explain many of the seemingly contradictory results obtained with cMyBP-C and show how cMyBP-C can provide an additional layer of regulation to actin-myosin interactions. (egelmanlab.org)
We examine the sponge Ephydatia muelleri and find tissue-wide organization of a contractile module composed of actin, striated-muscle myosin II, and transgelin, and that contractions are regulated by the release of internal Ca 2+ stores upstream of the myosin-light-chain-kinase (MLCK) pathway. (nsf.gov)
The coordinated interaction of the myofilaments actin and myosin within the myocytes gives muscle tissue the ability to contract. (amboss.com)
Myofilaments are protein fibers consisting of thick ( myosin ) and thin ( actin ) filaments and are responsible for the contractile properties of muscle cells. (amboss.com)
Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). (arigobio.cn)
Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. (elifesciences.org)
Work done using smooth muscle myosin and mammalian non-muscle myosin have demonstrated that phosphorylation of the RLC at conserved Serine and Threonine sites ( Figure 1B , Serine-19 and Threonine-18) activates myosin motor activity, enhances the affinity of myosin for actin, and promotes myosin filament assembly ( Heissler and Sellers, 2016 ). (elifesciences.org)
The bipolar myosin filaments promote the sliding of antiparallel actin filaments relative to one another resulting in contraction of an actin network. (elifesciences.org)
The muscles all begin the actual process of contracting (shortening) when a protein called actin is pulled by a protein called myosin. (bccampus.ca)
This occurs in striated muscle (skeletal and cardiac) after specific binding sites on the actin have been exposed in response to the interaction between calcium ions (Ca ++ ) and proteins (troponin and tropomyosin) that "shield" the actin-binding sites. (bccampus.ca)
All muscles require adenosine triphosphate (ATP) to continue the process of contracting, and they all relax when the Ca ++ is removed and the actin-binding sites are re-shielded. (bccampus.ca)
Skeletal muscles are made up of contractile proteins-actin and myosin. (bccampus.ca)
The actin and myosin proteins are arranged very regularly in the cytoplasm of individual muscle cells (referred to as fibers), which creates a pattern, or stripes, called striations. (bccampus.ca)

In the first place, two contractile substances might be present, a "phasic" and a "tonic" one, analogous to those supposed by Botazzi (4) in the vertebrate striated muscle, or the same substance might contract in both cases, the difference between the contractions being due solely to differences in the transmission mechanism between the nerve impulse and the contractile substance. (caltech.edu)

The myofilaments of striated muscle are arranged into sarcomeres while smooth muscle myofilaments lack a specific arrangement. (amboss.com)
Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). (arigobio.cn)
Myosin binding protein-C (MyBP-C) is a thick filament-associated protein localized to the crossbridge-containing C zones of striated muscle sarcomeres. (ox.ac.uk)
Moreover, it is assumed that a significant contribution to enhanced muscle capability lies in the sarcomeres itself. (frontiersin.org)

Methods were devised for the rapid removal of the stimulated cheliped to liquid air and for the analysis of the frozen muscle tissue. (caltech.edu)
We conclude that the contractile module of sponge tissues shares elements of homology with contractile tissues in other animals, including muscles, indicating descent from a common, multifunctional tissue in the animal stem-lineage. (nsf.gov)
Muscle tissue is a soft tissue that is primarily composed of long muscle fibers. (amboss.com)
Depending on the intracellular arrangement of these myofilaments , muscle tissue is classified as either striated (skeletal and cardiac) or nonstriated (smooth) muscle. (amboss.com)
An increase in blood cardiac troponin levels thus indicates cardiac muscle tissue damage. (amboss.com)
Woody breast syndrome is characterized by degenerative changes at the muscle fiber level and accumulation of connective tissue between the fibers. (iastatedigitalpress.com)
The operational aims were to study the sarcomere lengths in different breast muscle locations and the tensile strength of muscle tissue, longitudinally and transversely to the fiber direction. (iastatedigitalpress.com)
Overall, our data highlights that myosin activity is required for rapid cell contraction and tissue folding in developing Drosophila embryos. (elifesciences.org)
This transmission of impulses makes cardiac muscle tissue similar to nerve tissue, although cardiac muscle cells are notably connected to each other by intercalated discs . (wikidoc.org)
Intercalated discs support synchronized contraction of cardiac tissue. (wikidoc.org)
The protein performs different functions in the two organs, regulating contractility in the heart and playing a role in the development of fast and slow muscle fibers in skeletal muscle tissue. (uc.edu)
Muscle is one of the four primary tissue types of the body, and the body contains three types of muscle tissue: skeletal muscle, cardiac muscle, and smooth muscle ( Figure 1 ). (bccampus.ca)
The Three Types of Muscle Tissue. (bccampus.ca)
The body contains three types of muscle tissue: (a) skeletal muscle, (b) smooth muscle, and (c) cardiac muscle. (bccampus.ca)
A muscle can return to its original length when relaxed due to a quality of muscle tissue called elasticity . (bccampus.ca)
Contractility allows muscle tissue to pull on its attachment points and shorten with force. (bccampus.ca)
1. Why is elasticity an important quality of muscle tissue? (bccampus.ca)
Dedicated muscle tissue in multicellular organisms tends to exhibit a comforting structural homology, to effect that one could recognise striated muscle in a jellyfish and feel a warm kind of brotherly Verbundenheit, but it evolved probably at least four separate times in separate clades rather than arising from some early eumetazoan ancestor. (derangedphysiology.com)
At the most basic level we can separate muscle tissue into smooth and striated, where the striations originate from a repeating pattern of regularly arranged proteins, whereas "smoothness" is conferred by an irregular arrangement without a repeating pattern. (derangedphysiology.com)

Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus. (supp.ai)

Such muscles are innervated by two motor fibers only, each causing a different type of contraction. (caltech.edu)

Current areas of interest include thin and thick filament-based regulation of contraction in human cardiac and skeletal muscle, the molecular basis of length-dependent activation in cardiac muscle, and alteration of these mechanisms in ageing and diseases. (kcl.ac.uk)
There are no structural differences between cardiac and skeletal muscle TnC. (online-sciences.com)

Accordingly, the volume of SR tubules localized around the myofibrils is strongly reduced in skeletal muscle fibers of 4- and 10-month-old sAnk1 knockout (KO) mice, while additional structural alterations only develop with aging. (mdpi.com)
To verify whether the lack of sAnk1 also alters intracellular Ca 2+ handling, cytosolic Ca 2+ levels were analyzed in stimulated skeletal muscle fibers from 4- and 10-month-old sAnk1 KO mice. (mdpi.com)
Thus, we investigated the force output and work produced by single skinned fibers of rat soleus muscles during and after ramp contractions at a constant velocity. (frontiersin.org)
Skeletal muscle fibers are multinucleated structures that compose the skeletal muscle. (bccampus.ca)

Tropomyosin, together with the troponin complex, regulates muscle contraction and, along with tropomodulin and leiomodin, controls the uniform thin-filament lengths crucial for normal sarcomere structure and function. (nih.gov)
We suggest that the K15N mutation causes DCM by altering Ca 2+ -dependent thin-filament regulation and that one of the possible HCM-causing mechanisms by the R21H mutation is through alteration of leiomodin's function. (nih.gov)

Luca Fusi obtained a PhD in Physiology from the University of Florence (Italy), during which he investigated the structure-function relation of the molecular motor of skeletal muscle in situ, combining sarcomere mechanics and small-angle X-ray diffraction in single muscle fibres. (kcl.ac.uk)
In 2023 he was appointed as Lecturer in Muscle Physiology at the Centre for Human and Applied Physiological Sciences in the School of Basic and Medical Biosciences. (kcl.ac.uk)
Trying to guess the examiners' minds from the way this syllabus item is positioned (in the "musculoskeletal" section), we can infer that the detailed anatomy and physiology of cardiac muscle is probably intended for the cardiovascular section , and what they wanted from us here is more of a comparison of the ultrastructural elements that distinguish the three muscle types. (derangedphysiology.com)
This certainly seems to be the spirit of Question 11 from the second paper of 2015, which asked for a comparison of the anatomy and physiology of skeletal and smooth muscle. (derangedphysiology.com)

Found in both skeletal and cardiac muscle . (online-sciences.com)
To investigate the in vivo roles of HCDs, we developed the first carnosine synthase knockout (CARNS1-/-) rat strain to investigate the impact of an absence of HCDs on skeletal and cardiac muscle function. (fapesp.br)

Fast skeletal myosin binding protein-C modulates the speed and force of fast skeletal muscle contraction. (uc.edu)

In 2014 he was awarded a King's Prize Fellowship to study a novel form of regulation of contractility in skeletal muscle based on the myosin filament. (kcl.ac.uk)
During his Fellowship he extended the study of thick filament-based regulation to cardiac muscle and he contributed to develop a novel paradigm of regulation of contractility in striated muscle. (kcl.ac.uk)
Non-muscle cell contractility is critical for tissues to adopt shape changes. (elifesciences.org)

Puolanne, T. J. & Costandache, C. G. & Ertbjerg, P., (2021) "Influence of Woody Breast Myopathy on Sarcomere Length and Tensile Strength in Commercial Broiler Pectoralis major Muscle", Meat and Muscle Biology 5(1), 12, 1-11. (iastatedigitalpress.com)
Deduce the structural and functional and structural roles of nebulin in muscle contraction and their role in nemaline myopathy, collaboration with University of Arizona/NIH. (iit.edu)
Exertional myopathy in horses is a syndrome of muscle fatigue, pain, or cramping associated with exercise. (msdvetmanual.com)
Less common exertional myopathies that cause exercise intolerance without muscle necrosis include mitochondrial myopathies, type 2 polysaccharide storage myopathy, and myofibrillar myopathy in Warmblood and Arabian horses. (msdvetmanual.com)

The phosphorylation of MLC primarily regulates the force production and maintenance in the smooth muscle [ 6 ]. (hindawi.com)
Numerous studies have shown that MYL9 regulates ATPase activity and myosin contraction through phosphorylation and dephosphorylation. (cusabio.com)

Skeletal muscle is under voluntary control of the somatic nervous system. (amboss.com)
The external urethral sphincter, made up of striated muscles, contributes to voluntary control over the flow of urine. (helpmynursingpaper.com)

The level of myosin light chain (MLC) phosphorylation is an important determinant of smooth muscle contraction. (hindawi.com)
It is suggested that the phosphorylation of MLC catalyzed by Ca 2+ -calmodulin- (CAM-) dependent MLCK and dephosphorylation catalyzed by MLCP help regulate the contraction and relaxation of smooth muscle [ 8 , 9 ]. (hindawi.com)
The phosphorylation of smooth muscle regulatory light chain by MLCK is the basic requirement for smooth muscle contraction and hollow organ physiological activities [ 10 ]. (hindawi.com)

A new publication from King's researchers describes a new mechanism required for muscle contraction, which could have important implications for understanding. (kcl.ac.uk)
Hypothermia describes a state in which the body's mechanism for temperature regulation is overwhelmed in the face of a cold stressor. (medscape.com)
The theoretical implications of this finding are discussed and a hypothesis offered to explain the mechanism which makes the two contraction types possible. (caltech.edu)
It is concluded that all four contractions take place in all the muscle fibres and that the conception of the mechanism of crustacean nerve muscle system developed before is enlarged to include the new results. (caltech.edu)
The underlying mechanisms of contraction ( excitation-contraction coupling and the sliding filament mechanism ) are similar in all muscle types. (amboss.com)
Deduce the structural mechanism of delayed stretch activation in striated muscle, collaboration with Duke University Medical School. (iit.edu)

Small Ankyrins (sAnk1) are muscle-specific isoforms generated by the Ank1 gene that participate in the organization of the sarcoplasmic reticulum (SR) of striated muscles. (mdpi.com)
and skeletal muscle which is activated by calcium stored in the sarcoplasmic reticulum (SR). (wikidoc.org)

H1 appears in smooth muscles and endothelial cells, such as those that line the interior surface of blood vessels. (facty.com)
Histamine binds to endothelial cells and triggers contractions. (facty.com)

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene. (wikipedia.org)
Troponin (Tn), is a key protein complex in the regulation of striated muscle contraction, composed of three subunits. (wikipedia.org)
Cardiac myosin binding protein C (cMyBP-C) appears to modulate this Ca(2+)-dependent regulation and has attracted increasing interest due to links with inherited cardiac diseases. (egelmanlab.org)
May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. (arigobio.cn)
Pathophysiology Myasthenia gravis is an autoimmune disease of the neuromuscular junction resulting from the production of antibodies against the acetylcholine receptor protein of skeletal muscles. (medicscientist.com)
Researchers at the University of Cincinnati say a regulatory protein found in skeletal muscle fiber may play an important role in the body's fight or flight response when encountering stressful situations. (uc.edu)
The protein, fast skeletal myosin binding protein-C (fMyBP-C), plays a foundational role in the proper regulation of contractile structure and function in the body's fast twitch muscles - these muscles produce sudden bursts of power to sprint into action, jump or lift heavy objects. (uc.edu)
For that action, fast muscle is essential, and fast myosin binding protein-C is the key molecule to regulate the speed of action. (uc.edu)
Myosin-binding protein-C is a thick filament regulatory protein found in striated muscle in both the heart and skeletal system. (uc.edu)
Sadayappan along with researchers at UC College of Medicine, Florida State University, the University of Massachusetts Medical School and the Illinois Institute of Technology published research in the scholarly journal PNAS to further the understanding of the protein in skeletal function and regulation. (uc.edu)
Song says that research examined the role of the protein in fast-twitch muscles by generating a knockout mouse - an animal in which researchers have either inactivated, replaced or disrupted the existing fast myosin binding protein-C gene to study its impact. (uc.edu)
Our study concludes that fast myosin binding protein-C is essential in regulating the force generation and speed of contraction of fast muscles. (uc.edu)
We also think if we can manipulate the workings of fast myosin binding protein-C in skeletal muscle that we can prevent or at least slow down the loss of muscle function in genetic muscle disease such as distal arthrogryposis. (uc.edu)

One of these, resulting from stimulation of the thicker fiber, is termed the "fast" contraction, while the other is called the "slow. (caltech.edu)
In this case, a single impulse in the thicker motor fiber causes a twitch-like contraction, and the system behaves in almost all respects as does a single motor unit of a vertebrate muscle: single shocks of different strengths give twitches of a considerable strength and a constant height, and during tetanic contraction the action currents are all of the same magnitude. (caltech.edu)
In contrast to this, single shocks given to the thinner fiber produce no visible response in the muscle, but faradic stimulation causes action currents which grow in height and a contraction with a long latent period. (caltech.edu)
The chemical changes occurring in the adductor muscle of the cheliped of the crayfish Cambarus clarkii during these two types of contraction were investigated in order to obtain evidence on two possible mechanisms by which the two contractions might occur in the same muscle fiber. (caltech.edu)
Tensile strengths longitudinally and transversally to the muscle fiber direction in the cranial and middle parts of the muscles were determined. (iastatedigitalpress.com)
Tensile strength was much greater in diffuse woody breast muscles when extended longitudinally or transversely to the fiber direction. (iastatedigitalpress.com)
Electromyography with repeated neural stimulation shows progressive decrease in muscle-fiber contraction. (medicscientist.com)

Therefore, EA could reduce the bladder hypertrophy to ameliorate DBD by reversing the impairment in the mucosa layer and detrusor SMCs, which might be mainly mediated by the regulation of p-MLC and p-MLCK levels. (hindawi.com)

It allows muscle to return to its original length during relaxation after contraction. (bccampus.ca)

His laboratory uses a combination of mechanical and structural methods, such as small-angle X-ray diffraction and fluorescence polarisation microscopy, to study the molecular mechanisms that control force generation in striated muscle at cellular and subcellular level. (kcl.ac.uk)
This improved muscle capability is related to various mechanisms, including pre-activation, stretch-reflex responses and elastic recoil from serial elastic tissues. (frontiersin.org)

We used Förster resonance energy transfer to study effects of the tropomyosin mutations on the structure and kinetics of the cardiac troponin core domain associated with the Ca 2+ -dependent regulation of cardiac thin filaments. (nih.gov)
"It was expected answers would describe in detail the role of troponin, tropomyosin and calmodulin in mediating muscle contraction" , the examiners rejoined. (derangedphysiology.com)

Stimulation of this axon results, when appropriate stimuli are used, in two types of contractions comparable with the fast and slow contractions of doubly motor-innervated crustacean muscles. (caltech.edu)
Stimulation of the thick fibre causes a response, which, though it is not always faster than the response of the thin fibre, must be considered as a "fast" contraction. (caltech.edu)
Stimulation of the thickest fibre gives a fast contraction, stimulation of the second in size a slow contraction and stimulation of the third fibre, the smallest, causes inhibition. (caltech.edu)
Unlike skeletal muscle , which contracts in response to nerve stimulation, and like single unit smooth muscle, cardiac muscle is myogenic , meaning that it is self-excitable stimulating contraction without a requisite electrical impulse coming from the central nervous system. (wikidoc.org)

Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. (arigobio.cn)

Human skeletal muscle proteins. (wikipedia.org)
Cells with genetically inactivated components of pH regulation (SLC9A1), glycolysis (ALDOA), or mitochondrial respiration (NDUFS1) could be rescued through access to functional proteins in co-cultured wild-type cells. (bvsalud.org)
They make up 15%-25% of total body proteins and are mainly found in smooth muscle. (cusabio.com)

If synchronization of cardiac muscle contraction is disrupted for some reason (for example, in a heart attack ), uncoordinated contraction known as fibrillation can result. (wikidoc.org)

Smooth muscle is under involuntary control of the autonomic nervous system and external stimuli (e.g., chemical, mechanical). (amboss.com)
At the same time, histamine also stimulates the creation and release of many smooth muscle cell relaxants. (facty.com)
Smooth muscle is non-striated and performs involuntary movements. (facty.com)
Histamine can stimulate smooth muscle and cause it to contract. (facty.com)
The bladder detrusor smooth muscle cells (SMCs) and fibroblasts were observed under transmission electron microscopy (TEM). (hindawi.com)
The function of striated or smooth muscle is regulated by the balance of myosin light chain kinase (MLCK) and MLCP activity. (hindawi.com)
Cardiac muscle is one of three major types of muscle, the others being skeletal and smooth muscle . (wikidoc.org)
On the other hand, both cardiac muscle and smooth muscle can respond to other stimuli, such as hormones and local stimuli. (bccampus.ca)
Ca ++ also is required for the contraction of smooth muscle, although its role is different: here Ca ++ activates enzymes, which in turn activate myosin heads. (bccampus.ca)

Recent research by the Randall Centre for Cell and Molecular Biophysics provides evidence for the role of myosin-based regulation in the potentiation of heart. (kcl.ac.uk)

This is made up of striated muscle, which comprises of the following three parts: 1. (spiritsong.org)

Since cardiac muscle is myogenic, the pacemaker serves only to modulate and coordinate contractions. (wikidoc.org)

The physiological and anatomical features of the innervation of the four most distal muscles in the legs of Eupagurus are described. (caltech.edu)

Cardiac muscle is also under involuntary control of cardiac pacemaker cells and forms the walls of the cardiac chambers ( myocardium ). (amboss.com)
Specialized pacemaker cells in the sinoatrial node normally determine the overall rate of contractions, with an average resting pulse of 72 beats per minute. (wikidoc.org)
joined to one another at intercalated discs and under the regulation of pacemaker cells, which contract as one unit to pump blood through the circulatory system. (bccampus.ca)

Nephrons, the functional unit of the kidneys, remove waste products from the blood and play a major role in the regulation of fluid and electrolyte balance. (helpmynursingpaper.com)

The kidneys also affect calcium and phosphate regulation by producing a substance that converts vitamin D into its active form. (helpmynursingpaper.com)
In contrast to skeletal muscle , cardiac muscle cannot contract in the absence of extracellular calcium ions as well as extracellular potassium ions. (wikidoc.org)

The development of this contractile module appears to involve myocardin-related transcription factor (MRTF) as part of an environmentally inducible transcriptional complex that also functions in muscle development, plasticity, and regeneration. (nsf.gov)

The first stimulus of the thick fibre causes an action current top which is clearly distinguishable, the action currents of the slow contraction show up only after a number of stimuli. (caltech.edu)
A single impulse in the thick fibre does not cause a contraction, but sets up a muscle-action current. (caltech.edu)
The urethra passes through a thick layer of skeletal muscles called the pelvic floor muscles. (helpmynursingpaper.com)

Unfortunately, myoglobin is not cardiac specific, being also found in skeletal muscle , and thus is less useful in the diagnosis of acute myocardial infarction unless used in conjunction with other markets. (online-sciences.com)
CK-MB is found mainly in cardiac muscle Trace amounts of CK-MB are found in skeletal muscle. (online-sciences.com)

Shortening, lengthening, and SSCs were performed under physiological boundary conditions with 85% of the maximum shortening velocity and stretch-shortening magnitudes of 18% of the optimum muscle length. (frontiersin.org)

Episodes range from subclinical to severe muscle necrosis with recumbency and myoglobinuric renal failure. (msdvetmanual.com)

The four thicker fibres were found to be motor axons, each eliciting a contraction with different characteristics. (caltech.edu)

Myasthenia gravis is an autoimmune disorder that causes sporadic but progressive weakness and abnormal fatigability of striated (skeletal) muscles. (medicscientist.com)
Both anatomical abnormalities, including atrial dilatation and abnormal ventricular structures, and functional deficits such as reduced blood flow and reduced strength of contractions were observed. (e-enm.org)

These muscles stabilize the urethra and contribute to urinary continence. (helpmynursingpaper.com)

Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development. (nih.gov)

IHC-P: Human cardiac muscle and spleen tissues. (abcam.com)
This behavior has been observed for decades, but their contractile tissues remain uncharacterized with respect to their ultrastructure, regulation, and development. (nsf.gov)
3. Which of the following properties is not common to all three muscle tissues? (bccampus.ca)

Their function is the regulation of striated and cardiac muscle contraction. (online-sciences.com)
It is shown for the flexor of the carpopodite that each of the three fibres of this "completely" innervated muscle has a different function. (caltech.edu)
Muscle-specific type III intermediate filament essential for proper muscular structure and function. (arigobio.cn)
Skeletal muscle function was assessed by an exercise tolerance test, contractile function in situ and muscle buffering capacity in vitro. (fapesp.br)
Diagnostic test results Tensilon test confirms diagnosis-temporarily improved muscle function within 30 to 60 seconds after I.V. injection of edrophonium or neostigmine and lasting up to 30 minutes. (medicscientist.com)
Expression and function of non-muscle myosin-IIA in Fechtner syndrome]. (nih.gov)
In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
General Basic and applied investigation of neuromuscular function and establishing electrophysiological criteria of nerve and muscle dysfunction for clinical diagnosis. (gilai.com)

1972 : International course in Muscle Biophysics, Italy. (gilai.com)

Figure 427 from Chapter 16 (Cytoplasmic matrix and cytoskeleton) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Papillary muscle of cat heart shows the cross-banded organization of striated muscle. (ucsd.edu)

low tidal volume and vital capacity Clinical Tip Respiratory muscle weakness seen in myasthenic crisis may be severe enough to require emergency intubation and mechanical ventilation. (medicscientist.com)
i ) partial detachment of XBs during the eccentric phase of a SSC, ( ii ) significantly enhanced forces and mechanical work during the concentric phase of SSCs compared with shortening contractions with and without XB-inhibition, and ( iii ) no residual force depression after SSCs. (frontiersin.org)
Residual force depression (rFD) following active muscle shortening and residual force enhancement (rFE) following active muscle stretch ( Abbott and Aubert, 1952 ) are fundamentally accepted mechanical properties of skeletal muscle ( Rassier, 2017 ). (frontiersin.org)
As a result, we developed a hardware-software complex for studying the mechanical properties of biological materials (muscles) in real-time mode. (scirp.org)

In this paper we propose an alternative approach for the implementation of real-time mode in the experiments on muscle preparations (papillary muscles, trabeculae, walls of vessels) based on an external input-output cards with built-in analog-to-digital/digital-to-analog converters and signal processor. (scirp.org)

Deduce the structural and functional l roles of My-BP-C in muscle contraction, collaboration with University of Massachusetts Medical School. (iit.edu)

Cardiac muscle is a type of involuntary striated muscle found in the walls of the myocardium . (wikidoc.org)

Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. (nih.gov)

Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. (nih.gov)

Anatomy69

Organisms14

Diseases12

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Psychiatry and Psychology2

Phenomena and Processes51

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena3

Information Science2

Health Care1

Actin14

Vertebrate striated muscle1

Sarcomeres4

Tissue19

Esophagus1

Type of contraction1

Cardiac and skeletal muscle2

Fibers4

Thin-filament2

Physiology4

Skeletal and cardiac2

Fast skeletal muscle1

Contractility3

Myopathy4

Regulates2

Voluntary2

Phosphorylation3

Mechanism6

Sarcoplasmic reticulum2

Endothelial cells2

Protein13

Fiber7

Hypertrophy1

Relaxation1

Mechanisms2

Troponin2

Stimulation4

Contributes1

Proteins3

Synchronization1

Smooth muscle9

Molecular1

Made up of striated1

Modulate1

Distal1

Pacemaker cells3

Role in the regulation1

Calcium2

Transcriptional1

Thick3

Found in skeletal muscle2

Physiological1

Renal1

Characteristics1

Abnormal2

Urinary1

Isoforms1

Tissues3

Function8

Biophysics1

Heart1

Mechanical4

Papillary1

Structural1

Myocardium1

Dilated cardiomyopathy1

Isoform1