• Strategies for addressing antimicrobial drug resistance stress the need for new drugs ( 1 - 3 ), and yet the rate of drug development is in decline ( Figure 1 ) ( 4 ). (cdc.gov)
  • Resistance limits the market life of antimicrobial drugs, while limited markets exist for agents only active against resistant pathogens. (cdc.gov)
  • PK/PD research aims to identify antimicrobial drug exposures relative to the in vitro MIC that best predicts efficacy and reduced selection of resistance, i.e., the PK/PD index ( Figure 2 ) ( 10 - 13 ). (cdc.gov)
  • During the COVID-19 pandemic, we've also been battling a second serious global health crisis: antimicrobial resistance. (merck.com)
  • After being exposed to antimicrobials, some bacteria survive and can become resistant to these medicines - this is called antimicrobial resistance, or AMR. (merck.com)
  • Since 2018, five countries (Liberia, Nepal, Pakistan, Samoa [based on self-assessment], and Zimbabwe) with estimated high typhoid fever incidence (≥100 cases per 100,000 population per year) ( 8 ), high antimicrobial resistance prevalence, or recent outbreaks introduced typhoid conjugate vaccines into their routine immunization programs ( 2 ). (cdc.gov)
  • WHO recommends that countries with endemic typhoid fever § establish health facility-based surveillance with laboratory confirmation to determine disease burden, ¶ monitor antimicrobial resistance patterns, facilitate rapid outbreak detection, and assess vaccine impact ( 3 ). (cdc.gov)
  • Whether one focuses on WHO's global action plan on antimicrobial resistance or the international response to health emergencies like the Ebola and Zika viruses, there were countless venues for official and unofficial decisions and discussions on every health issue under the sun. (unfoundation.org)
  • Commission Decision 2007/407/EC of 12 June 2007 on a harmonised monitoring of antimicrobial resistance in Salmonella in poultry and pigs was adopted. (europa.eu)
  • Commission Decision 2007/516/EC of 19 July concerning a financial contribution from the Community towards a survey on the prevalence and antimicrobial resistance of Campylobacter spp. (europa.eu)
  • Moreover, they are widely seen as critical for addressing emerging infectious diseases, for example by containing or limiting outbreaks of infectious diseases or combatting the spread of antimicrobial resistance. (who.int)
  • Previous clinical studies and randomized controlled trials have revealed that low serum vitamin D levels are associated with the risk of developing insulin resistance. (frontiersin.org)
  • Magnesium has been reported to be a protective factor for insulin resistance, and magnesium has been considered an important co-factor for vitamin D activation. (frontiersin.org)
  • However, the effect of dietary magnesium intake on the relationship between vitamin D and the risk of developing insulin resistance has not been comprehensively investigated. (frontiersin.org)
  • Therefore, we designed this cross-sectional analysis to assess whether dietary magnesium intake modifies the association of vitamin D and insulin resistance. (frontiersin.org)
  • We assessed differences between serum vitamin D levels and the risk of developing insulin resistance (interaction test), using a weighted multivariate logistic regression to analyze differences between participants with low and high magnesium intake levels. (frontiersin.org)
  • Among adults in the United States, we found an independent association between vitamin D level and insulin resistance, and this association was modified according to different levels of magnesium intake. (frontiersin.org)
  • Insulin resistance (IR) refers to an efficiency decline in the performance of insulin to promote glucose uptake and utilization in tissues or cells ( 1 , 2 ). (frontiersin.org)
  • This change disrupts glucose regulation and contributes to insulin resistance and type 2 diabetes. (weeksmd.com)
  • Chronic low grade inflammation accelerate insulin resistance and chronic high grade inflammation, such as arthritis have also profound impact on bone integrity. (uni-ulm.de)
  • Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance. (uni-ulm.de)
  • Regular physical activity has anti-inflammatory effects and improves insulin sensitivity in the brain, protecting against cognitive decline and brain diseases. (bodykind.com)
  • The current epidemic of dementia is driven, at least in part, by the concurrent epidemics of obesity, insulin resistance, T2D, and metabolic syndrome. (nih.gov)
  • Moreover, there are evidences supporting a mechanistic link between Alzheimer's disease and insulin resistance (one of the first hallmarks of Type 2 diabetes). (ibecbarcelona.eu)
  • On the other hand, neuronal insulin resistance is known to be associated to Alzheimer's disease since early stages. (ibecbarcelona.eu)
  • Our results suggest that monomeric amyloid beta-peptide 1-40 contributes to mimic insulin effects in the brain, which could be good when neurons have an extra requirement of energy beside the well-known protective effects on insulin intracellular signalling, while its accumulation and subsequent oligomerization blocks the insulin receptor producing insulin resistance and compromising neuronal metabolism and protective pathways. (ibecbarcelona.eu)
  • The Minkowski Prize Lecture will address the regulation of energy and glucose metabolism by the dual incretin receptor agonists, while the EASD-Lilly Anniversary Prize Lecture will be about the role of ectopic lipid in insulin resistance and cardiometabolic disease. (medscape.com)
  • For type 1 diabetes, "disease-modifying" and "disruptive" approaches on the meeting agenda include new data on immune modulation for people in early stages in order to prevent or delay insulin dependence, islet transplantation including the use of stem cell-derived beta cells, and the latest in technology including automated insulin delivery systems, also known colloquially as the "artificial pancreas. (medscape.com)
  • The enterosalivary nitrate‐nitrite‐nitric oxide pathway is an alternative pathway of nitric oxide generation, potentially linking the oral microbiome to insulin resistance and blood pressure (BP). (ahajournals.org)
  • ORIGINS (Oral Infections, Glucose Intolerance, and Insulin Resistance Study) enrolled 300 diabetes mellitus-free adults aged 20 to 55 years (mean=34±10 years) (78% women). (ahajournals.org)
  • The overall purpose of our research is to understand the molecular determinants underlying cognitive impairment associated with diabetes and metabolic syndrome components, including obesity, dyslipidaemia, hypertension, insulin resistance and hyperglycaemia. (lu.se)
  • Our current research is unveiling mechanisms of insulin-dependent metabolic regulation in insulin resistance. (lu.se)
  • A few affected individuals have developed problems with blood sugar (glucose) regulation including insulin resistance and diabetes. (medlineplus.gov)
  • PI3K's role in insulin activity may be related to the development of insulin resistance and diabetes, and problems with adipocyte maturation might contribute to lipoatrophy in affected individuals. (medlineplus.gov)
  • Controlling the balance between immunity and immunopathology is crucial for host resistance to pathogens. (nature.com)
  • Plant disease resistance protects plants from pathogens in two ways: by pre-formed structures and chemicals, and by infection-induced responses of the immune system. (wikipedia.org)
  • Elevated CO 2 (eCO 2 ) is a determinant factor of climate change and is known to alter plant processes such as physiology, growth and resistance to pathogens. (portlandpress.com)
  • Proper regulation of immune responses mediated by NLRs is important as over-activation results in growth defects, while under-activation leads to vulnerability to pathogens. (ubc.ca)
  • The Public Health Agency performs microbiological laboratory analysis, including diagnostics, and supports quality and method development at laboratories engaged in diagnostics of communicable disease pathogens. (folkhalsomyndigheten.se)
  • Loss of vitamin D-dependent homeostatic mechanisms may promote disease progression. (springer.com)
  • Many of our inquiries are initiated by multilevel examinations of explanted human heart tissues obtained at the time of transplantation or organ donation to permit insights into both the heterogeneity of myocardial adaptations to disease and identification of dominant mechanisms and responses. (upenn.edu)
  • In addition, the lab is actively engaged in studies examining regulation of contractility by microtubules and other cytoskeletal elements, cardiotoxicity associated with VEGF-anti-angiogenic tyrosine kinase inhibitors, disease-associated shifts in cardiac metabolism, mechanisms of inherited cardiomyopathies, advanced myocardial phenotyping using digital pathology and machine learning techniques, and integrated genomic inquiries designed to identify molecular mechanisms of myocardial pathology. (upenn.edu)
  • However, the role of MitoTEMPO on nonalcoholic fatty liver disease (NAFLD) and its possible mechanisms are largely unknown. (hindawi.com)
  • Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications. (springer.com)
  • As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)
  • This review details the findings surrounding the impact of running on various health outcomes and premature mortality, highlights plausible underlying mechanisms linking running with chronic disease prevention and longevity, identifies the estimated additional life expectancy among runners and other active individuals, and discusses whether there is adequate evidence to suggest that longevity benefits are attenuated with higher doses of running. (researchgate.net)
  • Elucidation of the mechanisms underlying the resistance to systemic therapies and the appropriate response strategies to solve this issue will contribute to improved outcomes in the multidisciplinary treatment of uHCC. (bvsalud.org)
  • In this review , we summarize recent findings on the mechanisms of resistance to drugs such as sorafenib , regorafenib, and lenvatinib in molecularly targeted therapy , with a focus on epigenetic regulation and the tumor microenvironment and outline the approaches to improve the therapeutic outcome for patients with advanced HCC. (bvsalud.org)
  • The kidney is both the contributing and the target organ of the hypertensive processes,[1] and the disease involves the interaction of multiple organ systems and numerous mechanisms of independent or interdependent pathways. (medscape.com)
  • After reviewing recent literature, University of Missouri researchers contend that physical inactivity is the primary cause of chronic diseases such as diabetes, obesity and fatty liver disease and that even people who set aside time for exercise regularly but are otherwise sedentary, may not be active enough to combat these diseases. (weeksmd.com)
  • Osteoporosis and Diabetes are common diseases with a high prevalence in the aging population. (uni-ulm.de)
  • Chronic stress can also lead cardiovascular disease (CVD), diabetes, autoimmune diseases, upper respiratory infections (URIs), and poorer wound healing (Cohen et al. (open.ac.uk)
  • Alzheimer's disease and Type 2 diabetes are pathological processes associated to ageing. (ibecbarcelona.eu)
  • HAMBURG, Germany - This year's meeting of the European Association for the Study of Diabetes (EASD) offers an in-depth look into "disease-modifying and disrupting therapies" in both type 1 and type 2 diabetes. (medscape.com)
  • Mathieu told Medscape that a unifying theme for much of the EASD meeting's content is "We are now entering the era of disease-modifying and disease-disrupting therapies" in both diabetes types. (medscape.com)
  • A third debate will tackle the question of whether all people with type 2 diabetes and chronic kidney disease should be on [sodium-glucose co-transporter 2] (SGLT2) inhibitors "by default. (medscape.com)
  • Hormonal control and regulation of inflammation and metabolism. (uni-ulm.de)
  • The hallmark of the pathologic report was the marked infiltration by foamy macrophages of joints and aortic valves, and prominent deposits of fat within intestinal mucosa and mesenteric lymph nodes, which made Whipple consider this case an obscure disease of fat metabolism and propose the name intestinal lipodystrophy. (medscape.com)
  • Bacteria can become resistant and no longer respond to these drugs: this phenomenon is known as antibiotic resistance and resistant bacteria. (pasteur.fr)
  • 33,000 deaths a year resulting from antibiotic resistance in Europe. (pasteur.fr)
  • Antibiotic resistance does not just affect disease-causing bacteria. (pasteur.fr)
  • If the bacterial species responsible for an infection has been identified, it is preferable to use an antibiotic targeted against this bacteria, as this will have a lesser impact on the microbiome and the development of antibiotic resistance. (pasteur.fr)
  • Underdosage of antibiotics, which can occur when treatment is interrupted mid-course or with the use of counterfeit drugs sold in some low-income countries, can also encourage the acquisition of antibiotic resistance. (pasteur.fr)
  • Although antibiotic resistance can be observed in all countries, some are affected to a greater extent than others. (pasteur.fr)
  • In addition, we coordinate national efforts concerning antibiotic resistance, infection control and healthcare-associated infections. (folkhalsomyndigheten.se)
  • The re-emergence of stem rust on wheat in Europe and Africa is reinforcing the ongoing need for durable resistance gene deployment. (nature.com)
  • The co-location of these genes on a small non-recombinogenic segment simplifies their deployment as a gene stack and potentially enhances their resistance durability. (nature.com)
  • Consequently, there is an ongoing need to expand resistance resources and to enhance gene stewardship through co-deployment of multiple resitance (R) genes, rather than single genes, to increase resistance durability. (nature.com)
  • Since genetic dissection of genes within alien segments in wheat was not possible due to lack of recombination, the question arose as to whether the apparent durability of such resistances might be due to multiple genes rather than a single gene. (nature.com)
  • However, as there is no current Pgt race known to be virulent to either resistance gene, it was not possible to unambiguously determine whether the recombinant introgression carried a single or both genes. (nature.com)
  • The segregation ratios of these families were consistent with expression of major gene resistance (MGR) controlled by a dominant R locus. (frontiersin.org)
  • Resistance-type exercise results in functional adaptation and reduced PMP22 gene expression in CMT rat muscle. (cdc.gov)
  • PURPOSE: To examine effects of chronic resistance-type training in a CMT1A rat model, using stretch-shortening contractions (SSCs), on muscle performance, physiology and PMP22 gene expression. (cdc.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Minnesota Department of Health, Infectious Disease Division convened a multi-disciplinary Advisory Group (referred to as the Minnesota HAI Prevention Advisory Group) to establish statewide HAI prevention leadership. (mn.us)
  • In Europe, the European Center for Disease Prevention and Control (ECDC) estimates that 33,000 people die each year as a direct result of resistant bacteria. (pasteur.fr)
  • ScienceDaily (Aug. 1, 2011) "" According to the Centers for Disease Control and Prevention, 25 percent of Americans have inactive lifestyles (they take fewer than 5,000 steps a day) and 75 percent do not meet the weekly exercise recommendations (150 minutes of moderate activity each week and muscle-strengthening activity twice a week) to maintain good health. (weeksmd.com)
  • From 2005, the European Food Safety Authority (EFSA), in collaboration with the European Centre for Disease Prevention and Control (ECDC), has been entrusted to prepare the yearly EU summary. (europa.eu)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Announcer] This program is presented by the Centers for Disease Control and Prevention. (cdc.gov)
  • Despite recent advancements in HCC prevention and diagnosis , over 50% of patients are diagnosed at Barcelona Clinic Liver Cancer Stage B or C. Systemic therapies are recommended for unresectable HCC (uHCC) with major vascular invasion, extrahepatic metastases , or intrahepatic lesions that have a limited response to transcatheter arterial chemoembolization, but the treatment outcome tends to be unsatisfactory due to acquired drug resistance . (bvsalud.org)
  • U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Prevention Services, Division of TB Elimination. (cdc.gov)
  • Last October, the Centers for Disease Control and Prevention (CDC) and the Office of the Assistant Secretary for Preparedness and Response (ASPR) began working together to arrange for the team to visit the U.S. (cdc.gov)
  • Vaccines are critical to the prevention and control of many communicable diseases and therefore underpin global health security. (who.int)
  • A clear risk is a reduction in essential services and particularly vaccination and prevention of other communicable diseases. (who.int)
  • The Ebola crisis in West Africa made it clear that countries need to greatly enhance their capacities to prevent, detect, and respond to infectious disease outbreaks. (unfoundation.org)
  • He has served as the lead author of numerous WHO guidance documents on topics such as ethical issues in infectious disease outbreaks, tuberculosis care and control, and clinical trials oversight. (shu.edu)
  • One important task is to provide expert support to investigations of suspected or confirmed outbreaks of communicable diseases and to maintain laboratory preparedness needed for effective communicable disease control in the country. (folkhalsomyndigheten.se)
  • Regional outbreaks (e.g. of Ebola virus disease), the COVID-19 pandemic and the threat of future pandemics (such as with a novel flu strain) have and will continue to strain even the most resilient health systems. (who.int)
  • However, in an era of emerging drug resistance, controlled clinical data are often not available to guide regulatory policy. (cdc.gov)
  • In recent years, there has been an increase in Leishmania drug resistance and treatment failure . (rosslandtelegraph.com)
  • Recent studies have found that not only do the size and shape of these vesicles differ between sensitive and drug-resistant strains of Leishmania , but vesicles produced by drug-resistant parasites contain special drug-resistance molecules . (rosslandtelegraph.com)
  • A better understanding of extracellular vesicles' function is another step towards understanding how drug resistance spreads among Leishmania populations with the goal of preventing it. (rosslandtelegraph.com)
  • Early research sought to elucidate the cause(s) for the apparent role of metabolic dysfunction in the increased prevalence of neurocognitive dysfunction and dementia, tentatively attributed to vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). (nih.gov)
  • Thus, the fine tuning of NK cell functions by the HPA axis preserved tissue integrity without impairing pathogen elimination, which reveals a novel aspect of neuroimmune regulation. (nature.com)
  • Relative to a susceptible plant, disease resistance is the reduction of pathogen growth on or in the plant (and hence a reduction of disease), while the term disease tolerance describes plants that exhibit little disease damage despite substantial pathogen levels. (wikipedia.org)
  • Disease outcome is determined by the three-way interaction of the pathogen, the plant and the environmental conditions (an interaction known as the disease triangle). (wikipedia.org)
  • Although obvious qualitative differences in disease resistance can be observed when multiple specimens are compared (allowing classification as "resistant" or "susceptible" after infection by the same pathogen strain at similar inoculum levels in similar environments), a gradation of quantitative differences in disease resistance is more typically observed between plant strains or genotypes. (wikipedia.org)
  • resistance is usually specific to certain pathogen species or pathogen strains. (wikipedia.org)
  • Disease control is achieved by use of plants that have been bred for good resistance to many diseases, and by plant cultivation approaches such as crop rotation, pathogen-free seed, appropriate planting date and plant density, control of field moisture, and pesticide use. (wikipedia.org)
  • We found that the COR and jasmonate isoleucine (JA-Ile) co-receptor JAZ2 is constitutively expressed in guard cells and modulates stomatal dynamics during bacterial invasion We analyzed tissue expression patterns of AtJAZ genes and measured stomata opening and pathogen resistance in loss- and gain-of-function mutants. (nih.gov)
  • tritici ( Pgt ) races over the past two decades 1 , 2 has motivated global efforts to identify effective stem rust (Sr) resistance genes. (nature.com)
  • Bacteria can become resistant to antibiotics either through mutation or by acquiring resistance genes that confers resistance to one or more antibiotics. (pasteur.fr)
  • While the acquisition of resistance through mutation is extremely rare - occurring in approximately one in every hundred million bacteria - resistance genes can be acquired between bacteria much more frequently, by as many as one bacterium in every hundred. (pasteur.fr)
  • The friendly, non-pathogenic bacteria that colonize us and make up our microbiome and are essential to our health can also develop resistance, creating a reservoir of resistance genes that can then spread to pathogenic bacteria. (pasteur.fr)
  • Taking antibiotics disrupts our microbiome and contributes to an increase in our reservoir of resistance genes. (pasteur.fr)
  • This study applies knowledge from structural and evolutionary studies of the rice NLR protein Pik-1 and cognate effector protein AVR-Pik to engineering of new disease resistance genes. (elifesciences.org)
  • Many of the characterized resistance (R) genes used to confer disease resistance in crop breeding programs encode NLR proteins ( Kourelis and van der Hoorn, 2018 ). (elifesciences.org)
  • Our lab aims to unravel the endocrine control of cross-talk of immune and stromal cells during these pathologies and how resolution of inflammation can be fine tuned to alleviate disease and to allow repair of tissue integrity. (uni-ulm.de)
  • When I was health policy staff director of the U.S. Senate Health, Education, Labor and Pensions Committee for the Chairman, I remember infectious disease doctors from Johns Hopkins University telling the committee about cases year after year of drug-resistant forms of pneumonia. (merck.com)
  • Two years ago, the Global Health Security Agenda (GHSA) gave countries common targets they can work toward to stop infectious disease in its tracks. (cdc.gov)
  • Nonalcoholic fatty liver disease (NAFLD) is a common pandemic disease [ 1 ], which is affecting about 1/3 of the adult population in developed countries [ 2 , 3 ]. (hindawi.com)
  • 2018). Running provides many health benefits, such as lower risks of cardiovascular, metabolic, neurological, pulmonary, and even psychological and psychiatric diseases (Lee et al. (researchgate.net)
  • We discuss research approaches that can aid regulatory decision making on the treatment of resistant infections and minimization of resistance selection. (cdc.gov)
  • Unfortunately, quantitative data concerning the clinical implications of resistance are lacking for many common infections ( 8 ). (cdc.gov)
  • Antibiotics are drugs used to fight bacterial infections such as pneumonia, bronchitis, ear infections, meningitis, urinary tract infections, septicemia and sexually transmitted diseases. (pasteur.fr)
  • PK/PD models may be used to identify the determinants and implications of resistance, although clinical data on symptom resolution or survival remain the standard ( 9 ). (cdc.gov)
  • Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
  • In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)
  • Changes in vascular permeability are commonly present in certain clinical diseases and when occurring in the lung or brain lead to serious consequences related to impaired gas exchange and cerebral function, respectively. (bvsalud.org)
  • Our study aims to decipher the effect of eCO 2 on plant responses to PM. Oak seedlings were grown in controlled environment at ambient (aCO 2 , ∼400 ppm) and eCO 2 (∼1000 ppm), and infected with Erysiphe alphitoides, the causal agent of oak PM. Plant growth, physiological parameters and disease progression were monitored. (portlandpress.com)
  • However, the physiological regulation of this improvement is not known. (cdc.gov)
  • 3) Where a person in charge of a laboratory knows or suspects, as a result of analysis, examination or tests of or on a specimen, that an animal or another person is suffering from or has died from a communicable disease listed in Schedule B, he shall, within 7 days and in accordance with section 4, make a report to the medical health officer. (gov.bc.ca)
  • 3 In addition to the requirements of section 2, the administrator or other person in charge of a hospital shall, within 7 days, make a report to the medical health officer respecting a patient admitted to the hospital who is suffering from a reportable communicable disease or from rheumatic fever. (gov.bc.ca)
  • The Public Health Agency has the overall national responsibility for protecting the population against communicable diseases and coordinates communicable disease control on a national level. (folkhalsomyndigheten.se)
  • We develop regulations, recommendations and guidance for healthcare professionals to ensure effective communicable disease control. (folkhalsomyndigheten.se)
  • Some of the agency's responsibilities include vaccination programmes, emergency preparedness for health threats and national stockpiles of communicable disease medications. (folkhalsomyndigheten.se)
  • ScienceDaily (Aug. 1, 2011) "" Even small amounts of physical activity will help reduce heart disease risk, and the benefit increases as the amount of activity increases, according to a quantitative review reported in Circulation , journal of the American Heart Association. (weeksmd.com)
  • Sattelmair said this work differs from previous reviews of studies examining physical activity and heart disease risk because it included quantitative assessments of the amount of physical activity a person may need to reduce their risk as well as the magnitude of benefit. (weeksmd.com)
  • Irwin, M. R. & Cole, S. W. Reciprocal regulation of the neural and innate immune systems. (nature.com)
  • Cain, D. W. & Cidlowski, J. A. Immune regulation by glucocorticoids. (nature.com)
  • Vitamin D has immunomodulatory, anti-inflammatory, antioxidant, and anti-fibrotic actions that may impact on the occurrence and outcome of immune-mediated disease. (springer.com)
  • Vitamin D deficiency has been commonly present in patients with immune-mediated liver and non-liver diseases, and it has been associated with histological severity, advanced hepatic fibrosis, and non-response to conventional glucocorticoid therapy in autoimmune hepatitis. (springer.com)
  • In conclusion, vitamin D has properties that could ameliorate immune-mediated disease, and vitamin D deficiency has been a common finding in immune-mediated liver and non-liver diseases, including autoimmune hepatitis. (springer.com)
  • A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
  • As the original intention of the SNS response is to survive a short-term threat, long term health regulation such as the digestive and immune system shut down. (open.ac.uk)
  • Ubiquitin proteasome system (UPS)-mediated NLR turnover plays a pivotal role in the fine-tuned regulation of immune responses. (ubc.ca)
  • The work includes receiving reports of communicable diseases and monitoring the occurrence of diseases in general. (folkhalsomyndigheten.se)
  • However, one pitfall observed throughout the years in in vitro and in in a multitude of human trials in vivo , is the resistance of cancer cell lines to hTRAIL-induced apoptosis. (csuohio.edu)
  • This epigenetic regulation makes the marbled crayfish extremely interesting for tumor researchers. (dkfz.de)
  • The Roles of Epigenetic Regulation and the Tumor Microenvironment in the Mechanism of Resistance to Systemic Therapy in Hepatocellular Carcinoma. (bvsalud.org)
  • We also outline current and future measures that regulatory agencies may employ to help control resistance and promote drug development. (cdc.gov)
  • In the second half, we outline measures that regulatory agencies may use to help control resistance and facilitate drug development. (cdc.gov)
  • Measures to control resistance should be based on scientific evidence concerning its effect on human health and the effectiveness of available interventions. (cdc.gov)
  • However, disease control is reasonably successful for most crops. (wikipedia.org)
  • Other Member States or region of a Member States can obtain special guarantees if it has a control programme recognised as equivalent to that approved for Sweden and Finland in accordance with Regulations (EC) No 853/2004 (foodstuffs) and 2160/2003 (animals). (europa.eu)
  • Pherobio provides green biological control products, technical services, and ecological regulation solutions with insect pheromone as the core. (cbinsights.com)
  • Plant disease resistance is crucial to the reliable production of food, and it provides significant reductions in agricultural use of land, water, fuel and other inputs. (wikipedia.org)
  • Other epidemics include Chestnut blight, as well as recurrent severe plant diseases such as Rice blast, Soybean cyst nematode, Citrus canker. (wikipedia.org)
  • Across large regions and many crop species, it is estimated that diseases typically reduce plant yields by 10% every year in more developed nations or agricultural systems, but yield loss to diseases often exceeds 20% in less developed settings. (wikipedia.org)
  • My research interests include studies on the biology, epidemiology and management of bacterial diseases of plant especially citrus canker, blackleg of potato and bacterial blight of rice. (edu.pk)
  • Strawberry production in California is limited by plant diseases such as Macrophomina root rot (caused by Macrophomina phaseolina ) and Botrytis fruit rot (BFR) (caused by Botrytis cinerea ). (calpoly.edu)
  • Host plant resistance evaluations for Macrophomina root rot were conducted for the 2020-2021 and 2021-2022 growing seasons. (calpoly.edu)
  • A wide range of plant resistance to Macrophomina root rot was observed. (calpoly.edu)
  • Pharmacokinetic/pharmacodynamic research models offer promising approaches to define the determinants of resistance selection and drug doses that optimize efficacy and reduce resistance selection. (cdc.gov)
  • There are now vaccines to protect against malaria, dengue and Ebola virus disease, and promising vaccines against respiratory syncytial virus, tuberculosis and all influenza virus strains are in the pipeline. (who.int)
  • Remarkably, dominant jaz2Δjas mutants are resistant to Pseudomonas syringae but retain unaltered resistance against necrotrophs. (nih.gov)
  • This study was conducted to characterize Alberta limber pine seed families for WPBR resistance and to develop reliable molecular tools for marker-assisted selection (MAS). (frontiersin.org)
  • The authors nicely demonstrate that it is indeed possible to engineer resistance proteins with broad recognition specificity for the rice blast fungus. (elifesciences.org)
  • The Infectious Diseases Society of America (IDSA) ( 5 ), the World Health Organization ( 6 ), and other experts ( 7 ) have drawn attention to this potentially serious threat to public health. (cdc.gov)
  • Advances in Health and Disease. (novapublishers.com)
  • The globally accepted, fundamental framework to improve global health security is WHO's International Health Regulations (IHR). (unfoundation.org)
  • These actions can be identified through comprehensive tools such as all-hazards National Action Plans for Health Security (NAPHS), disease-specific plans, contingency plans, and other sources. (who.int)
  • Leishmaniosis is classified as a neglected tropical disease by the World Health Organization, primarily affecting those in tropical and subtropical regions. (rosslandtelegraph.com)
  • The regulations for bringing pets into Canada are lax - generally, the only requirements are proof of rabies vaccination and a certificate from a veterinarian declaring the animal to be in apparent good health . (rosslandtelegraph.com)
  • Watering is particularly important to trees for growth, resistance to disease and insects, temperature regulation, and overall health. (newwestcity.ca)
  • Near the turn of this century, the emergence of diseases like severe acute respiratory syndrome (SARS) and H5N1 influenza was a big wake-up call and showed the world more clearly than ever that a health threat anywhere is a threat everywhere - what affects one country affects us all. (cdc.gov)
  • Eleven years ago, countries came together to sign the International Health Regulations (IHR), a historic agreement which gave the world a new framework for stopping the spread of diseases across borders. (cdc.gov)
  • We work to ensure good public health and to ensure that the population is protected against communicable diseases and other health threats. (folkhalsomyndigheten.se)
  • The Public Health Agency also disseminates scientifically based knowledge to promote health and to prevent disease and injury. (folkhalsomyndigheten.se)
  • The factors controlling vascular permeability in health and disease are poorly understood. (bvsalud.org)
  • Therefore, the number of laboratory-confirmed S . Typhi cases represents a small proportion of the actual disease incidence. (cdc.gov)
  • Our results demonstrate the existence of a COI1-JAZ2-MYC2,3,4-ANAC19,55,72 module responsible for the regulation of stomatal aperture that is hijacked by bacterial COR to promote infection. (nih.gov)
  • He identified periodic acid-Schiff (PAS)-staining granules, most likely representing degenerating bacterial forms, within macrophages isolated from the small bowel as well as other tissue and fluid specimens (eg, pericardium, endocardium, lymph nodes, synovia, lung, brain, meninges) obtained from patients in whom Whipple disease was suspected. (medscape.com)
  • "susceptible person" means a person not possessing adequate resistance against a specific infectious agent. (gov.bc.ca)
  • Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. (springer.com)
  • Regarding Alzheimer's disease, amyloid beta-peptide aggregation into beta-sheets is the main hallmark of Alzheimer's disease. (ibecbarcelona.eu)
  • More than 20 life-threatening diseases can now be prevented by immunization (2) . (who.int)
  • Here we found that the regulation of natural killer (NK) cell function by the glucocorticoid receptor (GR) was required for host survival after infection with mouse cytomegalovirus (MCMV). (nature.com)
  • Fig. 1: Organ-specific glucocorticoid regulation of the production of IFN-γ by NCR1 + ILCs in the spleen and liver after infection with MCMV. (nature.com)
  • Renal disease progression in autosomal dominant polycystic kidney disease. (rug.nl)
  • According to Scott Rector, assistant professor in the departments of Nutrition and Exercise Physiology and Internal Medicine, nonalcoholic fatty liver disease (NAFLD) is a relatively new epidemic related to the recent increase in obesity and physical inactivity rates. (weeksmd.com)
  • Due to the antagonistic interactions between the salicylic acid (SA) and JA defense pathways, efforts to increase resistance to biotrophs result in enhanced susceptibility to necrotrophs, and vice versa. (nih.gov)
  • AMPK pathways are energy regulation pathways. (springer.com)
  • To identify novel pathways that can be targeted by drugs or life-style interventions in order to improve brain function in metabolic disease. (lu.se)
  • Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells. (nature.com)
  • According to disease severity, NAFLD could progress from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis and finally develop to hepatocellular carcinoma (HCC) [ 4 ]. (hindawi.com)
  • Disease severity varied among years for specific genotypes as well as the average final mortality for all genotypes in the experiments. (calpoly.edu)