These studies ultimately led the researchers to angiogenesis-related pathways that "all converged" onto the angiogenesis-promoting cytokinesinterleukin-8 and CXCL1, he said. (genomeweb.com)
Pro-inflammatory cytokines IL-1beta, IL-8, and chemokines K203, ah221 (CCL7), ah294, CCL3, CCL20, K60 (CXCL1) and CXCL14 were all upregulated from 1.3 to 26.7 fold in A/ph/CA/2373/98 (H9N2) virus infected Macrophages. (usda.gov)
2-fold including key cytokines [IL1F6, IL1B], chemokines [CXCL1, CCL10, IL8] as well as markers of epithelial suppression and neutrophil recruitment/ activation. (scienceblog.com)
In macrophage-colony stimulating factor (MCSF) generated macrophages, Sia + IgG induced increased production of numerous cytokines/ chemokines including IL-6, TNFα, CXCL1, and IL-10, and the expression of the macrophage surface marker CD163. (scirp.org)
Therefore CXCR4 may travel EMT with an up-regulation regarding chemokine receptors along with cytokines crucial in cellular migration, lymphatic system attack, as well as growth metastasis.Long-term meth (Mum) misuse ends in a severe psychosis indistinguishable coming from paranoid schizophrenia. (aktsignals.com)
CXCR28
CXCR2, c-Raf and MAPKs was found to regulate CXCL1-induced IL-6 expression in OASFs and RASFs. (researchsquare.com)
Our present work suggests that the CXCL1/CXCR2 axis helps to orchestrate inflammatory responses in OA and RA SFs. (researchsquare.com)
Chemokine (CXC motif) ligand 1 (CXCL1) acts as a key chemoattractant for neutrophils by binding specifically to its corresponding G protein-coupled receptor chemokine (CXC motif) receptor 2 (CXCR2) (11, 12). (researchsquare.com)
We have elucidated the molecular mechanisms involved in the increase in IL-6 expression caused by CXCL1 incubation in SFs, which was regulated by its receptor CXCR2, c-Raf and MAPK signaling components, and activator protein-1 (AP-1) transcriptional activation. (researchsquare.com)
Chemokine (C-X-C motif) ligand 1 (CXCL1), also known as growth-regulated oncogene-alpha or melanoma growth stimulatory activity, alpha, is a secreted growth factor that interacts with the G-protein coupled receptor CXCR2, also known as interleukin-8 receptor type beta (IL8RB) [ 7 , 8 ], that plays a key role in inflammation and as a chemoattractant for neutrophils [ 9 , 10 ]. (thno.org)
Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis. (busitema.ac.ug)
In contrast to the actual 2D surroundings, MCF-7 CXCR4WT cellular material classy inside 3D rBM showed the EMT phenotype, combined with expression involving CXCR2, CXCR7, CXCL1, CXCL8, CCL2, interleukin-6, and granulocyte-macrophage nest exciting aspect. (aktsignals.com)
Chemokine2
Lung lavage fluid was analyzed for PMN count and the concentration of CXCL1, a hallmark PMN chemokine. (jax.org)
The expression of the chemokine (C-X-C motif) ligand 1 (CXCL1), an inflammatory protein, has been reported to be up-regulated in many human cancers. (thno.org)
Genes9
1. Extensive Regulations of immune genes in chicken macrophages and lungs infected with influenza virus H9N2. (usda.gov)
Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
Expression of genes involved in the regulation of lymphatic vessels was evaluated by RT 2 Profiler™ PCR array (Qiagen, Hilden, Germany) in intestinal tissue. (emjreviews.com)
In addition, the up-regulation of genes associated with peptidoglycan and urease synthesis and the restriction of major virulence genes might be immune evasion strategies of App . (biomedcentral.com)
The regulation of metabolic genes and major virulence genes indicate that the dominant antigens might differ during the infection process and that vaccines based on these antigens might allow establishment of a precise and targeted immune response during the early phase of infection. (biomedcentral.com)
MgSO 4 treatment of human placental explants significantly reversed the expression of numerous genes sensitive to LPS regulation and suppressed LPS-induced NFκB activation. (mssm.edu)
In this dissertation, I have focused on understanding the basic principles underlying IL-17-induced post-transcriptional regulation of inflammatory genes. (pitt.edu)
Arid5a stabilizes mRNAs encoding IL-17-driven genes such as Il6, Cxcl1 and Cxcl5 by directly binding to their 3'UTR. (pitt.edu)
HOX and homeobox genes play an important role in the regulation of many processes including cell proliferation, differentiation, angiogenesis, receptor signaling, apoptosis and regulate transcription of target androgen receptor genes [ 16 ]. (biomedcentral.com)
Angiogenesis4
CXCL1 modulates angiogenesis, tumorigenesis and wound healing (13). (researchsquare.com)
At the same time, the cancer types in which miR-200 regulated angiogenesis - ovarian, lung, renal, and basal-like breast - were also found to have "markedly elevated" IL-8 and CXCL1 expression when compared with luminal breast cancers. (genomeweb.com)
Additional in vitro and in vivo experiments confirmed that IL-8 and CXCL1 are direct targets of the miR-200 family, and that the miRNA family can directly affect angiogenesis in endothelial cells by targeting production of IL-8 and CXCL1. (genomeweb.com)
1 Paneth cells are a part of the intestinal innate immune system and have a central role in regulation of intestinal angiogenesis. (emjreviews.com)
CXCL21
Greater inflamma tion inside the pancreas of KrasG12DPdx1 Cre spontaneous PDAC mice correlated with a rise in inflammatory cytokineschemokines this kind of as INF, CXCL1, CXCL2 and lymphocyte and macrophage infiltration. (micrornainhibitors.com)
Inflammation2
Genetic regulation of Zfp30, CXCL1, and neutrophilic inflammation in m" by Holly Rutledge, David L Aylor et al. (jax.org)
We show that Zfp30 is expressed in airway epithelia in the normal mouse lung and that altering Zfp30 expression in vitro affects CXCL1 responses to an immune stimulus. (jax.org)
STARD12 and STARD14 were expected to be potential biomarkers for LUAD, which were associated with epigenetic regulation, immune infiltration and ferroptosis. (medsci.org)
Inulin, a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. (bvsalud.org)
Interleukin3
Here, we found that both diseases feature elevated levels of CXCL1 and interleukin (IL)-6, an important proinflammatory cytokine that participates in OA and RA pathogenesis. (researchsquare.com)
This study details how we found that CXCL1 promoted interleukin (IL)-6 expression in RA and OA synovial fibroblasts (SFs), worsening the inflammatory status in the joints of both diseases. (researchsquare.com)
Furthermore, novel mechanistic investigations revealed that CXCL1 expression stimulated interleukin 6 (IL6) expression and repressed tissue inhibitor of metalloproteinase 4 (TIMP4). (thno.org)
Monocytes1
In addition, the production of IL-6, TNFα, IL-1β, and CXCL1 by monocytes was profoundly increased by treatment with Sia + IgG. (scirp.org)
Neutrophil1
Neutrophil recruitment activation, epithelial suppression, TLR2 pathway up-regulation, T cell activation and bone resorption appear as major activation themes in stomatitis. (scienceblog.com)
Vitro1
We described the anticancer effects and mechanism of action of HL2401, a monoclonal antibody directed at CXCL1 with in vitro and in vivo data on bladder and prostate cancers. (thno.org)
Regulates2
This genetic variant regulates both CXCL1 and PMN by altering Zfp30 expression, and we model the relationships between the QTL and these three endophenotypes. (jax.org)
Finally, CXCL1 triggered the transcriptional activities of c-Jun (which regulates the expression of proinflammatory proteins) in OASFs and RASFs. (researchsquare.com)
Lung4
We used lung eQTL data to implicate a variant in the gene Zfp30 in the CXCL1/PMN response. (jax.org)
High expression of IL-8 and CXCL1 were also associated with worse overall survival in lung and renal cancers. (genomeweb.com)
Intranasal instillation of purified protease increased lung CXCL1, IL-6 and TNF levels in mice. (cdc.gov)
The host DEGs were mainly enriched in inflammatory signaling pathways, such as the TLR, NLR, RLR, BCR and TCR signaling pathways, resulting in large-scale cytokine up-regulation and thereby yielding a cytokine cascade for anti-infection and lung damage. (biomedcentral.com)
Expression7
The Western blot and qPCR were performed to analyze expression levels of CXCL1, as well as CXCL-promoted IL-6 expression in both OASFs and RASFs. (researchsquare.com)
The signal cascades that mediate the CXCL1-promoted IL-6 expression were identified by using chemical inhibitors, siRNAs and shRNAs. (researchsquare.com)
In OASFs and RASFs, CXCL1 promoted IL-6 expression in a dose- and time-dependent manner. (researchsquare.com)
In OASFs and RASFs overexpressing CXCL1 or transduced with shRNA plasmid, IL-6 expression was markedly upregulated. (researchsquare.com)
CXCL1 expression appears to be increased in RA and OA patients (14). (researchsquare.com)
Differences in clinical outcome were not observed in any breast cancer subtype based on CXCL1 expression, suggesting that miR-200 regulation of IL-8 is a key mediator explaining the divergence in clinical outcome between these breast cancer subtypes," they wrote. (genomeweb.com)
Further experiments revealed that TRIM28 could upregulate the expression of CXCL1 by activating NF-κB signaling. (biomedcentral.com)
Responses1
In the setting of cancer, instead of eliciting effector pathways that would lead to tumor elimination, these antibodies might promote down-regulation of the cellular inflammatory responses to the tumor. (scirp.org)
Colorectal cancer2
EMT-mediated regulation of CXCL1/5 for resistance to anti-EGFR therapy in colorectal cancer. (nih.gov)
Herein, we provide novel mechanistic evidence for the chemopreventive effects of curcumin and AKBA through regulation of specific miRNAs in colorectal cancer. (arjunanatural.com)
Contributes1
Previous research has reported that CXCL1 contributes to the ingress of neutrophils into the RA joint (15) and induce hypertrophy and apoptosis of chondrocytes (16). (researchsquare.com)
Tumor4
The mechanisms through which aberrant cellular CXCL1 levels promote specific steps in tumor growth and progression are unknown. (thno.org)
Our findings reveal a previously undocumented relationship between CXCL1, IL6 and TIMP4 in solid tumor biology. (thno.org)
Understanding the regulation of MDSC recruitment and function by TRIM28 provides crucial insights into the association between TRIM28 signaling and the development of an immunosuppressive tumor microenvironment. (biomedcentral.com)
The regulation of the stem cell-like properties by several important signaling pathways have been found to endow the tumor cells with an increased level of tumorigenicity, chemoresistance, and metastatic ability. (molcells.org)
Cellular1
Two-dimensional cultures regarding MCF-7 CXCR4 Delta CTD cellular material, however, not CXCR4WT, showed a good epithelial-to-mesenchymal cross over (Paramedic) characterized by up-regulation of zinc oxide kids finger Elizabeth box-binding homeobox 1, loss in E-cadherin, up-regulation regarding cadherin Eleven, p120 isoform switching, initial associated with extracellular signal-regulated kinase 1/2, and also matrix metalloproteinase-2. (aktsignals.com)
Cancers1
Targeting these critical interactions with a CXCL1 monoclonal antibody offers a novel strategy to therapeutically manage bladder and prostate cancers. (thno.org)
Critically involved1
These findings demonstrate that the CeA-LPB pathway is critically involved in pain regulation, and in the pathogenesis of chronic pain. (iasp-pain.org)
Pathway1
There was strong up-regulation of TLR2, CD14, MYD88, IKKA and NFKB as the dominant toll-like receptor signaling pathway. (scienceblog.com)
Pathogenesis1
According to this evidence, CXCL1 plays a pivotal role in RA and OA pathogenesis. (researchsquare.com)
Progression1
Given the functional and pathological significance of MUC1, MUC4 and MUC5AC in Computer progression and their regulation by inflammatory setting inside the human disorder, we analyzed the irritation in the pancreas of KrasG12DPdx1 Cre mice. (micrornainhibitors.com)
Levels1
In general, CXCL1 levels are extremely low under normal physiological conditions and greatly increased during inflammatory conditions. (researchsquare.com)
Zinc1
Improved antiviral immunity by zinc may also occur through up‑regulation of interferon α production and increasing its antiviral activity. (spandidos-publications.com)
Mice1
PMN and CXCL1 were strongly correlated in preCC mice. (jax.org)
Biology2
He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
Regulatory non-coding RNAs and RNA-binding proteins (RBPs) are important research areas in gene regulation and RNA biology. (rochester.edu)
Role1
Taken together, our results argue that CXCL1 plays an important role in sustaining the growth of bladder and prostate tumors via up-regulation of IL6 and down-regulation of TIMP4. (thno.org)
Specific1
Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation. (bvsalud.org)
Data1
Recent data suggest that the chemopreventive effects of these botanicals may, in part, be mediated through regulation of key cancer-related microRNAs (miRNA) and their downstream gene targets. (arjunanatural.com)