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  • cytokine
  • Expression of tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-8, monocyte chemoattracting protein 1 (MCP-1), and IL-10 was studied by enzyme linked immunosorbent assays (cytokine secretion) and by semiquantitative reverse transcription-polymerase chain reaction. (bmj.com)
  • CD59
  • DAF up-regulation was first detectable at 6 hours and maximal 24 hours poststimulation, whereas no up-regulation of CD59 or MCP was seen. (bloodjournal.org)
  • DAF prevents the formation and accelerates the decay of C3 and C5 convertases, 2 while MCP binds C3b and C4b and allows their degradation by factor I. 4 In contrast, CD59 operates at the distal end of the complement cascade, binding to C9 and preventing its incorporation into the C5b-9 complex, thereby inhibiting the function of the membrane attack complex (MAC). (bloodjournal.org)
  • Transfer of functional prostasomal CD59 of metastatic prostatic cancer cell origin protects cells against complement attack. (springer.com)
  • marker
  • Jiang ZH, Gibson JP (1998) Rapid communication: a PCR-RFLP marker at the porcine complement factor B gene locus shows between-population frequency variation. (edu.pl)
  • gene
  • 4 They are approximately 22 to 25 nucleotides long and provide a second layer of posttranscriptional gene regulation by targeting messenger RNAs (mRNAs) for degradation or repression of translation, 5 and are found in abundance in the central nervous system (CNS). (arvojournals.org)
  • protein
  • Factor H consists of a single strand of protein that, because of the nature of the amino acids along its length, is capable of folding back upon itself, thereby forming bunches, similar to beads on a string. (townsendletter.com)
  • Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component. (semanticscholar.org)
  • Circulating complement factor H-related protein 5 levels contribute to development and progression of IgA nephropathy. (amedeo.com)
  • Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. (springer.com)
  • fluid phase
  • Because the multimers involve the C-terminus of FH, which is bound to host cell surfaces, our results provide new insight on FH regulation during excessive complement activation, both in the fluid phase and at host cell surfaces decorated by C3d. (ucl.ac.uk)
  • membrane
  • The final stage of this assembly is the formation of the complement system's killing machine, namely, the membrane attack complex (MAC). (townsendletter.com)
  • Four proteins of complement assemble on the cell surface in a specific pattern, thereby forming a basic unit that binds to a fifth component that is polymerized with additional such components, forming a cylinder or circular pore in the membrane of the organism under attack. (townsendletter.com)
  • antibodies
  • Since the body does not normally generate antibodies against itself unless cells have been modified or altered in some fashion (chemical, bacterial, or viral infection, injury, etc.), complement components will not aggregate at cell surface sites protected by factor H. (townsendletter.com)
  • Normally, without bound factor H, antibodies would be developed against the antigenic site, complement would assemble on the antigen-antibody complex, and cell lysis would eventually occur. (townsendletter.com)
  • components
  • 6 Complement components assemble only on antigen-antibody complexes. (townsendletter.com)
  • The complement components will assemble on the antigen-antibody complexes thereby generated and will destroy the invaders through the action of the MAC ( see Chart 1 , a 93 KB .pdf). (townsendletter.com)
  • 1 ) recently demonstrated that superoxide dismutase 1 (SOD1) transgenic mice deficient in complement components C1q and C3 do not have extended survival, concluding that global complement activation does not affect overall disease in amyotrophic lateral sclerosis (ALS). (pnas.org)
  • mediators
  • TABLE 1 Regulation of macrophage-derived mediators by C5a C5a promotes release of G-CSF via Akt and MEK1/2 The current studies were focused on G-CSF, which was the mediator most potently enhanced by C5a in PEMs(Table 1). (bio-zentrum.com)
  • These include an increase in endothelial permeability to proteins 10 and the release of soluble mediators, including platelet-activating factor and prostacyclin, 6 the chemokines interleukin-8 and MCP-1, 11 12 growth factors, 13 14 and matrix metalloproteinases. (bloodjournal.org)
  • role
  • Barber MC, Clegg RA, Finley E, Vernon RG, Flint DJ (1992) The role of growth hormone, prolactin and insulin-like growth factors in the regulation of rat mammary gland and adipose tissue metabolism during lactation. (edu.pl)
  • significantly
  • In a 4 year study of longevity of 491 nonagenarians in the Finnish Vitality 90+ study, risk factor-adjusted mortality was significantly higher among the rs1061170 (C) carriers compared to non-carriers (odds ratio 1.78, CI 1.19-2.67, p = 0.005), and the survival curves of these carriers and non-carriers deviated significantly (p = 0.016). (snpedia.com)