• They can trigger apoptosis, a process of programmed cell death, when a cell becomes irreparably damaged or poses a risk of becoming cancerous. (pharmiweb.com)
  • To investigate in vivo molecular mechanisms of silibinin efficacy, tumors and uninvolved skin from tumor-bearing mice were examined immunohistochemically for proliferation, p53, apoptosis, and activated caspase-3. (nih.gov)
  • Together, these results show a strong preventive efficacy of silibinin against photocarcinogenesis, which involves the inhibition of DNA synthesis, cell proliferation, and cell cycle progression and an induction of apoptosis. (nih.gov)
  • It is involved in cell cycle regulation, and induction of apoptosis. (wikipedia.org)
  • The over-expression of p73 in cultured cells promotes a growth arrest and/or apoptosis similarly to p53. (wikipedia.org)
  • Similar to p53 the protein product of p73 induces cell cycle arrest or apoptosis, hence its classification as a tumor suppressor. (wikipedia.org)
  • In addition, it can stimulate apoptosis of cells containing damaged DNA. (medscape.com)
  • Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
  • In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
  • These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
  • If a cell has an error in its DNA that cannot be repaired, it may undergo self-destruction ( apoptosis ). (medlineplus.gov)
  • Apoptosis is a common process throughout life that helps the body get rid of cells that no longer work or that it doesn't need. (medlineplus.gov)
  • Apoptosis protects the body by removing genetically damaged cells that could lead to cancer, and it plays an important role in the development of the embryo and the maintenance of adult tissues. (medlineplus.gov)
  • In other situations the response is cell cycle arrest or programmed cell death (apoptosis), providing a barrier to further tumour development that the tumour may ultimately circumvent through the acquisition of a mutation in one of the genes within the stress-response pathway. (southampton.ac.uk)
  • Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
  • Indeed, in colons of mice carrying mutations in Apc (ApcMin/+) or exposed to the carcinogen azoxymethane, elimination of GCC increased tumor initiation by corrupting genomic integrity in the context of disabled compensatory apoptosis. (jefferson.edu)
  • In addition, cell cycle distribution analysis revealed that G0/G1 phase arrest was induced following pristimerin treatment in CAL‑27 and SCC‑25 cells, which was strongly associated with upregulation of p21 and p27, coupled with downregulation of cyclin D1 and cyclin E. Meanwhile, pristimerin induced significant apoptosis of CAL‑27 and SCC‑25 cells, alongside decreased levels of caspase‑3 and specific cleavage of poly (ADP‑ribose) polymerase. (spandidos-publications.com)
  • Pristimerin has also been reported to induce apoptosis of various human cancer cells, including in multiple myeloma ( 10 ), breast ( 11 ), liver ( 12 ), pancreatic ( 13 ) and prostate cancer ( 14 ). (spandidos-publications.com)
  • Pristimerin exhibited potent anti-proliferative and apoptosis-inducing effects on the OSCC cell lines CAL-27 and SCC-25. (spandidos-publications.com)
  • Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
  • Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
  • It also stops proliferation of cancer cells by arresting them at different phases of the cell cycle and/or by inducing their apoptosis (programmed cell death). (beatcancer.org)
  • Stimulate Apoptosis - Curcumin encourages programmed cancer cell death. (beatcancer.org)
  • The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
  • Histone deacetylase (HDAC) inhibitors may be useful for cancer prevention and therapy by virtue of their ability to 'reactivate' the expression of epigenetically silenced genes, including those involved in differentiation, cell cycle regulation, apoptosis, angiogenesis, invasion, and metastasis. (oregonstate.edu)
  • induces growth arrest or apoptosis depending on the physiological circumstances and cell type. (lsbio.com)
  • LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. (lsbio.com)
  • p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. (lu.se)
  • The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
  • Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
  • Many tumor suppressor proteins play a role in DNA repair, helping to correct genetic mutations and maintain the stability of the genome. (pharmiweb.com)
  • Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
  • Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)
  • 1 nM IC 50 ) to inhibition of two cell cycle-regulating proteins, polo-like kinase 1 and Aurora kinase A. Finally, we show that two of these cell lines, CUTO32 and CUTO42, successfully establish xenografted tumors in nude mice. (nih.gov)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • Some Example Projects: Regulation of HDM2 and HDMX proteins The HDM2 oncoprotein is the major negative regulator of p53 function in the cell. (southampton.ac.uk)
  • Role of CtBP transcriptional repressors in cancer cell proliferation and survival In common with p53, CtBP1 and CtBP2 proteins were discovered through their physical association with a viral oncoprotein. (southampton.ac.uk)
  • Cell cycle proteins are altered in differently in HPV-positive and HPV-negative cancers, suggesting that treating these cancers should be treated according to their subtype. (cancer.gov)
  • Hinck's lab has identified a family of cellular proteins that help regulate cell proliferation and migration and act as breast tumor suppressors. (ucsc.edu)
  • Recent work has shown that these proteins are also involved in hormonal regulation of breast cancer cells. (ucsc.edu)
  • E2 also interacts with a variety of host proteins, including the p53 tumour suppressor protein. (bris.ac.uk)
  • Abdul Hamid, N, Brown, C & Gaston, K 2009, ' The regulation of cell proliferation by the papillomavirus early proteins ', Cellular and Molecular Life Sciences , vol. 66 (10), pp. 1700 - 1717. (bris.ac.uk)
  • Olsson I, Gatanaga T, Gullberg U, Lantz M, Granger GA. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. (aaem.pl)
  • His early research includes seminal work done in 1989, demonstrating the importance of cell cycle proteins in the functioning of DNA tumor viruses. (newswise.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
  • These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
  • Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
  • This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)
  • Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
  • We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase ( TS ) and Survivin , in case of non-small-cell lung cancer (NSCLC). (aacrjournals.org)
  • How do genes control the growth and division of cells? (medlineplus.gov)
  • A variety of genes are involved in the control of cell growth and division. (medlineplus.gov)
  • The cell cycle has checkpoints (also called restriction points), which allow certain genes to check for problems and halt the cycle for repairs if something goes wrong. (medlineplus.gov)
  • HPV-negative tumors contained novel co-amplifications of 11q13 and 11q22, an event that likely promotes the interaction of BIRC2 and FADD , genes that together work to inhibit cell death. (cancer.gov)
  • 687 genes differentiated tumor samples before and after treatment, among which 310 genes did not show the same differential expression in the placebo group or normal samples. (karger.com)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
  • Prevent DNA Damage - Curcumin protects against DNA damage to genes regulating cell replication by toxins, radiation, and other environmental factors. (beatcancer.org)
  • Normalize Cell Growth - Curcumin restores normal growth controls, reverses uncontrolled reproduction of malignant cells, blocks access of cancer cells to growth factors, turns on genes that prevent cell growth and turns off genes that promote cancer growth. (beatcancer.org)
  • Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. (elifesciences.org)
  • Although hundreds of genes are known to be mutated in cancers our understanding of mutational events in cancer cells remains incomplete ( Futreal PA et al, 2004 ). (intechopen.com)
  • Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. (lsbio.com)
  • In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
  • This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
  • During the progression of NSCLC, E2F1 overexpression could produce more aggressive tumors with a high proliferation rate and chemoresistance. (aacrjournals.org)
  • It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
  • This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
  • DNA repair and damage response contribute to genomic instability that accompanies tumor progression. (hindawi.com)
  • Developmental regulation of cell cycle progression during male meiosis. (stanford.edu)
  • Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)
  • Curcumin has been found to suppress initiation, progression, and metastasis of a variety of tumors. (beatcancer.org)
  • Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. (lsbio.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
  • Immunohistochemical identification of molecular genetic events in the progression of preneoplastic lesions to spindle cell squamous-cell carcinoma enables early detection of lesions with the potential for malignant progression, thus permitting timely intervention 1,2 . (bvsalud.org)
  • We discovered that our RET + cell lines had differential regulation of the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B (AKT) pathways. (nih.gov)
  • In single celled organisms these pathways are generally involved in ensuring the survival and replication of the individual cell. (southampton.ac.uk)
  • Stress-response pathways play a key role in the patho-physiology and treatment of many diseases, including cancer.At almost every stage of the development of a tumour, cells are exposed to some form of stress. (southampton.ac.uk)
  • Many current and prospective treatments for cancer work by either inhibiting, or re-activating stress response pathways.Our work focuses on the role of regulators of gene transcription in the response of cancer cells to stress. (southampton.ac.uk)
  • We have also developed interests in other pathways which regulate gene transcription and cancer cell proliferation in response to stress and changes in cell metabolism. (southampton.ac.uk)
  • A particular interest of our work has been how HDM2 and HDMX protein synthesis is controlled in response to cell-signalling pathways in different cell types, and how this affects p53 function in these cells. (southampton.ac.uk)
  • Furthermore, KIN17 is associated with cancer cell proliferation, migration, invasion and cell cycle regulation by regulating pathways including the p38 MAPK, NF‑κB‑Snail and TGF‑β/Smad2 signaling pathways. (spandidos-publications.com)
  • An evolving paradigm expanding the genetic basis of cancer suggests that developmental programs indelibly imprint restricted repertoires of homeostasis, forming the substrate for lineage-dependent tumor induction by deregulation of tissue-specific survival pathways. (jefferson.edu)
  • The underlying mechanisms of these effects were primarily mediated by G 1 phase cell cycle arrest and inhibition of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulate kinase 1/2 (Erk 1/2) and protein kinase B (Akt) signaling pathways. (spandidos-publications.com)
  • Strikingly, contrary to its role as a tumor suppressor, excessive SETD2 results in the upregulation of cell cycle-associated pathways. (frontiersin.org)
  • GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)
  • The TGFβ and Ras-MAPK pathways play critical roles in cell development and cell cycle regulation, as well as in tumor formation and metastasis. (biomedcentral.com)
  • Curcumin can help normalize disrupted biological signaling pathways, improve abnormal gene regulation, support the body's response to chemical stresses and toxic load, and reduce inflammatory processes. (beatcancer.org)
  • They participate in multiple cellular processes and signaling pathways in living organisms, including cell cycle, growth, and metabolism, and mediate chromatin modification, transcriptional regulation, post-translational modification, and cellular autophagy. (techscience.com)
  • P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. (elifesciences.org)
  • CD4 + T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. (nature.com)
  • In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • This study provides fundamental insight into the functional impact of CDK4 inhibition on cells in the tumor microenvironment, which is of high importance and interest to the field. (elifesciences.org)
  • We demonstrated that the RET inhibitor BLU-667 was effective at inhibiting tumor growth in CUTO42 tumors but had a much less profound effect in CUTO32 tumors, consistent with our in vitro experiments. (nih.gov)
  • In line with this observation, elevated extracellular lactate concentrations up to 40 mM and corresponding low extracellular pH (pH e ) have been found in solid tumors under hypoxic conditions [ 18 - 22 ]. (hindawi.com)
  • A phase I/II trial investigating safety and efficacy of autologous TAC01-HER2 in relapsed or refractory solid tumors. (newswise.com)
  • Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)
  • Gefitinib and erlotinib would be effective for tumors with epidermal growth factor receptor (EGFR) mutations or increased EGFR gene copy numbers ( 6 ). (aacrjournals.org)
  • EXO1 mutations also have been reported concerning different types of tumor and prognosis of cancers, such as breast, ovarian, pancreatic, and lung cancer [ 23 - 25 ]. (hindawi.com)
  • Smoking-related tumors featured TP53 mutations, CDKN2A inactivation, and frequent copy number alterations. (cancer.gov)
  • Angela Brooks is developing computational and experimental approaches to determine which mutations in cancer cells are functionally important. (ucsc.edu)
  • Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
  • Herein we selected a Mendelian genetics form of familial cancer such as hereditary tumor syndromic endocrine neoplasias caused by highly penetrant germline mutations leading to pheochromocytoma-paraganglioma syndromes. (intechopen.com)
  • Multiple endocrine neoplasia syndrome type 1 (MEN-1), loss-of-function germline mutations in the tumor suppressor gene MEN1 increase the risk of developing pituitary, parathyroid and pancreatic islet tumors, and less commonly thymic carcinoids, lipomas and benign adrenocortical tumors. (intechopen.com)
  • In the case of multiple endocrine neoplasia type 2 (MEN 2), gain-of-function germline mutations clustered in specific codons of the RET proto-oncogene increase the risk of developing medullary thyroid carcinoma (MTC), phaeochromocytoma and parathyroid tumors. (intechopen.com)
  • Patients with EGFR activating mutations or ALK- positive tumour mutations should also have received targeted therapy (i.e. (who.int)
  • TAK-285 was examined in a model of breast cancer brain metastasis using direct intracranial injection of BT-474-derived luciferase-expressing cells and showed greater inhibition of brain tumor growth compared to animals treated with lapatinib. (jcancer.org)
  • [ 5 ] Targeted disruption of TP53 in the mouse leads to the development of various tumors. (medscape.com)
  • Both STARD12 and STARD14 were corelated with epigenetic regulation, especially TP53 mutation and m6A modification. (medsci.org)
  • Reduction of KIF1C decreases PRKAR1A expression and activates the PKA, which causes an increase in ERK1/2 phosphorylation and SRC-mediated STAT3 activation, a reduction of CDH1, TP53, CDKN1A, and BAX, and eventually promotes tumor formation both in vitro and in vivo. (bvsalud.org)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • Folkman, J. Tumor angiogenesis: therapeutic implications. (nature.com)
  • Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)
  • For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
  • ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)
  • Curcumin can slow the growth of these tumors by inhibiting angiogenesis. (beatcancer.org)
  • After inhibition of RET, the CUTO42 cells had robust inhibition of phosphorylated AKT (pAKT), whereas CUTO22 and CUTO32 cells had sustained AKT activation. (nih.gov)
  • SIGNIFICANCE STATEMENT: We have derived and characterized three novel rearranged during transfection (RET) fusion non-small cell lung cancer cell lines and demonstrated that they have differential responses to RET inhibition as well as regulation of downstream signaling, an area that has previously been limited by a lack of diverse cell line modes with endogenous RET fusions. (nih.gov)
  • Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)
  • Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. (lsbio.com)
  • Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. (cshlpress.com)
  • Current Research and Scholarly Interests Regulation of self-renewal, proliferation and differentiation in adult stem cell lineages. (stanford.edu)
  • Developmental tumor suppressor mechanisms and regulation of the switch from proliferation to differentiation. (stanford.edu)
  • Cell type specific transcription machinery and regulation of cell differentiation. (stanford.edu)
  • It also helped to open a very exciting avenue of research involving investigators with expertise in different aspects of growth control and cancer.Giordano's lab also discovered the tumor suppressor gene RB2/p130 and the cell cycle kinases CDK9 and CDK10, two other key players in cell cycle regulation and cell differentiation. (newswise.com)
  • Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
  • Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
  • Both the Kaplan‑Meier survival analysis and multivariate Cox regression analysis indicated that KIN17 is aberrantly high expressed in various tumor tissues and is also associated with poor prognosis in patients with various tumor types. (spandidos-publications.com)
  • Because it is very invasive, the prognosis of oral squamous cell carcinoma (OSCC) is poor ( 5 ). (spandidos-publications.com)
  • Previous studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor patients. (techscience.com)
  • The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8 + T cells (Tex) in HNSCC. (elifesciences.org)
  • Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects. (elifesciences.org)
  • We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. (ncl.ac.uk)
  • Doug Kellogg's lab is working to elucidate these mechanisms, using biochemistry, genetics, and mathematical modeling to understand signaling networks that are required for control of cell size and cell growth. (ucsc.edu)
  • He has published over 600 papers on gene therapy, cell cycle, genetics of cancer, and epidemiology. (newswise.com)
  • Developmental genetics and tumour genetics. (lu.se)
  • 2014). genetic StudieS are carried out, uSing tuMour SaMPleS froM PatientS with excellent clinical data that have been collected at a PoPulation level or internationally, to Provide unique data coMbining the Pathology, geneticS, clinical featureS, and ePideMiology of tuMourS. (who.int)
  • Some suggest that the TP73 locus encodes both a tumor suppressor (TAp73) and a putative oncogene (ΔNp73). (wikipedia.org)
  • The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)
  • 2-3) a locus commonly deleted in various tumor entities and human cancers. (wikipedia.org)
  • A deficiency of p53 almost certainly leads to unchecked cell proliferation and is noted in 60% of cancers. (wikipedia.org)
  • Lung cancer is a major cause of cancer-related deaths, and non-small-cell lung cancer (NSCLC) comprises ∼75% of all lung cancers ( 1 ). (aacrjournals.org)
  • The p53 tumour suppressor protein is a key component of one such stress-response pathway, and virtually all cancers loose functionality of the p53-stress response pathway. (southampton.ac.uk)
  • KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. (spandidos-publications.com)
  • These membranes are made up of squamous cells and the head and neck cancers that grow in these cells are called squamous cell carcinomas. (cancer.gov)
  • 1 In 2010, about 36,000 Americans are estimated to have been diagnosed with head and neck cancers and an estimated 7,880 were expected have died of squamous cell carcinomas. (cancer.gov)
  • It is mutated in a variety of cancers and is believed to be a tumor suppressor. (frontiersin.org)
  • In mouse and rat xenograft tumor models, TAK-285 showed antitumor activity against cancers that expressed HER2 or EGFR. (jcancer.org)
  • The introduction of HPV vaccines has also drawn more attention to the fact that HPV is associated not only with cervical cancer and genital warts but also with other tumors, such as head neck and anogenital cancers ( 3 ). (cdc.gov)
  • Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)
  • Deaths from sporadic cancers (i.e. cancers for which no recognized exposure accounts for tumour development) may be prevented by screening or earlier diagnosis. (who.int)
  • Klein, G. Foulds' dangerous idea revisited: the multistep development of tumors 40 years later. (nature.com)
  • The accumulation of mutation in the genome led to genomic instability that accompanies the development of tumors [ 9 , 10 ]. (hindawi.com)
  • Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)
  • Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
  • We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
  • Tenacigenin B had anti-tumor effects on lymphoma via regulation of Aurora-A in vitro and in vivo . (medscimonit.com)
  • In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
  • Combination treatment with entinostat and cisplatin significantly decreased tumor growth in vivo . (sciencenet.cn)
  • Several natural and synthetic HDAC inhibitors have been shown to affect the growth and survival of tumor cells in vitro and in vivo. (oregonstate.edu)
  • Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
  • The two-hit hypothesis has now been adopted as a key mechanism for the loss of function of tumor suppressors leading to oncogenesis. (medscape.com)
  • Breast cancer is one of the most common primary tumors to develop associated brain metastases ( 1 , 2 ), and while recent progress in cancer therapy has improved control of primary breast tumors, methods to effectively treat brain metastases from breast cancer remain inadequate. (jcancer.org)
  • p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
  • Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)
  • This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
  • Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
  • However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
  • At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)
  • Thus, the secretion of gall wasps stimulates plant cell growth and overrules homeostasis of the affected leaf area - this is similar to tumour outgrowth. (nature.com)
  • In turn, the plant produces GA, which seems to combat the improper growth signals and re-establishes cell-cycle control. (nature.com)
  • explains the growth of cancerous tumors. (medlineplus.gov)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
  • The nests of tumor cells in Xp11.2 translocation-associated renal cell carcinomas may become centrally discohesive, giving rise to a pseudoalveolar growth pattern. (medscape.com)
  • Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
  • The mechanisms by which cells control their growth and size are poorly understood and represent a fundamental unsolved problem in cell biology. (ucsc.edu)
  • Curcumin can help protect against cancer initiation, slow its growth when it occurs, and even sensitize cancer cells to treatment. (beatcancer.org)
  • Its anti-cancer effects are predominantly mediated through its negative regulation of tumor growth factors, inflammatory cytokines, and other oncogenic molecules. (beatcancer.org)
  • Endometrial cancer invasion depends on cancer-derived tumor necrosis factor-alpha and stromal derived hepatocyte growth factor. (aaem.pl)
  • Principles of how dysregulation causes tumour growth and deviant embryonic development. (lu.se)
  • Receptors on the cell surface bind with hormones that regulate enzyme activity or affect ion channels (eg, growth hormone, thyrotropin-releasing hormone). (msdmanuals.com)
  • They facilitate adhesion between leukocytes and endothelial cells, enabling leukocyte extravasation into tissues during inflammation. (pharmiweb.com)
  • Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
  • Analyses of many tumors typically found in humans including breast and ovarian cancer show a high expression of p73 when compared to normal tissues in corresponding areas. (wikipedia.org)
  • We found that cytoplasmic linker protein 170 (CLIP170) was overexpressed in HNSCC tissues and cells compared to normal controls. (nih.gov)
  • Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. (aaem.pl)
  • Guerra-Infante FM, Flores-Medina S, López-Hurtado M, Zamora-Ruíz A, Sosa González IE, Narcio Reyes ML, Villagrana-Zessati R. Tumor necrosis factor in peritoneal fluid from asymptomatic infertile women. (aaem.pl)
  • Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects. (aaem.pl)
  • Engelmann H, Holtmann H, Brakebusch C, Avni YS, Sarov I, Nophar Y, Hadas E, Leitner O, Wallach D. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. (aaem.pl)
  • Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. (aaem.pl)
  • Chegini N. An inverse relation between the expression of tumor necrosis factor alpha (TNF-alpha) and TNF-alpha receptor in human endometrium. (aaem.pl)
  • Onsrud M, Shabana A, Austgulen R, Nustad K. Comparison between soluble tumor necrosis factor receptors and CA125 in peritoneal fluids as a marker for epithelial ovarian cancer. (aaem.pl)
  • Opala T, Rzymski P, Wilczak M, Woźniak J. Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients. (aaem.pl)
  • CDC is aware of three Monkeypox virus (MPXV) cases in California in which preliminary data show a significant deletion in the tumor necrosis factor (TNF) receptor gene. (cdc.gov)
  • Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease. (nature.com)
  • Lymphendothelial gaps, adjacent to tumour bulks, can be considered as gates facilitating metastatic spread. (nature.com)
  • Patients diagnosed with locally advanced/metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy. (who.int)
  • The Carney complex (CNC) is an autosomal dominant disorder characterized by endocrine and nonendocrine tumors. (bvsalud.org)
  • The endocrine system coordinates functioning between different organs through hormones, which are chemicals released into the bloodstream from specific types of cells within endocrine (ductless) glands. (msdmanuals.com)
  • In biology, cells use a variety of mechanisms to deal with sudden changes in their surroundings. (sciencedaily.com)
  • It is important to design an optimal therapeutic strategy according to tumor biology to improve the treatment of NSCLC ( 2 ). (aacrjournals.org)
  • Cancer research at UC Santa Cruz includes faculty in a wide range of departments, including Applied Math and Statistics, Biomolecular Engineering, Chemistry and Biochemistry, Electrical Engineering, Microbiology and Environmental Toxicology, and Molecular, Cell, and Developmental Biology. (ucsc.edu)
  • The course is an optional second-cycle course for a degree of Bachelor or Master of Science in Biology and Molecular Biology. (lu.se)
  • Gene regulation in developmental biology and the cell cycle. (lu.se)
  • The p73 gene encodes a protein with a significant sequence homology and a functional similarity with the tumor suppressor p53. (wikipedia.org)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
  • CtBP activity is modified by UV radiation and glycolytic metabolism, suggesting that CtBPs regulate cell survival in response to cellular stress. (southampton.ac.uk)
  • Mechanisms that regulate development from single cell to multicellular organisms. (lu.se)
  • Receptors inside cells interact with hormones that regulate gene function (eg, corticosteroids, vitamin D , thyroid hormone). (msdmanuals.com)
  • Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
  • The present review was the first, to the best of our knowledge, to systematically summarize and clarify the relevance between KIN17 and tumor development from different aspects ( Table I ), including the structure, function, expression level and regulatory mechanisms of KIN17, so as to explore the potential of KIN17 as a tumor diagnostic and prognostic biomarker and as a potential therapeutic target. (spandidos-publications.com)
  • however, the antitumor effects and underlying mechanisms of pristimerin in oral cancer cells have not yet been identified. (spandidos-publications.com)
  • Although highly preliminary, the findings suggest that different tumor biological factors may predict response to different chemotherapy regimens with distinct mechanisms of action. (lu.se)
  • Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
  • Mechanisms for maintaining genetic information during cell division and the generation of genetic variation: replication, mitosis, meiosis, recombination. (lu.se)
  • The determination of testosterone in the female is helpful in the evaluation of congenital adrenal hyperplasia, PCOS, and when an ovarian tumor, adrenal tumor, adrenal hyperplasia or ovarian insufficiency is suspected. (cdc.gov)
  • Relationship between hematogenous tumor cell dissemination and cellular immunity in DCIS patients. (nature.com)
  • Examples include exposure to toxic compounds or radiation, loss of contact with other cells or the extra-cellular matrix, lack of oxygen (hypoxia), acidic pH, the activation of oncogenes, induction of cellular senescence, oxidative damage or depletion of essential metabolites. (southampton.ac.uk)
  • Another characteristic architectural feature found in many of these tumors is a pseudoalveolar pattern in which cells are arranged in alveolae with central cellular discohesion (see the fourth image below). (medscape.com)
  • The transforming gene products of these viruses, such as the E1A oncoproteins of adenovirus 5, led to the identification of cellular factor p60, known as cyclin A. This research was the first demonstration of a physical link between cellular transformation and the cell cycle, thereby paving the way for the melding of these two areas of research. (newswise.com)
  • Cardiac myxoma (CM) is the most common benign cardiac tumor, and most CMs are left atrial myxomas (LAMs). (bvsalud.org)
  • von Hippel-Lindau (VHL) disease, or von Hippel-Lindau syndrome, is a rare genetic disorder characterized by visceral cysts and benign tumors in multiple organ systems that have subsequent potential for malignant change. (medscape.com)
  • The above biological processes have important roles in tumorigenesis, cancer development and chemoresistance in tumor cells. (spandidos-publications.com)
  • Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. (sciencenet.cn)
  • Using a similar pressure-regulating mechanism to that found in cells, scientists created an artificial cell that responds to a sudden and possibly catastrophic change in its surroundings. (sciencedaily.com)
  • It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. (nih.gov)
  • Here, we report a novel molecular target and antimetastatic mechanism of ATO in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
  • The exact biological mechanism(s) by which the BBB limits drug exposure is not clear, but in addition to epithelial tight junctions, enhanced efflux of chemotherapeutic agents out of the CNS space by endothelial cell membrane transporters in brain blood vessels plays a primary role ( 2 ). (jcancer.org)
  • The overall survival rate was significantly lower in patients with high- E2F1 tumors than in those with low- E2F1 tumors ( P = 0.0027), especially among patients with stage II to III NSCLCs ( P = 0.0188). (aacrjournals.org)
  • A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
  • A proliferative exhausted CD8 + T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. (elifesciences.org)
  • The compelling conclusion that proliferative exhausted T cells are associated with response in HPV+ head and neck cancer is supported by the cohort of 14 patients with paired tumor and adjacent normal tissue and rigorous bioinformatic analysis of nearly 50,000 single CD3+ T cell transcriptomes. (elifesciences.org)
  • Patients usually do not increased incidence of oropharyngeal squamous cell carci- seek counseling until the tumors are large because small noma (OSCC), the head and neck cancer in which HPV is tumors cause little distress and may not be noticed by the most commonly found ( 4 ). (cdc.gov)
  • [ 2 ] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)
  • Tumors involving other organs and the CNS (brain, spinal cord) are present in 25% of patients with VHL disease. (medscape.com)
  • Patients usually do not seek counseling until the tumors are large because small tumors cause little distress and may not be noticed by the patient. (cdc.gov)
  • It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
  • Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair. (sciencenet.cn)
  • Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)
  • Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)
  • In Xp11.2 translocation-associated renal cell carcinoma (RCC), cells typically have voluminous cytoplasm, which can range from eosinophilic and granular to clear. (medscape.com)
  • In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • Early identification of VHL is important because of the increased risk of serious complications (eg, renal cell carcinoma) to foster more effective treatment options and better prognoses. (medscape.com)
  • Proteomic analysis comparing the groups of SCLC cell lines with synergistic and additive response patterns indicated alterations in cell cycle regulation and DNA damage repair. (sciencenet.cn)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • PTEN gene is considered an established tumor suppressor gene in different types of cancer including breast cancer. (cancerindex.org)
  • With its absence, the human body will be functioning without its "brake" of cell proliferation. (pharmiweb.com)
  • A naturally occurring p73 mutation in a p73-p53 double-mutant lung cancer cell line encodes p73α protein with a dominant-negative function TP73+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural information available in the PDB for UniProt: O15350 (Tumor protein p73) at the PDBe-KB. (wikipedia.org)
  • The National Human Genome Research Institute's Talking Glossary provides information about the cell cycle . (medlineplus.gov)
  • Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
  • Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
  • Current Research and Scholarly Interests The thread of Ariadne that connects germ cells, preimplatation development and pluripotent stem cells is the focus of my research, with a specific interest in human development. (stanford.edu)
  • Although SETD2 is functionally important, the protein does not accumulate in human cells. (frontiersin.org)
  • The human papillomavirus (HPV) E6 and E7 oncogenes have direct effects on host cell proliferation. (bris.ac.uk)
  • Single entinostat- or chemotherapy significantly reduced cell viability in human neuroendocrine SCLC cells. (sciencenet.cn)
  • Ben-Yosef T, Yanuka O, Halle D, Benvenisty N. Involvement of Myc targets in c-myc and N-myc induced human tumors. (bdbiosciences.com)
  • We performed cell-level multi-omics sequencing on human HNSCC samples to decipher the multi-dimensional characteristics of Tex cells. (elifesciences.org)
  • Here, we utilize human induced pluripotent stem cell cardiomyocytes (iPSC-CMs) to identify STK25 as a kinase of the type Iα regulatory subunit PRKAR1A. (bvsalud.org)
  • A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
  • The integration of HPV, a virus harboring oncoproteins E6 and E7 that cause HPV positive head and neck squamous cell carcinomas, is linked to increased somatic copy number variants. (cancer.gov)
  • Molecular characteristics may help clinicians improve the specificity of the diagnosis and treatment of head and neck squamous cell carcinomas. (cancer.gov)
  • 90% are squamous cell carcinomas. (spandidos-publications.com)
  • Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. (nature.com)
  • Currently, it consists of histological subtypes of small lung cancer (SCLC) and non-small lung carcinoma (NSCLC), including adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma [ 4 , 5 ]. (hindawi.com)
  • Head and Neck Squamous Cell Carcinoma Study was originally published by the National Cancer Institute. (cancer.gov)
  • In the present study, the anticancer potential of pristimerin was investigated in two oral squamous cell carcinoma (OSCC) cell lines, CAL‑27 and SCC‑25. (spandidos-publications.com)
  • HNSCC is the sixth oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • the goal is to cause as little functional squamous cell carcinoma type (HNSCC) and includes and cosmetic damage as possible ( 6 , 9 ). (cdc.gov)
  • Methods: fifteen histological specimens of spindle cell squamous cell carcinoma of the lower lip were obtained from the Department of Oral Pathology, Bahia Federal University. (bvsalud.org)
  • Other markers, such as retinoblastoma and p53, may be related with early steps of carcinogenesis in oral cavity squamous cell carcinoma. (bvsalud.org)
  • We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
  • The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)
  • VCAMs are involved in mediating the adhesion of leukocytes to vascular endothelial cells, facilitating the recruitment of immune cells during inflammation. (pharmiweb.com)
  • PECAM-1 is expressed on the surface of platelets and endothelial cells and is involved in cell adhesion and signaling during immune responses. (pharmiweb.com)
  • Tumor Suppressor Gene p16/INK4A/CDKN2A: Regulation Into and Out of the Cell Cycle in a Spontaneous Canine Model of Breast Cancer. (auburn.edu)
  • Goss, P. E. & Chambers, A. F. Does tumour dormancy offer a therapeutic target? (nature.com)
  • These data offer important insight into regulation of response to RET tyrosine kinase inhibitors and other potential therapeutic targets. (nih.gov)
  • The present study aimed to summarize the influence of KIN17 on tumor development and the possibility of KIN17 as a tumor diagnostic and prognostic biomarker and as a potential therapeutic target. (spandidos-publications.com)
  • Immunohistochemistry in diagnostic surgical pathology: contributions of protein life-cycle, use of evidence-based methods and data normalization on interpretation of immunohistochemical stains. (lsbio.com)
  • Cancer Cell 18 , 485-498 (2010). (nature.com)
  • We developed three novel RET fusion-positive ( RET +) patient-derived cancer cell lines, CUTO22 [kinesin 5B ( KIF5B )- RET fusion], CUTO32 ( KIF5B - RET fusion), and CUTO42 (echinoderm microtubule-associated protein-like 4- RET fusion), to study RET signaling and response to therapy. (nih.gov)
  • Mar. 16, 2022 Biological processes such as wound healing and cancer cell invasion rely on the collective and coordinated motion of living cells. (sciencedaily.com)
  • Furthermore, di-GA inhibited the generation of lymphendothelial gaps by cancer cell spheroid-secreted lipoxygenase metabolites. (nature.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • In addition, knockdown of KIN17 was found to enhance the sensitivity of tumor cells to chemotherapeutic agents. (spandidos-publications.com)
  • This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)