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BacteriocinsLactobacillusLactobacillaceaeGram-Positive Asporogenous RodsStreptococcus mutansAntibiosisMitomycinsLactobacillus plantarumMeat ProductsEnterococcus faeciumLactobacillus acidophilusSodium NitriteFermentationStreptococcusFood PreservationLactococcus lactisCulture MediaGene Expression Regulation, BacterialTransformation, BacterialDNA, BacterialBacterial ProteinsPediococcusPlasmidsMolecular Sequence DataExtrachromosomal InheritanceFood MicrobiologyAmino Acid SequenceBacteriological TechniquesSodium ChlorideDrug Resistance, MicrobialConjugation, GeneticBase SequenceListeriaOperonHydrogen-Ion ConcentrationTemperatureNisinLactococcusEnterococcus faecalisPropionibacteriumCloacinSerratia marcescensPyocinsMutationLeuconostocListeria monocytogenesBrevibacillusGram-Positive BacteriaColicinsCheeseAnti-Bacterial AgentsGenes, BacterialPectobacterium carotovorumSequence Analysis, DNABacteriocin PlasmidsMicrobial Sensitivity TestsMegacinsOpen Reading Frames
BacterialHydrogen peroxideInhibit the growthAntimicrobial peptidesStrainsToxinLacticPathogenicListeriaPutativeLactobacillusMicrobiotaGenes2022VaginalNutrientsMetabolitesSynthesisMechanismsAntibioticsMicroorganismsLactobacilliProteinResistanceCompositionGenePlantarumMethodsMoleculesAbsorptionRolePathogensMetabolicBenefitsImmune responseFactorsPaper
Bacterial9
  • Most surprisingly, one-third of pneumococcal genomes also possessed a cassette encoding a novel circular bacteriocin that we called pneumocyclicin, which shared a similar genetic organisation to well-characterised circular bacteriocin cassettes in other bacterial species. (biomedcentral.com)
  • Given that the producer and target strains are often of the same bacterial species, the bacteriocins are largely believed to be involved in competition for limited resources within an ecological niche, but they may also be contributing to the maintenance of microbial diversity at a population level [ 14 - 16 ]. (biomedcentral.com)
  • The bacteriocin Angicin interferes with bacterial membrane integrity through interaction with the mannose phosphotransferase system. (uni-ulm.de)
  • My main research interests are in bacterial pathogenesis and molecular bacteriology namely: intracellular persistence, antimicrobial resistance mechanisms, peptidoglycan biosynthesis, stringent response, transcription regulation, genetic competence and mechanobiology (rheology). (cienciavitae.pt)
  • During these postdocs I was responsible for the introduction on new research lines in the host labs such as the production of bacterial cellulose for wound dressing applications and the development of copper and silver NHC conjugated compounds as antimicrobials against several pathogens. (cienciavitae.pt)
  • This is another important reason to study bacteriocins and tap their therapeutic potential to combat drug resistant bacterial infections. (bbrc.in)
  • Methods are described for increasing levels of healthy vaginal bacteria by treating the vaginal mucosa with bacteriocins derived from Lactobacillus paragasseri, Lactobacillus gasseri, and other bacterial strains. (justia.com)
  • His main research interests concern the identification of genes and enzymes involved in this pathway, the regulation of this metabolism, the mode of action of antibiotics and bacteriocins interfering with this pathway and the corresponding resistance mechanisms, as well as the molecular bases for the recognition of bacterial cell-wall peptidoglycan by host innate immunity mechanisms. (degruyter.com)
  • Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)
Hydrogen peroxide2
  • This is reinforced by Lactobacilli through the production of hydrogen peroxide (H 2 O 2 ), bacteriocins and biosurfactants, as well as the inhibition of the physical attachment of pathogens to the epithelium by competitive exclusion and the promotion of the engulfment and degradation of infected epithelial cells (autophagy). (frontiersin.org)
  • Like other lactobacilli, Lactobacillus rhamnosus A also releases acids, bacteriocins, and hydrogen peroxide which inhibit the growth of pathogens. (nexabiotic.com)
Inhibit the growth1
  • Stimulating Antimicrobial Defenses: Probiotics produce antimicrobial substances, such as bacteriocins, that inhibit the growth of pathogenic bacteria. (subagon.com)
Antimicrobial peptides2
  • Bacteriocins are small, ribosomally-synthesised antimicrobial peptides or proteins produced by bacteria to inhibit other bacteria, and the producer strain has a dedicated immunity system that protects it from its own bacteriocin. (biomedcentral.com)
  • The IPC conference was co-hosted 18-21st June with the probiotics in foods and feeds regulatory workshop, SOMED (Society for Microbial Ecology and Diseases), BAMP (Bacteriocins and Antimicrobial Peptides symposium) and the Animal Health Symposium. (probiotical.com)
Strains4
  • Antilisterial strains of L. sakei are used in Europe for the production of saucisson and can be used for the conservation of fresh meat. (wikipedia.org)
  • Lactiplantibacillus plantarum D13 shows antistaphylococcal and antilisterial activity, probably due to the synthesis of a presumptive bacteriocin with antibiofilm capacity released in the cell-free supernatant (CFS), whose inhibitory effect is enhanced by cocultivation with susceptible strains. (bvsalud.org)
  • The purpose of the research paper was firstly to identify bacteriocin-producing lactic acid bacteria characterizing strains with anti-listeria activity and, secondly, to characterize bacteriocin evaluating its in vitro efficiency as a natural preservative and, thirdly, to evaluate the anti-listeria effect of the bacteriocinogenic strain of Lactiplantibacillus plantarum in cheeses and produce an edible film with anti-listerial effect. (bvsalud.org)
  • Of 355 lactic acid bacteria strains tested, two were able to produce bacteriocin against Listeria monocytogenes and were identified as Lactiplantibacillus plantarum and Lactiplantibacillus pentosus. (bvsalud.org)
Toxin2
  • However, detailed information about the regulation of toxin gene expression has only recently emerged. (pasteur.fr)
  • TcdR, BotR, TetR and UviA are now known to be related alternative RNA polymerase sigma factors that drive transcription of toxin A and toxin B genes in C. difficile, the neurotoxin genes in C. botulinum and C. tetani, and a bacteriocin gene in C. perfringens. (pasteur.fr)
Lactic7
  • A glycogen-rich vaginal milieu is a haven for the proliferation of Lactobacilli facilitated by the production of lactic acid and decreased pH. (frontiersin.org)
  • Neither lactic acid nor H2O2 production by Lj 62B was responsible for this effect. (bvsalud.org)
  • It is known that bacteriocins, most successfully used today are products of secondary metabolism of lactic acid bacteria. (mdpi.com)
  • A non-pathogenic species of LACTOCOCCUS found in DAIRY PRODUCTS and responsible for the souring of MILK and the production of LACTIC ACID . (lookformedical.com)
  • Lactic acid bacteria also produce bacteriocins which help prevent the growth of pathogenic microorganisms. (nexabiotic.com)
  • L. helveticus is yet another lactic acid producer that is used in dairy production. (nexabiotic.com)
  • Sourdough starter is used to prepare lactic acid bacteria and yeast for bread production ( The Clever Carrot 2014 ). (kenyon.edu)
Pathogenic2
  • Many Clostridium species are pathogenic for humans and animals, and most of the resulting diseases, such as tetanus, botulism, gas gangrene and pseudomembranous colitis, are due to the production of potent extracellular toxins. (pasteur.fr)
  • Bacteriocins are powerful bactericidal peptides produced and secreted by a varied group of micro- organisms including yeast, protozoa and of course bacteria and they cause death and removal of non bacteriocin producing pathogenic bacteria. (bbrc.in)
Listeria3
Putative1
  • The composition of the 'bacteriocin/immunity region' of the blp cassette was highly variable: one cassette possessed six bacteriocin genes and eight putative immunity genes, whereas another cassette had only one of each. (biomedcentral.com)
Lactobacillus4
  • Lactocin S is a bacteriocin produced by strain L45 of Lactobacillus sakei. (wikipedia.org)
  • Strain 5 produces a plasmid-encoded bacteriocin that is identical to sakacin P, as well as two chromosomally encoded bacteriocins, which were designated sakacin T and sakacin X. LasX is a transcriptional regulator of the lactocin S biosynthetic genes in strain L45 of Lactobacillus sakei. (wikipedia.org)
  • The bacteriocins are surprisingly advantageous as being selectively active against Lactobacillus iners but relatively inactive against H2O2-producing Lactobacillus species. (justia.com)
  • The Lactobacillus constructed in the disclosure can be used to prepare a vaccine for regulation of intestinal flora disorder, and has advantages in regulation of intestinal flora and intestinal immune response and maintenance. (justia.com)
Microbiota6
  • Her research includes nutritional aspects of dairy and functional foods, probiotic cultures, bioactive metabolite production, infant gut microbiota, and healthy proteins and fats (including conjugated linoleic acid, short chain fatty acids) that are produced by gut bacteria. (ucc.ie)
  • A new theory suggests that gut microbiota contribute to the regulation of energy homeostasis, provoking the development of an impairment in energy homeostasis and causing metabolic diseases, such as insulin resistance or TDM2. (frontiersin.org)
  • The metabolic endotoxemia, modifications in the secretion of incretins and butyrate production might explain the influence of the microbiota in these diseases. (frontiersin.org)
  • Currently, as a means of intestinal microecological regulation in addition to microecological preparations, fecal microbiota transplantation (FMT) has become popular in recent years. (hindawi.com)
  • Bifidobacteria may exert a range of beneficial health effects, including the regulation of intestinal microbial homeostasis, the inhibition of pathogens and harmful bacteria that colonize and/or infect the gut mucosa, the modulation of local and systemic immune responses, the repression of procarcinogenic enzymatic activities within the microbiota, the production of vitamins, and the bioconversion of a number of dietary compounds into bioactive molecules. (nexabiotic.com)
  • Through the production of a large variety of compounds, the commensal microbiota contributes to the homeostasis that develops during childhood and remains unique to each person throughout adulthood. (dunianusantara.io)
Genes4
  • Bacteriocin genes are located either on chromosomes or on plasmids. (wikipedia.org)
  • The key elements of these vectors are a regulatable promoter involved in the production of the bacteriocins sakacin A and sakacin P and the genes encoding the cognate histidine protein kinase and response regulator that are necessary to activate this promoter upon induction by a peptide pheromone. (wikipedia.org)
  • We found that all genomes maintained a blp bacteriocin cassette and we identified several novel blp cassettes and genes. (biomedcentral.com)
  • Hans-Wilhelm Nützmann from the University of Bath leads the next study that looks at the co-regulation of clustered biosynthetic pathway genes. (garnetcommunity.org.uk)
20221
  • I was recently awarded with a Research Grant, as PI, from the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) - Research Grant 2022, to study the role of a new bacteriocin system in S. aureus. (cienciavitae.pt)
Vaginal1
  • These results suggest that, in medium mimicking vaginal fluid and growth conditions similar to the vaginal environment, Lj 62B produces a potential bacteriocin-like inhibitory substance (Lj-BLIS) that clearly targets Gardnerella spp. (bvsalud.org)
Nutrients3
  • In strain CCUG 42687, their production is dependent on nutrients, temperature and pH. (wikipedia.org)
  • In strain CTC 494, the presence of salt and a curing agent (sodium chloride and sodium nitrite) reduces the production of the antilisterial bacteriocin sakacin K. Growth of CTC 494 is also dependent on nutrients availability. (wikipedia.org)
  • It inhibits their growth by consuming available nutrients and/or producing bacteriocins (antibacterial metabolites). (tgd.care)
Metabolites1
  • Plant cell cultures are widely used in the micro-propagation of clonal plants, especially virus-free plants, and in the production of useful metabolites such as paclitaxel. (go.jp)
Synthesis1
  • It regulates the sensation of satiety and modulates the concentration of glucose and cholesterol in the blood, the synthesis of amino acids, the metabolism/recycling of bile acids, the metabolism of polyphenols and antioxidants, energy production, and vitamin production. (tgd.care)
Mechanisms3
  • Bacteriocins are a diverse group of compounds in terms of size, mode of action and immunity mechanisms, and are produced by both Gram-positive and Gram-negative bacteria. (biomedcentral.com)
  • Probiotics interact with the immune system through multiple mechanisms, contributing to enhanced immune response and regulation. (subagon.com)
  • At the same time, bacteria compete for substrates by employing diverse predatory mechanisms, like the production of bacteriocins [ 8 ]. (nature.com)
Antibiotics2
  • The potential of Bacteriocins as an alternate or adjuvant to antibiotics needs to be studied and made available to the medical community. (bbrc.in)
  • Recent trends suggest that if an effective alternate to antibiotics is not found quickly then the very existence of mankind could come under threat .The safety profile of bacteriocins is much superior to antibiotics. (bbrc.in)
Microorganisms1
  • 2015) as well as synthesized by ribosomes with antimicrobial properties against various groups of microorganisms (Chikindas, et a., 2017).The activity of bacteriocins is influenced by temperature, pH, and composition of culture medium (Guinane et al. (bbrc.in)
Lactobacilli1
  • 3 Ding YH, Qian LY, Pang J, Lin JY, Xu Q, Wang LH, Huang DS, Zou H. The regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapy. (chucklinggoat.co.uk)
Protein1
  • Pneumococci reside in the paediatric nasopharynx, where they compete for space and resources, and one competition strategy is to produce a bacteriocin (antimicrobial peptide or protein) to attack other bacteria and an immunity protein to protect against self-destruction. (biomedcentral.com)
Resistance2
  • This paper is a review of MDR (Multiple rug Resistance) related issues which have become a global problem and on the possible role of bacteriocins as an effective option for fighting against MDR disease causing bacteria. (bbrc.in)
  • Bonhi K. L. R, Imran S. Role of Bacteriocin in Tackling the Global Problem of Multi-Drug Resistance : An Updated Review. (bbrc.in)
Composition1
  • We analysed a collection of 336 diverse pneumococcal genomes dating from 1916 onwards, identified bacteriocin cassettes, detailed their genetic composition and sequence diversity, and evaluated the data in the context of the pneumococcal population structure. (biomedcentral.com)
Gene1
  • In strain LTH677, a starter organism used in meat fermentation, there is an oxygen-dependent regulation of the expression of the catalase gene katA. (wikipedia.org)
Plantarum1
  • More focused in cholesterol management, Vasili Kachrimanidou from the Univ of Reading, UK, worked on the enzymatic production of GOS, using L. plantarum LPLDL, selected for its ability to produce bile salt hydrolase (BSH) and retain cholesterol in its membranes. (probiotical.com)
Methods2
  • Methods for producing bacteriocins have been studied. (mdpi.com)
  • The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. (justia.com)
Molecules1
  • The bacteriocins are very small ribosomally synthesized peptide molecules secreted by archea, gram-positive and some of gram-negative bacteria (Klaenhammer et al. (bbrc.in)
Absorption1
Role1
  • The next paper is from Durham and looks at the role of GA-regulated DELLA proteins in the regulation of stomatal aperature. (garnetcommunity.org.uk)
Pathogens1
  • They enhance the production of mucin, a protective layer that prevents pathogens from entering the bloodstream, and support the integrity of tight junction proteins, which maintain the barrier's tightness. (subagon.com)
Metabolic1
  • So whether you're a synthetic biologist developing living therapeutics, a metabolic engineer enhancing biofuel production, or an enzymologist designing biocatalysts for bioplastics, give us a shout! (basecamp-research.com)
Benefits2
  • Benefits as well as challenges, such as the need for further research for implementation and governmental regulation, will be highlighted. (hindawi.com)
  • These bacteriocin treatments offer more benefits over antibiotic therapies in present time as they are natural bioactive peptides having no side effects. (bbrc.in)
Immune response1
  • They can enhance the production of immune factors and cytokines, promoting a balanced immune response. (subagon.com)
Factors1
  • They can reduce the production of pro-inflammatory cytokines while promoting the release of anti-inflammatory factors, promoting a balanced immune environment. (subagon.com)
Paper1