• CgA is co-stored with a tissue-specific peptide hormone or neuropeptide and exerts an autocrine and paracrine effect on secretory activity of the neuroendocrine cells. (medscape.com)
  • Some hormones exert an effect on cells of the organ from which they were released (paracrine effect), some even on the same cell type (autocrine effect). (msdmanuals.com)
  • We propose that lcn2 is an autocrine mediator of reactive astrocytosis based on the multiple roles of lcn2 in the regulation of cell death, morphology, and migration of astrocytes. (jneurosci.org)
  • Our results suggest that lcn2 acts in an autocrine manner to induce cell death sensitization and morphological changes in astrocytes under inflammatory conditions and that these phenotypic changes may be the basis of reactive astrocytosis in vivo . (jneurosci.org)
  • We report here that NC cells themselves express and release SLF protein, which in turn acts as an autocrine factor to induce melanogenesis in nearly NC cells. (elsevierpure.com)
  • Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation. (thieme-connect.com)
  • EETs are synthesized from arachidonic acid by cytochrome P450 as autocrine and paracrine mediators. (nymc.edu)
  • Functional regulation by B cells appeared to activate an interleukin-10 autocrine pathway in CD4 + T cells that, in turn, impacted on antigen-specific responses. (uni-luebeck.de)
  • Insulin-like growth factor 2 (IGF2), produced and secreted by adult β-cells, functions as an autocrine activator of the β-cell insulin-like growth factor 1 receptor signaling pathway. (unige.ch)
  • Autocrine Action of IGF2 Regulate. (unige.ch)
  • Wnt5a is a member of the WNT family of secreted glycoproteins that function as paracrine or autocrine signals to regulate growth control and tissue patterning. (umassmed.edu)
  • Proliferating cholangiocytes display a neuroendocrine phenotype and secrete and respond to a number of hormones, neuropeptides and neurotransmitters in autocrine and paracrine signaling mechanisms. (iu.edu)
  • These cells express both transforming growth factor alpha and amphiregulin and require autocrine signaling through the EGFR for proliferation and migration. (nih.gov)
  • In addition, we have identified an autocrine signaling role for Wnt5a in the regulation of B-cell proliferation and in suppressing B-cell lymphomas and myeloid tumorigenesis in mice and humans. (umassmed.edu)
  • The Alpini Lab, led by Gianfranco Alpini, PhD, evaluates the regulation of cholangiocyte proliferation/damage during the progression of cholangiopathies, the chronic diseases that target intrahepatic cholangiocytes. (iu.edu)
  • We also show that Int 407 cells produce CysLTs and blocking this autocrine signaling using three different CysLT1 receptor antagonists for longer time points led to attenuation in cell proliferation and induction of apoptosis in the cells. (lu.se)
  • Neuroendocrine regulation of body weight and glucose homeostasis. (otago.ac.nz)
  • Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. (avivasysbio.com)
  • This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. (avivasysbio.com)
  • The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. (prosci-inc.com)
  • This is the first demonstration of essential pathways regulating oocyte maturation and ovulation in ascidians and will facilitate investigations of the evolutionary process of peptidergic regulation of oocyte maturation and ovulation throughout the phylum Chordata. (elifesciences.org)
  • EETs upregulate HO-1-adiponectin-AKT signaling and play essential roles in the regulation of adipocyte differentiation, indicating the existence of a crosstalk between HO-1 and EETs. (nymc.edu)
  • In the human heart, adenosine functions as an autacoid in the regulation of various cardiac functions such as heart rate, contractility, and coronary flow. (wikipedia.org)
  • STC1 is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. (prosci-inc.com)
  • Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate.This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. (prosci-inc.com)
  • The second area of study is to understand the regulation of the immune response to cellular and solid organ grafts. (stanford.edu)
  • This is the autocrine/paracrine system of developing follicles. (glowm.com)
  • Similarly, the role of the arterial baroreflex system in moment-to-moment regulation of BP is well known. (medscape.com)
  • Ionesco The renin-angiotensin system (RAS) is a major hormonal autocrine/paracrine system that under normal conditions contributes to the regulation of. (cyberounds.com)
  • Cumulative evidences suggest that CgA's derived peptides are involved in a wide range of activities, like regulation of blood pressure (catestatin), glucose metabolism (pancreastatin, catestatin), neuroprotection (serpinin), and tumor angiogenesis (vasostatin I, vasostatin II). (medscape.com)
  • Whether this autocrine activity of IGF2 plays a physiological role in β-cell and whole-body physiology is not known. (unige.ch)
  • Thus, the autocrine action of IGF2 regulates adult β-cell mass and function to preserve in vivo GSIS in aging and to adapt β-cell mass in response to metabolic stress, pregnancy hormones, and acute induction of insulin resistance. (unige.ch)
  • Blocking release of EGFR ligands also strongly inhibited autocrine activation of the EGFR and reduced both the rate and persistence of cell migration. (nih.gov)
  • Thus, our data significantly enhance the understanding of graft dysfunction associated with chronic antibody-mediated rejection and provide the foundation for strategies to prolong renal allograft survival, based on regulation of interferon-γ production. (uni-luebeck.de)
  • Because membrane-anchored EGFR ligands are thought to be biologically active, the role of ligand release in the regulation of EGFR signaling is unclear. (nih.gov)
  • Interestingly, either kiss1 or kiss2 or both have been lost during evolution in many vertebrate species, and the functional significance of kiss1 or kiss2 for the central regulation of reproduction is suggested to vary according to the species. (frontiersin.org)
  • EGFR is frequently activated in human tumors due to overexpression, mutation, or sustained autocrine/paracrine stimulation. (gla.ac.uk)
  • Regulation of normal blood pressure (BP) is a complex process. (medscape.com)
  • The regulation of vascular tone in the endothelium of blood vessels is mediated by purinergic signalling. (wikipedia.org)
  • 2. Disease-specific expression of VEGF and its receptors in AML cells: possible autocrine pathway of VEGF/type1 receptor of VEGF in t(15;17) AML and VEGF/type2 receptor of VEGF in t(8;21) AML. (nih.gov)
  • Our findings support a cell-autonomous role for postsynaptic neuronal SR in regulating synaptic NMDAR function and suggests a possible autocrine mode of d -serine action. (jneurosci.org)
  • BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. (thermofisher.com)
  • Our results indicate that glia-derived PAI-1 may regulate microglial migration and phagocytosis in an autocrine or paracrine manner. (biomedcentral.com)
  • These results, as a whole, suggest that activin can interact with dopaminergic input from the hypothalamus to regulate follistatin expression in carp pituitary, which may contribute to GH regulation by activin/follistatin system via autocrine/paracrine mechanisms. (frontiersin.org)
  • 11. Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms. (nih.gov)
  • The central goal of Dr. Kemper's research is to define the functional roles and regulative mechanisms of intracellular/autocrine complement and assess their biological relevance with an eye on identifying new therapeutic targets for autoimmune diseases. (nih.gov)
  • The Laboratory of Molecular Immunology, led by Dr. Warren J. Leonard, focuses on the biology, signaling, and molecular regulation of a key family of these cytokines, the interleukins, with studies ranging from basic molecular mechanisms to human disease. (nih.gov)
  • Here we demonstrate Wnt pathway activation in around 50% of human NSCLC cell lines and primary tumors, through different mechanisms, including autocrine Wnt pathway activation involving upregulation of specific Wnt ligands. (mssm.edu)
  • This review evaluates the HIF-1 structure, the regulation mechanisms, the functions in cancer and corresponding anticancer strategies. (eurekaselect.com)
  • Neural and humoral control of the cardiovascular system in vertebrate animals including systems analysis of autonomic physiology involving central and peripheral mechanisms of cardiovascular regulation. (nih.gov)
  • Mechanisms that regulate arterial blood pressure, role of kidneys and other tissues/organs, nervous and endocrine systems, autocrine, paracrine factors. (nih.gov)
  • Feasible explanations for these dichotomic observations range from the doses of galectin9 applied in the experiments, alternative regulations in various cell kinds, distinct receptors this lectin binds, various galectin9 topographic localization in these cells (interaction with glycoreceptors exposed in the extracellular space contrasting to intracellular effects), different phases of your illness, and also the activation of various signaling pathways in inflammatory versus tolerogenic microenvironments. (idhinhibitor.com)
  • Model for intracellular trafficking of granule proteins and autocrine regulation of DCG biogenesis by the CgA-derived peptide serpinin in endocrine cells. (nih.gov)
  • We observed significant differences in the phosphorylation status of several intracellular signaling mediators (CREB, PDK1, SRC, STAT1, p38, STAT3, rpS6) that are important for PI3K-Akt-mTOR signaling and/or transcriptional regulation. (oncotarget.com)
  • This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. (novusbio.com)
  • Implication in autocrine and paracrine regulation of angiogenesis. (nih.gov)
  • We further review the impact of microRNA-dependent regulation of tumor-associated macrophages and the relative implication for tumor biology. (frontiersin.org)
  • 1. Placenta growth factor stimulates the growth of Philadelphia chromosome positive acute lymphoblastic leukemia cells by both autocrine and paracrine pathways. (nih.gov)
  • 3. Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. (nih.gov)
  • Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. (novusbio.com)
  • The expression, activity and stability of HIF-1 are not only induced in response to reduced oxygen availability but also modulated through PI-3K, MAPKs, autocrine signaling pathways, E3 ubiquitin ligases, and other regulators. (eurekaselect.com)
  • In particular, a complex and highly regulated network of miRNAs exerting a pervasive regulation of inflammatory pathways by targeting multiple component of the TLR signaling pathway and thus affecting the profile of inflammatory cytokines induced downstream has been defined ( 10 ). (frontiersin.org)
  • In this review, we summarize the most recent findings addressing the role of miRNAs in macrophage-mediated inflammatory response, with particular emphasis on the molecular pathways affected by miRNA-mediated regulation during macrophage polarization, bacterial infection, endotoxin tolerance, and tissue regeneration. (frontiersin.org)
  • In coculture, TGF beta acts as an autocrine cytokine, increasing endothelin precursor mRNA and inhibiting the rate of microvascular endothelial cell proliferation. (jci.org)
  • Sakaue, M., Adachi, H., and Jetten, A.M. Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis. (nih.gov)
  • Cumulative evidences suggest that CgA's derived peptides are involved in a wide range of activities, like regulation of blood pressure (catestatin), glucose metabolism (pancreastatin, catestatin), neuroprotection (serpinin), and tumor angiogenesis (vasostatin I, vasostatin II). (medscape.com)
  • Unlike early hepatocarcinogenesis, which depends on paracrine IL-6 production by inflammatory cells, due to upregulation of LIN28 expression, HcPCs had acquired autocrine IL-6 signaling that stimulates their in vivo growth and malignant progression. (nih.gov)
  • 13 This regulation of adiponectin results, at least in part, from the upregulation of tumor necrosis factor (TNF)-α and other proinflammatory cytokines which inhibits the synthesis of adiponectin in the obese state. (ahajournals.org)
  • CCL2 has been shown to have direct effects on tumor cells in an autocrine and paracrine fashion in multiple cancers, including breast, lung, cervix, ovary, sarcoma, and prostate. (biolegend.com)
  • The Laboratory for Complement and Inflammation Research, led by Dr. Claudia Kemper, aims to understand the unexpected roles of complement proteins in the regulation of key basic processes of the cell in health and disease. (nih.gov)
  • Regarding ADAM17 it really is mixed up in losing of many proteins ectodomains from your cell surface including TNF-α c-kit FasL Notch APP and TrkA amongst others indicating solid involvement in autocrine paracrine and juxta/paracrine signaling [8] [9]. (bioinf.org)
  • One of the most interesting topics in ADAM proteins biology is normally their regulation in various cellular contexts. (bioinf.org)
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (nih.gov)
  • This regulation of endothelial cell phenotype in heterotypic primary cultures suggests that dynamic, reciprocal cell-cell signaling may also be occurring between microvascular endothelium and ventricular myocytes in vivo. (jci.org)
  • Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. (nih.gov)
  • However, it remains unclear as to whether the inhibition of the activation of mTOR via the regulation of the function of GSK3β can prevent the progression of AD. (spandidos-publications.com)
  • Furthermore, IGF signaling-mediated cell-cell interaction between the cellular domains highlights the pivotal role of autonomous regulation of the dental mesenchyme. (nature.com)
  • 2021). Autocrine Signalling and Cellular Responses. (medicaljournalshouse.com)
  • BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. (thermofisher.com)
  • Cliff Lanewas working on a project about the regulation of the immune system, which was the fundamental area that my laboratory had been involved in since 1968. (nih.gov)
  • Center investigators explore research areas, including the normal function, signaling processes, gene regulation, and epigenetics related to the activation and function of immune cells. (nih.gov)
  • Although the antitumor effect of galectin9 was demonstrated in numerous experimental models [111,21719], other techniques demonstrated galectin9 has apparent Aurintricarboxylic acid Inhibitor diametrical opposite roles in immune regulation [22024]. (idhinhibitor.com)
  • Galectin9 also promotes immune regulation. (idhinhibitor.com)
  • Vascular inflammation, immune regulation and dysregulation. (nih.gov)
  • CgA is co-stored with a tissue-specific peptide hormone or neuropeptide and exerts an autocrine and paracrine effect on secretory activity of the neuroendocrine cells. (medscape.com)
  • Galectin9 is, hence, a paracrine and autocrine issue that enhances the expansion and suppressive phenotype of iTregs [113]. (idhinhibitor.com)
  • In the human heart, adenosine functions as an autacoid in the regulation of various cardiac functions such as heart rate, contractility, and coronary flow. (wikipedia.org)
  • A number of bioactive molecules secreted from fat tissue, referred to as adipokines, could participate in the development of obesity-related complications through regulation of inflammatory responses. (ahajournals.org)
  • To investigate the role of interleukin-6 (IL-6) and transforming growth factor beta 1 (TGF beta 1) in the regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) synthesis in human articular chondrocytes. (uni-bielefeld.de)
  • Microcirculation and tissue transport processes, lymphatics, autonomic regulation. (nih.gov)
  • 5. Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid. (nih.gov)
  • Transforming growth factor beta-1 (TGF-beta 1), which is being produced in active form by mesothelial cells was evaluated for its potential role in regulation of the differential PDGF receptor expression in these cells. (nih.gov)
  • Recent work from Dr. Kemper's lab, has highlighted an equally profound impact of complement on adaptive immunity through intracellularly and/or autocrine active complement that mediates direct regulation of CD4+ T cells: signals mediated by T cell-expressed anaphylatoxin receptor C3aR and the complement regulator CD46 (which binds the complement activation fragment C3b) are critical checkpoints in human T cell lineage commitment and control initiation and resolution of inflammatory Th1 responses. (nih.gov)
  • Macrophages play a key role in the regulation of pro- or anti-inflammatory actions at the lesion sites of disease. (researchgate.net)
  • In this paper we studied regulation of this differential PDGF receptor mRNA expression. (nih.gov)
  • Specifically, he modeled the autocrine and paracrine regulation of viral. (nih.gov)
  • Basic and applied aspects of cardiovascular regulation are reviewed that focus on the physiology of blood pressure regulation, the pathogenesis of hypertension and the microcirculation, biology of the endothelium and vascular smooth muscle cells and vascular homeostasis and dysfunction in experimental models. (nih.gov)
  • In addition, we have pioneered the field of metabolic regulation of T cell motility and migration and have discovered molecules - implicated in T cell metabolism - that can be pharmacologically targeted to therapeutically modulate T lymphocyte trafficking. (qmul.ac.uk)
  • In mammals (e.g., rodents), the activin/follistatin system is a key component for reproductive function both in the pituitary (for gonadotropin regulation) and at the gonadal level (for oocyte/sperm maturation and steroid production) ( 5 ). (frontiersin.org)
  • However, whether the inhibition of the activation of mTOR via the regulation of the function of GSK3β affects the pathology of AD remains unclear. (spandidos-publications.com)
  • regulation of ion channel function and expression. (nih.gov)
  • Altogether, these benefits indicate a good regulation of T cell activation and expansion by galectin9. (idhinhibitor.com)
  • Such an analysis is of importance in view of the suggested PDGF autocrine activity involving the PDGF beta-receptor mesothelioma cells. (nih.gov)
  • AM is involved centrally in regulation of blood pressure but it is also a potent player in tumorigenesis, where it has innate tumour cell to tumour cell actions, and roles in which AM released by the tumour upregulates AM2R expression in host cells around the tumour. (sheffield.ac.uk)
  • A variety of factors contribute to the regulation of this process, including hormones and paracrine and autocrine factors that are still being identified. (hersmartchoice.com)
  • IL-10, IL-22, IL-24 and IL-26 are critical for the regulation of host defense against Mycobacterium tuberculosis infections. (ijbs.com)
  • These results support an autocrine mode of d -serine action at synapses. (jneurosci.org)
  • This may have important implications in the regulation of brain microglial activities in health and disease. (biomedcentral.com)
  • Since GH stimulation by DA via pituitary D1 receptor is well-documented in fish models, the receptor specificity for follistatin regulation by DA was also investigated. (frontiersin.org)
  • The regulation of memory and regulatory T lymphocyte trafficking is the main focus of my research. (qmul.ac.uk)