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  • cytoplasmic
  • Immediately after the completion of cytokinesis, newly divided plant cells form cytoplasmic microtubules (MTs) that radiate from the nuclear envelope toward the plasma membrane, and generate dynamic MT arrays at the cell cortex, which persist during interphase ( Hashimoto, 2015 ). (biologists.org)
  • spindles
  • Anastral meiotic spindles are thought to be organized differently from astral mitotic spindles, but the field lacks the basic structural information required to describe and model them, including the location of microtubule-nucleating sites and minus ends. (rupress.org)
  • We measured the distributions of oriented microtubules in metaphase anastral spindles in Xenopus laevis extracts by fluorescence speckle microscopy and cross-correlation analysis. (rupress.org)
  • essential
  • Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). (uniprot.org)
  • These proteins are essential for the nucleation activity of the complex. (biologists.org)
  • metaphase
  • Based on these data, we propose a model for maintenance of the metaphase steady-state that depends on continuous nucleation of microtubules near chromatin, followed by sorting and outward transport of stabilized minus ends, and, eventually, their loss near poles. (rupress.org)
  • nuclei
  • The few researchers who had succeeded in isolating g-TuRC found that when they put it in a test tube, it spectacularly underperformed at creating microtubule nuclei. (princeton.edu)
  • center
  • Utilization of Src-family kinases by C. trachomatis includes tyrosine phosphorylation of the secreted effector Tarp during the entry process, a functional role in microtubule-dependent trafficking to the microtubule organizing center, and a requirement for Src-family kinases for successful initiation of development. (asm.org)
  • 100 years ago, is the main microtubule-organizing center in mammalian organisms. (dovepress.com)
  • Mitchison
  • In 1984 Mitchison and Kirschner discovered an intriguing property of microtubules they termed `dynamic instability' ( Mitchison and Kirschner, 1984 ). (biologists.org)