Regulation metabolic networks and pathways. Medical search. Frequent questions

Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis. (nih.gov)
Previously, by modeling the gene regulation of cancer metabolism we have reported that cancer cells can acquire a stable hybrid metabolic state in which both glycolysis and OXPHOS can be used. (nih.gov)
Saltiel, A. R. & Kahn, C. R. Insulin signalling and the regulation of glucose and lipid metabolism. (nature.com)
Petersen, M. C., Vatner, D. F. & Shulman, G. I. Regulation of hepatic glucose metabolism in health and disease. (nature.com)
Four metabolic pathways and one oxidative stress pathway were identified in the miPPSPC, whereas linoleic acid metabolism and the pentose phosphate pathway were identified in the mPPSPC. (aging-us.com)
Key factors of the pentose phosphate pathway and linoleic acid metabolism, G6PD and CYP2C8/9/18/19, respectively, are related to the survival of PC patients according to our tissue microarray. (aging-us.com)
After network pharmacology and GO analysis, risperidone was found to influence cellular metabolism. (frontiersin.org)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Metabolism underpins development and physiology, but little is known about how metabolic genes and pathways are regulated, especially in multicellular organisms. (biorxiv.org)
However, compared to developmental processes, knowledge about the epigenetic regulation of metabolism is limited in multicellular organisms. (biorxiv.org)
To determine how metabolism is regulated epigenetically, we first identified regulatory patterns of epigenetic modification across all metabolic domains. (biorxiv.org)
To map the epigenetic marks on metabolic enzymes, pathways, and domains, we used the genome-wide functional annotations of metabolism we generated previously ( 6 ). (biorxiv.org)
Energy metabolism is governed by intricate signaling pathways that sense nutrient availability, energy demands, and cellular stress. (alliedacademies.org)
This article explores the pathways of cellular signaling in energy metabolism, highlighting their physiological roles and implications in pathological conditions. (alliedacademies.org)
The insulin signaling pathway is a central regulator of energy metabolism, particularly in the context of glucose homeostasis. (alliedacademies.org)
They modulate energy metabolism through the deacetylation of various substrates, including transcription factors, metabolic enzymes, and histones. (alliedacademies.org)
In response to the switch of carbon sources during the growth, the central metabolism (TCA cycle, glyoxylate shunt and futile pathways) of MR-1 also changes. (umsystem.edu)
To describe this dynamic metabolism, we combine the enzyme kinetic modeling with the isotopomer analysis to quantitatively understand the regulation of metabolic network and profile the flux distribution as the function of the time. (umsystem.edu)
This thesis is a contribution to the field of systems biology, where mathematical and computational models are used to study large biological networks such as the metabolism or the signaling pathways of living organisms. (fu-berlin.de)
One of the largest networks studied within systems biology is the metabolism, which comprises all the biochemical reactions happening inside a cell. (fu-berlin.de)
Besides, amino acid metabolism is important in the regulation of the immune response. (cancer-research-network.com)
It is a snapshot of the substrates, metabolites, enzymes, reactions and pathways of primary and intermediary metabolism in rice. (oregonstate.edu)
Some bacterial pathogens have been shown to substantially modify their surface components in response to the host immune system and modify their energy metabolism and transport pathways to allow efficient growth within the host. (cdc.gov)
Biochemical genetic testing and newborn screening are essential laboratory services for the screening, detection, diagnosis, and monitoring of inborn errors of metabolism or inherited metabolic disorders. (cdc.gov)
Some of the studied proteins were involved in glucose and iron metabolism, immune evasion, and chemotactic cytokine regulation. (lu.se)

The metabolic and oxidative stress pathways may participate in PC progression. (aging-us.com)
NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. (biomedcentral.com)

The dynamic behavior of metabolic networks is governed by numerous regulatory mechanisms, such as reversible phosphorylation, binding of allosteric effectors or temporal gene expression, by which the activity of the participating enzymes can be adjusted to the functional requirements of the cell. (mpg.de)
Enzymes act as biological catalysts and play a central role in regulating metabolic pathways. (trendingbird.com)
In garlic, the major flavor precursor is sulfur-alk(en)yl cysteine sulfoxide (ACSO, alliin), which is degraded by alliinase enzymes upon tissue disruption to give pyruvate, ammonia, and thiosulfinate. (springeropen.com)

The EcoCyc project performs literature-based curation of the E. coli genome, and of E. coli transcriptional regulation, transporters, and metabolic pathways. (wikipedia.org)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)
INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)

Network biology has been widely used in molecular biology and genetics, where several network properties have been shown to be functionally important. (biomedcentral.com)

Database objects also describe molecular interactions, including metabolic pathways, transport events, and the regulation of gene expression. (wikipedia.org)
EcoCyc provides several genome-scale visualization tools to aid in the analysis of omics data, such as by painting gene expression or metabolomics data onto the full regulatory network of E. coli. (wikipedia.org)
We are testing the hypothesis that specific transcription factors form regulatory networks to execute gene expression programs important for SSC fate decisions (self-renewal and differentiation), and ultimately, spermatogenesis. (utsa.edu)
Surprisingly, specialized metabolic genes, often involved in defense, were predominantly regulated by two modifications that have opposite effects on gene expression, H3K27me3 (repression) and H3K18ac (activation). (biorxiv.org)
hypothesized that associations between gene expression and somatic mutations can be translated into the associations between gene expression and mutational signatures for showing the regulation effects between somatic mutation and gene expression dysregulation. (hep.com.cn)
BC204, applied via a soil drench at a low concentration of 0.01% (v/v), stimulated above-ground biomass production whilst eliciting a large change in gene expression levels across several biochemical pathways in Arabidopsis thaliana. (sun.ac.za)
Conclusions: We performed gene expression profiling of GDFMD-treated WD model mice using RNA-Seq analysis and found the genes, pathways, and processes effected by the treatment. (uni-frankfurt.de)
Such annotations in majority provide information about the function of genes and gene families but not necessarily in association to the gene expression, metabolic and regulatory networks. (oregonstate.edu)
These products have several anti-inflammatory properties of any/multiple islet autoantibodies (242 and 151 events, respec- such as regulation of immune-related gene expression and cy- tively) and T1D (71 events) by soluble fiber intake were calculated tokine release (8). (lu.se)

In Arabidopsis, trimethylation of lysine 36 in histone 3 (H3K36me3) activates energy related pathways ( 3 ) and trimethylation of lysine 27 in histone 3 (H3K27me3) represses lipid biosynthesis pathways ( 4 ). (biorxiv.org)
For triterpene saponin biosynthesis, we found the genes in MVA and non-MVA pathways were differentially expressed among three examined tissues, indicating the parallel but compartmentally separated biosynthesis pathways of IPP and DMAPP in A. mongolicus . (biomedcentral.com)

We first identified 51 active compounds from SZT and their 81 potential molecular targets by high-throughput computational analysis, from which we identified 4 major pathways including Th17 cell differentiation, metabolic pathways, pathways in cancer, and the PI3K-Akt signaling pathway. (hindawi.com)

We focus on modeling and understanding resource allocation in large (sometimes genome-scale) metabolic models. (fu-berlin.de)

These models are simplified representations of the studied biological systems and come in different granularities and abstraction levels, depending on the size of the networks and on the modeling formalisms. (fu-berlin.de)
Biological functions and signaling pathways in which the DEGs were involved were determined by gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses. (uni-frankfurt.de)
Most of the biological processes were associated with cellular processes, biological regulation, metabolic processes, and developmental processes. (bvsalud.org)
While the term metabolome was coined in 1998 and the metabolomics field was considered emerging until recently, metabolic profiles have been studied in biological fluids for centuries. (cdc.gov)

Our modeling results demonstrate a direct association between the activities of AMPK and HIF-1, master regulators of OXPHOS and glycolysis, respectively, with the activities of three major metabolic pathways: glucose oxidation, glycolysis, and fatty acid oxidation. (nih.gov)
Insulin signaling pathway activates phosphatidylinositol 3-kinase (PI3K), which phosphorylates and activates Akt (also known as protein kinase B). Akt regulates glucose transport by promoting the translocation of glucose transporters, such as GLUT4, to the plasma membrane. (alliedacademies.org)

To see if there are any interactions between epigenetic modifications across metabolic genes, we computed pairwise Pearson's correlation coefficients between the 16 epigenetic modifications based on their relative abundance at each metabolic gene region. (biorxiv.org)
In contrast, metabolic genes involved in specialized and hormone metabolic domains, which are generally involved in interactions with biotic and abiotic environmental stimuli, showed distinct patterns with the enrichment of a repression mark H3K27me3 and an activation mark H3K18ac ( Fig. 1B ). (biorxiv.org)
The DEGs were further analysed for their gene ontologies (GO), pathway, protein-protein interactions and co-expression. (bvsalud.org)
Garlic contains various bioactive compounds whose metabolic pathways, plant-pathogen interactions, defensive genes, identify interaction networks, and functional genomics were not previously predicted in the garlic at the genomic level. (springeropen.com)

Although roots are the primary material harvested for medical use, the biosynthesis of the bioactive compounds and its regulation in A. mongolicus are not well understood. (biomedcentral.com)
The results revealed a comprehensive profile for metabolic activities among tissues, pointing to the equal importance of leaf, stem, and root in A. mongolicus for the production of bioactive compounds. (biomedcentral.com)

Here, transcriptome analysis and fatty acid profiling from developing V. galamensis seeds were integrated to uncover the critical metabolic pathways responsible for high EFA accumulation and identify the targets that could be used in assembly of EFA biosynthesis pathway in existing oilseed crops. (researchsquare.com)
Global transcriptome analysis profiles metabolic pathways in traditional herb Astragalus membranaceus Bge. (biomedcentral.com)

Whole-genome sequencing also revealed divergence in malic enzyme-encoding genes between the strains predicted to impact the activity of the malate metabolic pathway. (nih.gov)
Comparative growth assays in urine comparing wild-type ABSA and gene-deficient mutants that were functionally inactivated for the malic enzyme metabolic pathway by targeted disruption of the maeE or maeK gene in ABSA demonstrated attenuated growth of the mutants in normal human urine as well as synthetic human urine containing malic acid. (nih.gov)
and the regulation of the expression of enzyme-coding genes associated with important metabolic pathways. (oregonstate.edu)
METABOLON clearly introduces a new level of analysis and intervention into metabolic engineering, by examining the efficiency of complex formation and the fine molecular details that could affect enzyme performance. (europa.eu)
RiceCyc version 3.3 features 316 pathways and 6,643 peptide-coding genes mapped to 2,103 enzyme-catalyzed and 87 protein-mediated transport reactions. (oregonstate.edu)
To explore the possible dynamic behavior of metabolic networks in cases of lacking or incomplete enzyme-kinetic information, we present a computational approach based on structural kinetic modeling. (mpg.de)
Our findings show that allosteric enzyme regulation significantly enhances the stability of the network and extends its potential dynamic behavior. (mpg.de)
Enzyme activity can be modulated through various mechanisms, such as allosteric regulation, feedback inhibition, and post-translational modifications. (trendingbird.com)

EcoCyc is also a description of the genome and cellular networks of E. coli that supports scientists to carry out computational analyses. (wikipedia.org)
Systems analysis of robustness in cellular networks. (mpg.de)

As a case study to demonstrate the use of RiceCyc network as a discovery environment we carried out an integrated bioinformatics analysis of rice metabolic genes that are differentially regulated under diurnal photoperiod and biotic stress treatments. (oregonstate.edu)
Our study identified key genes differentially methylated already in primary infection and in tissues that could contribute to the persisting metabolic disorders and inflammation in HIV-infected individuals despite effective treatment. (biomedcentral.com)
The differentially expressed genes (DEGs) between SQC and metformin groups were screened, and the co-expression modules of the DEGs were constructed based on the weighted correlation network analysis (WGCNA) method. (benthamscience.com)

Dysregulation of these signaling pathways can lead to metabolic disorders and contribute to the development of various pathologies. (alliedacademies.org)
Mete Civelek uses big data analytics to understand the molecular pathways of disease and develops personalized medicine approaches to cardiovascular and metabolic disorders. (virginia.edu)
Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. (biomedcentral.com)
It also analyzes the link between NAFLD and psychiatric disorders, looking into common pathophysiological pathways, such as metabolic, genetic, and lifestyle factors. (biomedcentral.com)
These recommendations are intended for laboratories that perform biochemical genetic testing to improve the quality of laboratory services and for newborn screening laboratories to ensure the quality of laboratory practices for inherited metabolic disorders. (cdc.gov)

Untargeted metabolomics, in combination with molecular networking and in silico structure prediction, alluded to 28 previously unreported metabolites from S. clavuligerus along with associated BGCs in some cases. (mdpi.com)
Targeted metabolomics studies apply single to multianalyte quantitative approaches to analyze a predefined selection (1 to 100s) of compounds originating from a specific metabolic pathway. (cdc.gov)

Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)

Genes responsible for the biosynthesis of these compounds are wired into a complex network. (biorxiv.org)
So far, synthesis of many of these high-value compounds in microbes is simply based on putting together all the players in a pathway. (europa.eu)

AMPK activation stimulates catabolic pathways that generate ATP while inhibiting anabolic processes that consume ATP. (alliedacademies.org)
One of the well-studied sirtuins is Sirtuin 1 (SIRT1), which is involved in the regulation of multiple metabolic processes. (alliedacademies.org)
Metabolic pathways are the intricate chemical reactions that power the life processes of all living organisms. (trendingbird.com)
At the heart of metabolic pathways are molecules, often called metabolites, which serve as the building blocks and intermediates in these chemical processes. (trendingbird.com)
In essence, metabolic pathways are the chemistry of life itself, orchestrating the processes that keep organisms alive and thriving. (trendingbird.com)

Mathematical Modeling of Complex Regulatory Networks. (mpg.de)
Modular Mathematical Modeling of Complex Regulatory Networks: Application to Cell Cycle Regulation in Saccharomyces Cerevisiae. (mpg.de)
Further, regulatory networks were constructed by the DEGs which are also co-expressed and the hub genes were identified. (bvsalud.org)
The additional information generated by whole genome studies goes far beyond that derived by characterizing in isolation more genes and gene products, because analysis of the whole genome allows complete regulatory networks to be identified and characterized. (cdc.gov)

Akbari MR, Malekzadeh R, Nasrollahzadeh D, activates EGFR pathway signaling in the lung. (who.int)

Conclusions: Here we describe the RiceCyc network development and discuss its contribution to rice genome annotations. (oregonstate.edu)

Fig. 4: Transfer of steatotic and metabolic phenotypes to mice through FMT of material from patients with liver steatosis grade 3. (nature.com)
We provide a transcriptomic and phosphoproteomic atlas of fibrin-, iC3b- and lipopolysaccharide (LPS)-selective activation of innate immunity and reveal ligand-selective pathways with differential functions in MS and AD mice. (nature.com)
They use data science, systems biology, and traditional molecular biology approaches to discover novel disease pathways in human cells and in mice. (virginia.edu)

Catabolic pathways like glycolysis, as mentioned earlier, play a crucial role in extracting energy from nutrients. (trendingbird.com)

Importantly, it introduces the concept of altering the host environment to mimic that of the native pathway host, and suggests approaches to achieve this in the case of the ER membrane. (europa.eu)
Two approaches for metabolic pathway analysis? (mpg.de)
Using cancer as an example, we review how network biology can facilitate system-wide approaches to identify targeted small molecule inhibitors. (biomedcentral.com)

Laboratories that perform biochemical genetic testing are required by CLIA regulations to meet the general quality systems requirements for nonwaived testing and the personnel requirements for high-complexity testing. (cdc.gov)
As the number of inherited metabolic diseases that are included in state-based newborn screening programs continues to increase, ensuring the quality of performance and delivery of testing services remains a continuous challenge not only for public health laboratories and other newborn screening facilities but also for biochemical genetic testing laboratories. (cdc.gov)

Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
Results: A total of 962 DEGs between SQC and Met groups were screened, and these DEGs were significantly enriched in various functions, such as sensory perception of the chemical stimulus, NADH dehydrogenase (ubiquinone) activity, and positive regulation of the fatty acid metabolic process. (benthamscience.com)

The autonomic nervous system (ANS) is a very complex, multifaceted neural network that maintains internal physiologic homeostasis. (medscape.com)
The central autonomic network is a complex network in the central nervous system (CNS) that integrates and regulates autonomic function. (medscape.com)

We compared the ortholog gene family of the A. sativum transcriptome to A. thaliana , O. sativa , and Z. mays and found that 12,077 orthologous gene families are specific to A. sativum L. Furthermore, we identified genes involved in plant defense mechanisms, their protein-protein interaction network, and plant-pathogen interaction pathways. (springeropen.com)

Here, to comprehensively characterize cancer metabolic activity, we establish a theoretical framework by coupling gene regulation with metabolic pathways. (nih.gov)
To further characterize pathways involved in naphthalene degradation in NaphS2, the draft genome was sequenced, and gene and protein expression examined. (elsevierpure.com)

We reveal molecular networks linking the gut microbiome and the host phenome to hepatic steatosis. (nature.com)
However, the administration of SGA could generate several reported adverse effects, such as weight gain, obesity, metabolic disturbances, and hepatic and renal dysfunctions ( 5 - 7 ). (frontiersin.org)

The experimental results confirm that TNBC cells can maintain a hybrid metabolic phenotype and targeting both glycolysis and OXPHOS is necessary to eliminate their metabolic plasticity. (nih.gov)

Peripheral signals from our gut and fat stores relay information in a bidirectional pathway to our brain to tell us when we are hungry or full. (medscape.com)

Until recently, such large metabolic networks have been studied mainly in isolation and under stationary conditions, without considering the environment dynamics or the enzymatic resources needed to catalyze all the biochemical reactions. (fu-berlin.de)
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. (mpg.de)
Structure discrimination of continuous models for biochemical reaction networks via finite state machines. (mpg.de)

Through network analysis of the compound-target pathway, we identified hub molecular targets within these pathways including carbonic anhydrase II (CA2), peroxisome proliferator activated receptor γ (PPAR γ ), retinoid X receptor α (RXRA), and vitamin D receptor (VDR). (hindawi.com)

Gat-Viks I, Meller R, Kupiec M, Shamir R: Understanding gene sequence variation in the context of transcription regulation in yeast. (tau.ac.il)
In unicellular organisms like E. coli and yeast, the benefits of between potential cost and benefit, regulation can make the most a well-adapted regulatory system are readily quantified, as the difference to the long-term growth rate if the resource in question fitness of an individual can be estimated by its growth rate in is only available a similarly small fraction of the time. (lu.se)
The case of mitotic control in budding yeast cell cycle regulation. (mpg.de)

The RiceCyc database is hierarchically browsable from pathway diagrams to the associated genes, metabolites and chemical structures. (oregonstate.edu)

Moreover, our approach allows to differentiate quantitatively between metabolic states related to senescence and metabolic collapse of the human erythrocyte. (mpg.de)

We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)

However, it is still largely unknown how cancer cells orchestrate gene regulation to balance their glycolysis and OXPHOS activities. (nih.gov)
Our model further characterizes the hybrid metabolic state and a metabolically inactive state where cells have low activity of both glycolysis and OXPHOS. (nih.gov)

The potential signaling pathways for RIL were identified and experimentally validated using gene ontology (GO) enrichment and Kyoto encyclopedia of genes and genomes (KEGG) analysis. (frontiersin.org)
Results: Total of 2124 DEGs were screened through the Model vs. control and Model vs. GDFMD comparisons, and dozens of GO and KEGG pathway terms modulated by GDFMD were identified. (uni-frankfurt.de)

Noradrenaline-stimulated adenylyl cyclase stimulates the hypothalamus, which involves additional metabolic resources to increase the strength of the bird beak. (novapublishers.com)

Various levels of regulation, including epigenetic modifications and transcription factors, play important roles in coordinating the expression of genes. (biorxiv.org)
Genes related to transcription and RNA regulation were both strongly up- and downregulated, which suggests that BC204 plays a role in inducing and suppressing several pathways. (sun.ac.za)

Gene set variation analysis (GSVA) was used to establish and validate a miRNA set-based pathway prognostic signature for PC (miPPSPC) and a mRNA set-based pathway prognostic signature for PC (mPPSPC) in independent datasets. (aging-us.com)
Gene set variation analysis (GSVA), a functional enrichment analysis method similar to gene set enrichment analysis (GSEA), allows the assessment of underlying pathway activity variation in each sample by pre-inputting a selected gene set [ 11 ]. (aging-us.com)
RILs were systematically analyzed by integrating multiple databases through integrated network pharmacology, transcriptomics, molecular docking, and molecular experiment analysis. (frontiersin.org)
A. Correlation analysis reveals four groups of epigenetic marks, activating (red) and repressing (blue), based on their relative abundance on metabolic genes. (biorxiv.org)
RiceCyc, along with additional species-specific pathway databases hosted in the Gramene project, facilitates comparative pathway analysis. (oregonstate.edu)
The analysis of publicly available rice transcriptome datasets led to the hypothesis that the complete tryptophan biosynthesis and its dependent metabolic pathways including serotonin biosynthesis are induced by taxonomically diverse pathogens while also being under diurnal regulation. (oregonstate.edu)
We think that the proposed method represents an important intermediate step on the long way from topological network analysis to detailed kinetic modeling of complex metabolic networks. (mpg.de)
Comparison of network-based pathway analysis methods. (mpg.de)
Combinatorial complexity of pathway analysis in metabolic networks. (mpg.de)
To better understand the function of the altered genes, gene ontology and pathway analysis are performed. (bvsalud.org)
In garlic, the next-generation sequencing analysis based on RNA from renewal buds resulted in de novo assembly of 128,000 unigenes that were annotated and analyzed with respect to Gene Ontology (GO) and metabolic pathways [ 28 ]. (springeropen.com)

Additionally, hormones and signalling molecules, like insulin and glucagon, are vital in coordinating metabolic pathways throughout the body. (trendingbird.com)

Traditional Chinese Medicine (TCM) has demonstrated significant success in treating complex diseases by regulating multiple pathways working to return dysfunctional organ systems back to normal [ 8 ]. (hindawi.com)
From the clinicians' point of view, it is necessary to bridge the gap between theoretical network biology and practical biomedical research, in order to improve the diagnosis, prevention, and treatment of the world's major diseases. (biomedcentral.com)
The recommended practices address the benefits of using a quality management system approach, factors to consider before introducing new tests, establishment and verification of test performance specifications, the total laboratory testing process (which consists of the preanalytic, analytic, and postanalytic phases), confidentiality of patient information and test results, and personnel qualifications and responsibilities for laboratory testing for inherited metabolic diseases. (cdc.gov)
Pharmacovigilance of drug-induced rare diseases such as EMS are being monitored by the French Network of Regional Pharmacovigilance Centers. (medscape.com)

The intricate web of metabolic pathways is tightly regulated to adapt to varying conditions and meet the organism's energy and metabolic needs. (trendingbird.com)
Metabolic pathways are the intricate web of chemical reactions that sustain life at the molecular level. (trendingbird.com)

When a second nutrient and its metabolic pathway are introduced, the system must further decide whether and how to activate both pathways. (lu.se)
Even the crudest transcriptional network is shown to substantially increase the fitness of the organism, and this effect persists even when the range of nutrient levels is kept very narrow. (lu.se)
We show that maximal growth is achieved when pathway activation is a more or less steeply graded function of the nutrient concentration. (lu.se)

Protein engineering can create or improve the key component for enhancing biosynthesis efficiency, while pathway engineering has the potential to balance the overall metabolic flux toward the biosynthesis of products of interest. (keaipublishing.com)
FluxAnalyzer: exploring structure, pathways, and flux distributions in metabolic networks on interactive flux maps. (mpg.de)

A transcriptome study was performed for A. mongolicus tissues to construct and profile their metabolic pathways, especially for the important bioactive molecules. (biomedcentral.com)
These complex networks of reactions drive the conversion of nutrients into energy, the synthesis of essential molecules, and the regulation of metabolic homeostasis. (trendingbird.com)
These pathways drive energy production, synthesize essential molecules, and regulate metabolic homeostasis. (trendingbird.com)
Network representation is frequently used to capture the presence of these molecules as well as their relationship. (biomedcentral.com)

Steatosis due to secondary causes, such as viruses, autoimmune responses, metabolic or hereditary factors, and drugs or toxins, should be ruled out (Table 1 ). (biomedcentral.com)

The balance between anabolism and catabolism is vital for maintaining metabolic homeostasis. (trendingbird.com)
Full-length parathyroid hormone (PTH 1-84) is crucial for the regulation of calcium and phosphate homeostasis and bone remodeling. (cdc.gov)

A protein-protein interaction (PPI) network was constructed using the STRING database, and the modules were identified using MCODE plugin with the Cytoscape software. (uni-frankfurt.de)

Understanding the chemistry of metabolic pathways is a fundamental aspect of biology and a key to unravelling the complexities of health. (trendingbird.com)
In this review, we aim to improve the understanding of challenges in biomedical research and establish a common ground between clinicians and systems biologists to further promote the application of network biology in translational medicine. (biomedcentral.com)

Most of the existing research has focused on genes for prognosis prediction, whereas pathways based on mRNAs or miRNAs have never been used to predict survival. (aging-us.com)

for example, in 1858 Louis Pasteur was the first to show that there is a complex balance of oxygen use in animal cells, and that cells use multiple pathways to accomplish energy con-version (Pasteur, 1858). (nobelprize.org)

Anatomy4

Organisms14

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes46

Disciplines and Occupations12

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture4

Humanities1

Information Science22

Health Care7

Metabolism26

Oxidative stress pathways2

Enzymes3

Transcriptional regulation4

Genetics1

Gene expression9

Biosynthesis pathways2

PI3K-Akt1

Genome-scale1

Biological4

Glucose2

Interactions4

Bioactive compounds2

Transcriptome analysis2

Enzyme8

Cellular2

Differentially3

Disorders5

Metabolomics2

Lipid1

Compounds2

Processes5

Regulatory networks4

Activates1

Conclusions1

Mice3

Catabolic1

Approaches3

Genetic2

Fatty2

Autonomic2

Genes involved1

Characterize2

Hepatic2

Phenotype1

Bidirectional1

Biochemical3

Targets1

Yeast3

Metabolites1

Quantitatively1

Proteins1

Glycolysis2

KEGG2

Stimulates1

Transcription2

Analysis11

Insulin1

Diseases4

Intricate2

Nutrient3

Flux2

Molecules4

Responses1

Homeostasis2

Interaction1

Understanding2

Prediction1

Cells1