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  • synaptic
  • This single element, when positioned immediately upstream of a minimal promoter, was necessary and sufficient to replicate crucial properties of endogenous Arc / Arg-3.1' s transcriptional regulation, including rapid onset of transcription triggered by synaptic activity and low basal expression during synaptic inactivity. (pnas.org)
  • Aberrance of adaptive responses such as long-term memory or late-phase synaptic plasticity has indeed been the hallmark of several genetically engineered mouse mutants in which the expression or the function of key transcription factors have been altered ( 2 , 3 ). (pnas.org)
  • kinase
  • Bhatnagar S, Kumar A, Makonchuk DY, Li H, Kumar A. Transforming growth factor-beta-activated kinase 1 is an essential regulator of myogenic differentiation. (springer.com)
  • Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. (springer.com)
  • Regulation of EphA4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. (greer-lab.com)
  • expression
  • Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. (springer.com)
  • We are currently investigating how calcineurin signal is integrated into MEF2 for Nur77 expression and how Cabin1 achieves transcriptional repression of MEF2. (jhmi.edu)
  • These findings demonstrate that MEF2D, a broadly expressed TF, contributes to retina-specific gene expression in photoreceptor development by binding to and activating tissue-specific enhancers cooperatively with CRX, a tissue-specific co-factor. (harvard.edu)
  • These findings demonstrate that observed TF binding significantly overestimates direct TF regulation of gene expression. (harvard.edu)
  • Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster. (semanticscholar.org)
  • Exercise also affects transcription factors and coactivators, which change the target gene expression and are related to muscle adaptations such as increasing glucose transport-related protein, mitochondrial biogenesis, and the muscle fiber type transition over a long period. (springer.com)
  • Tt.eya , Tt.FoxC , Tt.FoxF , Tt.Mox , Tt.paraxis , Tt.Limpet , and Tt.Mef2 all showed initial mesodermal expression during later gastrula or early larval stages. (biomedcentral.com)
  • Expression of multiple mesodermal factors in the archenteron wall during gastrulation supports previous morphological observations that this region gives rise to larval mesoderm. (biomedcentral.com)
  • Localized expression domains during gastrulation and larval development evidence early regionalization of the mesoderm and provide a basis for hypotheses regarding the molecular regulation underlying the complex system of musculature observed in the larva. (biomedcentral.com)
  • An understanding of gene regulation is key if we are to understand the mechanisms by which correct expression is achieved during development, and how variations in these mechanisms drive phenotypic change. (biologists.org)
  • Molecular
  • We are interested in a molecular understanding of intracellular signal transduction pathways involved in T lymphocyte activation and apoptosis and regulation of endothelial cell proliferation. (jhmi.edu)
  • These analyses illustrate how a systems biology approach based on gene networks can yield insights into the molecular mechanisms of neural development and function, and provide clues as to the functional impact of the downstream effects of Ca 2+ signaling dysregulation on transcription. (biomedcentral.com)
  • The homology of the mesoderm among bilaterians is supported by the deployment of a conserved set of transcription factors in the specification and differentiation of the mesoderm in the classical model systems of the mouse, Drosophila , and Caenorhabditis elegans , where the molecular basis for mesoderm development has been investigated in the greatest detail [ 3 - 6 ]. (biomedcentral.com)
  • pigment-disper
  • Circadian remodeling of the small ventral lateral neuron (sLNv) dorsal terminals was first described at the peak and trough levels of pigment-dispersing factor (PDF) immunoreactivity, that is at zeitgeber time 2 (ZT2) and ZT14 (2 hr after lights ON and lights OFF, respectively), as well as their counterparts under constant darkness (DD) (circadian time 2 [CTand CT14). (sdbonline.org)
  • Family
  • We assess the importance of epidermal growth factor receptor family signalling through ERK1/2 in models of breast cancer progression and the influence of ERK1/2 on its substrate, the oestrogen receptor, in this context. (biomedcentral.com)
  • protein
  • RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. (proteopedia.org)
  • mechanism
  • In addition to Cabin1, calcineurin is also required for full activation of MEF2, the mechanism of which remains unknown. (jhmi.edu)
  • cancer
  • Epidemiologic studies indicate that physical inactivity and excess body weight as abdominal fat are risk factors to develop a colorectal cancer, in particular as a result of an unbalanced diet (high in saturated fats, low in vegetables and fruits) [ 2 ]. (hindawi.com)
  • roles
  • Migraine is a common, chronic, polygenic neurovascular disorder in which both genetic and environmental factors play their roles. (springer.com)
  • influx
  • TCR-induced calcium influx leads to the dissociation of MEF2 from Cabin1, as a result of competitive binding of activated calmodulin to Cabin1. (jhmi.edu)
  • cytokines
  • MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. (proteopedia.org)