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HepcidinsAntimicrobial Cationic PeptidesIronIron OverloadHemochromatosisBone Morphogenetic Protein 6Anemia, Iron-DeficiencyCation Transport ProteinsFerritinsReceptors, TransferrinIron, DietaryAnemiaTransferrinErythropoiesisIron Isotopesbeta-ThalassemiaSmad8 ProteinIron CompoundsHepatocytesInterleukin-6LiverBone Morphogenetic ProteinsHomeostasisMembrane ProteinsHistocompatibility Antigens Class IHep G2 CellsGrowth Differentiation Factor 15GPI-Linked ProteinsGene Expression RegulationPhlebotomyErythropoietinFursultiaminHemoglobinsDuodenumRNA, MessengerSmad ProteinsInflammationGrowth Differentiation Factor 2Mice, Inbred C57BLSmad5 ProteinCytophagocytosisIntestinal AbsorptionGrowth Differentiation FactorsPhenylhydrazinesLeprosy, MultibacillarySTAT3 Transcription FactorMice, KnockoutCCAAT-Enhancer-Binding Protein-alphaSmad1 ProteinPolycythemiaIron Chelating AgentsIron-Regulatory ProteinsBone Morphogenetic Protein 2Reverse Transcriptase Polymerase Chain ReactionSerine EndopeptidasesInhibitor of Differentiation Protein 1ApoferritinsSchnitzler SyndromeFish ProteinsBone Morphogenetic Protein 4Inflammation MediatorsMacrophagesBiological MarkersSignal TransductionAngelica sinensisBassSmad4 ProteinPromoter Regions, GeneticIron-Binding ProteinsUpstream Stimulatory FactorsChelation TherapyDown-RegulationSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBlood TransfusionHylobatidaeC-Reactive ProteinNeriumChronic DiseaseHematinicsSpleenAnoxiaEnterocytesChemistry, ClinicalMutationUrinalysisAcute-Phase ReactionFerrocyanidesDisease Models, AnimalIpomoea batatasBlood Chemical AnalysisLipopolysaccharidesMass SpectrometryTurpentineMononuclear Phagocyte SystemBone Morphogenetic Protein ReceptorsAnemia, HypochromicAnemia, HemolyticEnzyme-Linked Immunosorbent AssaySulfoxidesHomeopathy
Maternal and fetalBovine serumSystemic iron homeostasisInductionSerumProduced by the liverBmp6OutcomesPregnancyIron regulationDevelopmentResponseExpressionStudyPlasmaLevelsCellsRoleFerritinPeptide hormoneMembranesPlacentaFerroportinInflammationNeonatalMaternalRegulatorConsequencesIronProspectiveWomenGreater
Maternal and fetal2
  • These fetal growth patterns are also associated with blood flow and nutrient transfer by the placenta, demonstrating a complex interaction between maternal and fetal nutrition early in pregnancy that influences postnatal weight and eventually adult health. (ox.ac.uk)
  • Pregnancy, delivery, and the puerperium are associated with increased rates of iron deficiency and anemia, which correlates with worse maternal and fetal outcomes and places pregnant women at increased risk of obstetric hemorrhage. (karger.com)
Bovine serum2
  • Foetal bovine serum (FBS) was from GIBCO BRL (Grand Isle, NY, USA). (biosemiotics2013.org)
  • VWR provides the cell culture community with access to the most reliable supply of exceptional quality Fetal Bovine Serum: VWR Life Science Seradigm. (vwr.com)
Systemic iron homeostasis1
Induction1
  • Merlin Nithya Gnanapragasam, PhD, of Icahn School of Medicine at Mount Sinai in New York City , is performing experiments in HuDEP-2 cells to examine the consequences of mutation of the EKLF upstream enhancer region in her project, "Genome Editing of EKLF Enhancer Elements for Fetal Homoglobin Induction. (thalassemia.org)
Serum1
  • Hemoglobin (Hb), serum iron (Fe 2+ ), serum ferritin (SF), soluble transferrin receptor (sTfR), hepcidin and the dosage of recombinant human erythropoietin (rhEPO) before and after intervention in patients were analyzed. (biomedcentral.com)
Produced by the liver1
  • The master regulator of iron balance in humans is hepcidin, a peptide produced by the liver [ 20 ]. (hindawi.com)
Bmp63
  • Treatment with BMP6 increased hepcidin expression in human liver-derived cells but not in bovine liver-derived cells. (bvsalud.org)
  • MATERIAL AND METHODS: We used mice models with genetic iron overload (GIO) related to hepcidin deficiency (Hfe-/- and Bmp6-/- ) and secondary iron overload (SIO) exhibiting a hepcidin increase secondary to iron excess. (bvsalud.org)
  • Alterations in bone microarchitecture in the Bmp6-/- model were positively correlated with hepcidin levels (BV/TV (ρ = +.481, p (bvsalud.org)
Outcomes2
  • The paper complements work published by the same groups in 2021 that identified fetal head growth trajectories that are associated with different developmental, behavioural, visual and growth outcomes at 2 years of age. (ox.ac.uk)
  • There was limited data reporting on prevalence of anaemia and direct maternal and foetal outcomes. (biomedcentral.com)
Pregnancy5
  • Unaltered maternal plasma IL-6 levels suggest mechanism other than inflammation being involved in altered iron regulation in PE pregnancy. (lu.se)
  • In order to supply adequate iron during pregnancy, the levels of the iron regulatory hormone hepcidin in the maternal circulation are suppressed, thereby increasing dietary iron absorption and storage iron release. (bvsalud.org)
  • Supported by a grant from the Bill & Melinda Gates Foundation, the INTERBIO-21st Study monitored the growth inside the womb of over 3,500 babies in six countries (Brazil, Kenya, Pakistan, South Africa, Thailand, and the United Kingdom) using serial fetal ultrasound scans throughout pregnancy, and analysed blood samples taken from the women early in pregnancy and from the umbilical cord at birth. (ox.ac.uk)
  • They found that maternal fat metabolism as early as the 5th month of pregnancy, and the growth of the fetal abdomen growth patterns of fetal abdominal growth associated with maternal lipid metabolites that track newborn growth, adiposity and development into childhood. (ox.ac.uk)
  • Very importantly, in both studies, the same critical time period close to the 5th month of pregnancy is the starting point for accelerated or decelerated fetal growth that is sustained into early childhood. (ox.ac.uk)
Iron regulation1
  • She will be using mouse strains exhibiting different extremes of iron regulation to conduct her experiments. (thalassemia.org)
Development3
  • Further, several retrospective studies have noted an increased incidence of spina bifida occurring after low maternal intake of iron during embryonic and fetal development. (wikipedia.org)
  • AIM: The aim of the study was to investigate the respective roles of iron excess and hepcidin, the systemic iron regulator, in the development of iron-related osteoporosis. (bvsalud.org)
  • CONCLUSION: Together, these data suggest that iron in excess alone is not sufficient to induce osteoporosis and that low hepcidin levels also contribute to the development of osteoporosis. (bvsalud.org)
Response2
  • Hepcidin is synthesized in response to various cytokines, as described in the Hepcidin article, as well as in this article by Ganz. (wikipedia.org)
  • Hepcidin production is increased in response to an increase in systemic iron via the activation of the bone morphogenetic protein (BMP) pathway. (bvsalud.org)
Expression7
  • Regulation of hepcidin expression by iron status has been proposed on the basis of evidence mainly from rodents and humans. (bvsalud.org)
  • We evaluated the effect of iron administration on plasma hepcidin concentrations in calves and the expression of bovine hepcidin by the BMP pathway in a cell culture study. (bvsalud.org)
  • The lower expression levels of bovine Smad4 were responsible for the lower activity of the hepcidin reporter, which might be due to the instability of bovine Smad4 mRNA. (bvsalud.org)
  • We revealed the unique regulation of bovine hepcidin expression and the characteristic TGF-ß family signaling mediated by bovine Smad4. (bvsalud.org)
  • The present study suggests that knowledge of the regulatory expression of hepcidin as well as TGF-ß family signaling obtained in murine and human cells is not always applicable to bovine cells. (bvsalud.org)
  • Hepcidin supplementation of cells had a rescue effect on the collagen 1 and alkaline phosphatase expression level decrease. (bvsalud.org)
  • Hypoxia downregulates the expression of hepcidin, which leads to both increased intestinal iron absorption and increased release of recycled iron from the reticuloendothelial system [ 21 , 22 ]. (hindawi.com)
Study2
  • Methods: In this retrospective study, we investigated the regulation of maternal and placental iron availability and storage, in normotensive and pregnancies complicated by early- or late-onset PE. (lu.se)
  • Karen Finberg, MD, of Yale Medical School, is studying the process of how the gene NCOA4 mediates the degradation of ferritin in her study, "The Role of NCOA4 in the Regulation of Hepatic Iron Stores. (thalassemia.org)
Plasma3
  • In addition, maternal plasma ERFE levels were elevated in both early- and late-onset PE and hepcidin levels reduced in early-onset PE. (lu.se)
  • hepcidin binds to Fpn and limits its iron-efflux activity, thereby reducing iron delivery to the blood plasma. (wikipedia.org)
  • Although intramuscular administration of iron increased iron-related parameters, plasma hepcidin concentrations were unaffected. (bvsalud.org)
Levels1
  • Hepcidin negatively regulates systemic iron levels by inhibiting iron entry into the circulation. (bvsalud.org)
Cells3
  • The reporter activity of hepcidin was lower in the cells transfected with bovine Smad4 than in those transfected with murine Smad4. (bvsalud.org)
  • The osteoblastic MC3T3 murine cells that are able to mineralize were exposed to iron and/or hepcidin. (bvsalud.org)
  • Around the same time, research began to show that the regulation of iron is a central function of the immune system, and that this seems to have evolved because iron is a basic requirement for the survival and growth of cells of all types, including bacteria, parasites, and cancer. (raypeatforum.com)
Role1
  • The exact role of placental ERFE in regulating maternal-placental-fetal iron transport axis requires further investigation. (lu.se)
Ferritin2
  • Secondary objectives were to investigate the development of hepcidin, plasma ferritin and inflammatory markers over the course of pregnancy dependent on weight status. (cambridge.org)
  • 10. Expression of Hepcidin and Ferroportin in the Placenta, and Ferritin and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes. (nih.gov)
Peptide hormone2
  • Hepcidin, a circulating peptide hormone, is the key regulator of both iron absorption and the distribution of iron throughout the body, including in plasma [ 1 , 2 , 6 ]. (nih.gov)
  • The hierarchical master determinant of dietary iron absorption and iron distribution within the body is the peptide hormone hepcidin. (ox.ac.uk)
Membranes2
  • Is unexplained where there has been prolonged rupture of the fetal membranes alkaline phosphatases are found in the hospital centres. (hybridnutrition.co.za)
  • In recent years, we have in particular implemented RNA sequencing approaches on isolated cells from fetal membranes and placenta. (institutcochin.fr)
Placenta1
  • 3. Transferrin receptor 1 mRNA is downregulated in placenta of hepcidin transgenic embryos. (nih.gov)
Ferroportin1
  • Ferroportin is inhibited by hepcidin, which binds to ferroportin and internalizes it within the cell. (wikipedia.org)
Inflammation4
Neonatal1
  • Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. (ox.ac.uk)
Maternal2
  • Further, several retrospective studies have noted an increased incidence of spina bifida occurring after low maternal intake of iron during embryonic and fetal development. (wikipedia.org)
  • Although as noted above, there are significant maternal-fetal implications even with mild reductions in hemoglobin. (glowm.com)
Regulator1
Consequences1
  • Therefore, regulation of the intake of macronutrients or micronutrients could be used as a strategy to reduce the consequences of COVID-19. (nutrition-evidence.com)
Iron9
  • 4. Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency. (nih.gov)
  • 5. Changed iron regulation in scrapie-infected neuroblastoma cells. (nih.gov)
  • 16. Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency. (nih.gov)
  • hepcidin binds to Fpn and limits its iron-efflux activity, thereby reducing iron delivery to the blood plasma. (wikipedia.org)
  • Therefore, the interaction between Fpn and hepcidin controls systemic iron homeostasis. (wikipedia.org)
  • Low levels of hepcidin allow iron absorption and effective iron incorporation into red blood cells. (ox.ac.uk)
  • here too, biomarkers including hepcidin may be useful to actively and beneficially manage iron status. (ox.ac.uk)
  • We have made significant contributions to understanding how hepcidin and iron are controlled in health and disease, including iron deficiency, thalassaemia, HIV, HCV, typhoid fever, Influenza virus infection, and most recently COVID19. (ox.ac.uk)
  • We utilise experimental models of key diseases, including malaria and tumour models, and manipulate hepcidin to test how controlling iron homeostasis influences immune responses and the course of disease. (ox.ac.uk)
Prospective1
  • Prenatal diagnosis of fetal skeletal dysplasia using 3-dimensional computed tomography: a prospective study. (researchmap.jp)
Women1
  • Hepcidin was still significantly higher in the owob women in the 3 rd trimester. (cambridge.org)
Greater1
  • Variation in the SITAR size parameter was ≥90% explained by the combination of average length within the first 60 days of birth (as a proxy for fetal growth) and intensity, regardless of sex, with much greater contribution by postnatal intensity (r≥0.89 between size and intensity). (ox.ac.uk)