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  • HDAC
  • Antiproliferative and proapoptotic effects of several HDAC inhibitors, including trichostatin A, depsipeptide, MS-275, sodium butyrate, valproic acid, pyroxamide, and suberoylanilide hydroxamic acid (SAHA), have been reported for prostate cancer cell lines ( 9 - 12 ). (aacrjournals.org)
  • vitro
  • We have shown that SAHA can inhibit the growth of prostate cancer cell lines in vitro and suppresses the growth of the androgen-dependent human prostate cancer xenograft, CWR22, at high doses ( 16 ). (aacrjournals.org)
  • human
  • Velvet L. Worstell: "Analysis of the Down Regulation of Deleted in Liver Cancer 1 (DLC1) and Caveolin 1 (CAV1) in Human Meningiomas" December 2008. (wvstateu.edu)
  • Indirubin, an indigoid active ingredient of a traditional Chinese recipe, was the first example of a CDK inhibitor used to treat human chronic myelogenous leukemia (CML). (aacrjournals.org)
  • function
  • Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation. (pubfacts.com)
  • Sumanth Manohar: "Nuclear Localization Mediated Function of CHMP1A in the Regulation of Ataxia Telangiectasia Mutated Signaling" May 2011. (wvstateu.edu)
  • However
  • No mevalonate kinase was detected in crude extracts of Saccharomyces cerevisiae strains, however, because of background interference measured in the absence of mevalonate. (ebscohost.com)
  • However, the number of structural classes that act as CDK inhibitors is limited, and most of them derive from relatively nonspecific protein kinase inhibitor scaffolds such as staurosporines ( 27 -29 ), flavonoids ( 29 ), indigoids ( 30 ), paulones ( 31 ), and purines ( 32 ). (aacrjournals.org)
  • highly
  • Although considerable efforts are still devoted to these chemical families and their structurally related analogues, the identification of new structural classes of protein serine/threonine kinase inhibitors remains highly desirable. (aacrjournals.org)