Regulation cardiac volume. Medical search. Frequent questions

We hope this study could lead to the development of new therapeutic strategies targeting chloride and pH regulation to prevent cellular damage from cardiac ischemia and arrhythmia," Zhang said. (ucdavis.edu)
According to the HEMO study, cardiac arrhythmia and ST-segment changes during deaths account for 39.4% of all deaths in HD in young patients with no concomitant patients on chronic haemodialysis (HD). (who.int)
Cardiac arrhythmia was found to gering the patient's life. (who.int)

In broad terms, there are 3 types of cardiac hypertrophy: normal growth, growth induced by physical conditioning (i.e., physiologic hypertrophy), and growth induced by pathologic stimuli. (wustl.edu)
Dorn, GW & Force, T 2005, ' Protein kinase cascades in the regulation of cardiac hypertrophy ', Journal of Clinical Investigation , vol. 115, no. 3, pp. 527-537. (wustl.edu)
Recent studies suggest that cardiac fibroblast-specific p38α MAPK contributes to the development of cardiac hypertrophy, but the underlying mechanism is unknown. (whiterose.ac.uk)
Our study used a novel fibroblast-specific, tamoxifen-inducible p38α knockout (KO) mouse line to characterize the role of fibroblast p38α in modulating cardiac hypertrophy, and we elucidated the mechanism. (whiterose.ac.uk)
Cardiac function was assessed by pressure-volume conductance catheter analysis and was evaluated for cardiac hypertrophy at tissue, cellular, and molecular levels. (whiterose.ac.uk)
Isoproterenol infusion in control mice promoted overt cardiac hypertrophy and dysfunction (reduced ejection fraction, increased end systolic volume, increased cardiac weight index, increased cardiomyocyte area, increased fibrosis, and up-regulation of myocyte fetal genes and hypertrophy-associated microRNAs). (whiterose.ac.uk)
In vitro mechanistic studies determined that cardiac fibroblasts responded to damaged myocardium by secreting several paracrine factors known to induce cardiomyocyte hypertrophy, including IL-6, whose secretion was dependent upon p38α activity. (whiterose.ac.uk)
In conclusion, cardiac fibroblast p38α contributes to cardiomyocyte hypertrophy and cardiac dysfunction, potentially via a mechanism involving paracrine fibroblast-to-myocyte IL-6 signaling. (whiterose.ac.uk)

Endothelial-to-mesenchymal transition (EndMT) is an important mechanism underlying cardiac fibrosis. (dovepress.com)
This study aimed to investigate the possible effect of TMZ on cardiac fibrosis exerted via the inhibition of NOX2-mediated EndMT. (dovepress.com)
A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)
Rats injected with ISO exhibited severe interstitial cardiac fibrosis and perivascular fibrosis, decreased left ventricular ejection fraction, and increased NOX activity. (dovepress.com)
TMZ treatment mitigated cardiac fibrosis, ameliorated left ventricular dysfunction, and reduced NOX activity. (dovepress.com)
TMZ may ameliorate EndMT and ISO-induced cardiac fibrosis through the NOX2/NF-κB/Snail pathway. (dovepress.com)
The findings of the study may provide new insights into the potential role of TMZ in the pathophysiology of cardiac fibrosis. (dovepress.com)
Myocardial fibrosis, characterized as interstitial fibroblast proliferation and excessive collagen deposition, is the structural basis of myocardial stiffness and the key process of cardiac function transformation from the compensatory phase to heart failure. (dovepress.com)
Cardiac fibroblasts are generally the primary effector cells of fibrosis and have been reported to be partly derived from cardiac endothelial cells through the endothelial to mesenchymal transition (EndMT) process. (dovepress.com)
Recently, EndMT has been increasingly recognized as a vital process that contributes to various cardiovascular pathologies in adults, which include atherosclerosis, valvular heart disease, cardiac fibrosis, and myocardial infarction. (dovepress.com)

Within the cardiac muscle ( myocardium ), chloride also contributes to the excitability of the cardiac cells, but the resting chloride conductance is not very high. (ucdavis.edu)
however, this produces increased afterload that causes further cardiac stress and damages myocardium. (medscape.com)

End-users in the global transcatheter market include cardiac catheterization laboratory, ambulatory surgical centers (ASCs), and hospitals. (medgadget.com)
This article will address the technical principles for cardiac procedures, both diagnostic and therapeutic/interventional, recognizing best practices for radiation safety in the cardiac catheterization laboratory. (imagewisely.org)
Assessment of radiation dose in the cardiac catheterization laboratory is much more than fluoroscopy time (FT, min), which does not take into account cine imaging, frame rate, angulations, patient size, etc. (imagewisely.org)

Analysis of rhythmic patterns embedded within beat-to-beat variations in heart rate (heart rate variability) is a tool used to assess the balance of cardiac autonomic nervous activity and may be predictive for prognosis of some medical conditions, such as myocardial infarction. (biomedcentral.com)
Decreased HRV may be predictive of poor prognosis of myocardial infarction and cardiac failure [ 2 ] and has been used to evaluate the impact of manual therapeutic procedures (such as spinal manipulation and massage) on cardiac autonomic nervous activity. (biomedcentral.com)
Patients with previous CABG, ST-elevation myocardial infarction (MI) or cardiac shock were excluded. (bvsalud.org)

Scholars@Duke publication: Physiology and regulation. (duke.edu)
Physiology and regulation. (duke.edu)

MGF-2 is a growth factor that is naturally present in the heart as well as cardiac myocytes and possesses growth promoting and cardioprotective properties, which make it an important therapeutic tool for reducing or preventing damage by ischemia and/or improving cardiac prognosis subsequent to cardiac injury. (umanitoba.ca)
In addition, my results also demonstrate that endogenous production of FGF-2 can be targeted and is significantly increased in adult mouse cardiac myocytes using the natural catecholamine, norepinephrine. (umanitoba.ca)
Overexpression of FGFR-1 resulted in FGF-2 mediated mitogenic response in FGFR-1 deficient cardiac H9c2 cells as well as primary neonatal cardiac myocytes. (umanitoba.ca)
0.01), providing direct evidence for a role for the mitochondria.Conclusions: Our data suggest that mitochondria appear to be involved in oxygen sensing, regulation of cellular ROS, and the function of ICa-L during acute hypoxia in cardiac myocytes and NAD(P)H oxidase does not appear to contribute substantially. (edu.au)
Methods: We used formamide-induced detubulation of mouse ventricular myocytes to investigate differential functional distribution and regulation by PKA of α 1 and α 2 in T-tubule versus SSL membranes by measuring NKA current (I pump ) and NKA-mediated Na + efflux (- d[Na] i /dt). (uky.edu)

They also are involved in pathologies such as cardiac arrhythmias, congestive heart failure, the elevated calcium levels in muscular dystrophy and the growth of brain tumors. (buffalo.edu)
Cardiac arrhythmias are often observed sity Hospital from April to August 2005. (who.int)

The factors affecting cardiac output include sodium intake, renal function, and mineralocorticoids. (medscape.com)

This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies. (biomedcentral.com)

This likely contributed to the increased cardiac myocyte viability observed after ischemia-reperfusion injury in isolated FGF-2 transgenic mouse hearts, representing the first account of the cardioprotective potential of endogenous FGF-2. (umanitoba.ca)
Find the mechanistic roles of Slc26a6 in cardiac ischemia/reperfusion . (ucdavis.edu)

It is a striated muscle protein, which is highly expressed in skeletal muscles and to a lesser extent cardiac muscles. (biomedcentral.com)

However, the mechanisms of pH regulation in heart cells remain incompletely understood. (ucdavis.edu)
Determine the regulatory mechanisms of Slc26a6 on cardiac pH i and function. (ucdavis.edu)
Identify the roles and regulatory mechanisms of Slc26a6 in cardiac pacemaking activities. (ucdavis.edu)
In this study, we performed a literature review in order to investigate the relationship between auditory mechanisms and cardiac autonomic regulation. (bvsalud.org)
In this review, we summarize the biological function of MG53 with its potential mechanisms in cardiac tissue (Fig. 1 ), discuss current debates regarding the role of MG53 in diabetic cardiomyopathy (Table 1 ), and potential clinical applications of recombinant MG53 protein in the management and treatment of heart diseases (Table 2 ). (biomedcentral.com)

In this review we discuss our current knowledge about the role of CD36 in cardiac fatty acid uptake and metabolism in health and disease with focus on the regulation of the subcellular trafficking of CD36 and its selective modulation as therapeutic approach for cardiac disease. (ox.ac.uk)

quantium Medical Cardiac Output (qCO) uses impedance cardiography in a simple, continuous, and non-invasive way to estimate the cardiac output (CO) and other hemodynamic parameters such as the stroke volume (SV) and cardiac index (CI). (wikipedia.org)

The inotropic effects occur via extracellular fluid volume augmentation and an increase in heart rate and contractility. (medscape.com)
Additionally, the team examined whether the activity of Slc26a6 regulated heart rhythm and cardiac contractility via its pH-controlling mechanism. (ucdavis.edu)
Reduction in myocardial contractility results in decreased cardiac output, hypotension, systemic vasoconstriction, and cardiac ischemia. (medscape.com)

There is a progressive decrease in sympathetic activity, blood pressure (BP), stroke volume, heart rate, cardiac output, and systemic vascular resistance, during deeper NREM sleep stages [ 4 ]. (hindawi.com)

This figure illustrates the functional roles of Slc26a6 in cardiac chloride and pH regulation as well as in ischemic cardiac disease. (ucdavis.edu)

Furthermore, changes in cardiac fatty acid utilization that occur in both acute and chronic cardiac disease appear to be accompanied by concomitant changes in the sarcolemmal presence of CD36. (ox.ac.uk)
This chest radiograph shows an enlarged cardiac silhouette and edema at the lung bases, signs of acute heart failure. (medscape.com)

With regard to the analysis of the parameters, the calculation of the baro-receptor cardiac reflex sensitivity based on the Bertinieri's method, and the analysis of the power spectrum density and the transfer function were made, and it was continued to be able to estimate the vagal and sympathetic activities under daily activities except strong exercises. (nii.ac.jp)
6 ] examined modulation of sympathetic and parasympathetic components of autonomic drive to the heart (before cardiac catheterisation), during back massage of patients in the lateral recumbent posture. (biomedcentral.com)

FGF-2 signaling also plays a major role in embryonic and neonatal cardiac myocyte proliferation 'in vitro' and as a result, is implicated in cardiac regeneration. (umanitoba.ca)
Cardiac ischemia is modelled in vitro through the application of hypoxic and oxidative stress. (biomedcentral.com)

Studies in various animal and cell models suggest that interventions aimed at modulating the sarcolemmal presence or functioning of CD36 hold promise as therapy to rectify aberrant rates of fatty acid uptake in order to fight cardiac metabolic remodeling and restore proper contractile function. (ox.ac.uk)
Soluble cluster of differentiation 26 (sCD26) has a wide range of enzymatic functions affecting immunological, metabolic and vascular regulation. (frontiersin.org)

Pitx2(-/-) mice present with severe cardiac malformations and embryonic lethality, demonstrating a role for PITX2 in heart development. (lu.se)

This raised the question - how is chloride transported in the cardiomyocytes (cells responsible for the heart's contraction) to maintain the relatively higher chloride concentration in the cardiac muscle cells? (ucdavis.edu)
Conclusion: These data suggest that NKA α 1 and α 2 subunits are differentially localised and regulated by PKA in T-tubule and SSL membranes and may have distinct regulatory roles in cardiac excitation-contraction coupling. (uky.edu)
Regulation of Cardiac Contraction by Calcium. (comprehensivephysiology.com)

We studied time to cardiac arrest, comorbidities, survival, and cerebral performance category (CPC) score. (bvsalud.org)
Time from VHD diagnosis to cardiac arrest was 3.7 years in AS, 4.5 years in AR and 4.1 years in MR. ROSC occurred in 28% with AS, 33% with AR, 36% with MR and 35% without VHD. (bvsalud.org)
On average, less than 8% of people who experience an out-of-hospital cardiac arrest survive. (cdc.gov)
A person experiencing cardiac arrest is 2 to 3 times more likely to survive if a bystander applies an automated external defibrillator (AED) before EMS arrival (3-5). (cdc.gov)

All these points are associated with distinct physiological events within the systolic part of the cardiac cycle, i.e., located after the QRS complex onset. (wikipedia.org)

In conclusion, my doctoral studies have provided substantial evidence that regulating the FGF-2 axis can be used as a means to exploit the effects of FGF-2 on cardioprotection and cardiac myocyte regeneration in an effort to provide the basis for novel treatments and prevention strategies for cardiac disease. (umanitoba.ca)

In contrast, pathological or reactive cardiac growth is triggered by autocrine and paracrine neurohormonal factors released during biomechanical stress that signal through the Gq/phospholipase C pathway, leading to an increase in cytosolic calcium and activation of PKC. (wustl.edu)

We provide a new mechanism for the regulation of heart development by PITX2 isoforms through the regulation of ANF and PLOD1 gene expression and Nkx2.5 transcriptional activity. (lu.se)

The research described in this thesis is focussed on developing and testing multiple strategies to regulate cardiac myocyte protection and regeneration in an effort to provide the basis for novel treatments and/or prevention of cardiac disease. (umanitoba.ca)
My results also provide direct evidence that transforming growth factor (TGF)-B plays an important role in antagonizing FGF-2 mediated cardiac myocyte entry into the cell cycle. (umanitoba.ca)
Overexpression of the kinase-deficient TGF-B receptors (TGF-BRII) resulted in serum-induced cardiac myocyte cell cycle entry as well as an amplification of FGF-2 induced S phase entry (13 fold versus 3 fold with FGF-2 alone). (umanitoba.ca)

These cardiac extracellular matrix (ECM) remodeling processes are affected by T-lymphocyte function and phenotype. (arizona.edu)

A newly designed circuit which reduces the influence of the external light, a high-speed cuff pressure controller, and a digital filtering technique for the measurement of pulsatile admittance signal were embedded in the new cardiovascular monitoring system based on the volume-compensation and the electrical admittance method. (nii.ac.jp)

Compr Physiol Year, Volume: Pages. (comprehensivephysiology.com)

Cardiac output is the product of stroke volume and heart rate. (medscape.com)

Hypotension: Correct volume or salt depletion prior to administration. (nih.gov)
Clinically, patients with neurogenic shock may present with temperature dysregulation, bradycardia, and hypotension that is not responsive to volume resuscitation. (medscape.com)

The relative importance of nervous, endocrine, and vascular regulation in the response of the cardiac output to anoxemia. (nih.gov)

Heart failure always causes circulatory failure, but the converse is not necessarily the case, because various noncardiac conditions (eg, hypovolemic shock, septic shock) can produce circulatory failure in the presence of normal, modestly impaired, or even supranormal cardiac function. (medscape.com)
Cardiogenic shock is shock that is due to cardiac pump failure. (medscape.com)

BP is the product of cardiac output and total peripheral vascular resistance. (medscape.com)
The assessment of cardiac output (CO) is important because it reveals the main cardiac function: the supply of blood to tissues. (wikipedia.org)
Although a function of cardiac output and peripheral vascular resistance, both of these variables are influenced by multiple factors. (health-care-articles.info)

The results should provide novel insights into the roles of Slc26a6 in cardiac pH i regulation, cardiac excitability and function under physiological and pathological conditions. (ucdavis.edu)

Impaired cardiac function, including reduced cardiac mass and blood volume. (meresearch.org.uk)
These results led us to believe that chloride is actively involved in regulating cardiac excitability and function," Zhang added. (ucdavis.edu)
Fibroblast-specific p38α KO mice exhibited marked protection against myocardial injury, with isoproterenol-induced alterations in cardiac function, histology, and molecular markers all being attenuated. (whiterose.ac.uk)
These differences should be considered when autonomic regulation of cardiovascular function is studied in different postures. (biomedcentral.com)
In addition to its function in skeletal muscle, MG53 has been shown to have protective effects on various forms of cardiac muscle injury. (biomedcentral.com)
Heart failure develops when the heart, via an abnormality of cardiac function (detectable or not), fails to pump blood at a rate commensurate with the requirements of the metabolizing tissues or is able to do so only with an elevated diastolic filling pressure. (medscape.com)
Heart failure (see the images below) may be caused by myocardial failure but may also occur in the presence of near-normal cardiac function under conditions of high demand. (medscape.com)

Children exposed to the same levels of 1,3-dichlorobenzene vapor as adults may receive larger doses because they have greater lung surface area:body weight ratios and higher minute volumes:weight ratios. (cdc.gov)

It plays an important role in cellular functions, including the regulation of electrical activity, pH and volume. (ucdavis.edu)
Define The Molecular And Cellular Bases Of Physiological Regulation And Cell Signaling. (uaeu.ac.ae)

Recent evidence suggests that normal and exercise-induced cardiac growth are regulated in large part by the growth hormone/IGF axis via signaling through the PI3K/Akt pathway. (wustl.edu)

Blood lactate measurements have been used more frequently in the last 5 years, despite decreases in overall laboratory test volume. (duke.edu)

Publications] 中川原実: 'Non-invasive and ambulatory system for monitoring beat-by-beat cardiovascular haemodynamic variables based on the volume-compensation and electrical admittance method'Medical & Biological Engineering & Computing. (nii.ac.jp)

Nitric oxide and the autonomic regulation of cardiac excitability. (ox.ac.uk)

Do chloride and pH regulation affect the heart muscle's ability to contract? (ucdavis.edu)
UC Davis Health cardiovascular researchers are investigating the understudied but potentially critical connections between chloride and pH regulation and the heart muscle's ability to contract. (ucdavis.edu)
To examine possible signs of pandemic-related emotional (dys)regulation, subjects were shown images at follow-up that recalled the most dramatic lockdown phase while heart rate variability was recorded. (nature.com)
The aim of this study was to investigate the effect of recreational aerobic physical activity (PA) type and volume on heart rate variability (HRV) in Arab men. (mdpi.com)
An original research article, "Critical Cytokine Pathways to Cardiac Inflammation," by Noel Rose, PhD, The Johns Hopkins Schools of Medicine and Public Health (Baltimore, MD), describes a mouse model of autoimmune myocarditis -- inflammation of the heart muscles -- that is triggered by infection with Coxsackievirus B3. (sciencedaily.com)
Remarkably, in non-infection-triggered ME/CFS lower sCD26 in patients with higher heart rate after orthostatic challenge and postural orthostatic tachycardia syndrome (POTS) suggest an association with orthostatic regulation. (frontiersin.org)
Cardiac autonomic activity was not measurably different in prone and supine postures, but heart rate and blood pressure were. (biomedcentral.com)

Regulation of normal blood pressure (BP) is a complex process. (medscape.com)
Lower blood pressure, and abnormal blood pressure regulation. (meresearch.org.uk)
However, they also have been implicated in biological functions as diverse as muscle coordination, blood pressure and volume regulation. (buffalo.edu)
4. endocrinology, hormone physiopathology o endocrinology of development o stress endocrinology o sexual endocrinology o hormones and integrated homeostatic controls (blood volume, glycemia, body temperature. (uninsubria.eu)
People figured out that foxglove might have some cardiac benefit and that rauwolfia could lower blood pressure-sometimes a good tradeoff for suicidal ideation, sometimes not. (medscape.com)

The impedance plethysmography allows determining changes in volume of the body tissues based on the measurement of the electric impedance at the body surface. (wikipedia.org)

Large number of cardiac disorders is likely to influence the market growth tremendously. (medgadget.com)
Geriatric population with their vulnerability to cardiac disorders can also facilitate segment growth. (medgadget.com)

In normal physiologic sleep, distinct sleep stage-related changes occur in cardiovascular regulation. (hindawi.com)

Recently, Zhang and his team identified and cloned Slc26a6 (a membrane protein involved in transporting chloride, oxalate, sulfate and bicarbonate) as the most active and abundant chloride transporter in the cardiac muscle. (ucdavis.edu)
Lactate measurements appear to have clinical value, particularly for children having major cardiac surgery or extracorporeal membrane oxygenation. (duke.edu)

The global transcatheters market will thrive in the region due to favorable regulations and a large patient pool with expendable income levels to afford the high-level treatment. (medgadget.com)
Regulation has had both favorable and unfavorable consequences. (medscape.com)

Our recent findings showed that pH i in the cardiac cycle is not stable and experiences beat-to-beat changes," Zhang explained. (ucdavis.edu)

These results demonstrate for the first time a direct relation between oral ethanol intake and measures of decreased brain gray matter volume in vivo in primates. (nature.com)

Anatomy3

Diseases2

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes4

Arrhythmia3

Hypertrophy8

Fibrosis10

Myocardium2

Catheterization laboratory3

Myocardial infarction3

Physiology2

Myocytes5

Arrhythmias2

Affecting cardiac output1

Pathologies1

Ischemia-reperfusion2

Skeletal muscles1

Mechanisms5

Therapeutic1

Hemodynamic1

Contractility3

Systemic1

Ischemic1

Acute2

Sympathetic2

Vitro2

Metabolic2

Embryonic1

Contraction3

Arrest4

Systolic1

Conclusion1

Calcium1

Mechanism1

Myocyte3

Extracellular1

Cardiovascular monito1

Physiol1

Stroke1

Hypotension2

Vascular regulation1

Shock2

Output3

Pathological1

Function7

Lung1

Cellular2

Pathway1

Laboratory1

Ambulatory1

Excitability1

Heart7

Blood5

Tissues1

Disorders2

Occur1

Membrane2

Favorable2

Cycle1

Vivo1