Regulation and expression over expression cell cycle. Medical search. Frequent questions

Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)
Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)
Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence. (nih.gov)
In this Review, we discuss the multiple molecular mechanisms of p53 regulation and how they modulate the induction of apoptosis or cell cycle arrest following DNA damage. (nih.gov)
In addition, it can stimulate apoptosis of cells containing damaged DNA. (medscape.com)
Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. (nih.gov)
BRCA1 expression mediates apoptosis, cell cycle arrest and decreased viability in response to doxorubicin treatment. (conicet.gov.ar)
Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. (lu.se)
Raloxifene induces apoptosis in estrogen receptor-negative human cancer cells through the AhR. (oregonstate.edu)
We identified Y134 as a raloxifene analog that activates AhR-mediated transcriptional activity and induces apoptosis in MDA-MB-231 human triple negative breast cancer cells. (oregonstate.edu)
Suppression of AhR expression strongly reduced apoptosis induced by Y134, indicating the requirement of AhR for Y134-induced apoptosis. (oregonstate.edu)
Y134 also induced apoptosis in hepatoma cells without having an effect on cell cycle regulation. (oregonstate.edu)
Sodium butyrate induces mitophagy and apoptosis of bovine skeletal muscle satellite cells through the mammalian target of rapamycin signaling pathway. (usda.gov)
The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)

Choline kinase alpha (ChoKalpha) is an enzyme involved in the metabolism of phospholipids recently found to play a relevant role in the regulation of cell proliferation, oncogenic transformation and human carcinogenesis. (nih.gov)
Using differential microarray analysis, we identify target genes that provide the basis for the understanding of the molecular mechanism for the regulation of cell proliferation and transformation mediated by over-expression of the human ChoKalpha. (nih.gov)
At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)
In addition, differences in the proliferation rates of cells within a malignancy may shape their proliferation or metastatic potential. (genengnews.com)
Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
Here, we demonstrate that a systemic factor found in the circulation of young mice is able to increase the proliferation rate of old pancreatic β-cells. (diabetesjournals.org)
In some cases, the decline in proliferation reaches an irreversible state called cellular senescence, which is characterized by a total lack of cell divisions and altered cellular morphology, gene expression profile, and chromatin organization ( 3 ). (diabetesjournals.org)
We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins. (antikoerper-online.de)
During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)
Functional loss of p16 may lead to uncontrolled cell proliferation 3,4 . (bvsalud.org)
Through this role in regulating the activity (expression) of genes, the Dicer protein is involved in many processes, including cell growth and division (proliferation) and the maturation of cells to take on specialized functions (differentiation). (medlineplus.gov)
Similarly, depletion in the STRIPAK component STRIP1 affects activation of GCKIII kinases and cell cycle disruption through elevated expression of cyclin dependent kinase inhibitors p21 and p27, enhanced levels of which lead to a protective effect from therapeutic treatments and increased proliferation. (lu.se)

The regulation of transcription of histone genes differs between eukaryotes. (news-medical.net)
The replication independent histone genes are transcribed at a relatively constant low rate, regardless of cell cycle stage. (news-medical.net)
However, most of the vertebrate histone genes are replication dependent and are therefore more highly expressed during the cell cycle's S phase. (news-medical.net)
Therefore, NPAT could be the link between cell cycle machinery and shared heightened transcription of histone genes during S phase. (news-medical.net)
In the context of DNA damage, p53 is thought to be a decision-making transcription factor that selectively activates genes as part of specific gene expression programmes to determine cellular outcomes. (nih.gov)
Gene-Expression Analysis of Cell-Cycle Regulation Genes in Virus-Infected Rice Leaves. (routledge.com)
We also observed a correlation between gbM and gene expression flexibility: genes with low DNA methylation tend to show flexible gene expression and plasticity under changing conditions. (nature.com)
We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase ( TS ) and Survivin , in case of non-small-cell lung cancer (NSCLC). (aacrjournals.org)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
A focused survey of BRCA1 regulated genes in prostate carcinoma reveals that multiple regulators of genome stability and cell cycle control, including: BLM, FEN1, DDB2, H3F3B, BRCA2, CCNB2, MAD2L1 and GADD153, are direct transcriptional targets of BRCA1. (conicet.gov.ar)
Moreover, we find that the distal NDRs are enriched specifically for binding motifs of the pluripotency and germ cell master regulators such as NANOG, SOX17, AP2γ and OCT4 in human FGCs, indicating the existence of a delicate regulatory balance between pluripotency-related genes and germ cell-specific genes in human FGCs, and the functional significance of these genes for germ cell development in vivo . (nature.com)
The results indicate that TCE induces changes in expression of certain important cell cycle regulation genes. (cdc.gov)
Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. (prosci-inc.com)
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. (thebiogrid.org)
Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). (biolegend.com)
Previous studies have shown the involvement of cell-autonomous factors in this phenomenon, particularly the decline of polycomb genes and accumulation of p16/INK4A. (diabetesjournals.org)
After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. (antikoerper-online.de)
Research into Gene Expression & Epigenetics aims to understand how our genes and the way they are regulated influence who we are. (umassmed.edu)
Who's studying Genes Expression & Epigenetics? (umassmed.edu)
In human cells, the expression of ∼1,000 genes is modulated throughout the cell cycle. (iric.ca)
Although some of these genes are controlled by specific transcriptional programs, very little is known about their post-transcriptional regulation. (iric.ca)
Without appropriate regulation by miRNA, genes are likely expressed abnormally, which could cause cells to grow and divide uncontrollably and lead to tumor formation. (medlineplus.gov)

Here, we report a novel molecular target and antimetastatic mechanism of ATO in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
HNSCC is the sixth oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
the goal is to cause as little functional squamous cell carcinoma type (HNSCC) and includes and cosmetic damage as possible ( 6 , 9 ). (cdc.gov)
Methods: fifteen histological specimens of spindle cell squamous cell carcinoma of the lower lip were obtained from the Department of Oral Pathology, Bahia Federal University. (bvsalud.org)
Immunohistochemical identification of molecular genetic events in the progression of preneoplastic lesions to spindle cell squamous-cell carcinoma enables early detection of lesions with the potential for malignant progression, thus permitting timely intervention 1,2 . (bvsalud.org)
Other markers, such as retinoblastoma and p53, may be related with early steps of carcinogenesis in oral cavity squamous cell carcinoma. (bvsalud.org)
A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)

Furthermore, ATO dysregulated microtubule polymerization via the CLIP170/LIS1/NDEL1/dynein signaling pathway in Cal27 cells as a functional consequence of CLIP170 zinc finger disruption. (nih.gov)
It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
Transcription factor involved in the regulation of the insulin signaling pathway. (prosci-inc.com)

It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. (wikipedia.org)
The mechanism, which is based on the synthesis and degradation of three ''master regulator'' proteins (CtrA, GcrA, and DnaA), is converted into a quantitative model, in order to study the temporal dynamics of these and other cell cycle proteins. (ebi.ac.uk)
Since many of the proteins involved in regulating the cell cycle of C. crescentus are conserved among many genera of a-proteobacteria, the proposed mechanism may be applicable to other species of importance in agriculture and medicine. (ebi.ac.uk)
Whole cell extracts (15 µg protein) from NIH3T3 cells transfected with non-targeting control siRNA (siCON) or siRNA targeting Ahr (siAhr) were resolved on a 4-12% Bis-Tris gel, transferred to PVDF and probed with 1.0 µg/mL (1:500 dilution) of Purified anti-AHR Antibody, clone W16012A, overnight at 4°C. Proteins were visualized by chemiluminescence detection using HRP goat anti-rat IgG antibody (Cat. (biolegend.com)
I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
Here, we analyze the expression signature associated with all 687 RNA-binding proteins (RBPs) and identify 39 that significantly correlate with cell cycle mRNAs. (iric.ca)
Animal cell technology is an area of rapid expansion and one that produces a wide range of high-value products, including vaccines, recombinant proteins, drugs for cardiovascular, respiratory and immune diseases, and monoclonal antibodies. (imperial.ac.uk)
Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
Both of these altered proteins lead to the eventual ability of cancer cell recurrence. (lu.se)
These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. (lu.se)

In a recent study, Dr. Hindson and colleagues described 10x Genomics' GemCode technology, a droplet-based platform that combines microfluidics with molecular barcoding and custom bioinformatics software to enable 3′ mRNA counting from thousands of single cells. (genengnews.com)
Chowdhury T, Koceja C, Eisa-Beygi S, Kleinstiver B, Kumar S, Lin CW, Li K, Prabhudesai S, Joung K, and Ramchandran R . Temporal and spatial post-transcriptional regulation of zebrafish tie1 mRNA by long non-coding RNA during brain vascular assembly. (navbo.org)
The expression of p16/INK4A mRNA did not change in heterochronic parabiosis, suggesting the involvement of other pathways. (diabetesjournals.org)
Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
Increases in the amount of PAPP-A mRNA in granulosa cells during follicular development occurs in some but not all species, indicating that other proteases or protease inhibitors may be involved in IGFBP degradation. (bioone.org)
relative mRNA expression was evaluated by real-time polymerase chain reaction (RT-PCR), and relative protein expressions were measured by western blot assay in an in vitro study. (medscimonit.com)
relative protein expressions were evaluated by immunohistochemistry assay, and relative mRNA expression was evaluated by RT-PCR. (medscimonit.com)
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. (iric.ca)

Here, we study gene body DNA methylation (gbM) and gene expression patterns in ecotypes from contrasting thermal environments of two marine plants with contrasting life history strategies in order to explore the potential role epigenetic mechanisms could play in gene plasticity and responsiveness to heat stress. (nature.com)
Although we cannot discern whether gbM regulates gene expression or vice versa, or if other molecular mechanisms play a role in facilitating transcriptome responsiveness, our findings point to the existence of a relationship between gene responsiveness and gbM patterns in marine plants. (nature.com)
The mechanisms by which gene expression, and thus phenotypic plasticity, are influenced and regulated remain poorly understood in most organisms. (nature.com)
Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. (frontiersin.org)
Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
Mechanisms for maintaining genetic information during cell division and the generation of genetic variation: replication, mitosis, meiosis, recombination. (lu.se)
Mechanisms that regulate development from single cell to multicellular organisms. (lu.se)
In this study, we explore mechanisms in breast cancer cells that potentially lead to recurrence. (lu.se)

Several of these processes change during the cell cycle, but unlike transcriptional changes, the post-translational changes occur throughout the cell cycle. (news-medical.net)
However, the mechanism by which this enzyme is involved in the regulation of these processes is not yet understood. (nih.gov)
Cell Ranger is a set of analysis pipelines that processes Chromium single-cell 3′ RNA-Seq output to align reads, generate gene-cell matrices, and perform clustering and gene-expression analysis. (genengnews.com)
The Ahr is well known to be involved in a variety of cellular processes, such as the cell cycle, epithelial barrier function, cell migration, and immune function. (biolegend.com)
Substantial portion of molecules in an organism is involved in regulation of a wide spectrum of biological processes. (researchsquare.com)
Although the processes are very different, the principles of the regulation are the same in all these systems. (researchsquare.com)
The Flores Kim lab studies how bacteria build their cell envelopes and how antimicrobials disrupt these processes. (umassmed.edu)
Models of animal cell culture systems have a wide range of potential applications, such as analysis and prediction of experimental results, optimisation of culture conditions for prolonged viability, and perhaps most importantly, the investigation of fundamental metabolic processes and their subsequent elucidation. (imperial.ac.uk)
The integration of these three research tools represents a unique, novel, and interdisciplinary approach to addressing the complicated research and industrial problem of model-based control and optimisation of mammalian cell culture processes. (imperial.ac.uk)
Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)

Finally, GADD153 depletion significantly abrogates BRCA1 influence on cell cycle progression and cell death in response to doxorubicin treatment. (conicet.gov.ar)
Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome replication and partitioning to daughter cells. (ebi.ac.uk)
p53, mdm-2, p21, and mib-1 expression were not significantly associated with response to chemotherapy, time to progression, or overall survival in the whole patient population or in the docetaxel group. (lu.se)
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
Studies suggest that expression of cystatin A is inversely associated with malignant progression of cancer 9 . (bvsalud.org)

Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)
In Xp11.2 translocation-associated renal cell carcinoma (RCC), cells typically have voluminous cytoplasm, which can range from eosinophilic and granular to clear. (medscape.com)
In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)

Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells. (navbo.org)
Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)

p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
Interestingly, tumors with both negative mdm-2 and p21 expression, irrespective of p53 status, had a high response rate to docetaxel but no response to MF. (lu.se)
Another characteristic architectural feature found in many of these tumors is a pseudoalveolar pattern in which cells are arranged in alveolae with central cellular discohesion (see the fourth image below). (medscape.com)
Psammoma bodies and scattered xanthoma cells have been described in some tumors. (medscape.com)
Patients usually do not increased incidence of oropharyngeal squamous cell carci- seek counseling until the tumors are large because small noma (OSCC), the head and neck cancer in which HPV is tumors cause little distress and may not be noticed by the most commonly found ( 4 ). (cdc.gov)
DICER1 syndrome is also associated with tumors in the ovaries known as Sertoli-Leydig cell tumors, which typically develop in affected women in their teens or twenties. (medlineplus.gov)
Sertoli-Leydig cell tumors usually do not metastasize. (medlineplus.gov)

Specifically, we discuss how the interaction of p53 with DNA and chromatin affects gene expression, and how p53 post-translational modifications, its temporal expression dynamics and its interactions with chromatin regulators and transcription factors influence cell fate. (nih.gov)
pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
Quantitative reverse transcription-PCR was done to evaluate the gene expression of E2F1, TS , and Survivin . (aacrjournals.org)
With GemCode, cells are captured in droplets, and the reverse transcription that occurs within each droplet is used to generate barcoded cDNA. (genengnews.com)

Both STARD12 and STARD14 were corelated with epigenetic regulation, especially TP53 mutation and m6A modification. (medsci.org)
STARD12 and STARD14 were expected to be potential biomarkers for LUAD, which were associated with epigenetic regulation, immune infiltration and ferroptosis. (medsci.org)
Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. (nature.com)
Although the genome-wide histone modification landscapes of mouse in vivo germ cells and in vitro PGCLCs have been profiled and several germline-specific properties of epigenetic reprogramming have been revealed, the study of genome-scale chromatin states in human FGCs is still challenging, due to the scarcity of materials and technical difficulties. (nature.com)

In a proof-of-concept analysis that used 68,000 fresh peripheral blood mononuclear cells obtained from a healthy donor, Dr. Hindson and colleagues showed that GemCode can be used to interrogate cellular heterogeneity and cluster large immune cell populations. (genengnews.com)
The single-cell transcriptome and chromatin accessibility datasets of peripheral blood mononuclear cells in Chinese Holstein cattle. (usda.gov)
Single-cell transcriptomic and chromatin accessibility analyses of dairy cattle peripheral blood mononuclear cells and their responses to lipopolysaccharide. (usda.gov)

Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. (springer.com)
We explore signalling alterations resulting in cancer stem cells as well as cell cycle arrest and cell fate determination. (lu.se)

Due to their affiliation with DNA, histones are important for successful cell replication, which takes place via the cell cycle. (news-medical.net)
Histones can be classified as replication dependent or replication independent, which is decided by their expression pattern during the cell cycle. (news-medical.net)
The frequency of pancreatic β-cell replication declines dramatically with age, potentially contributing to the increased risk of type 2 diabetes in old age. (diabetesjournals.org)
Old mice parabiosed to young mice have increased β-cell replication compared with unjoined old mice or old mice parabiosed to old mice. (diabetesjournals.org)
conversely, young β-cells transplanted into old mice decrease their replication rate compared with young cells transplanted into young recipients. (diabetesjournals.org)

Their promoter activity during the cell cycle is governed by a subtype-specific consensus element (SSCE). (news-medical.net)
Methods for analysis of gene expression: microarray, hybridisation, promoter analyses. (lu.se)
Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
Jakobsson expression under a human GFAP (hGFAP) promoter. (lu.se)

The Laboratory of Microbial Genomics studies how gene expression is regulated during the cell cycle and in response to various stimuli, such as nutrients or stress. (google.com)
More even lucky to join Mike Blower's lab at MGH in 2016, learning and growing as a scientist using Xenopus and human cells to understand how gene expression is regulated as cells transit through mitosis. (bu.edu)

The role of DNA methylation and its interaction with gene expression and transcriptome plasticity is poorly understood, and current insight comes mainly from studies in very few model plant species. (nature.com)
The Human Cell Atlas relies, to a great extent, on the use of transcriptome sequencing to profile the gene expression of individual cells. (genengnews.com)
Using the GemCode approach, Dr. Hindson and colleagues collected transcriptome data from about 250,000 cells across 29 samples. (genengnews.com)
We find that NF45 and NF90 play essential roles in mitosis, and transcriptome analysis reveals that they are necessary for the expression of a subset of mitotic mRNAs. (iric.ca)

Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. (biolegend.com)

however, we have recently found that a residual replicative potential is retained even in β-cells of very old mice ( 8 ). (diabetesjournals.org)

This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)
within a given tumor, cells may be variably arranged in broad sheets, nests, trabeculae, true papillae, or pseudopapillae (see the first 3 images below). (medscape.com)
at least focally, tumor cells often have abundant clear cytoplasm, mimicking clear cell RCC. (medscape.com)
The nests of tumor cells in Xp11.2 translocation-associated renal cell carcinomas may become centrally discohesive, giving rise to a pseudoalveolar growth pattern. (medscape.com)
The main goal of RT consists in delivering a precise dose of radiation in a target volume, such as tumor, promoting the tumor cells eradication with as minimal damage as possible in surrounding normal tissues ( 13 ). (frontiersin.org)

On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)

Also involved in negative regulation of the cell cycle. (prosci-inc.com)

Our focus is on the endothelial cell and how it communicates with surrounding cells that reside in the microenvironment. (navbo.org)
We are particularly interested in brain vessel patterning, and the role of the cilia, a microtubule-based organelle that projects from the apical surface of an endothelial cell and is thought to be a flow sensor. (navbo.org)

The model accounts for important details of the physiology, biochemistry, and genetics of cell cycle control in stalked C. crescentus cell. (ebi.ac.uk)

Our research programme sets out to integrate modelling, experiment design and validation, and control and optimisation into a single framework that would lead to increased productivity, regulated product quality, and reduced costs for mammalian cell culture systems. (imperial.ac.uk)

0.0001), although no correlation was observed between E2F1 gene expression and the apoptotic index. (aacrjournals.org)

Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

Heterogeneity is generated both passively, e.g. by differential gene expression in cells of a tissue, and actively, such as the generation of the immense variation for immunological recognition molecules. (researchsquare.com)
Population balance models capture the heterogeneity but little structure with which to differentiate the cells due to the computationally intense nature of their solution while single-cell models are good at describing structure but cannot describe heterogeneity. (imperial.ac.uk)

The prevalence of replicating pancreatic β-cells declines dramatically with age in both rodents and humans ( 4 , 5 ). (diabetesjournals.org)

Molecular Cell, 2020. (bu.edu)
Journal of Cell Biology, 2020. (bu.edu)

Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
In vitro studies and gene expression profiles showed that the transcriptional changes by the activated Ahr are ligand specific and are highly cell specific. (biolegend.com)
Tenacigenin B had anti-tumor effects on lymphoma via regulation of Aurora-A in vitro and in vivo . (medscimonit.com)

These findings define a novel transcriptional pathway through which BRCA1 orchestrates cell fate decisions in response to genotoxic insults, and suggest that BRCA1 status should be considered for new chemotherapeutic treatment strategies in prostate cancer. (conicet.gov.ar)

Finally, the STARDs expression were confirmed by RT-qPCR and western blot. (medsci.org)
Western Blot: MORF4L2 Antibody [NBP2-47370] -Analysis in human cell line MCF-7. (novusbio.com)

WBV exposure resulted in a significant reduction in number of developing follicles, and decrease in circulating estradiol concentrations, ovarian luteinizing hormone receptor protein levels, and marked changes in transcript levels for several factors involved in follicular development, cell cycle, and steroidogenesis. (cdc.gov)

These multiple layers of regulation enable p53 to execute cellular responses that are appropriate for specific cellular states and environmental conditions. (nih.gov)
The same proportions of cellular subpopulations were also captured from frozen cells, indicating that this method can be used on frozen samples. (genengnews.com)
However, the functional consequences of MCT4 expression on the distinct hallmarks of cancer have not yet been explored at the cellular level. (hindawi.com)
The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)

Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)

Dr. Pryciak studies how protein kinases regulate cell signaling and the cell cycle. (umassmed.edu)
The ability to regulate transgene expression will be crucial for development of gene therapy to the brain. (lu.se)
An aspect of gene delivery to the brain that is currently being regulate the endogenous GFAP expression in a lesioned brain. (lu.se)
We, developed is the ability to regulate transgene expression. (lu.se)
Materials and methods approach to regulate transgenic expression. (lu.se)

The differential gene expression data analysis was performed using GeneChip(r) 4.0 software. (cdc.gov)

In our studies, we employ a range of genetic, biochemical, cell biology, computational and genomic methods using predominantly the fission yeast Schizosaccharomyces pombe as a model. (google.com)
We are part of the Department of Cell Biology , Faculty of Science, Charles University. (google.com)
Trends in Cell Biology, 2021. (bu.edu)
2023 the Department of Biochemistry & Cell Biology ventured. (bu.edu)
The Department of Biochemistry and Cell Biology at the Boston University Chobanian. (bu.edu)
In-depth models can be utilised as tools in predictive cell biology. (imperial.ac.uk)
It is clear that the biological behaviour of cells is of such complexity that any model, to be robustly predictive, must be sufficiently structured and detailed in terms of the captured biology. (imperial.ac.uk)
The course is an optional second-cycle course for a degree of Bachelor or Master of Science in Biology and Molecular Biology. (lu.se)
Gene regulation in developmental biology and the cell cycle. (lu.se)
Frontiers in cell and developmental biology. (lu.se)

The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1, and transcriptional control of the mitotic cyclins that reflects some of the current literature. (ebi.ac.uk)
Cohesin Removal Reprograms Gene Expression upon Mitotic Entry. (bu.edu)
We show that depletion of SMD components increases the binding of mitotic mRNAs to the NF45-NF90 complex and rescues cells from mitotic defects. (iric.ca)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Immunohistochemistry was done to investigate the protein expression of E2F1, TS, and Survivin. (aacrjournals.org)
In this compiled work, we elaborate on the effect of protein expression alterations and their resulting effect on recurrence capability of cells. (lu.se)

In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)

In the present study, we examined the relationship between MCT4 expression, alterations in pH e , and extracellular lactate concentrations. (hindawi.com)
In males, WBV resulted in a significant reduction in spermatids and circulating prolactin levels, elevation in number of males having higher circulating testosterone concentrations, and marked alterations in levels of transcripts associated with oxidative stress, inflammation, and factors involved in regulating the cell cycle. (cdc.gov)

We found that cytoplasmic linker protein 170 (CLIP170) was overexpressed in HNSCC tissues and cells compared to normal controls. (nih.gov)
protein sorting and protein maturation by passage through the cytoplasmic organelles of the cell. (lu.se)

The tumour microenvironment (TME) contains several other cell types apart from cancer cells which play a role not only in the regulation of the environment but in response to treatments. (lu.se)

[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)

The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. (lu.se)

CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. (who.int)

ATO at non-cytotoxic level (1 μM) inhibited the migration and invasion of HNSCC cells by displacing zinc in the zinc finger motif of CLIP170, which is a key protein that controls microtubule dynamics. (nih.gov)
Moreover, MCT4 overexpression enhances cell migration and invasiveness via reorganization of the actin cytoskeleton. (hindawi.com)

Human wild-type HeLa cell line ( ab255928 ). (abcam.com)
This initiative, called the Human Cell Atlas, proposes to create comprehensive reference maps of all human cells as a basis for both understanding human health and diagnosing, monitoring, and treating disease. (genengnews.com)
In a study on human and mouse cell lines, Dr. Hindson and colleagues showed that GemCode captured about half of the cells loaded. (genengnews.com)
Xenograft studies using human prostate carcinoma PC3 cells demonstrate that BRCA1 depletion results in increased tumor growth. (conicet.gov.ar)
However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). (nature.com)
Here we use nucleosome occupancy and methylation sequencing method to analyze both the genome-wide chromatin accessibility and DNA methylome at a series of crucial time points during fetal germ cell development in both human and mouse. (nature.com)
But these treatments, to some extent, easily produce side effects on normal cells, organs, and other tissues of the human body, thus accelerating the death process of cancer patients. (hindawi.com)
Gene expression patterns in normal human liver cells exposed to tetrachloroethylene using microarray analysis. (cdc.gov)
In this study, we have investigated TCE exposure and global gene expression pattern in normal human liver cells using microarray analysis. (cdc.gov)
Immunocytochemistry/ Immunofluorescence: MORF4L2 Antibody [NBP2-47370] - Staining of human cell line A-431 shows localization to nucleoplasm. (novusbio.com)
Immunohistochemistry-Paraffin: MORF4L2 Antibody [NBP2-47370] -Staining of human placenta shows strong nuclear positivity positivity in trophoblastic cells. (novusbio.com)
I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
The aim of the present study was to evaluate the influence of angiotensin II (Ang II) on human EC cells. (spandidos-publications.com)
Biological assays were performed on well-[Ishikawa (ISH)] moderately (MFE-296) and poorly (MFE-280) differentiated human adenocarcinoma cancer cell lines, representing the G1, G2 and G3 stage of EC. (spandidos-publications.com)
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. (bu.edu)

Cell , 2015 Nov., doi: 10.1016/j.cell.2015.11.001. (weizmann.ac.il)

We want to understand how this regulation affects the organization and dynamics of the cell nucleus, and how it contributes to the maintenance of genome integrity. (google.com)
The dynamics of chromatin accessibility prompted by butyrate-induced chromatin modification in bovine cells. (usda.gov)

Lung cancer is a major cause of cancer-related deaths, and non-small-cell lung cancer (NSCLC) comprises ∼75% of all lung cancers ( 1 ). (aacrjournals.org)
Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
In breast cancer patients, it is unclear whether measuring p53, mdm-2, or p21 expression provides information on how patients will respond to chemotherapy. (lu.se)
One of the treatments applied in cancer is radiotherapy (RT), a therapeutic modality that uses ionizing radiation to induce damage in unwanted cells. (frontiersin.org)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

To find ways of improving cell-level intelligence gathering, a global initiative was organized in late 2016. (genengnews.com)
The Plant Cell, 2016. (bu.edu)

BRCA1 plays numerous roles in the regulation of genome integrity and chemoresistance. (conicet.gov.ar)
In particular, ubiquitin-mediated degradation is critically important at transition points where it provides directionality and irreversibility to the cell cycle, which is essential for maintaining genome integrity. (intechopen.com)

From published experimental evidence, we propose a molecular mechanism for control of the cell division cycle in Caulobacter crescentus. (ebi.ac.uk)
The main objective of the project is to study the effects of hyperosmotic pressure on the antibody production process in the GS-NS0 cell line, with particular attention to the antibody production mechanism. (imperial.ac.uk)

In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
Current understanding of mammalian cell cultures lies in the association of their metabolic behaviour to their antibody production output. (imperial.ac.uk)
Indeed, it has been shown that miRNAs play an important role in gene expression, mainly when associated with the monitoring of several cell and metabolic pathways, being also an essential component of the gene silencing machinery in most eukaryotic organisms ( 4 , 8 ). (frontiersin.org)

Entry into the S phase in animal cells is regulated to a large extent by the cyclin E-CDK2 kinase complex. (news-medical.net)
The approach provided expression profiles of cyclin A2, cyclin B1, and phospho-S10-histone H3. (ebi.ac.uk)
The model was built by integrating and modifying two previously published models such that the model outputs for cyclins A and B fit cyclin expression measurements and the activation of B cyclin/Cdk1 coincided with phosphorylation of histone H3. (ebi.ac.uk)

Gene expression" refers to the process by which a DNA sequence (i.e. a gene) is used to make a specific RNA or protein, while "epigenetics" refers to the ways phenotypes are impacted by factors other than genetic sequence (e.g. gene repression by chromatin packing). (umassmed.edu)
As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. (frontiersin.org)

In our lesioned brain and a substantially less pronounced expression in the laboratory, we have investigated the characteristics of lentiviral vec- normal, intact brain. (lu.se)

Anatomy24

Organisms12

Diseases4

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes82

Disciplines and Occupations1

Information Science3

Health Care2

Apoptosis16

Proliferation22

Genes24

Squamous cell carc9

Signaling pathway3

Proteins11

MRNA8

Mechanisms9

Processes10

Progression6

Renal cell carc3

Epithelial cells2

Tumors7

Transcription5

Epigenetic4

Peripheral blood mononuclear cells3

Arrest2

Replication5

Promoter5

Gene expression is regulated2

Transcriptome4

Regulates1

Mice1

Tumor cells5

Neoplastic1

Negative regulation1

Endothelial2

Genetics1

Mammalian cell culture1

Apoptotic1

Phenotype1

Heterogeneity2

Humans1

20202

Vitro4

Fate1

Western blot2

Follicular1

Cellular5

Differentiation1

Regulate5

Differential gene expression1

Biology10

Mitotic3

Protein expression3

Dendritic cells2

Alterations2

Cytoplasmic2

Tumour1

Mononuclear1

Role in the regulation1

Significantly1

Migration2

Human15

10.10161

Dynamics2

Cancer6

20162

Genome integrity2

Mechanism2

Metabolic3

Cyclin3

Genetic2

Laboratory1