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  • transcription
  • Here we show that the transcription factors Ets-1 and Ets-2 regulate miR-126 expression. (ahajournals.org)
  • Conclusion- Taken together, these data show that the transcription factors Ets-1 and Ets-2 play a key role in controlling the expression of miR-126 and suggest that miR-126 may mediate some of their vascular effects. (ahajournals.org)
  • 19 Although miR-126 plays a prominent role in vascular biology, the transcription factors that regulate miR-126 in endothelial cells have not been defined. (ahajournals.org)
  • The E26 transformation-specific sequence (ETS) factors are a family of transcription factors that share a highly conserved DNA binding domain and regulate cell development, senescence, death, and tumorigenesis. (ahajournals.org)
  • cDNA synthesis was performed for each RNA sample using a Reverse Transcription system (Promega Corporation, Madison, WI, USA), and oligo dT from the system was used to prime cDNA synthesis. (spandidos-publications.com)
  • However, the transcription factors that regulate the expression of MIR169 have remained unknown. (frontiersin.org)
  • Taken together, our results suggest that HYH is a transcription factor that binds to a G-box-like motif in the MIR169a promoter and negatively regulates ambient temperature-responsive expression of MIR169a at higher temperatures in Arabidopsis. (frontiersin.org)
  • In mammals, the hypoxia-dependent changes, on a gene expression level, are primarily mediated by the α-subunits of hypoxia-inducible transcription factors (HIFs). (spandidos-publications.com)
  • Hypoxia inducible factor-1 (HIF-1) is recognized as the master transcription factor consisting of a constitutively expressed HIF-1β subunit and an oxygen-regulated HIF-1α subunit in response to hypoxia [ 7 ]. (biomedcentral.com)
  • In this study, we supposed that miR-1285 potentially can bind to the OCT4 promoter and might regulate transcription of the OCT4 in the human cancer cell lines and differentiated cells. (openaccesspub.org)
  • A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. (semanticscholar.org)
  • early embryonic
  • We recently reported the cloning and expression of bovine NOBOX during early embryonic development and our gene knockdown studies indicate that NOBOX is a maternal effect gene essential for early embryonic development. (biomedcentral.com)
  • Expression analysis of miR-196a in bovine oocytes and during early embryonic development indicated that it is expressed both in oocytes and embryos and tends to increase at the four-cell and eight-cell stages. (biomedcentral.com)
  • suppresses
  • Microrna-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. (springer.com)
  • miR-133 suppresses Prdm16 expression in skeletal muscle stem cells (satellite cells), which controls myogenic vs. brown adipogenic lineage determination in these cells. (wikipedia.org)
  • biological
  • MicroRNAs are involved in many biological processes and diseases, particularly multifactorial diseases, providing an excellent tool with which to research the mechanisms of these diseases. (frontiersin.org)
  • senescence
  • Here, we review microRNAs, inflammatory factors, referred to as the senescence- which are commonly downregulated with age and in- associated secretory phenotype (SASP) . (deepdyve.com)
  • Role
  • Callegari E, Elamin BK, Sabbioni S, Gramantieri L, Negrini M. Role of micrornas in hepatocellular carcinoma: A clinical perspective. (springer.com)
  • Also, in vitro studies in the cell lines and primary neuron cultures further established the role of miR-205 in modulating the expression of LRRK2 protein. (pubmedcentralcanada.ca)
  • Arabidopsis microRNA169 (miR169) is an ambient temperature-responsive microRNA that plays an important role in stress responses and the floral transition. (frontiersin.org)
  • Recent studies in zebrafish have identified the role of microRNAs during the maternal-to-embryonic transition (MET). (biomedcentral.com)
  • AD is a multifactorial disorder, and accumulating evidence shows that microRNAs play a critical role in the pathogenesis of AD. (frontiersin.org)
  • Indeed, high levels of miR-17-92 expression are observed in aggressive lung cancer ( 5 ), pointing to a role for the cluster in lung cancer oncogenesis. (frontiersin.org)
  • pathway
  • It is proposed that Insulin activates the translocation of SREBP-1c (BHLH) active form from the endoplasmic reticulum (ER) to the nucleus and, concomittantly, induces SREPB-1c expression via PI3K signaling pathway. (wikipedia.org)