AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Carcinoma, LobularChemokine CCL27Carcinoma, Ductal, BreastNatural Cytotoxicity Triggering Receptor 1AlternariaInterleukinsBreast NeoplasmsNuclear Receptor Subfamily 1, Group F, Member 3LymphocytesInterleukin-13GATA3 Transcription FactorStrongylida InfectionsCitrobacter rodentiumNippostrongylusImmunity, InnateCadherinsLymphocyte SubsetsMastectomy, SegmentalInterleukin-5Neoplasm InvasivenessCarcinoma in SituMice, Inbred C57BLReceptors, EstrogenInterleukin-17Receptor, erbB-2Retrospective StudiesCell LineageReceptors, ProgesteroneCytokinesDisease-Free SurvivalImmunohistochemistryTreatment OutcomePrognosisMice, TransgenicFollow-Up Studies
ILC3DifferentiationInnateILCsImmunityMacrophagesIntestinal homeostasisGene expressionResponsesPathwaysActivationDifferentiallyPopulationsHomeostasisInflammatoryChemokineCellsProteinsLungInhibitsTherapiesMechanismsCrucialAllergic rhinitisAsthmaSubsetsMechanismCommitmentCell developmentHumanized monoclonMolecularFoundReviewStudiesResearch
ILC38
  • One of these cell types is the population called innate lymphoid cells (ILCs) which comprise several families of cells that can be classified into three groups: ILC type 1 (ILC1), ILC2 and ILC3. (europa.eu)
  • Both ILC2 and ILC3 populations are able to internalize and present peptide antigens on MHC-II and control T cell responses (3-7). (europa.eu)
  • ILC are a family of innate immune cells comprising cytotoxic Natural Killer (NK) cells and the non-cytotoxic helper like ILC1, ILC2 and ILC3. (uni-frankfurt.de)
  • The dependency of NKp65 surface expression on sustained STAT5 signaling provided by IL-7 underlines the connection of NKp65 expression and an ILC3 phenotype which might contribute to promote future research in discerning the interspersed pathways of ILC3 and NK cell development. (uni-frankfurt.de)
  • This family of ILCs can be divided into two major subsets: cytotoxic ILCs, which consist of NK cells, and noncytotoxic ILCs, which consist of ILC1, ILC2 and ILC3. (the-rheumatologist.org)
  • Here, we characterized the whole-genome distribution of methyl-CpG and 5-hydroxymethylcytosine (5hmC) in mouse innate lymphoid cell 3 (ILC3), ILC2 and natural killer (NK) cells. (stanford.edu)
  • Human ILC precursors contain populations of KLRG1 + ILCs biased towards the ILC2 lineage and NKp46 + ILCs biased towards the ILC3 lineage. (silverchair.com)
  • KLRG1 + ILCs are biased toward the ILC2 lineage, whereas NKp46 clearly defines ILC3-lineage-biased cells. (silverchair.com)
Differentiation7
  • LncRNA and miRNA both participate in immune regulatory responses by regulating the differentiation of bone marrow hematopoietic stem cells and activating mononuclear macrophages and DCs [ 13 ]. (hindawi.com)
  • At the same time, the role of miRNA in regulating innate immune responses, especially macrophages and granulocytes, has been shown to alter cell development, differentiation, and the release of inflammatory factors. (hindawi.com)
  • He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
  • that regulate the differentiation and activation of these cells. (cdc.gov)
  • This work further provides insights into NK cell development by in vitro differentiation studies in which NKp65 expressing cells are generated in presence of OP9 feeder cells and cytokines to support development. (uni-frankfurt.de)
  • During cytotrophoblast to syncytiotrophoblast differentiation, cells undergo regulated metabolic and transcriptional reprogramming. (biomed.news)
  • capacity of NICD1 to mobilize the ILC2 differentiation Solanesol program was sufficiently potent to override commitment to the T cell lineage in CD34+CD1a+ progenitors and force them into the ILC2 lineage. (nonamimaho.com)
Innate5
  • IL-33 activates group 2 innate lymphoid cells (ILC2) to produce the type 2 cytokines IL-5 and IL-13 that initiate innate immunity-driven allergic responses. (justia.com)
  • Therefore, IL-33 is a central mediator of both innate and adaptive immunity regulated allergic inflammation in the lung that have a role in the pathogenesis of conditions such as asthma, and IL-33 has been deemed to be an important therapeutic target in inhibiting allergic diseases. (justia.com)
  • These data indicate that GLP-1R agonists down-regulate innate inflammatory responses to endotoxins or endogenous inflammatory mediators. (justia.com)
  • However, no studies have reported the effect of GLP-1R agonists on lung IL-33 expression or release, the effect of GLP-1R agonists on the innate allergic inflammatory response that is mediated by ILC2, or the effect of GLP-1R agonists on respiratory syncytial virus (RSV) infection. (justia.com)
  • Spatial distribution of LTi-like cells in intestinal mucosa regulates type 3 innate immunity. (stanford.edu)
ILCs3
  • The development of ILCs is initiated in response to the presence of transcription factors that are switched on due to the presence of surrounding microenvironmental factors, such as: cytokines, notch ligands, and circadian rhythm (inbuilt behavioural changes following a daily cycle). (wikipedia.org)
  • The classification of ILCs is therefore based on the differences in the transcription factor and cytokine profiles associated with the development and function of the different ILC subtypes. (wikipedia.org)
  • As mentioned above, the project aimed to investigate the mechanisms regulating lipid-mediated immunity in the intestinal mucosa by examining the crosstalk between ILCs and NKT cells. (europa.eu)
Immunity3
  • Type 2 immunity against pathogens is tightly regulated to ensure appropriate inflammatory responses that clear infection and prevent excessive tissue damage. (broadinstitute.org)
  • The current project titled Regulation of lipid-mediated immunity in the intestine aimed to explore the mechanisms regulating lipid-mediated immunity in the intestine. (europa.eu)
  • As potent cytokine producers being enriched in mucosal tissue, ILC play an essential role in tissue maintenance and regulating immunity to chronic inflammation and infection (Vivier et al. (uni-frankfurt.de)
Macrophages3
  • Programmed cell death ligands 1 (PD-L1, B7-H1, CD274) and (PD-L2, B7-DC, CD273) belong to the B7 family and are widely expressed in activated T cells, B cells, monocytes, dendritic cells, macrophages, and other cells to regulate activation or inhibition [ 20 ]. (hindawi.com)
  • The phagocytosis of dying cells by macrophages, termed efferocytosis, is a tightly regulated process that involves the sensing, binding, engulfment, and digestion of apoptotic cells. (biomed.news)
  • Ly6G is expressed differentially during development by cells in the myeloid lineage including monocytes, macrophages, granulocytes, and neutrophils. (bioxcell.com)
Intestinal homeostasis1
  • Therefore, the enteric neuroimmune network is the core of regulating intestinal homeostasis. (biomedcentral.com)
Gene expression3
  • In addition, Th2 cells are important mediators of type I allergy, and it has been reported that ncRNA promotes Th2 cell migration to target organs by regulating chemokine gene expression [ 17 ]. (hindawi.com)
  • We aim to elucidate the precise epigenetic mechanisms through which TCF-1 interacts with chromatin remodeling enzymes to unwrap DNA from nucleosomes, thus leading to a highly orchestrated cascade of gene expression events that drive T cell development and function. (vahedilab.com)
  • Additionally, BRDs contain several catalytic domains that enable them to act as methyltransferases, ATP-dependent re-modellers or histone acetyltransferases and helicases ( 8 ) Bromodomain and extra-terminal domain (BET) proteins are a family of transcriptional mediators that regulate gene expression ( 8 , 9 ). (frontiersin.org)
Responses4
  • We also review recent discoveries about ILC2 plasticity and heterogeneity in different tissues, as revealed partly through single-cell RNA sequencing of transcriptional responses to various stimuli. (broadinstitute.org)
  • Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens. (umn.edu)
  • From a physiological standpoint, MDSC can be thought of as effectors of a homeostatic mechanism that regulate T cell-mediated inflammatory responses to pathogens [ 5 ]. (iospress.com)
  • This review discusses how neural signals regulate leukocyte migration around the body and within tissues and contributions by diverse neural signals to effective immune responses. (rupress.org)
Pathways2
  • In this review, we discuss the regulation of ILC2 activation by transcription factors and metabolic pathways, as well as by extrinsic signals such as cytokines, lipid mediators, hormones, and neuropeptides. (broadinstitute.org)
  • Understanding the tissue-specific pathways that regulate ILC2 diversity and function is a critical step in the development of potential therapies for allergic diseases. (broadinstitute.org)
Activation3
  • Their function is regulated by the activation of a number of activating and inhibitory receptors that bind to specific ligands expressed on the surface of target cells. (frontiersin.org)
  • Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
  • Allergic (or atopic) asthma is characterized by the presence of ILC2 and T helper 2 (Th2) response that covers the production of cytokines such as, interleukin (IL)-4, IL-5 and IL-13 which all together orchestrate the migration of eosinophils, mast cells activation and Immunoglobulin E (IgE) production [ 5 , 6 ]. (biomedcentral.com)
Differentially1
  • Nineteen genes were differentially regulated in all 4 of the long-lived populations relative to wild type. (refine.bio)
Populations2
  • Several evidences propose that the dysregulation of the intestinal immune system or the alteration in the commensal bacteria populations can lead to inflammatory and autoimmune diseases development, such as inflammatory bowel disease (IBD). (europa.eu)
  • Studies in the laboratory focus on how immune cell populations (M2-macropahges and IL-C2 cells) regulate the induction of metaplasia and its progression to more aggressive and proliferative pre-cancerous lesions. (vumc.org)
Homeostasis1
  • Once activated ILC2s can regulate metabolic homeostasis, promote anti-inflammatory conditions, and improve glucose homeostasis. (bioxcell.com)
Inflammatory1
  • It will also identify novel targets for therapeutics to treat inflammatory RV failure, such as inhibitors of the NLRP3 inflammasome, which regulates the immune system. (queensu.ca)
Chemokine1
  • The E-protein transcription factors E2A and HEB regulate thymocyte expression of the chemokine receptor CXCR4 to retain preselection thymocytes in the thymic cortex. (silverchair.com)
Cells10
  • Both cells can also produce IFN-γ when the cytokines IL-15 or IL-12 are up-regulated in tissues after infection or injury, and secrete TGFβ1 in tandem with IFN-γ when stimulated. (wikipedia.org)
  • Although both cell types use T-bet for development, NK cells have been found to be present in T-bet deficient hosts, but ILC1s are completely dependent on its presence. (wikipedia.org)
  • Development of NK cells is, however, completely dependent on the presence of the transcription factor Eomes, whereas ILC1s can develop independent of its presence. (wikipedia.org)
  • There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
  • His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
  • The overarching goal of the Vahedi laboratory is to understand the molecular mechanisms through which genomic information in our immune cells is interpreted in normal development and further dissect how common genetic variation can lead to misinterpretation of the genetic material in immune mediated diseases, particularly autoimmune disorders. (vahedilab.com)
  • Despite decades of studies defining proteins functionally required for T cell development, the detailed molecular mechanisms through which the chromatin of T cells becomes unpacked are not clearly understood. (vahedilab.com)
  • We demonstrated for the first time that a transcription factor called TCF-1, which has been known to be required for T cell development for two decades, has an exceptional property to unwrap DNA from nucleosomes and create open chromatin, establishing the epigenetic identity of T cells (Johnson et al. (vahedilab.com)
  • A detailed molecular understanding of the interactions between transcription factors and chromatin remodelers in packaging of DNA into chromatin in T cells is a significant contribution since it forms the foundation for the development of highly selective and efficient strategies including epigenetic therapies that could alter T cell fate and function at will. (vahedilab.com)
  • IFN gamma and IL-4, have each been found to negatively regulate the generation of these Th-17 cells. (thermofisher.com)
Proteins1
  • CAPE- em p /em NO2 suppressed the appearance of metastasis- and growth-associated proteins by restraining the EGFR/STAT3/Akt indication pathway, and EMT could possibly be regulated with the indication pathway. (foodexpowest.com)
Lung1
  • Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. (imperial.ac.uk)
Inhibits1
  • Open in another window Amount 9 The feasible system of CAPE- em p /em NO2 inhibits TNBC development and metastasis. (foodexpowest.com)
Therapies1
  • In this context, understanding the immune mechanisms involved in the pathology of this disease is crucial for its prevention and for the development of efficient therapies. (europa.eu)
Mechanisms1
  • These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications. (imperial.ac.uk)
Crucial1
  • Circadian rhythms play a crucial role in regulating various aspects of life, including immune and nervous system functions. (queensu.ca)
Allergic rhinitis1
  • These results suggest that the noncoding RNA regulatory network may play a potential role in the development of allergic rhinitis (Figure 1 ). (hindawi.com)
Asthma1
  • In this narrative review we will assess the most recent developments in the treatment of severe pediatric asthma, as well as potential biomarkers to assess treatment efficacy for this patient population. (bvsalud.org)
Subsets1
  • His work is focused on T cell receptor signaling and the development of T cell subsets. (rupress.org)
Mechanism1
  • A Mg 2+ -dependent mechanism regulates proximal T cell receptor signaling by modulating ITK activity through a low-affinity Mg 2+ binding pocket in the catalytic domain. (silverchair.com)
Commitment1
  • These findings have been recognized as a paradigm shift in how T cell commitment is regulated. (vahedilab.com)
Cell development2
  • Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation. (umn.edu)
  • Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing. (umn.edu)
Humanized monoclon1
  • Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development. (umn.edu)
Molecular1
  • Consequently, it is critical that we understand the cellular and molecular immune factors that regulate the uterine environment. (elifesciences.org)
Found1
  • It was going after processes that were so subtly and precisely regulated that I found interesting to study. (scireq.com)
Review1
  • In this review, we summarized the interactions of noncoding RNAs and viruses in the occurrence and development of AR, along with the treatments focusing on the noncoding RNAs in the past five years. (hindawi.com)
Studies1
  • This information may serve to aid in interpreting assessments in risk models, epidemiologic studies, and development of occupational exposure limits, relating to health effect endpoints identified in toxicological studies considering similar instruments evaluated in this study. (cdc.gov)
Research3
  • Research areas Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. (broadinstitute.org)
  • Dr. Goldenring is internationally recognized for his research contributions defining cancerous and precancerous development and disease in the intestines and stomach. (vumc.org)
  • SCRIPS will expand opportunities for surgeons and other procedure-based physicians through mentored basic research training in the medical school, residency and fellowship years and through early faculty career development. (vumc.org)