Regulating gene expression knockdown regulating the expression micro rna that regulates. Medical search. Frequent questions

The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
This study confirms that alterations in the expression of exosomal miRNAs can promote osteogenic differentiation of ADSCs, which also provides the foundation for further research on the regulatory functions of exosomal miRNAs in the context of ADSC osteogenesis. (hindawi.com)
In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. (molcells.org)
The expression patterns of those miRNAs were examined in hamster lung samples infected by SARS-CoV-2. (molcells.org)
Five miRNAs (hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-221-3p, hsa-miR-140-3p, and hsa-miR-422a) showed differential expression patterns in lung tissues before and after infection. (molcells.org)
MicroRNAs (miRNAs) are a class of small non-coding RNA, 20-22 nucleotides in length. (molcells.org)
The seed region in miRNAs, approximately six nucleotides long, recognizes and binds to the complementary binding site of the target mRNA 3'untranslated region (3'UTR) to regulate its expression. (molcells.org)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
In the case of RNA molecules that bind target RNA segments, such as microRNAs (miRNAs), the altered base pairing can change binding specificities. (biomedcentral.com)
These miRNAs which targeted β -catenin mRNA were confirmed by dual-luciferase reporter system and RNA-pulldown. (hindawi.com)
In most cases, circRNAs usually act as a competitive endogenous RNA (ceRNA) that can absorb miRNAs to regulate the expression of targeted genes [ 9 ]. (hindawi.com)
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)
The recent publication by Wagh and colleagues sought to identify the novel miRNAs regulating cardiac-specific transcription factors that determine left versus right ventricular determination [ 1 ]. (biomedcentral.com)
In the current study, the investigators focused their sights on short noncoding RNAs or microRNAs (miRNAs), which are well-known inhibitors of gene expression. (genengnews.com)
They first searched for miRNAs that, when overexpressed in fat tissue, affected feeding behavior, and second for the gene targets of those miRNAs. (genengnews.com)
MicroRNAs (miRNAs) are ~22-nt non-coding RNAs that negatively regulate gene expression at the post-transciptional level via direct binding with the 3′ untranslated regions (UTR) of target mRNAs ( 16 , 17 ). (spandidos-publications.com)
Objective: To identify miRNAs that regulate angiogenesis. (ca.gov)
Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). (biomedcentral.com)
A series of studies indicate that lncRNAs serve as competing endogenous RNAs (ceRNA) by sponging miRNAs, and modulate the targets of miRNAs [ 15 , 16 ]. (biomedcentral.com)
MicroRNAs (miRNAs) negatively regulate gene expression post-transcriptionally by binding to the 3'-untranslated region (3'-UTR) of the target mRNA sequences and have been shown to be involved in various types of cancers. (biomedcentral.com)
MicroRNAs (miRNAs), with the length of 18-22 nucleotides, have been shown to downregulate target mRNA expression post-transcriptionally by binding to the 3'-untranslated region (UTR) of the target mRNA sequences [ 9 ]. (biomedcentral.com)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
We highlight the role of SE-driven genes, enhancer RNAs (eRNAs), lncRNAs, and miRNAs in the digestive system tumor growth and progression. (ijbs.com)

Noncoding RNAs, including circRNAs, microRNAs, and lncRNAs, have become a significant focus of research attention due to their crucial role in regulating the progression of multiple malignancies [ 5 ], including bladder cancer, gastric cancer, nasopharyngeal carcinoma, and pancreatic cancer. (hindawi.com)
Current Long noncoding RNAs (lncRNAs) LINC00958 showed some benefit to this cancer, but the mechanism is unknown. (researchsquare.com)
Long noncoding RNAs (lncRNAs) regulate a number of physiological and pathological processes, including gene transcription and translation, chromatin modification, cell cycle progression, cell proliferation, and oncogenic and tumor-suppressive signals in cancer 6 . (researchsquare.com)
In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
Pseudogene, a subclass of long non-coding RNAs (lncRNAs), are considered as genomic loci that resemble real gene, but lost some functionality because they are lack of protein-coding ability because of disabling mutation, lack of transcription, or their inability to encode RNA [ 3 ]. (biomedcentral.com)
We have discovered a set of lncRNAs that are differentially regulated in leukemia and particularly in poor-prognosis B-ALL with translocations of the mixed lineage leukemia (MLL) gene. (ucla.edu)
While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)
While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)
Here, we used RNAseq to identify a novel class of cardiac lncRNAs that are dynamically regulated by exercise. (researchgate.net)

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
The broad goal of the project is to understand the mechanisms by which RNA binding protein RBM3 regulates gene expression at the posttranscriptional level of mRNA stability and translation in cancer cells. (grantome.com)
RBM3 interacts with HuR and hnRNP A1, and with AU-RNA sequences to enhance mRNA stability and translation of AU-rich transcripts such as COX-2, VEGF and IL-8. (grantome.com)
The fact that and are up-regulated in HCC led us to hypothesize that normal and expressions are balanced by endogenous miR-31, which selectively regulates and mRNA translation in normal hepatic liver cells. (nos-nop.org)
We demonstrated that miR-146a expression is overexpressed, while FLAP protein and mRNA are suppressed in hepatocellular carcinoma tissues and HepG2 cells compared to para-carcinoma tissues and HL-7702 cells. (biomedcentral.com)
Dual luciferase reporter gene assay showed that miR-146a-5p can directly target FLAP mRNA. (biomedcentral.com)
Aberrant changes in epigenetic mechanisms regulating DNA methylation, histone methylation and acetylation, expression of noncoding RNAs, and mRNA methylation are associated with the initiation, growth, and progression of digestive system tumors [ 2 , 4 ]. (ijbs.com)
Through domain-mapping experiments and high throughput characterization of IGF2BP3 binding sites in mRNA, we determined that RNA-binding is necessary for the function of this protein. (ucla.edu)
Their function is based on their sequence homology-based binding to and regulation of mRNA targets, thereby modulating gene expression. (ucla.edu)
Conversely, hnRNPA1 overexpression reduced NP expression at the mRNA and protein levels and impeded virus replication by (60.70%), suggesting antagonistic function. (cdc.gov)

MicroRNAs are small non-coding RNA molecules that are critical in physiology and pathology. (ucla.edu)

By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
metastatic potential of HCC cells by selectively regulating epithelial-mesenchymal transition (EMT) regulatory proteins such as N-cadherin, E-cadherin, vimentin and fibronectin. (nos-nop.org)
HCC tissues derived from chemical-induced rat liver cancer models validated that miR-31 manifestation is significantly down-regulated, and that those cell cycle- and EMT-regulatory proteins are deregulated in rat liver cancer. (nos-nop.org)
Overall, we suggest that miR-31 functions like a tumor suppressor by selectively regulating cell cycle and EMT regulatory proteins in human being hepatocarcinogenesis providing a novel target FANCG for the molecular treatment of liver malignancies. (nos-nop.org)
Finally, we discuss clinical significance of the CRISPR-Cas9 gene editing system and inhibitors of SE-related proteins such as BET and CDK7 as potential cancer therapeutics. (ijbs.com)
A relatively new addition to the repertoire of gene expression regulatory molecules are the so-called RNA binding proteins, defined as proteins whose function is to bind ribonucleic acids (RNA). (ucla.edu)
These proteins participate in gene expression by binding to and regulating messenger RNA (mRNAs), which in turn are translated into proteins. (ucla.edu)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)

Quaking (QKI) was predicted as one of the major targets of miR-214, which was negatively regulated by miR-214. (oncotarget.com)
Taken together, these data indicate that miR-31 suppresses medulloblastoma tumorigenesis by negatively regulating DNA replication via MCM2. (oncotarget.com)

Circular RNAs (circRNAs) are a series of endogenous non-coding RNAs with a covalently closed loop structure ( 9 ). (spandidos-publications.com)
Mechanistically, PTTG3P upregulated the expression of miR-383 targets Cyclin D1 (CCND1) and poly ADP-ribose polymerase 2 (PARP2) by sponging miR-383, acting as a competing endogenous RNA (ceRNA). (biomedcentral.com)

Twenty-seven of these substitution mutations have been observed in genes encoding viral spike protein (S), although most differences were found in non-structural protein-coding genes. (molcells.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
We then performed the gene enrichment and protein-protein interaction (PPI) network analysis to obtain the interacting map. (researchsquare.com)
Insulin receptor substrate 1 (IRS-1) is an adaptor protein that integrates multiple transmembrane signals from growth factors and hormones, to regulate cell growth, survival, differentiation and metabolism ( 4 ). (spandidos-publications.com)
Genetic experiments in zebrafish revealed that miR-10 functions, in part, by directly regulating the level of a protein called FLT1, which inhibits the behavior of endothelial cells that promotes new blood vessel growth. (ca.gov)
We found that miR-10 functions, in part, by directly regulating the level of fms-related tyrosine kinase 1 (FLT1), a cell-surface protein that sequesters VEGF, and its soluble splice variant sFLT1. (ca.gov)
The increase in FLT1/sFLT1 protein levels upon miR-10 knockdown in zebrafish and in HUVECs inhibited the angiogenic behavior of endothelial cells largely by antagonizing VEGF receptor-2 signaling. (ca.gov)
In Aim 1, we will determine the mechanism by which RNA binding protein RBM3 regulates gene expression. (grantome.com)
Completion of these experiments should give us a better understanding of how the RNA binding protein RBM3 functions in normal epithelial cells, and whether changes in the RBM3 expression that is observed in tumor cells is responsible for tumor behavior. (grantome.com)
We have identified a protein, RBM3 whose expression is increased in cancer cells. (grantome.com)
As demonstrated in Fig. ?Fig.2B,2B, knockdown augmented HDAC2 and CDK2 protein expressions in SNU-449 and SKHep-1 cells, whereas co-transfection of miR-31 mimics attenuated knockdown effect on the same cells. (nos-nop.org)
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Abnormal expression of 5-Lipoxygenase Activating Protein (FLAP) has been detected in many tumor cells. (biomedcentral.com)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
In our lab, we identified that one particular RNA-binding protein, IGF2BP3, was responsible for driving a highly aggressive leukemia, based on patient materials, cell lines, and mouse models. (ucla.edu)
BALR-2 knockdown leads to activation of apoptosis pathways through the pro-apoptotic protein BIM. (ucla.edu)
The decreased expression and inhibition of nuclear transfer of GLI1 downregulated macrophage M1 polarization and osteoclast activation, the effect of which was achieved by modulation of DNA methyltransferases (DNMTs) via transcriptional regulation and protein interactions. (elifesciences.org)

The core transcription regulatory loop of the digestive system tumors is complex and a high density of transcription regulatory complexes in the SEs and the crosstalk between SEs and the noncoding RNAs. (ijbs.com)

This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
To this end, the authors performed miRNA expression profiling in undifferentiated hESCs and CMs at day 8 and day 14 after differentiation. (biomedcentral.com)
The research team identified a miRNA called miR-iab-4, which increased feeding by more than 27% and targeted a Drosophila gene called purple, which was expressed in fat bodies. (genengnews.com)
Thus, to support our hypothesis Anisole Methoxybenzene that HDAC2 and CDK2 expressions are controlled by miR-31 in HCC cell lines, we introduced specific siRNAs to block miRNA biogenesis in HCC cells. (nos-nop.org)

Circular RNAs (circRNAs) are a form of noncoding and closed loop RNA molecules and play vital roles in the progression of various types of cancer in humans. (hindawi.com)
In this study, we aim to identify the key molecules and signaling pathways by analyzing the RNA-seq data. (researchsquare.com)

Luciferase assay showed miR-214 substantially inhibited wild type, but not the mutant version of QKI-3-UTR-luciferase activity in differentiating ESCs, further confirming a negative regulation role of miR-214 in QKI gene expression. (oncotarget.com)
Recent studies indicate that dys-regulation of microRNA expression plays important roles in tumorigenesis. (oncotarget.com)
The objective of this study is to identify microRNAs-small, non-coding RNAs that help control gene expression-that contribute to the regulation of new blood vessel formation. (ca.gov)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
A central question in our research is how non-traditional mechanisms of gene regulation effect fundamental aspects of development and how these mechanisms go awry in cancer. (ucla.edu)
The recently discovered novel class of non-coding RNA, termed long non-coding RNA (lncRNA), play important roles in gene expression regulation, development and cancer. (ucla.edu)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)

Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
MicroRNA-214(miR-214) has been recently reported to regulate angiogenesis and embryonic stem cells (ESCs) differentiation. (oncotarget.com)
In the present study, we assessed the hypothesis that miR-214 and its target genes play an important role in VSMCs differentiation. (oncotarget.com)
Mechanistically, our data showed that miR-214 regulated VSMCs gene expression during VSMCs differentiation from ESCs through suppression of QKI. (oncotarget.com)
MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, differentiation, and regeneration. (biomedcentral.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)

We demonstrate that miR-31 inhibits MCM2 expression via its 3'-untranslated region, that knockdown of MCM2 in DAOY cells leads to a degree of growth inhibition comparable to that by miR-31 restoration, and that overexpression of miR-31 reduces the chromatin loading of MCM2 at the point of G1/S transition. (oncotarget.com)
We have also identified microRNAs regulated upon RBM3 overexpression, including downregulating one that inhibits its own expression. (grantome.com)
Knockdown of ALK7 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. (nih.gov)

Global gene expression profiling of mouse medulloblastomas and bioinformatics analyses of microRNA targets suggest that minichromosome maintenance complex component 2 (MCM2) is a likely target gene of miR-31 in suppressing cell growth. (oncotarget.com)
Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)

In conclusion, our work reveals the impacts of circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of β -catenin and activation Wnt/ β -catenin pathway. (hindawi.com)

ADARs have been shown to contribute to disease pathologies by editing of glutamate receptors, editing of serotonin receptors, mutations in ADAR genes, and by other mechanisms, including recently identified regulatory roles in microRNA processing. (biomedcentral.com)
however, most of these cancer associated genes are altered by noncancer-causing passenger mutations. (oncotarget.com)
In contrast, pediatric cancers, which occur early in life and are rare, have much fewer genetically altered genes, making them ideal places for finding cancer-causing driver mutations. (oncotarget.com)
miR-155 is a bona fide oncogenic microRNA that has functions in acute myeloid leukemia, particularly those with FLT3-ITD mutations. (ucla.edu)

miR-214 overexpression and knockdown in differentiating ESCs significantly promoted and inhibited VSMCs -specific genes expression, respectively. (oncotarget.com)
Knockdown of miR-10 led to premature truncation of intersegmental vessel growth (ISV) in the trunk of zebrafish larvae, while overexpression of miR-10 promoted angiogenic behavior in zebrafish and cultured human umbilical venous endothelial cells (HUVECs). (ca.gov)

A-to-I editing is a mechanism that regulates and diversifies the transcriptome, but the full biological significance of ADARs is not understood. (biomedcentral.com)
Eukaryotic RNA transcripts can undergo a range of post-transcriptional modifications, which increase the diversity of the transcriptome without requiring increases in genome size. (biomedcentral.com)

Also, the role of microRNAs in the tumorigenesis will be determined. (grantome.com)
Our current proposal deals with identifying mechanisms by which RBM3 expression is regulated, and also how RBM3 induces tumorigenesis. (grantome.com)

Although RNA editing has long been considered a relatively rare processing event, more recent research suggests that the vast majority of pre-mRNAs are edited [ 6 ]. (biomedcentral.com)
Hence, we have discovered a major, cancer-specific gene regulatory mechanism, which involves the direct binding of IGF2BP3 to specific mRNAs. (ucla.edu)

To further identify the potential signaling pathways after the knockdown of LINC00958 in Ishikawa cells, we performed the KEGG and GO analyses (Figure 2). (researchsquare.com)

These novel findings were confirmed by real-time polymerase chain reaction analysis: higher expression of HAND genes correlated with lower expression of miR-363, miR-367, miR-181a and miR-181c. (biomedcentral.com)
SEs are defined as large clusters of active enhancers in large clusters that are enriched with high levels of transcription factors (TFs), master co-factors, mediator complexes, RNA polymerase II (RNA pol II), and epigenetic modifications [ 5 , 7 ]. (ijbs.com)

ADAR3 contains an arginine-rich domain, shown in pink, which binds single-stranded RNA. (biomedcentral.com)

The target interaction between miR‑195‑5p and circ‑PVT1 or ETS1 was predicted through bioinformatics analysis, and verified by dual‑luciferase reporter gene assay. (spandidos-publications.com)

While scientists have often surmised that there must be some level of communication between adipose tissue and the brain, to regulate feeding behavior and monitor the energy reserves, the underlying molecular mechanisms are poorly understood. (genengnews.com)
Current work involves, first, understanding the molecular mechanisms that underlie the specificity of binding and downstream effects on gene expression. (ucla.edu)

Rationale: Formation and remodeling of the vasculature during development and disease involves a highly conserved and precisely regulated network of attractants and repellants. (ca.gov)
Methods and Results: We show that the highly conserved microRNA family encoding miR-10 regulates the behavior of endothelial cells during angiogenesis by positively titrating pro-angiogenic signaling. (ca.gov)

In conclusion, the present study indicated that propofol inhibited the proliferation and invasion, but enhanced the apoptosis of GC cells by regulating the circ‑PVT1/miR‑195‑5p/ETS1 axis. (spandidos-publications.com)
Peng and Zhang ( 8 ) indicated that propofol inhibited proliferation, but induced apoptosis of SGC-7901 cells by regulating matrix metalloproteinase (MMP)2 ( 8 ). (spandidos-publications.com)
Functional experiments demonstrated that knockdown of PTTG3P inhibited cell proliferation, migration and invasion, and promoted cell apoptosis, acting as an oncogene. (biomedcentral.com)

In the post-genomic era, the cancer research is focused on the dysregulation of transcriptional dysregulation mediated by epigenetic modifications in the enhancer, SE, and gene promoter regions of key tumor suppressor and tumor-promoting genes [ 5 , 6 ]. (ijbs.com)

Especially, hsa-miR-15b-5p and hsa-miR-195-5p showed a large difference in expression, indicating that they may potentially be diagnostic biomarkers for SARS-CoV-2 infection. (molcells.org)
Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)

By employing microRNA expression profiling and functional knockdown studies on human embryonic stem cell-derived cardiomyocytes, the authors identified miR-363 as an upstream negative regulator of left ventricular specification transcription factor HAND1 . (biomedcentral.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)

The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

We have recently published a paper on defective marginal zone B-cell development in miR-146a deficient mice, and collaborated on a manuscript that describes roles for miR-146a in regulating T-cell activation. (ucla.edu)

Then, to determine whether HDAC2 and CDK2 are selectively governed by miR-31 via immediate interaction using the 3-UTR of the genes, we cloned the 3-UTR of and right into a reporter vector linking the luciferase open up reading body downstream to create psi-CHECK2-HDAC2_3-UTR and psiCHECK-CDK2_3-UTR plasmid, respectively (Fig. (nos-nop.org)
It had been discovered that miR-31 could suppress reporter gene activity in these cells, whereas mutants plasmids showed zero noticeable adjustments. (nos-nop.org)
Luciferase reporter assay and RNA pull-down assay were carried out to detect the interaction between miR-383 and LncRNA PTTG3P. (biomedcentral.com)

These genes and biological processes may help understand the mechanism for inhibiting LINC00958 in cancers. (researchsquare.com)

A-to-I editing, which is catalyzed by enzymes of the adenosine deaminase acting on RNA (ADAR) family, is most prevalent in the central nervous system (CNS) but occurs in many tissues [ 1 - 3 ]. (biomedcentral.com)
By comparing microRNA levels between mouse medulloblastoma and normal cerebellar tissues, we identified a set of down-regulated microRNAs including miR-31. (oncotarget.com)
The expression levels of circ‑PVT1 and ETS1 were increased in GC tissues and cells, and miR‑195‑5p was decreased. (spandidos-publications.com)
In this study, we found that PTTG3P was up-regulated in HCC tissues and cells. (biomedcentral.com)
Herein, we aimed to demonstrate the expression of miR-146a and FLAP in human HCC tissues and liver cancer cell lines. (biomedcentral.com)

qPCR and Western blot were used to analyze LncRNA PTTG3P, miR-383 and other target genes' expression. (biomedcentral.com)

Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)

However, compared to the other forms of noncoding RNA, we know very little about the precise role of circRNA in cancer. (hindawi.com)
For example, increased expression of LINC00958 attributes to cell metastasis in gastric cancer 7 . (researchsquare.com)
In our study, we analyzed the effects of the knockdown of LINC00958 in endometrial cancer cells by using the RNA-seq data. (researchsquare.com)
The ability to regulate blood vessel growth is important for treating many diseases, including cancer. (ca.gov)
Consequently, we hypothesized that some cancer-driver genes targeted by miR-31 are up-regulated in HCC as miR-31 was down-regulated in Anisole Methoxybenzene HCC. (nos-nop.org)
Knockdown of miR-146a also resulted in increased FLAP expression of cancer cells. (biomedcentral.com)
Gene expression is a finely tuned, intricate process that normally regulates cellular identity, and becomes disrupted in cancer. (ucla.edu)

Therefore, loss of E-cadherin expression is not only the initial and essential step of EMT, but also a potential promoter of EMT. (spandidos-publications.com)
However, some studies have found that methylated miR-146a promoter leads to a significant decrease of its expression in HCC [ 12 ]. (biomedcentral.com)

Here, we will identify the RNA sequences that interact with RBM3. (grantome.com)
Next, to verify that miR-31 particularly binds to 3UTRs of also to interfere translation of these transcripts, mutant vectors harboring random mutation sequences of miR-31 biding sites from the 3UTR of and genes had been generated, and each vector was co-transfected with miR-31 into SNU-449 and SKHep-1 cells. (nos-nop.org)

Formation and remodeling of blood vessels during development and disease involves a precisely regulated network of attractants and repellants that is similar across species. (ca.gov)
ALK7 gene polymorphism is associated with metabolic syndrome risk and cardiovascular remodeling. (nih.gov)

I am molecular and cellular biologist with expertise in virus and microRNAs. (researchgate.net)

To determine the effects of the knockdown of LINC00958 in Ishikawa cells, we analyzed the RNA-seq data from the GEO database. (researchsquare.com)
However, recently Houghton et al ( 7 ) showed increased cell proliferation after silencing of IRS1 gene expression in A549 cells suggesting tumor suppression potential. (spandidos-publications.com)
miR-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting VEGF Signaling. (ca.gov)
We show that a microRNA called miR-10 regulates the behavior of endothelial cells during blood vessel formation by encouraging signals that promote blood vessel growth. (ca.gov)
MiR-31 was significantly down-regulated compared to related non-tumor cells. (nos-nop.org)
Propofol could inhibit Bcl‑2 and MMP9 expression, and increase P21 expression in GC cells. (spandidos-publications.com)
Additionally, the treatment with propofol could lead to decreased circ‑PVT1 expression in GC cells. (spandidos-publications.com)
These results could be reversed by ETS1 upregulation or miR‑195‑5p‑knockdown in GC cells. (spandidos-publications.com)
Additionally, the effects of transfection with circ‑PVT1 small interfering RNA (si‑circ‑PVT1) on HGC‑27 and AGS cells could be reversed by treatment with miR‑195‑5p inhibitor. (spandidos-publications.com)
The multistep transformation of normal cells into malignant cells involves genetic and epigenetic alterations that promote the aberrant expression of critical oncogenes and tumor suppressor genes [ 1 , 2 ]. (ijbs.com)
In this study, GLI1 expression in the synovial tissue of RA patients was positively correlated with RA-related scores and was highly expressed in collagen-induced arthritis (CIA) mouse articular macrophage-like cells. (elifesciences.org)
Most importantly, hnRNPA1 knockdown caused a significant increase in NP expression and enhanced viral replication (93.82%) in IAV infected A549 cells. (cdc.gov)

We perform a targeted genetic screen in Drosophila melanogaster and identify a role for the enzymatic cofactor tetrahydrobiopterin (BH4) in regulating ad libitum feeding behavior in fruit flies," the authors wrote. (genengnews.com)
Our study indicates fat tissue sends a molecular signal to the fly brain to regulate feeding behavior," concluded senior study investigator Walton Jones, Ph.D., assistant professor at KAIST. (genengnews.com)

Anatomy10

Organisms7

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes49

Disciplines and Occupations2

Information Science3

Health Care1

MiRNAs26

LncRNAs10

MRNA10

Small non-coding RNA mo1

Proteins9

Negatively2

Endogenous2

Protein20

Noncoding RNAs1

MiRNA4

Molecules2

Regulation9

Differentiation6

Inhibits3

Targets2

Progression1

Mutations4

Overexpression2

Transcriptome2

Tumorigenesis2

MRNAs2

Analyses1

Polymerase2

Single-stranded1

Luciferase reporter gene1

Mechanisms2

Highly conserved2

Apoptosis3

Genomic1

Biomarkers2

Transcription3

Play important roles1

Roles1

Reporter3

Mechanism1

Tissues5

Target1

Inflammation1

Cancer7

Promoter2

Sequences2

Remodeling2

Cellular1

Cells12

Feeding behavior2