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  • vitro
  • Adherens junctions (AJs) and VE-cadherin (VEC, encoded by CDH5) are required for endothelial apicobasal polarity in vitro and during embryonic development. (optistem.org)
  • Expression
  • APE1/ref-1 upregulates H-ras expression and leads to H-ras-mediated, phosphoinositide-3 kinase/Akt kinase-dependent calcium sensitization of endothelial NO synthase (eNOS), stimulating NO production. (ahajournals.org)
  • Intrigued by the latter possibility, we hypothesized that in addition to its DNA repair function, APE1/ref-1 expression in the vascular wall serves to regulate vascular tone. (ahajournals.org)
  • They regulate gene expression by inhibiting translation or promoting mRNA degradation mostly through canonical base paring between the seed sequence of the miRNA and its complementary seed match sequence, present in the 3′ untranslated regions (UTRs). (ahajournals.org)
  • Silencing of CDH5 gene expression leads to abrogation of endothelial polarity accompanied by strong alterations in lumenal structure. (optistem.org)
  • Here we show that the transcription factors Ets-1 and Ets-2 regulate miR-126 expression. (ahajournals.org)
  • Conclusion- Taken together, these data show that the transcription factors Ets-1 and Ets-2 play a key role in controlling the expression of miR-126 and suggest that miR-126 may mediate some of their vascular effects. (ahajournals.org)
  • In the present study, we investigated the role of TGase-4 in tumor-endothelial cell interactions, by creating a panel of prostate cancer cell lines that have different expression profiles of human TGase-4. (cf.ac.uk)
  • Beiter K, Hiendlmeyer E, Brabletz T, Hlubek F, Haynl A, Knoll C, Kirchner T and Jung A 2005 beta-Catenin regulates the expression of tenascin-C in human colorectal tumors. (springer.com)
  • adhesion
  • Platelet endothelial cell adhesion molecule (PECAM), a mechanosensory protein, is necessary for the production, secretion, and assembly of FN matrix by ECs. (ahajournals.org)
  • Interactions between neutrophil and endothelial adhesion molecules promote disassembly of tight junctions, permitting neutrophils to extravasate and enter damaged or infected tissues. (jimmunol.org)
  • Balsamo J, Leung T, Ernst H, Zanin MK, Hoffman S and Lilien J 1996 Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin. (springer.com)
  • transcription factors
  • The E26 transformation-specific sequence (ETS) factors are a family of transcription factors that share a highly conserved DNA binding domain and regulate cell development, senescence, death, and tumorigenesis. (ahajournals.org)
  • cell
  • Objective- The function of the endothelial cell (EC)-enriched Rho family guanine nucleotide exchange factor, facio-genital dysplasia-5 (FGD5), is poorly understood. (ahajournals.org)
  • We hypothesize that endothelial PECAM and FN signaling promotes a pro-inflammatory smooth muscle cell phenotype in response to atheroprone shear stress patterns. (ahajournals.org)
  • FITC-dextran, matrigel, and Trans-well assays were used to evaluate the vascular density, tube formation, and cell migration respectively. (ac.ir)
  • Inflammatory cell infiltration was almost completely eliminated and loss of BBB integrity was significantly inhibited following infection of neutropenic mice, indicating that neutrophils play a critical role(s) in regulating subsequent CNS inflammatory events. (jimmunol.org)
  • As such, many common diseases such as atherosclerosis, heart disease, cancer, macular degeneration and diabetes have a common signature of endothelial cell dysfunction. (yale.edu)
  • migration
  • Moreover, miR-342-5p promoted the migration of ECs, accompanied by reduced endothelial markers and increased mesenchymal markers, indicative of increased endothelial-mesenchymal transition. (nih.gov)
  • tyrosine kinase
  • Endocytosis and subsequent intracellular trafficking spatiotemporally regulate receptor tyrosine kinase signaling, whereas signaling endosomes provide a platform for the compartmentalization of signaling events. (ahajournals.org)
  • vasculature
  • Although mitochondrial alterations have been associated to endothelial dysfunction, the role of mitoAKAPs in the vasculature is currently unknown. (ovid.com)
  • Objective
  • Objective- The Pin1 prolyl isomerase acts in concert with proline-directed protein kinases to regulate function of protein substrates through isomerization of peptide bonds that link phosphoserine or phosphothreonine to proline. (ahajournals.org)
  • progression
  • In most cardiovascular diseases, diabetes, as well as in cancer, dysregulation of the vascular endothelium contributes directly to disease progression. (yale.edu)
  • protein
  • 8 - 10 Hsp90 is known to regulate signal transduction via modulation of signaling molecules, such as protein kinases and eNOS. (ahajournals.org)
  • The extracellular matrix protein fibronectin (FN) is deposited in the sub-endothelial layer of pre-atherosclerotic and advanced lesions. (ahajournals.org)
  • Nogo-B receptor stabilizes Nieman Pick Type C2 protein and regulate intracellular cholesterol trafficking. (yale.edu)
  • endothelium
  • APE1/ref-1 +/− mice have impaired endothelium-dependent vasorelaxation, reduced vascular NO levels, and are hypertensive. (ahajournals.org)
  • Fluid shear stress generated by blood flowing over the endothelium is a major determinant of arterial tone, vascular remodeling, and atherogenesis. (ahajournals.org)
  • The vascular endothelium is the largest endocrine organ in the body, at the interface of blood and tissue. (yale.edu)
  • neovascularization
  • To test this, postischemic neovascularization, vascular function, and arterial blood pressure were analyzed in Akap1 knockout mice (Akap1−/−) and their wild-type (wt) littermates. (ovid.com)