Resultantly, all the mutant proteins significantly reduced the transcriptional activity required to regulate the downstream target gene expression. (bvsalud.org)
Proteins4
Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation. (biomedcentral.com)
POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. (embl.de)
The acronym POU (pronounced 'pow') is derived from the names of three mammalian transcription factors, the pituitary-specific Pit-1, the octamer-binding proteins Oct-1 and Oct-2, and the neural Unc-86 from Caenorhabditis elegans. (embl.de)
Moreover, Brn-3b levels significantly modified tumor growth in vivo with elevated Brn-3b resulting in faster tumor growth in xenograft models whereas decreasing Brn-3b resulted in slower growth compared with controls. (ox.ac.uk)
Boswellia sacra essential oil hydrodistilled at 100 o C was more potent than the essential oil prepared at 78 o C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression. (biomedcentral.com)
Human neuroblastoma1
In this study, we analyzed the effects of manipulating Brn-3b levels in the human neuroblastoma cell line, IMR-32 and showed that constitutive overexpression of Brn-3b consistently increased cellular growth and proliferation in monolayer as well as in an anchorage-independent manner compared with controls whereas stably decreasing Brn-3b can reduce the rate of growth of these cells. (ox.ac.uk)
Gene4
POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene. (wikipedia.org)
The PMP22 gene is located on chromosome 17p11.2 and mutations as well as alterations in the gene dosage are causative for a group of hereditary neuropathies affecting approximately 1 in 2500 humans 2 , 3 . (biorxiv.org)
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. (en-academic.com)
Proliferation2
Our results therefore suggest that Brn-3b transcription factor contributes to proliferation of neuroblastoma cells in vivo and in vitro but may also influence progression and/or invasion during tumorigenesis. (ox.ac.uk)
It is possible that decreasing Brn-3b levels may reverse some effects on growth and proliferation of these cells. (ox.ac.uk)
Molecular1
Alternative splicing of pre-mRNAs is an important means of regulating developmental processes, yet the molecular mechanisms governing alternative splicing in embryonic contexts are just beginning to emerge. (xenbase.org)
Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)
Significantly3
We previously showed that the Brn-3b transcription factor is highly expressed in actively proliferating neuroblastoma cells but is significantly decreased when these cells are induced to differentiate. (ox.ac.uk)
Interestingly, elevated Brn-3b levels also enhances the invasive capacity of these neuroblastoma cells with significantly larger numbers of migrating cells observed in overexpressing clones compared with controls. (ox.ac.uk)
Among 4,180 transcripts that changed significantly during development, approximately 2/3 of the genes were expressed at high levels up until PN5 and then declined whereas the other 1/3 of the genes increased expression from PN5 and remained at the higher levels until at least PN21. (biomedcentral.com)
Signalling pathway1
The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. (babraham.ac.uk)
Processes2
AKRs are tissue-specific hydroxysteroid dehydrogenases that interconvert weak steroid hormones to their more potent counterparts and regulate processes involved in development, homeostasis and reproduction. (biomedcentral.com)
Aldo-keto reductases interconvert weak androgens, estrogens, progestins, mineralocorticoids and glucocorticoids to their more potent counterparts by catalyzing the reduction and oxidation of keto- and hydroxysteroids, respectively, thereby regulating a wide range of physiological processes involved in development, homeostasis and reproduction [ 16 ]. (biomedcentral.com)
Genes2
Some other genes are also regulated, including those for immunoglobulin light and heavy chains (Oct-2) [ ( PUBMED:1967834 ) ( PUBMED:1967821 ) ], and trophic hormone genes, such as those for prolactin and growth hormone (Pit-1). (embl.de)
gatae and otx genes provide input into the pregastrular regulatory system of foxa , and Foxa represses its own transcription,resulting in an oscillatory temporal expression profile. (biologists.com)
Interact1
Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)
Subset1
however, mRNAs encoding a subset of factors important for error-free replication and chromosome segregation, including TIPIN, PLK2 and PLK3, remain at low abundance. (babraham.ac.uk)
Cells with high Brn-3b also fail to respond to growth inhibitory retinoic acid, as they continue to proliferate. (ox.ac.uk)
Genes10
The POU3F4 gene provides instructions for making a protein that helps regulate the activity of other genes. (medlineplus.gov)
The POU3F4 gene is part of a larger family of transcription factor genes called POU domain genes. (medlineplus.gov)
Researchers are working to determine which genes are regulated by this protein. (medlineplus.gov)
HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. (nih.gov)
Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. (nih.gov)
Of the probe sets, 1,597 (representing 1,081 genes) met the criteria for differential expression, of which 82 genes were significantly up-or down-regulated in treated retinas. (molvis.org)
Genes related to an early inflammatory reaction and to cell death were also significantly regulated in response to a radiation injury to the intraorbital optic nerve. (molvis.org)
We then applied a comprehensive set of tools, including histopathological and molecular analyses, RNA-seq, and electroretinography on these mouse lines to study Nrf1-regulated genes and Nrf1's roles in both developing retinas and differentiated rod PRs. (biomedcentral.com)
A recent study using chromatin immunoprecipitation sequencing (ChIP-seq) analysis identified 2470 potential Nrf1 targets in human neuroblastoma cells, indicating roles for Nrf1 in regulating genes for mitochondrial biogenesis and cell growth and in the pathogenesis of neurodegenerative diseases [ 16 ]. (biomedcentral.com)
MITF4
3. MITF and BRN2 contribute to metastatic growth after dissemination of melanoma. (nih.gov)
6. Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway. (nih.gov)
Microphthalmia-associated transcription factor (Mitf), downstream of the Wnt/β-catenin pathway, has become an important prognostic marker of melanoma. (nih.gov)
Fisetin-mediated interference with the functional cooperation between β-catenin and T-cell factor (TCF)-2 resulted in the downregulation of positively regulated TCF targets, such as c-myc, Brn-2, and Mitf. (nih.gov)
Invasiveness1
12. Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. (nih.gov)
Cortical1
17. NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development. (nih.gov)
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Melanoma3
5. Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. (nih.gov)
11. Microphthalmia-associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation. (nih.gov)
19. A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma. (nih.gov)
Epigenetic1
General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions. (canceropole-est.org)
Protein5
POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene. (wikipedia.org)
Based on this role, the protein is called a transcription factor. (medlineplus.gov)
HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Cell2
Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks. (canceropole-est.org)
Recent in vitro studies suggest that the resulting long noncoding RNA molecules can act as regulators of transcription, translation, and cell cycle. (elifesciences.org)
Pathway1
use DICARBOXYLIC ACIDS 1970-1979 MH - 3-Phosphoshikimate 1-Carboxyvinyltransferase UI - D051229 MN - D8.811.913.225.735 MS - An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylshikimate 3-phosphate and ORTHOPHOSPHATE from PHOSPHOENOLPYRUVATE and SHIKIMATE-3-PHOSPHATE. (nih.gov)
Cells2
Fisetin-treated cells showed increased cytosolic levels of Axin and β-TrCP and decreased phosphorylation of glycogen synthase kinase 3β associated with decreased β-catenin stabilization. (nih.gov)
In this report, we investigated the in vivo function of nuclear respiratory factor 1 (Nrf1), a major transcriptional regulator of mitochondrial biogenesis in both proliferating retinal progenitor cells (RPCs) and postmitotic rod photoreceptor cells (PRs). (biomedcentral.com)
Process1
This process is intricately regulated to maintain a healthy mitochondrial network, essential for energy homeostasis, metabolism, signaling, and apoptosis. (biomedcentral.com)
Role1
Researchers believe that this DNA may play a role in regulating the POU3F4 gene. (medlineplus.gov)