• CREB regulated transcription coactivator (CRTC) may refer to the following proteins and genes: CRTC1 CRTC2 CRTC3 CREB CRTC (disambiguation) This disambiguation page lists articles associated with the title CREB regulated transcription coactivator. (wikipedia.org)
  • The results showed that USF1 significantly regulates 350 differentially expressed genes (DEGs). (spandidos-publications.com)
  • Promoter region motif analysis indicated that ETV5 has more binding motifs and genes than USF1 itself for USF1‑regulated DEGs, indicating that USF1 may indirectly modulate gene expression by regulating ETV5 expression in Huh7 cells. (spandidos-publications.com)
  • Downstream genes, including lncRNA‑NEAT1 and TF‑ETV5, may also have potential functions in the regulated network by USF1 and have potential functions in the progression of HCC. (spandidos-publications.com)
  • As a TF, USF1 has a bidirectional regulatory function, being able to regulate gene expression by activating or suppressing the promoter region of target genes ( 5 , 6 ). (spandidos-publications.com)
  • In Brachypodium distachyon, the BdCathB gene that encodes a Cathepsin B-like thiol-protease, orthologous to the wheat Al21 and barley HvCathB, is highly induced in germinating seeds and its expression is regulated by transcription factors (TFs) encoded by genes BdGa-myb and BdDof24, orthologous to the barley HvGamyb and BPBF-HvDof24, respectively. (upm.es)
  • Various biochemical and cell biological assays, revealed that circZNF827 mechanistically functions as a scaffold for a complex of RNA-binding proteins, including its own host-gene-encoded protein, ZNF827, and two known transcriptional regulators, hnRNP K and L. Despite being localized mostly to the cell cytoplasm, circZNF827 apparently "moonlights" in the nucleus, where it nucleates these transcription factors to specific neuronal genes (e.g. (savesome.green)
  • One of thousands of VSG genes is transcribed by RNA polymerase I in a singular nuclear structure called the expression site body (ESB), but how monoallelic VSG transcription is achieved remains unclear. (ox.ac.uk)
  • RNA polymerase II (Pol II)-dependent transcription in stimulus-inducible genes requires topoisomerase IIβ (TOP2B)-mediated DNA strand break and the activation of DNA damage response signalling in humans. (elsevierpure.com)
  • Our biochemical and genomic analyses showed that the BRCA1-BARD1 complex interacts with TOP2B in the EGR1 transcription start site and in a large number of protein-coding genes. (elsevierpure.com)
  • GTF2IRD1 binds to enhancer and promoter regions in the mouse rhodopsin, M- and S-opsin genes, but regulates their expression differentially. (wustl.edu)
  • The broadest definition is that a coregulator is a protein that participates in a complex that is recruited to the genome by DNA-binding transcription factors, and through this recruitment, the complex regulates (up or down) the rate of transcription of one or more genes. (biodiversityhotspot.org)
  • A transcription factor is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
  • Transcription factor AP-2β regulates genes that are involved in development before birth. (medlineplus.gov)
  • Some of these variants prevent the protein from binding to DNA, while other variants render it unable to regulate the activity of other genes. (medlineplus.gov)
  • May regulate other genes in the cell. (lu.se)
  • Even if the DNA sequence - the set of genes - is the same in all cells, only certain genes are expressed, i.e. only information from certain genes is copied (transcribed) and used to build protein structures or regulate processes. (lu.se)
  • DNA methylation is a chemical process that regulates the function of the genes. (lu.se)
  • In this study, VGF (non-acronymic) was found regulated by NPAS3 in neuronal stem cells. (frontiersin.org)
  • Conversely, actin signaling regulates neuronal SRF-mediated gene expression. (jneurosci.org)
  • Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)
  • In addition, we found that Hippo effectors regulate neuronal migration to the cortical plate (CP) in a reciprocal fashion, that ApoE, Dab2 and Cyr61 are Tead targets, and these contribute to neuronal fate determination and migration. (verdontaylorlab.com)
  • Dendrites serve critical roles in establishing neuronal circuits and integration of synaptic signals, so mechanisms that regulate their arborization have significant impact on brain function. (jneurosci.org)
  • Translational profiling can determine, in an unbiased manner, which fraction of the genome is actually translated into proteins, as well as resolving whether transcription and translation respond concurrently, or differentially, to estrogen treatment. (kean.edu)
  • RLM1, Encoding an R2R3 MYB Transcription Factor, Regulates the Development of Secondary Cell Wall in Rice. (bvsalud.org)
  • Importantly, we identify putative ESRRa binding elements in upstream regions of sox9 to which ESRRa can directly bind, indicating that Esrra may directly regulate sox9 expression. (nature.com)
  • Taken together, our results indicate for the first time that ESRRa is essential for cartilage development by regulating sox9 expression during vertebrate development. (nature.com)
  • Induction of SRY box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of injured kidneys. (lu.se)
  • Using a wound healing assay, we also showed that SOX9 positively regulated the migratory capacity of PTECs. (lu.se)
  • C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)
  • Relationship between ETS Transcription Factor ETV1 and TGF-ß-regulated SMAD Proteins in Prostate Cancer. (ouhsc.edu)
  • Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
  • Second, Mutated enhancer box (E-box) of VGF promoter showed a significant response to this basic helix-loop-helix (bHLH) transcription factor, which suggested an indirect regulatory mechanism for controlling VGF expression by NPAS3. (frontiersin.org)
  • Furthermore, ectopically expressed NPAS3 in PC12 cells produced parallel responses for nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB (P65)] expression, which specifies that NPAS3 regulates VGF through the NF-κB signaling pathway. (frontiersin.org)
  • In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)
  • Transforming growth factor-beta (TGF-beta) signaling in naive T cells induces expression of the transcription factor Foxp3, a 'master' regulator of regulatory T cells (T(reg) cells). (nih.gov)
  • These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses. (nih.gov)
  • In conclusion, our results indicate that DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns in zebra finch telencephalon. (ugent.be)
  • This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. (elifesciences.org)
  • The aim of this dissertation is to identify and charaterize the factor(s) that binds the TRR and regulates NCF2 expression in response to TNF-alpha. (montana.edu)
  • Mechanistically, Foxi2 stimulated AgRP expression by directly binding to it and activating its transcription. (figshare.com)
  • Collectively, our data suggest that Foxi2 plays an important role in controlling energy metabolism by regulating AgRP expression. (figshare.com)
  • Strikingly, expression of theMtCEP7 and MtCLE13 peptide hormone encoding genesregulating antagonistically nodulation similarly involves the MtCRE1 cytokinin receptor and the MtNIN transcription factor. (u-psud.fr)
  • To our knowledge, this is the first example in plants where a specific transcription factor coordinates the expression of two antagonistic peptide hormones belonging to different families and regulating antagonistically the same developmental process. (u-psud.fr)
  • Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma brucei. (ox.ac.uk)
  • Molecular evidence showed ectopic expression of a MYB-type transcription factor LOC_Os05g46610 was responsible for the phenotype of rlm1-D. A series of experiments, including the transcription factor -centered technology , DNA -binding assay, and electrophoretic mobility shift assay , verified that RLM1 can bind to the promoter of OsCAD2, a key gene responsible for lignin biosynthesis in rice . (bvsalud.org)
  • Gene expression must be appropriately maintained to regulate development, differentiation, and proliferation of cells. (intechopen.com)
  • These findings suggest an important role for GTF2IRD1 in regulating the level and topology of rod and cone gene expression, and in maintaining normal retinal function. (wustl.edu)
  • Moreover, by using a GAL4-Sp1 fusion protein, we have directly demonstrated that Rb positively regulates Sp1 transcriptional activity in vivo. (umn.edu)
  • The results provide an interesting example of co-evolution of a circRNA, and its host-encoded protein product, that regulate each other's function, to directly impact the fundamental process of neurogenesis. (savesome.green)
  • In addition to protein-coding transcripts, estrogen can regulate long non-coding RNA (lncRNA) transcripts, plus diverse non-coding RNAs including antisense, enhancer, and intergenic. (kean.edu)
  • Here we report the importance of general transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) in maintaining M cone cell identity and function as well as rod function. (wustl.edu)
  • This gene provides instructions for making a protein known as transcription factor AP-2β. (medlineplus.gov)
  • Upstream transcription factor (USF) 1 belongs to the basic helix-loop-helix leucine zipper family and serves as a cellular transcription factor (TF). (spandidos-publications.com)
  • implying that this complex has functional roles that extend beyond its ability to regulate cell adhesion. (jneurosci.org)
  • OsMAPK10 positively regulated the lignin content in the leaves and stems of rice . (bvsalud.org)
  • Using Anatomics (anatomical phenotyping) coupled with GWAS, we identified and then validated a bHLH transcription factor that regulates the formation of root cortical aerenchyma, an important phenotype for water and nutrient acquisition. (psu.edu)
  • The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. (ox.ac.uk)
  • The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. (ox.ac.uk)
  • however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. (ox.ac.uk)
  • We designed and executed a massively parallel reporter assay (MPRA) to investigate the effect of transcription factor binding motifs and local sequence context on p53-bound CRE activity. (whiterose.ac.uk)
  • RNA stability assay was applied to characterize the mechanism of C1QBP regulating XDH transcription. (medsci.org)
  • Methylmercury (MeHg) exposure has been related to amyotrophic lateral sclerosis (ALS) pathogenesis and molecular mechanisms of its neurotoxicity has been associated to an overexpression of the Restrictive Element 1 Silencing Transcription factor (REST). (nih.gov)
  • Estrogen drives key transcriptional changes in breast cancer and stimulates breast cancer cells' growth with multiple mechanisms to coordinate transcription and translation. (kean.edu)
  • Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)
  • For instance, a previous study by the authors validated that USF1 binds to the core promoter of APOBEC3G and increases its transcription level in hepatocytes ( 7 ). (spandidos-publications.com)
  • C-terminally Encoded Peptides (CEPs) and CLAVATA3-like (CLE) signaling peptides positively and negatively regulate nodulation, respectively, through independent systemic pathways, but how these regulations are coordinated remains unknown. (u-psud.fr)
  • DNA methylation regulates transcripti. (ugent.be)
  • Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). (springer.com)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered by cells overexpressing DEFB1 , suggesting that this may be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • Transcription of nhr-67 is downregulated following post-translational degradation of its direct upstream regulator, HLH-2 (E/Daughterless) in VU cells. (elifesciences.org)
  • These results indicate that Rb can function as a positive regulator of transcription and that Sp1 is one potential target, either directly or indirectly, for transcriptional regulation by Rb. (umn.edu)
  • In conclusion, we have identified a novel regulator of NCF2 transcription and have further characterized the features of PLAGL2 binding and recognition of the TRR sequence in the intragenic region of NCF2. (montana.edu)
  • VGF and other neuropeptides such as secretogranin II and neuropeptide Y (NPY) are regulated in the hippocampus when voluntary exercise was employed as a mood stimulator. (frontiersin.org)
  • The vital and functionally limiting cytosolic component of the NADPH oxidase, p67 phox, is transcriptionally regulated by TNF-alpha at the TNF-alpha Responsive Region (TRR) in the intragenic region of Neutrophil Cytosolic Factor 2 (NCF2), the gene which codes for p67 phox. (montana.edu)
  • Upstream transcription factor 1 (USF1) is a canonical transcription factor (TF) and is associated with the pathogenesis of several cancers, but its biological functions and molecular targets in HCC remain unclear. (spandidos-publications.com)
  • Genome-wide association studies (GWAS) identified a single nucleotide polymorphism (SNP) mapping to a root cortex-expressed gene encoding transcription factor bHLH121. (psu.edu)
  • These complexes often have a universal reach throughout the genome with an overarching role in the regulation of transcription (Lonard & OMalley 2012). (biodiversityhotspot.org)
  • We have demonstrated that the retinoblastoma gene product (Rb) can positively regulate transcription from the fourth promoter of the insulinlike growth factor II gene. (umn.edu)
  • The activity of the promoter can therefore be regulated differently in different cells. (lu.se)
  • The dendritic phenotype observed after erbin depletion is rescued by overexpression of δ-catenin and requires a domain in δ-catenin that has been shown to regulate dendritic branching. (jneurosci.org)
  • Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. (nature.com)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that β-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • A multisubunit enzyme complex that regulates GENETIC TRANSCRIPTION by deacetylating the HISTONE residues of NUCLEOSOMES. (bvsalud.org)
  • but how these cell states are regulated in the context of development is not well understood. (elifesciences.org)
  • PI3Kα inhibitors, now in late-stage clinical development, elicit a robust compensatory increase in ER-dependent transcription that limits therapeutic efficacy. (bgu.ac.il)
  • [ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)
  • Summary of the presentations and discussions held at the symposium NF-KB, a Prototypical Cytokine-Regulated Transcription Factor: Implications for Alcohol-Mediated Responses, held during the Joint RSMSBRA meeting in Washington, D.C. in June 1996. (umassmed.edu)
  • Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
  • Notably, a nucleus-resident actin (R62D NLS ) also regulates SRF's transcriptional activity. (jneurosci.org)
  • Nevertheless, recruitment to nuclear receptors and additional sequence-specific transcription elements implies that coregulator activity can be directed to particular genomic loci resulting in particular adjustments in gene rules. (biodiversityhotspot.org)
  • The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
  • Finally, through identification of PLAGL2 binding partners, we have begun to determine a model by which PLAGL2 regulates transcription in a context dependent manner. (montana.edu)
  • We found that BRCA1 is phosphorylated at S1524 by the kinases ataxia-telangiectasia mutated and ATR during gene activation, and that this event is important for productive transcription. (elsevierpure.com)
  • After identification of the candidate transcription factor(s) that can be regulated by MDI-exposure, we investigate the roles of the candidate transcription factor in regulation of these candidate M2 macrophage associate markers and chemokines in relation to the exposure to MDI. (cdc.gov)
  • These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of δ-catenin. (jneurosci.org)
  • Our studies identify PML and SATB1 as a regulatory complex that governs transcription by orchestrating dynamic chromatin-loop architecture. (pasteur.fr)
  • Because many trypanosomatid parasites have divergent ESB1 orthologues yet do not undergo antigenic variation, ESB1 probably represents an important class of transcription regulators. (ox.ac.uk)
  • TFAP2B variants alter the structure of transcription factor AP-2β. (medlineplus.gov)
  • Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)