Regulates the proliferation and differentiation of hematopoietic cells. Medical search. Frequent questions

The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. (nature.com)
3 STAT5 regulated signaling controls important functions of innate and acquired immunity, hematopoiesis, and also growth and survival of many cell types in different organs responding to extracellular cytokines. (nature.com)
Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. (joplink.net)
The receptor tyrosine kinase FLT3 is of importance for proliferation, survival and differentiation of hematopoietic cells and is frequently mutated in acute myeloid leukemia. (lu.se)
Most are involved in regulating processes such as the growth and division (proliferation), maturation (differentiation), or survival of cells. (medlineplus.gov)
For example, the protein produced from the FLT3 gene stimulates the proliferation and survival of cells. (medlineplus.gov)
Although the proteins produced from two other genes involved in CN-AML, IDH1 and IDH2 , are not normally involved in proliferation, differentiation, or survival of cells, mutations in these genes lead to the production of proteins with a new function. (medlineplus.gov)
MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. (sunnybrook.ca)
The PI3K-Akt pathway is a similarly conserved signalling pathway which regulates processes such as differentiation, proliferation and survival. (ox.ac.uk)
In this so-called "niche", a variety of cytokines and growth factors regulate survival as well as proliferation and differentiation capacities of CPC. (baselstemcells.ch)
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. (cusabio.com)
Upregulate the expression in various malignant diseases, and play a role in promoting cancer proliferation, tumor survival and metastasis by activating JAK / STAT3, RAS / ERK, PI3K / mTOR and other signaling pathways. (creative-proteomics.com)
In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)

My research is focused on how the composition of the immune system is regulated, starting at the level of the hematopoietic stem cell. (texaschildrens.org)
We are interested in the ways that such short term hematopoietic stem cell responses may ultimately contribute to syndromes of bone marrow dysfunction that are related to infection or inflammation, such as bone marrow suppression following tuberculosis and HIV/AIDS or acquired aplastic anemia as a result of EBV infection. (texaschildrens.org)
This research will lead to critical insights into the basic biology of hematopoietic stem cell function, including how inflammation may contribute to hematologic changes seen in aging and cancer. (texaschildrens.org)
Myelodysplastic syndrome (MDS) is a malignant clonal hematopoietic stem cell disorder characterized by the proliferation of bone marrow primordial cells and a decrease in peripheral blood cells ( 1 ). (frontiersin.org)
8. Wright MH, Calcagno AM, Salcido CD, Carlson MD, Ambudkar SV, Varticovski L. Brca1 breast tumors contain distinct CD44 + /CD24 - and CD133 + cells with cancer stem cell characteristics. (southernbiotech.com)
Primary neural stem cells were prepared from the hippocampus of newly born SD rats, and cells were cultured in special stem cell culture medium. (biomedcentral.com)
Incubation of cells with icariin resulted in significant increase in the number of stem cell spheres as well as the increased incorporation of EdU when compared with cells exposed to control vehicle. (biomedcentral.com)
This study evidently demonstrates the potentiating effect of ICA on neural stem cell growth and proliferation, which might be mediated through regulation of cell cycle gene and protein expression promoting cell cycle progression. (biomedcentral.com)
We have established an influence of both compromised genomic maintenance (nuclear and mitochondrial), and alterations in external growth control to these processes, which also have direct relevance for the stability and potential reversibility of the aging stem cell state. (lu.se)
The Division of Molecular Hematology (DMH) aims to generate new knowledge about the regulation of blood cell development by applying recent advances in stem cell technology, in order to dissect the molecular regulation of hematopoiesis. (lu.se)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

MicroRNA (miRNA) belongs to the family of single-stranded noncoding RNA with approximately 22 nucleotides that negatively regulates the target genes at the posttranscriptional level, which is involved in a wide range of biological processes [ 11 ]. (hindawi.com)
Research in the Paralkar Lab spans the spectrum from human patient sample studies and mouse models to cutting-edge molecular biology tools, high-throughput sequencing approaches, and novel computational algorithms, all with the goal of gaining insight into how the transcription of coding genes and noncoding ribosomal DNA genes is regulated in hematopoietic stem cells, myeloid progenitors, and in leukemia. (upenn.edu)
The proteins produced from these genes have different functions in the cell. (medlineplus.gov)
The proteins produced from the CEBPA and DNMT3A genes regulate gene activity and help to control when cells divide and how they mature. (medlineplus.gov)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
the number of up-regulated genes was 4.38-times higher than the number of down-regulated genes. (bvsalud.org)
The NK3-4 treatment induced the differential transcription of genes in 1794 GO functional groups, with 1531 functional groups containing up-regulated genes. (bvsalud.org)
Specific growth-related genes up-regulated by NK3-4 are involved in biological processes, including responses to auxin, hormone biosynthesis, cellular component biogenesis, root system development, and other functions. (bvsalud.org)
The transcriptome analysis revealed 1137 and 239 rice genes with EsxA-induced up-regulated and down-regulated transcription levels, respectively. (bvsalud.org)
At 48 h after the EsxA treatment, the transcription of 611 and 160 genes was up-regulated and down-regulated, respectively, compared with the transcription levels for the untreated control at the same time-point. (bvsalud.org)
Many disease resistance-related PR genes had up-regulated transcription levels. (bvsalud.org)
EsxA triggered rice ISR to seedling blight and gene differential transcription, including the up-regulated transcription of rice PR genes. (bvsalud.org)
By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
Further, the mechanism of ICA-induced cell proliferation of neural stem cells was investigated by analyzing the gene and protein expression of cell cycle related genes cyclin D1 and p21. (biomedcentral.com)
In addition, it was found that icariin-induced effect on neural stem cells is associated with increased mRNA and protein expression of cell cycle genes cyclin D1 and p21. (biomedcentral.com)
Three amino acid substitutions in R2 alter the way Myb regulates genes and determine the leukemogenicity of the retrovirally transduced v-Myb oncogene. (mdc-berlin.de)
C-Myb binding facilitates histone tail acetylation, which is mandatory during activation of prevalent differentiation genes in conjunction with CCAAT enhancer-binding proteins (C/EBP). (mdc-berlin.de)
Leukemogenic mutations in v-Myb eliminate the interaction with H3 and acetylation of H3 tails and abolish activation of endogenous differentiation genes. (mdc-berlin.de)
In primary v-myb-transformed myeloblasts, pharmacologic enhancement of H3 acetylation restored activation of differentiation genes and induced cell differentiation. (mdc-berlin.de)
Our data link a novel chromatin function of c-Myb with lineage-specific expression of differentiation genes and relate the loss of this function with the leukemic conversion of Myb. (mdc-berlin.de)
IL-11 can regulate the expression of plasma protein genes in hepatocytes and induce acute phase protein production. (creative-proteomics.com)
More recently we have demonstrated that C/EBPβ regulates the expression of several genes involved in inflammatory processes and brain injury [ 14 ] and mice lacking C/EBPβ showed a reduced inflammatory response after kainic acid injection and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus [ 15 ]. (biomedcentral.com)
The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. (tgf-a.com)
Cardiovascular ageing is found to be significantly associated with common or rare variants in genes regulating sarcomere homeostasis, myocardial immunomodulation, and tissue responses to biophysical stress. (cdc.gov)

The maintenance of stem or progenitor cell fate relies on intrinsic factors as well as local cues from the cellular microenvironment and systemic signaling. (sdbonline.org)
The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. (biomedcentral.com)
In this study, we investigated how higher-order chromatin structure modulates differential expression of the human INK4b-ARF-INK4a locus during progenitor cell differentiation, cellular ageing and senescence of cancer cells. (biomedcentral.com)
During progenitor cell differentiation and ageing, PcG silencer EZH2 attenuates, causing loss of PRC binding and transcriptional activation of INK4b and INK4a . (biomedcentral.com)
Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. (biomedcentral.com)
The INK4b-ARF-INK4a tumor suppressor locus (Figure 1A ) plays a central role in controlling the equilibrium between progenitor cell renewal and cancer risk [ 1 - 8 ]. (biomedcentral.com)
By studying murine transgenic leukemia models developed in our laboratory, we are currently exploring the relationships between hematopoietic progenitor cell identities and the development and progression of acute leukemia. (lu.se)

The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. (wikipedia.org)
MDS was found to be related to genetic mutations or epigenetic modifications, which lead to abnormal autophagy, apoptosis of mature cells, chromosomal abnormalities, and a high level of inflammation in the bone marrow microenvironment ( 4 - 8 ). (frontiersin.org)
Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. (cusabio.com)
In the early stages of MDS, the main cause of cytopenias is increased apoptosis (programmed cell death). (medscape.com)

Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found. (nature.com)
Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling. (lu.se)
SOCS2 is known to regulate signal transduction by cytokine receptors and receptor tyrosine kinases. (lu.se)
Dive into the research topics of 'Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling. (lu.se)
MSC-mediated inhibition of T-cells is also associated with a reduction in inflammatory cytokine production. (uu.se)
Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. (thermofisher.com)
Interleukin (IL) -11 is an IL-6 family cytokine found in primate bone marrow stromal cells with a molecular weight of 23KD. (creative-proteomics.com)
IL-11 is a cytokine produced by hematopoietic microenvironmental stromal cells with multiple functions. (creative-proteomics.com)
Pathophysiologically, asthma exert different effects at different concentrations, can is characterized by constriction of airway smooth synergize or antagonize the effects of other cytokines muscle, hyper secretion of mucus, edema and airway and regulated in a complex manner and function via hyper responsiveness (AHR),[3] mucus secretion and cytokine cascade. (cdc.gov)

The FLT3 ligand itself does not stimulate the proliferation of early hematopoietic cells, but rather synergistically induces growth and differentiation with other CSFs and interleukins. (biofargo.com)
IL-11 cooperates with IL-3 and IL-4 to stimulate the proliferation of hematopoietic stem cells at rest, and affects the generation and differentiation of red blood cells. (creative-proteomics.com)

In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
Thus, we suggest that SOCS2 associates with activated FLT3 and negatively regulates the FLT3 signaling pathways. (lu.se)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Mice with disrupted Notch and PI3K signalling show phenotypic similarities during haematopoietic cell development, suggesting functional interaction between these pathways. (ox.ac.uk)
Such cell-based therapy is likely to simultaneously target several different immunological pathways, thereby utilizing numerous physiological mechanisms for re-establishing immune tolerance and induction of cellular repair mechanisms. (uu.se)
IL-23-dependent, IL-17A-producing CD4+ T cells (Th-17 cells) have been identified as a unique subset of Th cells that develops along a pathway that is distinct from the Th1- and Th2- cell differentiation pathways. (thermofisher.com)
However, depletion of beta-catenin failed to completely revert phenotype seen in Fam13-/- mice, suggesting additional pathways regulated by FAM13A may play a role in the lung repair/regeneration process. (hhs.gov)

A broader interest of our laboratory is to understand the molecular regulation of HSCs both from the perspectives of self-renewal and differentiation, and how these features become altered upon disease-causing or disease-associated perturbations. (lu.se)

We found that Syp, a phosphotyrosine phosphatase, widely expressed in all tissues in mammals became phosphorylated on tyrosine after stimulation with Epo in M07ER cells engineered to express high levels of human EpoR. (drugbank.com)
Little is known however about how rRNA transcription is regulated and fine-tuned across normal and malignant tissues, and whether this regulation can be targeted for leukemia treatment. (upenn.edu)
In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)

The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
Tregs may lose Foxp3 expression or be reprogrammed into cells that produce proinflammatory cytokines, for example, Th1-like Tregs, Th2-like Tregs, Th17-like Tregs, and Tfh-like Tregs. (bvsalud.org)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

18 Both enzymes, OGT and OGA as well as multiple O-GlcNAcylated proteins are enriched at sites of active transcription in human cells. (nature.com)
This review focuses on an up-to-date understanding of the functions of E3 ligases in cancers and debates the perspectives of cancer cells that rely on inhibition or activation of ubiquitylation of target proteins. (bmbreports.org)
The Paralkar Lab is interested in gaining a detailed mechanistic understanding of how chromatin proteins regulate the stemness-differentiation balance, and how mutations in them produce malignancy. (upenn.edu)
Proteins that regulate the proliferation and differentiation of hematopoietic cells. (foobrdigital.com)
Rohrschneider focused initially on cell-surface proteins in cells infected with avian oncorna viruses, identifying the envelope and group-specific antigens (gag proteins). (fredhutch.org)
The isolation of temperature-sensitive transformation-defective mutants of Rous sarcoma virus led to the hypothesis that the viral protein or proteins should be temperature-sensitive in its expression or function, and Dr. John Wyke and Rohrschneider found that expression of some of the cell-surface tumor antigens correlated with transformation, suggesting that they were under control of the transforming gene. (fredhutch.org)
p15 INK4b and p16 INK4a are closely related proteins and both act on the Rb-pathway through the inhibition of the proliferation-promoting cyclin-dependent kinases CDK4 and CDK6. (biomedcentral.com)
Besides, IL-11 can increase the production of proteins in the liver during acute inflammation, and inhibit the formation of fat cells. (creative-proteomics.com)

Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
They reduce the generation and differentiation of dendritic cells and B-cells, and down regulate NK cell cytotoxicity and proliferation. (uu.se)

The presence of neurotransmitter receptors in microglia illustrates their functional connection to neurons and this receptor activation could cause microglial cells to perform different activation phenotypes ( Pocock and Kettenmann, 2007 ). (frontiersin.org)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
Notably, inhibition of GPR171 synergistically enhanced the tumoricidal activity of an epidermal growth factor receptor (EGFR) inhibitor in lung cancer cells. (oncotarget.com)
Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals. (sunnybrook.ca)
Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling. (sunnybrook.ca)
It is secreted by activated keratinocytes and monocytes, and signals through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. (watson-int.cn)
FLT 3-ligand binds to cells expressing tyrosine kinase receptor FLT3. (biofargo.com)
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)
Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
Around this time, Dr. Chuck Sherr at St. Jude's and Dr. Richard Stanley at Albert Einstein identified the normal cellular Fms protein as the cell surface receptor for a growth factor known as the macrophage colony-stimulating factor or M-CSF. (fredhutch.org)
This was one of the initial discoveries that mutations in a cell surface receptor could initiate oncogenesis, just one year after the avian erythroblastosis virus oncogene was found to be a mutant EGF receptor. (fredhutch.org)
Rohrschneider became fascinated by the challenge of working on the normal function of the M-CSF receptor and understanding how it regulates macrophage function. (fredhutch.org)
Analogous to bone marrow-derived progenitor cells, CPC exhibit receptor systems that are responsive to hematopoietic growth factors and similar systems may be expressed on cardiomyocytes. (baselstemcells.ch)
Interleukin-1 receptor-associated kinase 4 (IRAK4) was the dominant alternatively spliced isoform in MDS and AML and is characterized by a longer isoform that retains exon 4, which encodes IRAK4-long (IRAK4-L), a protein that assembles with the myddosome, results in maximal activation of nuclear factor kappa-light-chain-enhancer of B cells (NF-κB) and is essential for leukaemic cell function. (cancer-genetics.org)
[ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)
In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan. (southernbiotech.com)
The Paralkar Lab has identified that key hematopoietic and leukemic transcription factors bind to rDNA and regulate rRNA transcription, and we are interested in understanding how the binding of cell-type-specific transcription factors regulates the activity of Polymerase I and the transcription of rRNA in normal hematopoiesis, and how this regulation is co-opted in leukemia to drive abundant ribosome biogenesis. (upenn.edu)
The NPM1 gene provides instructions for a protein that is likely involved in the regulation of cell growth and division. (medlineplus.gov)
Context-dependent regulation of hematopoietic lineage choice by HEBAlt. (sunnybrook.ca)
They also showed that cross-regulation between col and eya in muscle progenitor cells is required for specification of muscle identity, revealing a new parallel between the myogenic regulatory networks operating in Drosophila and vertebrates. (sdbonline.org)
Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (edu.au)
2 Macrophages' other roles include removal of senescent cells, antigen presentation, immune-regulation, and tissue repair. (mhmedical.com)
Together with Otmar Pfister, a clinical cardiologist and director of the division Heart Failure and Transplantation, they are studying the regulation and role of heart-resident cardiac progenitor cells (CPC) in this remodeling process. (baselstemcells.ch)
Development and homeostasis require the coordinate regulation of cell proliferation and differentiation. (biomedcentral.com)
Aberrant regulation of blood cell formation underlies a wide range of hematological disorders, including leukemia. (lu.se)

Inflammation, oxidative stress, and aging have been proven to contribute to cardiac fibrosis, which is regulated by multiple factors [ 7 - 9 ]. (hindawi.com)
Importantly, this article elucidates a plausible mechanism by which microglia regulate inflammation and neurogenesis in ameliorating MDD. (frontiersin.org)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
IL-20 has functions of regulating proliferation and differentiation of keratinocytes during inflammation, and causing cell expansion of multipotential hematopoietic progenitor cells. (watson-int.cn)
IL-11 is an anti-inflammatory factor that can inhibit inflammation by directly acting on macrophages and NK cells. (creative-proteomics.com)
CCL5 is a unique chemokine with distinct stage and cell-type specificities for regulating inflammation, but how these specificities are achieved and how CCL5 modulates immune responses is not well understood. (nature.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
Mast cells play an important role in a variety of biological processes including allergic reactions, atherosclerosis and inflammation 7,8 . (bvsalud.org)

Normal hematopoiesis requires an intricate balance in the bone marrow between the ability of stem cells to maintain themselves for decades of life while producing billions of mature blood cells every day. (upenn.edu)
The production of circulating erythrocytes, leukocytes and platelets from undifferentiated stem cells, is called hematopoiesis. (foobrdigital.com)
All 3 cell lineages in myeloid hematopoiesis can be involved, including erythrocytic, granulocytic, and megakaryocytic cell lines. (medscape.com)
Hematopoiesis, in particular the genetic control of hematopoietic cell proliferation and differentiation is also studied in human cell cultures and transgenic mouse model systems. (lu.se)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
However, all developmental processes originate from pluripotent precursor cell types. (amegroups.org)
The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
How developmental trajectories are encoded in the genome and how the interplay between intrinsic and extrinsic processes regulates development is one of the major questions in developmental biology. (amegroups.org)
In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)
PcG silencers bind and coordinately regulate INK4b and INK4a , but not ARF , during a variety of physiological processes. (biomedcentral.com)
Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. (tgf-a.com)
We have developed and applied FACS-based high-resolution cell fractionation procedures to map the differentiation processes from HSCs. (lu.se)
A sub line of our research deals with how proliferation dynamics, at defined cellular stages, associate with these processes. (lu.se)
Mast cells play an important role in a variety of biological processes and actively participate in the inflammatory response. (bvsalud.org)

Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors. (sunnybrook.ca)
In the lymph gland , an hematopoietic organ in Drosophila larva, a group of cells called the Posterior Signaling Centre (PSC), whose specification depends on the EBF transcription factor Collier (Col) and the HOX factor Antennapedia (Antp), has been proposed to form a niche required to maintain the pool of hematopoietic progenitors (prohemocytes). (sdbonline.org)
In contrast with this model, this study shows that genetic ablation of the PSC does not cause an increase in blood cell differentiation or a loss of blood cell progenitors. (sdbonline.org)
Collier is expressed in a core population of lymph gland progenitors and cell autonomously maintains this population. (sdbonline.org)
The PSC contributes to lymph gland homeostasis by regulating blood cell differentiation, rather than by maintaining core progenitors. (sdbonline.org)
In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. (thermofisher.com)
NSCs can be cultured in vitro as neurospheres that are composed of neural stems cells and progenitors. (biomedcentral.com)
During repair/regeneration process, tissue progenitor cells require optimal amount of energy supplies to fulfill cell proliferation and differentiation demands, which has been well documented in stem cells in other organs such as intestine stem cells, neuro-progenitors and hematopoietic stem cells. (hhs.gov)
However, whether and how Fam13a regulates alveolar repair/regeneration, especially through modulating metabolism in lung epithelial progenitors remain incompletely understood. (hhs.gov)
Our unpublished data suggested that Fam13a not only responds to Akt-mediated growth factor signaling but also represses the energy master regulator AMPK (c-AMP activated kinase) in cell lines and primary murine lung epithelial cells, suggesting an undiscovered metabolic control by Fam13a in lung epithelial progenitors. (hhs.gov)

Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
Overexpression of FLI1 in erythroblasts causes inhibition of differentiation and ultimately the development of pre-T cell lymphoblastic leukemia/lymphoma [ 11 ]. (biomedcentral.com)
We propose that the PI3K-Akt pathway exerts its influence on Notch primarily via inhibition of GSK3-beta, a kinase known to phosphorylate and regulate Notch signals. (ox.ac.uk)
Inhibition of IRAK4-L abrogates leukaemic growth, particularly in AML cells with higher expression of the IRAK4-L isoform. (cancer-genetics.org)

We observed that SOCS2 associates with activated FLT3 through phosphotyrosine residues 589 and 919, and co-localizes with FLT3 in the cell membrane. (lu.se)
SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5. (lu.se)
Furthermore, SOCS2 expression leads to a decrease in FLT3-ITD-mediated cell proliferation and colony formation. (lu.se)
FLT3 ligand is a growth factor that regulates the proliferation of early hematopoietic cells. (biofargo.com)
Unlike SCF, FLT3 ligand has no effect on mast cells. (biofargo.com)
In ongoing projects, the group is currently studying how reactive oxygen species and hematopoietic growth factors including Flt3 ligand and erythropoietin regulate the function and fate of CPC and cardiomyocytes. (baselstemcells.ch)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)

the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. (medlineplus.gov)
Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. (medlineplus.gov)
HEBAlt enhances the T-cell potential of fetal myeloid-biased precursors. (sunnybrook.ca)

The neutrophil maturation and differentiation pathway termed myelopoiesis takes approximately 12 days. (medscape.com)
All are characterized by a hypercellular or hypocellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. (medscape.com)

Accumulating studies have revealed that miRNAs that participate in the myocardial fibrotic program, such as miR-18a-5p, attenuate cardiac fibrosis via regulating the Notch2 pathway [ 13 ], and miR-24-3p alleviates myocardial fibrosis through PHB2 [ 14 ]. (hindawi.com)
For instance, miR-409-3p promotes epithelial to mesenchymal transition and tumor growth in prostate cancer and also accelerates osteoblastic differentiation through the Wnt/ β -catenin pathway [ 17 , 18 ], a crucial pathway in regulating cardiac fibrosis. (hindawi.com)
HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation. (sunnybrook.ca)
RESULTS: We show that cellular responsiveness to Notch signals depends on the activity of the PI3K-Akt pathway in cells as diverse as CHO cells, primary T-cells and hippocampal neurons. (ox.ac.uk)
Induction of the endogenous PI3K-Akt pathway in CHO cells (by the insulin pathway), in T-cells (via TCR activation) or in neurons (via TrKB activation) potentiates Notch-dependent responses. (ox.ac.uk)
Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. (tgf-a.com)

PAK2 kinase activity is stimulated by transforming growth factor β in fibroblasts, by proteinase inhibitor alpha2-macroglobulin binding to GRP78 in prostate cancer cells, by its phosphorylation by AMP-activated protein kinase in stem and cancer cells and eryptosis. (wikipedia.org)
Notably, transfection with miR-409-3p mimics promoted the proliferation of cardiac fibroblasts and fibroblast-to-myofibroblast differentiation, accompanied by upregulated expression of Col1a1, Col3a1, and α -SMA. (hindawi.com)
They promote the proliferation of fibroblasts, fibroblast-to-myofibroblast transdifferentiation (FMT), and ECM accumulation [ 10 ]. (hindawi.com)
We found that INK4b and INK4a , but not ARF , are upregulated following the differentiation of haematopoietic progenitor cells, in ageing fibroblasts and in senescing malignant rhabdoid tumour cells. (biomedcentral.com)

Loss‑of‑function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain‑of‑function NOTCH1 mutations are late events during T‑cell leukemogenesis and B‑cell lymphomagenesis. (spandidos-publications.com)
He also went proto-oncogene hunting, cloning out the normal cell version of the Fms oncogene and identifying the mutations that make it oncogenic. (fredhutch.org)
Activating mutations upstream may also underlie some epigenetic or within the ERK1/2 cascade are events that change cell signalling. (who.int)

Expression of CD44 3'-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis. (sunnybrook.ca)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)

In this regard, we have demonstrated that C/EBPβ serves as a critical factor in neuronal differentiation [ 13 ]. (biomedcentral.com)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)

rRNA transcription rates vary dramatically between different normal cell types in the hematopoietic tree, and leukemic cells have characteristic prominent nucleoli, indicating robust ribosome synthesis. (upenn.edu)
As the disease progresses and converts into leukemia, further gene mutation occurs, and a proliferation of leukemic cells overwhelms the healthy marrow. (medscape.com)

and miR-23b and miR-137 inhibits PAK2 expression in tumor cells. (wikipedia.org)
PAK2 activity negatively regulates the function and expression of c-Myc: PAK2 phosphorylation of c-Myc at T358-S373-T400 inhibits its transactivation function and PAK2 depletion stimulates c-Myc expression during granulocyte-monocyte lineage. (wikipedia.org)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
In patients with breast cancer, expression of FLI1 is strongly correlated with advanced stage, poor differentiation, and lymph node metastasis. (biomedcentral.com)
In non-small cell lung cancer, the FLI1 expression score is associated with the stage of SCLC. (biomedcentral.com)
Moreover, targeted knockdown and rescue experiments indicate that Col expression is required in the prohemocytes to prevent their differentiation. (sdbonline.org)
Considered together, these findings imply that NK3-4 may promote plant growth and enhance stress resistance by regulating gene expression, making it a potentially useful microbe for regulating rice growth and stress resistance. (bvsalud.org)
Neural stem cells were confirmed by immunofluorescence detection of nestin, NSE and GFAP expression. (biomedcentral.com)
Expression of the INK4b-ARF-INKa locus during cellular ageing and differentiation . (biomedcentral.com)
Here we identify two stage-specific enhancers: the proximal enhancer mediates the constitutive CCL5 expression during the steady state, while the distal enhancer located 1.35 Mb from the promoter induces CCL5 expression in activated cells. (nature.com)
Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse models. (nature.com)
Recent studies using neutralizing anti-CCL5 antibodies have suggested that the constitutive expression of CCL5 plays a regulatory role in maintaining tissue-resident memory (Trm) T cells in the human vaginal tract 9 and mouse skin 10 , suggesting that constitutive CCL5 expression in noninflamed conditions, hereafter referred to as homeostatic CCL5 expression, might be important for homeostasis of tissue-resident lymphocytes. (nature.com)
Other studies reported that some cancer cells could repress their own CCL5 expression to hinder migration of anticancer immune cells toward cancer sites 15 , 16 . (nature.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)
When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)

Promotes also differentiation and proliferation of hematopoietic cells. (joplink.net)
The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche. (sdbonline.org)
The present study showed that icariin promotes the growth and proliferation of neural stem cells from rat hippocampus in a dose-dependent manner. (biomedcentral.com)
In last funding cycle, we have published that Fam13a promotes the degradation of beta-catenin and inhibits cell growth. (hhs.gov)

Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature. (sunnybrook.ca)
The NSCs can grow and multiply in vitro medium, and then be activated to differentiate into different nerve cells to be transplanted within the brain to replace damaged cells. (biomedcentral.com)
In this regard, the growth and proliferation of the neural stem cells in vitro are critical as the number of cells available for transplantation is essential to achieve beneficial effect in replacing injury or loss of the neuronal cells. (biomedcentral.com)
In this work we have found that C/EBPβ regulates C3 levels in rodents glial in vitro and in the rat Substantia nigra pars compacta (SNpc) in vivo following an inflammatory insult. (biomedcentral.com)

On luminal surface of intestinal epithelial cells, divalent metal transporter 1 (DMT-1) is present, through which ferrous form of iron is actively transported. (foobrdigital.com)
Our published work has demonstrated that FAM13A is mainly expressed in alveolar type II epithelial cells, regarded as lung stem cells. (hhs.gov)
We, therefore, hypothesize that FAM13A may act as a key metabolic switch for cell growth through coupling energy homeostasis with cell growth demands in alveolar epithelial cells during lung regeneration. (hhs.gov)
Initial infection is thought to occur in the oral (tonsillar) compartment and the host cells of EBV are mainly lymphocytes and epithelial cells. (juniperpublishers.com)

The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
Moreover, they increase the percentage of regulatory T-cells, and suppress effector T-cell proliferation in response to nominal antigens or alloantigens. (uu.se)
Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

The Paralkar Lab has developed customized genomes and computational pipelines to map datasets to rDNA, and we are interested in developing advanced tools to map and interpret the genetic and epigenetic profiles of rDNA in normal and malignant cells. (upenn.edu)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

Using a CRISPR Cas9-guided immunoprecipitation assay, we identify a circular RNA in the FLI1 promoter chromatin complex, consisting of FLI1 exons 4-2-3, referred to as FECR1.Overexpression of FECR1 enhances invasiveness of MDA-MB231 breast cancer cells. (biomedcentral.com)

Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. (joplink.net)
Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)

In recent years, it has been an active research area to replace neural tissue loss through transplantation of neural stem cells (NSCs) for the treatment of AD [ 3 ]. (biomedcentral.com)
For the reconstruction of bone marrow hematopoietic function after bone marrow transplantation and radiotherapy Sexual blood cell deficiency is of great value. (creative-proteomics.com)

This work provides insight into how immune cells are sustained during infection, when the demand for immune effector cells is dramatically increased. (texaschildrens.org)
The hallmark effector molecules of Th1 and Th2 cells, e.g. (thermofisher.com)

The host immune system can be viewed as a product of hematopoietic stem cells that reside in the bone marrow. (texaschildrens.org)
We have found that inflammatory signals, particularly interferon gamma, influence the proliferation and differentiation of hematopoietic stem cells during infection, thus shaping the immune response as a whole. (texaschildrens.org)
As the immune cells of the central nervous system (CNS), microglia could influence neurogenesis through the M1 and M2 subtypes, and these may promote depressive-like behaviors. (frontiersin.org)
Microglial cells are the brain's immune cells in the CNS. (frontiersin.org)
Initial analysis of Collier/Early B Cell Factor function in the lymph gland revealed the role of the Posterior Signaling Center (PSC) in mounting a dedicated cellular immune response to wasp parasitism. (sdbonline.org)
The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Regulatory T cells (Tregs) expressing the Foxp3 transcription factor are indispensable for the maintenance of immune system homeostasis. (bvsalud.org)
They are produced by cells of the innate immune system such as neutrophils, monocytes, and macrophages. (mhmedical.com)
Therefore, host CCL5 can obviously work as an anticancer molecule to mount relevant immune responses against some cancer cells. (nature.com)
The production of distinct blood cell types can be selectively adapted to meet an individual's acute needs, such as for instance the rapid and enhanced generation of innate immune cells following infection. (lu.se)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)

CPC have the capacity to differentiate into all cardiac cell lineages including cardiomyocytes and they play an important role in the maintenance of the myocardial cell homeostasis over a lifespan. (baselstemcells.ch)

Under stress, microglial cells are induced into the M1 type, releasing inflammatory factors and causing neuroinflammatory responses. (frontiersin.org)
Altogether, these results indicate that C3 is a downstream target of C/EBPβ, and it could be a mediator of the pro-inflammatory effects of this transcription factor in neural cells. (biomedcentral.com)
The role of mast cells in the inflammatory dental pulp response is not clear. (bvsalud.org)
Since mast cells are active during inflammatory responses it becomes crucial to find out if these cells are actually present and play a role in dental pulp under normal and inflammatory conditions either in humans or in rats. (bvsalud.org)

NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are cell surface receptors that transduce juxtacrine signals of delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2 from adjacent cells ( 1 - 3 ). (spandidos-publications.com)

Myelodysplastic syndrome (MDS) refers to a heterogeneous group of closely related clonal hematopoietic disorders. (medscape.com)
MDS develops when a clonal mutation predominates in the bone marrow, suppressing healthy stem cells. (medscape.com)

O-GlcNAcylation regulates the transcriptional activity of p53, c-Myc, FoxO1 and CREB, as well as components of the basal transcription machinery, for example, the C-terminal domain of RNA polymerase II. (nature.com)
Given that rRNA accounts for the bulk of the transcriptional output of the cell, the inability to map datasets to rDNA has historically been a major limitation, and has created a significant knowledge gap in our understanding of the most abundant RNA in the cell. (upenn.edu)

We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)
Together, this study shows that the PSC is dispensable for blood cell progenitor maintenance and reveals the key role of the conserved transcription factor Col as an intrinsic regulator of hematopoietic progenitor fate. (sdbonline.org)
The c-Myb transcription factor coordinates proliferation and differentiation of hematopoietic precursor cells. (mdc-berlin.de)

PAK2-mediated phosphorylation of merlin at S518 modulates its tumor suppressor activity, c-Jun phosphorylation at T2, T8, T89, T93 and T286 contributes to the growth of growth factor-stimulated melanoma cells, Caspase-7 phosphorylation at S30, T173 and S239 inhibits apoptotic activity in breast cancer cells, Paxillin phosphorylation at S272 and S274 activates ADAM10 protease, and STAT5 phosphorylation at S779 modulates BCL-ABL-mediated leukemogenesis. (wikipedia.org)

CN-AML is not usually inherited but arises from genetic changes in the body's cells that occur after conception. (medlineplus.gov)
Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
3-8 It has also been associated with use of muromonab-CD3 (OKTS), Coley's toxins, genetic diseases such as inappropriate inflammasome activation or idiopathic multicentric Castleman's disease, CAR T-cell therapy, hemophagocytic lymphohistiocytosis, and most recently SARS-CoV-2 infection. (mhmedical.com)

CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. (southernbiotech.com)

J Cell Biol. (southernbiotech.com)
Mol Cell Biol. (sunnybrook.ca)
Nat Cell Biol. (cancer-genetics.org)

KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4 + T cells. (southernbiotech.com)
Erythropoietin (Epo) regulates the proliferation and differentiation of erythroid precursors. (drugbank.com)
Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt. (sunnybrook.ca)

Blood cell production in the Drosophila hematopoietic organ, the lymph gland , is controlled by intrinsic factors and extrinsic signals. (sdbonline.org)
MSC also protected from diabetes in the non-obese diabetic (NOD) mouse model by inducing regulatory T-cells in pancreatic lymph nodes. (uu.se)

We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)

IL-11 can enhance the differentiation of pluripotent stem cells under the growth factor, and promote the differentiation of B cells that produce immunoglobulin under T cell dependence. (creative-proteomics.com)
This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
These strat- egies provide a robust way to visualize and isolate specific cell pop- ulations of differentiated pluripotent stem cells. (lu.se)

16 Cancer cells exhibit elevated levels of O-GlcNAc, possibly to adjust to stringent metabolic demands and O-GlcNAcylation is a key metabolic regulator of glucose metabolism. (nature.com)

The hypothesis tested in these projects is that the development of TID may be halted at diagnosis by the immunomodulatory properties of mesenchymal stem cells (MSC). (uu.se)
The bone marrow contains not only hematopoietic cells, but also mesenchymal stem cells (MSC). (uu.se)

Insulin stimulation of neuronal cells also antagonizes PAK2 kinase activity, leading to an increased glucose uptake. (wikipedia.org)
Determined by the dose-dependent stimulation of the proliferation of AML5 cells. (biofargo.com)

The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)

This mechanism is regulated by the activities of both protein-tyrosine kinases and protein tyrosine phosphatases. (drugbank.com)
DNA DSB repair signaling contributes to general mechanism for various types of lesions in diverse cell cycle phases. (bmbreports.org)
The purpose of this study was to investigate the potentiating effect of ICA on the proliferation of rat hippocampal neural stem cells, and explore the possible mechanism involved. (biomedcentral.com)

A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (edu.au)

The rate of ribosome production has far-reaching influence on the fate of the cell, and dictates its size, proliferation, and ability to translate global or specific mRNAs. (upenn.edu)
BACKGROUND: Notch plays a wide-ranging role in controlling cell fate, differentiation and development. (ox.ac.uk)
Our goal is to understand, at cellular and molecular levels, what controls HSCs and the fate of other immature blood cells. (lu.se)

IFN gamma and IL-4, have each been found to negatively regulate the generation of these Th-17 cells. (thermofisher.com)

Anatomy53

Organisms14

Diseases9

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes52

Disciplines and Occupations1

Information Science3

Survival14

Stem cell11

Genes24

Progenitor cell7

Apoptosis4

Cytokine10

Stimulate the proliferation2

Pathways7

Self-renewal and differentiation1

Tissues3

Cytokines7

Proteins8

Dendritic2

Receptor18

Regulation10

Inflammation8

Hematopoiesis5

Processes10

Progenitors10

Inhibition4

FLT36

Stromal cells4

Myeloid3

Maturation2

Pathway6

Fibroblasts4

Mutations3

Endogenous2

Neuronal differentiation2

Leukemic cells2

Expression18

Promotes4

Vitro4

Epithelial cells4

Antigens5

Malignant2

Chromatin1

Induces2

Transplantation2

Effector2

Immune12

Homeostasis1

Inflammatory4

Ligand1

Clonal2

Transcriptional2

Transcription4

Phosphorylation1

Genetic3

Macrophages1

Biol3

Precursors3

Lymph2

Embryonic stem2

Pluripotent4

Regulator1

Mesenchymal2

Stimulation2

Microenvironment2

Mechanism3

Kinase1

Fate3

Negatively regulate1