Regulates the proliferation. Medical search. Frequent questions

Many of these miRNAs act as tumor suppressors and/or oncogenes, and are involved in cell activities that include development, differentiation, proliferation, apoptosis, metabolism and immunity ( 7 , 10 , 11 ). (spandidos-publications.com)
Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. (ca.gov)
DNA methylation is known to regulate cell differentiation and neuronal function in vivo. (ca.gov)
Thus, our work revealed a novel role for Dnmt3a in regulating both the timing of neural cell differentiation and the cell proliferation in the paradigm of mESC-derived-NSCs. (ca.gov)
Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
In addition, its action on the 3T3-F442A cell line was tested in terms of regulation of proliferation capacity and differentiation into mature adipocytes as well as its effects on mature adipocytes. (nature.com)
In addition, on the 3T3-F442A cell line, OBEX inhibited proliferation of pre-adipocytes, blocked the differentiation of pre-adipocytes into new adipocytes, and decreased the lipid load in mature adipocytes. (nature.com)
Additionally, RAD18 functions beyond DNA repair and may regulate many other key biological processes, such as chromatin strengthening, cell survival/death, stemness, and differentiation. (nature.com)
This control of cDC homeostasis is mediated by a number of factors that drive cDC differentiation, proliferation, and survival or apoptosis ( 4 ). (frontiersin.org)
However, these RNAs play an indispensable role in important activities such as cell proliferation, differentiation, senescence and apoptosis. (biomedcentral.com)
Here, we show that microbial polyamines reinforce colonic epithelial proliferation and regulate macrophage differentiation. (elsevierpure.com)
The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. (omicsdi.org)
The expression of REG3A by keratinocytes is induced by interleukin-17 (IL-17) via activation of keratinocyte-encoded IL-17 receptor A (IL-17RA) and feeds back on keratinocytes to inhibit terminal differentiation and increase cell proliferation by binding to exostosin-like 3 (EXTL3) followed by activation of phosphatidylinositol 3 kinase (PI3K) and the kinase AKT. (omicsdi.org)
In most biological systems the down-regulation of proliferation is necessary for initiation of key steps in the differentiation process. (elsevierpure.com)
Inhibition of CaMKII activity restricts cell proliferation, and correlates with growth arrest and differentiation. (unisa.it)
It's critical to regulatory actions in the gut, as it relates to proliferation and differentiation, intestinal barrier function, innate immunity, and host response. (medscape.com)
I've also used supplementation in patients with diverticulitis , which we know to occur more frequently in patients with lower vitamin D. When you get into some of the anti-inflammatory effects of vitamin D on proliferation, differentiation, barrier function, and immune response, it makes sense to start looking at this in inflammatory/infectious disease as well. (medscape.com)

Yang M, Zhai X, Ge T, Yang C and Lou G: MiR-181a-5p promotes proliferation and invasion, and inhibits apoptosis of cervical cancer cells via regulating inositol polyphosphate-5-phosphatase A (INPP5A). (spandidos-publications.com)
Zhu K, He Y, Xia C, Yan J, Hou J, Kong D, Yang Y and Zheng G: MicroRNA-15a inhibits proliferation and induces apoptosis in CNE1 nasopharyngeal carcinoma cells. (spandidos-publications.com)
Indeed, En2 -KO exhibits ~2-fold increases in stem cell proliferation and immature neuron apoptosis in the dentate gyrus, which implies that En2 activity in the brain can regulate proliferation and cell survival in the hippocampus. (confex.com)
This study seeks to examine cell autonomous roles for En2 in regulating hippocampal neurogenesis by showing that (1) stem cells cultured in vitro as neurospheres express En2 , and (2) the absence of En2 in cultured cells leads to increased proliferation and apoptosis. (confex.com)
Immunofluorescent labeling of whole neurospheres was performed to determine rates of proliferation (BrdU incorporation) and apoptosis (cleaved caspase-3, pyknosis). (confex.com)
This study suggests that En2 plays a role in regulating proliferation and apoptosis in hippocampal neural stem cells. (confex.com)
However, persistent and severe inactivation of neddylation by MLN4924 significantly inhibited cell proliferation by inducing G2 phase cell-cycle arrest and further triggered cell death by inducing apoptosis in RAW264.7 macrophages. (ewha.ac.kr)
CircVCAN regulates the proliferation and apoptosis of osteoarthritis chondrocyte through NF-κB signaling pathway. (illumina.com)
Overexpression of LEF1 increased the expression of hair follicle development-related genes and proteins, enhanced HFSC proliferation, and reduced HFSC apoptosis. (tressless.com)
Cell viability, apoptosis, and proliferation rate were not affected. (lu.se)

The role of miR‑497 in regulating the proliferation of HCC‑derived cells was also investigated in vitro and in vivo. (spandidos-publications.com)
si-Prok1 arrests cell cycle, induces apoptotic changes, and inhibits the proliferation of ovarian granulosa cells through a mechanism related to the regulation of Pi3k/Akt signaling pathway. (ajol.info)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
Zhou Y, Yang C, Wang K, Liu X and Liu Q: MicroRNA-33b inhibits the proliferation and migration of osteosarcoma cells via targeting hypoxia-inducible factor-1α. (spandidos-publications.com)
Proliferation-linked shifts in eligibility of DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)
For example, RAD18 plays a vital role in regulating the DNA stability of embryonic stem cells and cellular homeostasis in highly prolific cells [ 6 ]. (nature.com)
Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
The group led by Dr. Juan Carlos del Pozo has found that the transcription factor OBP4 activates cell proliferation in differentiated pericycle cells. (upm.es)
OBP4 does not induce cell division in the root meristem but it promotes pericycle cell proliferation, forming callus-likes structures at the root tip as shown by expression of stem cells markers. (upm.es)
With respect to its biological function, overexpression of IGBP1-AS1 had inhibitory effects on the invasion and proliferation of BC cells in vivo as well as in vitro. (biomedcentral.com)
LncRNA IGBP1-AS1/miR-24-1/ZIC3 axis as a loop can regulate the proliferation and invasion of BC cells. (biomedcentral.com)
Knockdown of RPL5 significantly inhibited the proliferation and migration of HCT16 and RKO cells, and arrested the cell cycle in G0/G1 phase. (biomedcentral.com)
Moreover, TBHQ could partially reverse the inhibitory effect of siRPL5 on the proliferation and migration of colon cancer cells. (biomedcentral.com)
Metformin also reduced cell proliferation and increased lipolysis in PCa cells at physiological obtainable doses (0.02 and 0.5 mM). (uwm.edu)
Tolentino, Miguel Angel, "Metformin-Induced PEDF Expression Regulates Cell Proliferation and Lipid Metabolism in Prostate Cancer Cells" (2013). (uwm.edu)
However, no direct evidence has shown that microbial polyamines are incorporated into host cells to regulate cellular responses. (elsevierpure.com)
Recent data, obtained in a new model of mouse lacking the BTG1 gene, indicate that BTG1 is essential for the proliferation and expansion of stem cells in the adult neurogenic niches, i.e. the dentate gyrus and sub ventricular zone (see for review). (wikipedia.org)
In fact the deletion of Btg1 leads in mouse to uncontrolled proliferation of the cerebellar precursor cells during the early postnatal period. (wikipedia.org)
The study investigated the role of exosomes derived from dermal papilla cells (DPC-Exos) in hair follicle stem cell (HFSC) proliferation. (tressless.com)
In proliferating cells transcription of the histone genes is up-regulated at the onset of S phase. (elsevierpure.com)
In myeloid leukemia cells, CaMKII, activated by the bcr-abl oncogene, promotes cell proliferation. (unisa.it)
The proliferation activity of RAW264.7 cells decreased after Mcart-1 was knocked out( P ＜0.001). (magtechjournal.com)
Conclusions The proliferation activity and oxidative phosphorylation level of RAW264.7 cells were both down-regulated after the Mcart-1 was stably knocked out. (magtechjournal.com)
Downregulation of miR-590-5p inhibited proliferation and invasion of hepatocellular carcinoma cells (HCCs). (molcells.org)
We also found that downregulation of miR-590-5p was associated with an elevation of TGF-beta RII and inhibition of proliferation and invasion in HepG2 cells. (molcells.org)
Furthermore, overex-pression of miR-590-5p was associated with upregulation of TGF-beta RII and could promote proliferation and invasion in L02 cells. (molcells.org)
Diethylstilbestrol (DES) is a nonsteroidal synthetic estrogen that disrupts the morphology and proliferation of gubernaculum testis cells , but the underlying mechanism is unclear. (bvsalud.org)
The results demonstrated that U-73122 impaired DES-evoked intracellular Ca2+ mobilization in gubernaculum testis cells and inhibited DES-induced proliferation of gubernaculum testis cells . (bvsalud.org)
Here we explore potential mechanisms how the proliferation and contractility of gubernaculum testis cells are regulated by diethylstilbestrol . (bvsalud.org)
Reduced proliferation corresponded with reduced P-S6 levels by Western blot, and effects were ablated by pretreatment of cells with mTOR-specific siRNA. (elsevierpure.com)
By genetic and pharmacological inhibition of the MRN complex in a MYCN overexpression model and in the more physiological context of the Hedgehog-dependent expansion of primary cerebellar granule progenitor cells, we also show that the MRN complex is required for MYCN-dependent proliferation. (unipa.it)
The expression of key molecules of β-cell function including Insulin, Pdx1, Gck, Glut2, and Insrβ was down-regulated in Chl1 -silenced cells at transcriptional and translational levels. (lu.se)
Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)

In inflammatory skin conditions, such as psoriasis, vascular enlargement is associated with endothelial cell proliferation, release of cytokines and adhesion molecule expression. (omicsdi.org)

Here we report that loss of cathepsin L (Cts L) is associated with a fast proliferation rate and enhanced glycolytic metabolism that depend on lactate dehydrogenase A (LDHA) activity. (ox.ac.uk)

Unpredictably, cell cycle progression, cell proliferation and DNA synthesis were unaffected fol lowing NDRG1 expression. (scirp.org)
However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)
We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
Gao YL, Zhao ZS, Zhang MY, Han LJ, Dong YJ and Xu B: Long noncoding RNA PVT1 facilitates cervical cancer progression via negative regulating of miR-424. (spandidos-publications.com)
This study examines the effect of RPL5 on the progression of colon adenocarcinoma (COAD), including cell proliferation, migration and determines its underlying molecular mechanism using CRC cell lines in vitro. (biomedcentral.com)
These findings suggest that RPL5 plays an important role in regulating COAD progression and may serve as a prognostic biomarker for COAD. (biomedcentral.com)

1,000 human miRNAs have been identified that regulate ~1/3 of the coding genes in the human genome ( 9 ). (spandidos-publications.com)
However, whether miR-497 regulates other target genes in HCC is unknown. (spandidos-publications.com)
Analysis of the WNK1-dependent transcriptome by RNA-Seq demonstrated that WNK1 regulates the expression of 1858 genes during decidualization. (bioone.org)
Twenty-two genes were found up-regulated and 18 down-regulated in benzene patients compared with controls. (cdc.gov)
Here we report the characterization of two benzene-regulated genes. (cdc.gov)

Inhibition of YAP or TGF-β breaks this loop and suppresses cancer stemness and proliferation In nude mice, RAD18 promoted subcutaneous transplanted tumor growth and M2-type TAM recruitment. (nature.com)
We also showed that expression of TGF-beta RII, which has been regarded as a regulator of tumor proliferation, invasion, and migration in hepatocellular carcinoma, is regulated by miRNA-590-5p. (molcells.org)
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages. (lu.se)

Yu M, Yu S, Gong W, Chen D, Guan J, Liu Y. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. (jcancer.org)
Moreover, loss-of-function studies reveal that restoration of linc01023 restrains glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
Moreover, linc01023 depletion inhibited glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)

It negatively regulates cell proliferation. (wikipedia.org)
Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation. (musc.edu)

We report that a membrane-tethered form of aPKC (aPKC-CAAX) suppresses primary neurogenesis and promotes cell proliferation. (bath.ac.uk)

Our data identify a critical role for the microtubule-severing protein katanin p60 in regulating neuronal progenitor proliferation in vivo during embryonic development and adult neurogenesis. (monash.edu)
Furthermore, increased proliferation and cell death observed in En2 -KO neurosphere cultures recapitulates what is observed in vivo , suggesting that En2 may inhibit proliferation and promote survival in a cell autonomous manner. (confex.com)

However, the role of neddylation in the proliferation and survival of macrophages has not been well defined. (ewha.ac.kr)
The findings revealed that neddylation serves as an important signaling pathway regulating the proliferation and survival of macrophages. (ewha.ac.kr)
Stable knockout of Mcart-1 down-regulates the proliferation and oxidative phosphorylation of RAW264.7 macrophages[J]. Basic & Clinical Medicine, 2023, 43(4): 568-575. (magtechjournal.com)

From these findings, it is concluded that ILK plays an important role in intestinal epithelial cell proliferation, and that it influences the development of colitis-associated cancer, through modulation of cyclin D1, the extracellular matrix and MMP9. (bmj.com)
Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota and regulate multiple biological processes. (elsevierpure.com)
These findings reveal that REG3A, a secreted intestinal antimicrobial protein, can promote skin keratinocyte proliferation and can be induced by IL-17. (omicsdi.org)

By retrieving TCGA database, we discovered that expression of linc01023 was up-regulated in glioma, however, the molecular mechanisms of linc01023 in glioma remain unclear. (jcancer.org)
High expression of RAD18 facilitated a highly stem-cell phenotype through the Hippo/YAP pathway, which supports the proliferation of TNBC. (nature.com)
Mechanistic studies revealed that the expression of p-MEK1/2, p-ERK, c-Myc were down-regulated, and the expression of FOXO3 was up-regulated after down-regulation of RPL5, ERK activator (TBHQ) could partially reverse the above-mentioned effects caused by siRPL5. (biomedcentral.com)
Keratinocyte activation in turn results in cell proliferation and chemokine expression, the latter of which fuels the inflammatory process through further immune cell recruitment. (omicsdi.org)
Conversely, expression of CaMKIV inhibits autophosphorylation and activation of CaMKII, and elicits G0/G1cell cycle arrest,impairing cell proliferation. (unisa.it)
Our data reveal a novel cross-talk between CaMKII and CaMKIV and suggest that CaMKII suppresses the expression of CaMKIV to promote leukemia cell proliferation. (unisa.it)
MicroRNAs (miRNAs) are regulatory small non-coding RNAs that can regulate gene expression by binding to gene elements, such as the gene promotor 5?UTR, mainly in the 3?UTR of mRNA. (molcells.org)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

The repressive effect of OGF on cell proliferation also was observed in SW626, CAOV-3, and HEY ovarian cancer cell lines. (nih.gov)
These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in human ovarian cancer. (nih.gov)

It has been proposed that metformin inhibits proliferation via activation of AMP-activated protein kinase (AMPK) or by blocking proliferation at the G0/G1 phase in the cell cycle with a reduction in cyclin D1. (uwm.edu)
DNA-dependent protein kinase catalytic subunit (DNAPKcs) regulates non-homologous end joining (NHEJ) in DNA double strand break (DSB) repair. (cdc.gov)

Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. (monash.edu)

One miRNA targets many mRNAs, which can be regulated by many miRNAs, leading to a complex metabolic network. (molcells.org)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)

the results suggest that CYP4F3A is a critical positive regulator of HL-60 proliferation. (cdc.gov)

Using small interfering RNA (siRNA) to knock down ILK in colonic cancer cell lines, it was confirmed that it is capable of regulating cyclin D1, Snail, MMP9 and fibronectin transcription. (bmj.com)

Katanin p60 haploinsufficiency induced an accumulation of neuronal progenitors in the subventricular zone during corticogenesis, and impaired their proliferation in the adult hippocampus dentate gyrus (DG) subgranular zone. (monash.edu)
Our data indicate the MRN complex is essential to restrain MYCN-induced replication stress during neural cell proliferation and support the hypothesis that replication-born DNA damage is responsible for the neuronal defects associated with MRN dysfunctions. (unipa.it)

Thus, the role of TGF-beta RII in regulating proliferation and invasion of human HCCs is controlled by miR-590-5p. (molcells.org)

Previous studies have demonstrated that IGF-1R activates the phosphoinositide 3- kinase (PI3K)/AKT signaling pathways and promotes glioblastoma cell proliferation and survival by ligand binding [ 10 ]. (jcancer.org)
While primary neurosphere assays revealed no change in numbers of primary spheres, measurement of sphere diameter showed increased frequency of larger spheres in En2 -KO, suggesting potential effects on proliferation and/or survival. (confex.com)

Met(5)]-enkephalin) and the OGF receptor (OGFr) form an endogenous growth-regulating pathway in homeostasis and neoplasia. (nih.gov)
These data demonstrate that phosphorylation and stability of the molecular scaffold KSR1 are critical regulators of growth factor-specific responses that promote cell proliferation. (nebraska.edu)
Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation. (ox.ac.uk)
The study concluded that DPC-Exos can regulate HFSC proliferation by stimulating LEF1, providing new insights into hair follicle growth and development regulatory mechanisms. (tressless.com)
A mutation in this gene disrupts a cell's ability to regulate its own growth, allowing it to grow and divide abnormally. (medlineplus.gov)
Increased cell proliferation in various tissues and organs leads to the abnormal growth characteristic of Proteus syndrome. (medlineplus.gov)

A constitutively active aPKC fused to a nuclear localisation signal has the same phenotypic effect as aPKC-CAAX in that it suppresses neurogenesis and enhances proliferation. (bath.ac.uk)

Endogenous OGF was found to be constitutively produced and tonically active on cell replicative activities, with neutralization of this peptide accelerating cell proliferation. (nih.gov)

The factors that trigger epithelial proliferation in these inflammatory processes are incompletely understood. (omicsdi.org)
Psoriasis is a chronic inflammatory skin disease with a clear genetic contribution, characterized by keratinocyte proliferation and immune cell infiltration. (omicsdi.org)

Mechanistically, PTPN22 mediates cDC2 homeostasis in a cell intrinsic manner by restricting cDC2 proliferation. (frontiersin.org)

Maintenance of cDC homeostasis is crucial for regulating immune responses, with deregulation resulting in infection and autoimmunity ( 19 - 22 ). (frontiersin.org)
The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

Hierarchy of chemokine and antigen signals regulating T cell migration and proliferation. (ox.ac.uk)

abstract = "Proliferation is a requirement during the initial stages of cell and tissue specialization. (elsevierpure.com)

Kinase suppressor of Ras (KSR) is a molecular scaffold that interacts with the components of the Raf/MEK/ERK kinase cascade and positively regulates ERK signaling. (nebraska.edu)

Exogenous OGF was observed to have a dose-dependent, serum-independent, reversible, and receptor-mediated inhibitory action on cell proliferation that was dependent on RNA and protein synthesis. (nih.gov)
IGBP1-AS1 could have inhibitory impact on the invasion and proliferation of BC and may serve as a promising biomarker for BC. (biomedcentral.com)

Our results show a novel role for DDX5 in cancer cell proliferation and suggest DDX5 as a therapeutic target in breast cancer treatment. (aacrjournals.org)
We examined the role of phosphorylation of both Ser 392 and Thr 274 in regulating ERK activation and cell proliferation. (nebraska.edu)

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism. (ox.ac.uk)

In a xenograft model Ttc7-mutated fibroblasts markedly increased epithelial proliferation of keratinocytes. (nih.gov)

Collectively, RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway. (biomedcentral.com)

Further, the mutually exclusive interactions of MYST1 with sirtuin 1 vs AR regulate the acetylation of lysine 16 on histone H4. (mssm.edu)

Anatomy42

Organisms13

Diseases13

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes55

Disciplines and Occupations1

Information Science3

Differentiation22

Apoptosis10

Cells34

Endothelial cell proliferation1

Metabolism1

Progression6

Genes5

Tumor3

Migration and invasion3

Negatively regulates2

Promotes cell proliferation1

Vivo2

Macrophages3

Intestinal3

Expression8

Ovarian2

Protein kinase2

Cellular1

MiRNAs2

Regulator1

Cyclin1

Neuronal2

Invasion of human1

Survival2

Growth6

Suppresses1

Endogenous1

Inflammatory2

Cell-intrinsic manner1

Immune2

Chemokine1

Abstract1

Kinase1

Inhibitory2

Role2

Mechanism1

Markedly1

Collectively1

Histone1