Regulates the expression gene expression regulation fungal. Medical search. Frequent questions

Our analysis of metabolic regulation shows that UV activates DNA repair, aromatic amino acid and carotenoid biosynthesis and represses central carbon metabolism and the fungal-like apoptotic pathway. (biorxiv.org)
We found that major cellulase genes ( cel7a , cel7b , and cel3a ) exhibited concomitant decrease in IR rates and increase in their gene expression in T . reesei under cellulase-producing condition (cellulose and lactose) that was accompanied with a more active NMD pathway, as compared to non cellulase-producing condition (glucose). (researchsquare.com)
In the presence of the NMD pathway inhibitor that successfully repressed the NMD pathway, the mRNA levels of cellulase genes were sharply down-regulated, but the rates of IR in these genes were significantly up-regulated. (researchsquare.com)
In addition, the NMD pathway inhibitor caused the downregulated mRNA levels of two important genes of the target of rapamycin (TOR) pathway, trfkbp12 and trTOR1 . (researchsquare.com)
The absence of gene trfkbp12 made the cellulase production in T . reesei more sensitive to the NMD pathway inhibitor. (researchsquare.com)
All these findings suggest that the IR of cellulase genes regulates their own gene expression by coupling with the NMD pathway, which might involve the TOR pathway. (researchsquare.com)
Fungi 2021, 7,expression on the ERG1 gene (inside the ergosterol pathway) is regulated by each the PdsreA and PdsreB genes, while only PdsreA is involved in the expression of ERG2. (hsvinhibitor.com)
The underlying principle is to identify the transcription factors that regulate the taxol pathway and establish a fungal engineering approach that can be implemented in industrial fermentation. (europa.eu)
Recent studies highlighted the importance of IMD pathway regulation as it is tightly controlled by numbers of negative regulators at multiple levels. (cnrs.fr)
Silencing of Velo led to constitutive expression of the IMD pathway dependent antimicrobial peptides (AMPs), and Escherichia coli stimulation further enhanced the AMP expression. (cnrs.fr)
Finally, our genetic and biochemical data suggest that PP2A regulates the phosphorylation of Tem1, which acts at the very top of MEN pathway. (fsu.edu)
By establishing the trimethylation pattern of H3K4me3 residues of the nucleosomes, ATX1/SDG27 (Arabidopsis Homolog of Trithorax) regulates the SA/JA signaling pathway for plant defense against bacterial pathogens by activating the expression of the WRKY70, which was a critical transcription factor15. (achrinhibitor.com)
By regulating H3K36 methylation of histone proteins in JA (jasmonic acid) and/or ethylene13 and brassinosteroids signaling pathway, Arabidopsis SDG8 (SET Domain Group 8) was shown to play a critical role against fungal pathogens MK-1439 web Alternaria brassicicola and Botrytis cinerea16. (achrinhibitor.com)
Regulation of gene expression by ambient pH in filamentous fungi and yeast is mediated by the pal/RIM signaling pathway and the transcription factor PacC/Rim101. (ucm.es)
The ambient pH signaling pathway is conserved in the fungal kingdom and has been mainly studied in the filamentous fungus Aspergillus nidulans and in the yeast Saccharomyces cerevisiae, although several studies have also been carried out in the yeasts Yarrowia lipolitica and Candida albicans 45. (ucm.es)
In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
He revealed a crucial role for MYC2, MYC3, and MYC4 as master regulators of defense gene expression in the JA pathway. (unil.ch)
Mutant analysis revealed complex genetic interactions between FLK and several major SA pathway genes. (nsf.gov)
In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges. (sdbonline.org)
Genetic epistasis and biochemical analyses revealed that Senju regulates the Toll signaling pathway at a step that converts Toll ligand Spatzle to its active form. (sdbonline.org)
While the defined roles of the c-Jun N-terminal kinase (JNK) pathway in regulating cell death have been well-established, additional factors that modulate JNK-mediated cell death have yet to be fully elucidated. (sdbonline.org)
This paper explores the involvement of the Toll/NF-kappaB pathway in the localized activation of wound repair genes around epidermal breaks. (sdbonline.org)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

Much of this work is carried out in the species Candida albicans, the most prevalent fungal pathogen of humans. (ucmerced.edu)
Candida glabrata is a prominent opportunistic fungal pathogen of humans. (bvsalud.org)
however Mn handling at the host-fungal pathogen interface remains largely unexplored. (bvsalud.org)
This work establishes the foundation of fungal resistance against Mn associated nutritional immunity through the characterization of NRAMP divalent metal transporters in the opportunistic fungal pathogen, Candida albicans. (bvsalud.org)
Candida albicans is the most important opportunistic fungal pathogen of humans. (ncl.edu.tw)
Detection of pathogen through PRRs triggers PAMP-triggered immunity (PTI, also called basal defense) which is accompanied with rapid production of reactive oxygen species (ROS), activation of mitogen-activated protein kinases (MAPKs) and changes in expression of immune-related genes [ 2 ]. (biomedcentral.com)
Within the citrus postharvest pathogen Pd, there is yet another SREBP homolog, PdsreB, which seems to become involved in fungicide resistance and within the control of CYP51 gene expression [126]. (hsvinhibitor.com)
Fungal pathogenesis is a sophisticated process including infectious development of the pathogen and fungus-host interactions, which requires a fine-tuned regulation of gene expression dynamics. (biomedcentral.com)
The resulting data provide new insights into how Zn2Cys6 TF genes regulate important traits during the infection cycle of this rice blast pathogen. (prelekara.sk)
The ISELs and their associated genes provide a comprehensive view of lncRNAs during fungal pathogen-plant interactions. (biomedcentral.com)
Candida albicans is an opportunistic human fungal pathogen that exists in normal flora but can cause infection in immunocompromised individuals. (korea.ac.kr)
Most DEGs were involved in plant hormone signal transduction, plant-pathogen interaction and phenylalanine metabolism, and the genes significantly up-regulated in PI 114490 at 6 DPI were associated with defense response pathways. (frontiersin.org)
In addition to late flowering, the flk mutants exhibited decreased resistance to the bacterial pathogen Pseudomonas syringae and increased resistance to the necrotrophic fungal pathogen Botrytis cinerea. (nsf.gov)
Thus, this study provides mechanistic support for flk suppression of acd6-1 and establishes that FLK is a multifunctional gene involved in regulating pathogen defense and development of plants. (nsf.gov)

Previous studies suggest the transcription factor Pdr1 and several target genes encoding ABC transporters are critical elements of pleiotropic defense against azoles and other antifungals. (bvsalud.org)
Proof around the transcriptional regulation of those target genes has emerged to explain the drug-resistant mechanisms of Pd. (hsvinhibitor.com)
A remarkable transcriptional response in the HacACA strain was the down-regulation of the AmyR transcription factor and its target genes. (tu-berlin.de)
LncRNAs can also be classified as cis-acting lncRNAs, which regulate target genes at adjacent regions, and trans-acting lncRNAs, which function at independent chromosomal loci [ 8 ]. (biomedcentral.com)
This analysis verified but also corrected conclusions from earlier data obtained by single gene analysis, identified new candidates of factors as part of the cellular copper homeostasis system including target genes of transcription factor GRISEA, and provides a rich reference source of quantitative data for further in detail investigations. (uni-frankfurt.de)

A bZIP transcription repressor of mitochondrial function (CIN5) positively regulated Pdr1 while hundreds of genes encoding mitochondrial proteins were confirmed as negative regulators of Pdr1. (bvsalud.org)
We speculated that the defect of protein synthesis attenuated expression of other exoglucanases or glucan synthesis-related proteins, and then induced release of Xog1p to the cell wall. (ncl.edu.tw)
Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
Furthermore, gene overexpression is also frequently associated to antifungal resistance as well as an increase in the activity of proteins that reduce oxidative damage. (intechopen.com)
It was shown that SET domain-containing proteins regulated plant developmental processes such as floral organogenesis, seed development11 and plant senescence12. (achrinhibitor.com)
Increasing evidence indicates the importance of posttranscriptional regulation of plant defense by RNA binding proteins. (nsf.gov)

This chapter summarizes the main molecular mechanisms to C. albicans antifungal drug resistance, besides offering an overview of new antifungal agents and new antifungal targets to combat fungal infections. (intechopen.com)
The complementary expertise of Dr Kamal (Fungal biotechnology) and the supervisor Prof. Dr. Frank Kempken (FK) (Fungal genetic and molecular biology) offer the unique combination to realize the fungal taxol biosynthetic potential. (europa.eu)
2012) The Top 10 fungal pathogens in molecular plant pathology. (prelekara.sk)
Therefore there is a great urge to screen and identify the potential genes conferring resistance to HT stress in molecular breeding of cotton. (achrinhibitor.com)
The findings are of interest in understanding molecular processes involved in regulating erythropoiesis, as well as the potential to develop host-directed therapies for malarial parasites that target human reticulocytes. (elifesciences.org)
Enhancement of Genetic Molecular Expression by Mineral Ions in Microbial Cells, and its Effect at the Cellular Level. (raulcuero.com)
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)

In addition, we show that the very early transcriptional regulation of the rice OsWAK genes is triggered by chitin and is partially under the control of the chitin receptor CEBiP. (biomedcentral.com)
Transcription Glycopeptide Inhibitor manufacturer Factors in Pd Fungicide Resistance Transcription things (TF) are involved in transcriptional regulation and play a relevant part in fungal interactions. (hsvinhibitor.com)
Fungi are known to work with the transcriptional regulation of genes encoding efflux transporters to detoxify certain compounds. (hsvinhibitor.com)
The expression of efflux transporters isefflux Fungi are recognized to use the transcriptional regulation of genes encoding controlled mainly by fungal zinc group transcription elements (TF [Zn2Cys6]) [127]. (hsvinhibitor.com)
ADC gene expression and enzyme activity increased during embryogenesis, which suggests the involvement of transcriptional regulation in the expression of ADC. (scite.ai)
Consequently, C. albicans maintains proper ROS levels via Set1-mediated transcriptional regulation, thus establishing a rapid defense against external ROS generated by the host. (korea.ac.kr)

Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae. (fsu.edu)
CNF1 is the first reported TF gene that strongly and negatively regulates asexual development in the rice blast fungus, and CCA1, CNF1, CNF2, CONx1, GPF1, GTA1, MoCOD1 and PCF1 are required for pathogenicity. (prelekara.sk)

Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. (nature.com)
A genome wide study of the gene regulation of human monocyte-derived dendritic cells (DCs) confronted with A. fumigatus, C. albicans or LPS was performed and Kruppel-like factor 4 (KLF4) was identified as the only transcription factor that was down-regulated in DCs by both fungi but induced by stimulation with LPS. (hki-jena.de)
The genome of the protochordate Ciona intestinalis has a compact size with an ancestral complement of many diversified gene families of vertebrates and is a good model system for studying protochordate to vertebrate diversification. (biomedcentral.com)
We have identified 169 gene products in the Ciona genome that code for putative GPCRs. (biomedcentral.com)
2007) Genome-wide functional analysis of pathogenicity genes in the rice blast fungus. (prelekara.sk)
However, only few studies have profiled fungal lncRNAs in a genome-wide manner during host infection. (biomedcentral.com)
2022. Analysis of Carbohydrate-Active Enzymes and Sugar Transporters in Penicillium echinulatum: a Genome-wide Comparative Study of the Fungal Lignocellulolytic System. (openwetware.org)
Here we report a genome-wide transcriptome analysis of the fungal aging model Podospora anserina. (uni-frankfurt.de)
Christelle did a whole-genome expression profiling of Arabidopsis and Brassica nigra plants that are challenged with different attackers. (unil.ch)

Invasive fungal infections are associated with high mortality rates and are mostly caused by the opportunistic fungi Aspergillus fumigatus and Candida albicans. (hki-jena.de)
The immunomodulatory effects of fungi were compared to the bacterial stimulus LPS to determine key players in the immune response to fungal infections. (hki-jena.de)

To decipher the potential roles of lncRNAs during infection, we identified 365 protein-coding genes that were associated with 214 ISELs. (biomedcentral.com)

In addition to the well known HacA targets such as the ER resident foldases and chaperones, GO enrichment analysis revealed up-regulation of genes involved in protein glycosylation, phospholipid biosynthesis, intracellular protein transport, exocytosis and protein complex assembly in the HacACA mutant. (tu-berlin.de)
Biofilms were stained with SYTO 9 ( green , live bacteria), FUN-1 (intracellular red , live fungal cells), calcofluor white ( blue , fungal cell wall). (asmblog.org)
CGD is a primary immunodeficiency that affects phagocytes of the innate immune system and leads to recurrent or persistent intracellular bacterial and fungal infections and to granuloma formation. (medscape.com)

Here we show using rice ( Oryza sativa ) loss-of-function mutants of four selected OsWAK genes, that individual OsWAKs are required for quantitative resistance to the rice blast fungus, Magnaporthe oryz ae. (biomedcentral.com)
Moreover, the expression of an apple defense-related F-box protein was strongly induced by infection with Cfhos2 deletion mutants. (biomedcentral.com)
To identify more negative regulators of MEN, we carried out a genetic screen for genes that are toxic to cdc5-1 mutants when overexpressed. (fsu.edu)
We developed a high-throughput gene knockout system, and using this system, we obtained null mutants of 104 fungal-specific Zn2Cys6 transcription factor (TF) genes by screening 8741 primary transformants in M. oryzae. (prelekara.sk)
Using available Arabidopsis mutants lacking important defense signals, she studied gene expression changes with microarrays and tried to correlate transcript profiles with insect performance in order to assess the effect of plant defenses on insect growth. (unil.ch)
In Medicago, Mting1 gene‐edited mutants developed and flowered normally, but an Mting2‐1 Tnt1 insertion mutant and gene‐edited Mting2 mutants had developmental abnormalities including delayed flowering particularly in VLD, compact architecture, abnormal leaves with extra leaflets but no trichomes, and smaller seeds and barrels. (nsf.gov)
Mting2 mutants had reduced expression of activators of flowering, including the FT ‐like gene MtFTa1 , and increased expression of the candidate repressor MtTFL1c , consistent with the delayed flowering of the mutant. (nsf.gov)
The MtING2 PHD finger bound H3K4me2/3 peptides weakly in vitro , but analysis of gene‐edited mutants indicated that it was dispensable to MtING2 function in wild‐type plants. (nsf.gov)

These stable associations have also been shown to regulate gene expression in vivo, and are prevented by mutations in MED12 that produce the human disease FG syndrome. (wikipedia.org)
As both genes regulate different elements, as has been shown with single and double mutations of your genes, it can be achievable that there are other transcription factors involved in ergosterol biosynthesis that could possibly be activated when both SREBPs are inhibited [126]. (hsvinhibitor.com)
Overall, the present study demonstrates the importance of systems biology approaches also in cases were mutations in single genes are analyzed to explain the underlying mechanisms controlling complex biological processes like aging and development. (uni-frankfurt.de)
Most patients (approximately 80%) are males, who have hemizygous mutations on the X-linked gene coding for gp91phox. (medscape.com)
Among the genes affected by FLK is ACD6, whose transcripts had increased intron retentions influenced by the flk mutations. (nsf.gov)
SCID results from mutations in any of more than 15 known genes. (medscape.com)

The lab is also beginning to study interspecies interactions between different fungal and bacterial species. (ucmerced.edu)
So far eight bacterial, four fungal PAMPs and 20 PRRs have been identified molecularly [ 3 ]. (biomedcentral.com)
The best studied PAMP recognition systems in plants are represented by the bacterial flagellin recognized by the Arabidopsis thaliana FLS2 receptor and the fungal chitin recognized by the CEBiP receptor [ 1 ]. (biomedcentral.com)
We also observed from in vivo analysis that Velo knock-down flies exhibit significant upregulation of the AMP expression and reduced bacterial load. (cnrs.fr)
Clearly, interspecies bacterial communication influences the regulation of gene expression. (asmblog.org)
This renders the patients susceptible to severe, recurrent bacterial and fungal infections. (medscape.com)

Most importantly, we find that Pdr1-a key determinant of fluconazole resistance-is not regulated directly through binding of fluconazole and instead is regulated indirectly by sensing the cellular stresses caused by fluconazole blockage of sterol biosynthesis. (bvsalud.org)
Among them, the Wall-associated kinases (WAKs) have been shown to be positive regulators of fungal disease resistance in several plant species. (biomedcentral.com)
While OsWAK14, OsWAK91 and OsWAK92 positively regulate quantitative resistance, OsWAK112d is a negative regulator of blast resistance. (biomedcentral.com)
Regulation of Fungicide Resistance 5.1. (hsvinhibitor.com)
In Pd, the SREBP protein SreA was initially identified and characterized, which plays an important function in prochloraz resistance and within the transcription of ergosterol synthesis genes [111]. (hsvinhibitor.com)
Functional characterization showed the two genes (PdsreA and PdsreB) act as global controllers in a fantastic selection of biological functions, especially in elements that mediate ergosterol biosynthesis and resistance to fungicides. (hsvinhibitor.com)
Climate induced physiological changes that occur in the host and influence mycotoxins and/or Fusarium infection will be useful as markers in plant breeding programs aimed at developing climate resilient fungal resistance strategies. (usda.gov)
Accumulation expression levels of 326 co-up regulated genes in both tomato lines at 6 DPI might be involved in basal defense, while the specific and strongly induced genes at 6 DPI might be correlated with the resistance in PI 114490. (frontiersin.org)
Identification and characterization of the host resistance as well as regulatory genes can provide insights into understanding the mechanisms of host resistance and the use of host resistance to develop new cultivars with durable resistance. (frontiersin.org)
HR is usually conditioned by single dominant genes, while field resistance is generally controlled by multiple genes ( Yang, 2013 ). (frontiersin.org)

Histone-modifying enzymes, which regulate eukaryotic chromatin conformation and gene expression, are key epigenetic factors controlling fungal development, virulence, and secondary metabolism. (biomedcentral.com)
Background: HacA/Xbp1 is a conserved bZIP transcription factor in eukaryotic cells which regulates gene expression in response to various forms of secretion stress and as part of secretory cell differentiation. (tu-berlin.de)
Eukaryotic fungal and animal clocks comprise transcription-translation-based feedback loops that control rhythmic transcription of a substantial fraction of these transcriptomes, yielding the changes in protein abundance that mediate circadian regulation of physiology and metabolism: Understanding circadian control of gene expression is key to understanding eukaryotic, including fungal, physiology. (dartmouth.edu)

We propose to biosynthesis de novo of fungal taxol® production by the regulation of transcription factors (TFs). (europa.eu)
The attractive features of this study, examining the elicitor-induced regulator of selected TFs genes to see whether their mRNA levels correlate with fungal taxol biosynthesis. (europa.eu)

Another example of structural variability is seen in vertebrates, in which 3 paralogues of subunits of the cyclin-dependent kinase module have evolved by 3 independent gene duplication events followed by sequence divergence. (wikipedia.org)
Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
The FLS2 protein belongs to the Receptor-like Kinase (RLK) gene family. (biomedcentral.com)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)

Xpp1 as regulator acting on the expression of xylanases, but not cellulases, is a highly promising candidate for knowledge-based strain design to improve the cellulases-to-xylanases ratio during industrial cellulase production. (biomedcentral.com)
In industrial applications, however, the co-secretion of xylanases is a disadvantage for cost-efficient cellulase production because T. reesei uses additional energy and nutrients for their expression. (biomedcentral.com)

Our findings elucidate the mechanisms of epigenetic targeting of germline genes and provide a paradigm for how transient repression signals by DNA-binding factors in early embryonic cells are translated into long-term epigenetic silencing during mouse development. (cnrs.fr)
The up-regulation of xyr1 transcription goes hand in hand with the up-regulation of gene expression of cellulolytic enzymes, whereas the regulation of xylanases seems to depend on additional mechanisms and factors [ 11 ]. (biomedcentral.com)
We further found via RNA-seq that GPF1 and CNF2 have similar mechanisms in gene expression regulation related to pathogenicity. (prelekara.sk)
The innate immune system is a multicomponent response governed by intricate mechanisms of induction, regulation and resolution to elicit antimicrobial defenses. (umassmed.edu)
Streptococcal pathogens continue to evade concerted efforts to decipher clear-cut virulence mechanisms, although numerous genes have been implicated in pathogenesis. (cdc.gov)

Dendritic cells (DCs) are crucial players in initiating innate and adaptive immune responses against fungal infections. (hki-jena.de)
The toes are prone to fungal infections because of the constant touching of skin to skin. (marketsampler.com)
And who wants to prevent fungal infections and bad odors? (marketsampler.com)
Together, this thesis provides new insights on how components of the innate immune system are regulated, and how dysregulation of immunity can potentially lead to adverse effects during active infections. (umassmed.edu)

Genetic manipulations allowed analysis of changes in gene expression underlying pheromone signaling, cell cycle control, and polarized morphogenesis. (nih.gov)
This programme of work will provide a new strategy for unlocking the full potential of fungal biotechnology at the interface with metabolic engineering and rDNA technology to establish of fungal fermentation through genetic engineering approaches. (europa.eu)
The extent to which environmental and secondary genetic factors influence phenotypic expression of disease is unknown. (medscape.com)
In a genetic screen for suppressors of Arabidopsis (Arabidopsis thaliana) accelerated cell death 6-1 (acd6-1), a small constitutive defense mutant whose defense level is grossly in a reverse proportion to plant size, we identified an allele of the canonical flowering regulatory gene FLOWERING LOCUS K HOMOLOGY DOMAIN (FLK) encoding a putative protein with triple K homology (KH) repeats. (nsf.gov)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)

To dissect the epigenetic regulation of GLS pathogenesis, we characterized a histone deacetylase gene Cfhos2 in Colletotrichum fructicola , the causing agent of GLS. (biomedcentral.com)
Taken together, we demonstrate that Cfhos2 is a key epigenetic factor regulating appressorium development, virulence gene expression, and GLS pathogenesis in C. fructicola . (biomedcentral.com)
We analyzed the functions of these TF genes in development, pathogenesis, and stress responses under 9 conditions. (prelekara.sk)
Analysis of the predicted functions of these associated genes suggested that lncRNAs regulate pathogenesis-related genes, including xylanases and effectors. (biomedcentral.com)

Moreover, C. albicans Hom6p affects expression of the cell wall protein Xog1p which is a major exoglucanase and is found to be involved in cell adhesion. (ncl.edu.tw)
The transition to pathogenic C. albicans requires a change of various gene expressions. (korea.ac.kr)
Because histone-modifying enzymes can regulate gene expression, they are thought to control the virulence of C. albicans. (korea.ac.kr)

Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. (dartmouth.edu)

RNA-seq based transcriptome analysis highlighted that Cfhos2 regulates secondary metabolism-related virulence genes during infection. (biomedcentral.com)
Notably, Xpp1 has neither influence on the d -xylose metabolism nor on the expression of cellulases. (biomedcentral.com)
PA metabolism was analyzed by fitting statistical regression models to the data of free and soluble conjugated PAs, to the enzyme activities of ADC and ornithine decarboxylase (ODC), as well as to the gene expression of ADC. (scite.ai)
Comparison of wild-type transcripts, which are continuously down-regulated during aging, with those down-regulated in the long-lived, copper-uptake mutant grisea, validated the relevance of age-related changes in cellular copper metabolism. (uni-frankfurt.de)

As bioactive molecule, ceramide is involved in the regulation of many cellular processes. (elifesciences.org)
These responses can lead to changes in cell behavior, activation of enzymes, regulation of gene expression, and various other essential cellular processes. (marketsampler.com)
The regulation of cellular copper homeostasis is crucial in biology. (uni-frankfurt.de)
Previously, a loss-of-function mutation in the gene encoding the copper-sensing and copper-regulated transcription factor GRISEA of the filamentous fungus Podospora anserina was reported to lead to cellular copper depletion and a pleiotropic phenotype with hypopigmentation of the mycelium and the ascospores, affected fertility and increased lifespan by approximately 60% when compared to the wild type. (uni-frankfurt.de)
In particular, levels of cellular mitochondrial reactive oxygen species (ROS) were higher in Δset1 than in the wild-type due to the defect of those genes' expression. (korea.ac.kr)
Together, these findings suggest that Set1 is required to regulate proper cellular ROS production by positively regulating the expression of mitochondrial protein genes and subsequently sustaining mitochondrial membrane integrity. (korea.ac.kr)

WAK genes are often transcriptionally regulated during infection but the pathways involved in this regulation are not known. (biomedcentral.com)
Finally, we show that OsWAK91 is required for H 2 O 2 production and sufficient to enhance defense gene expression during infection. (biomedcentral.com)
Hence, our results provide evidence for the involvement of Ac and ceramide in controlling P. yoelii infection by regulating red blood cell development. (elifesciences.org)
Suppression of the degalactosylation by senju overexpression resulted in reduced induction of Toll-dependent expression of an antimicrobial peptide, Drosomycin , and increased susceptibility to infection with Gram-positive bacteria. (sdbonline.org)

Here, we demonstrated that Set1 positively regulates the expression of mitochondrial protein genes by methylating H3K4. (korea.ac.kr)

However, the same main regulators regulate gene expression of cellulases and xylanases in T. reesei . (biomedcentral.com)

Conclusions: The results indicate that the constitutive activation of the HacA leads to a coordinated regulation of the folding and secretion capacity of the cell, but with consequences on growth and fungal physiology to reduce secretion stress. (tu-berlin.de)

This project offer de nova interactions between the TFs and the TB gene promoters, which results of DNA binding cis-elements. (europa.eu)

We found that 61 Zn2Cys6 TF genes play indispensable and diversified roles in fungal development and pathogenicity. (prelekara.sk)
Systematic Analysis of ZnCys Transcription Factors Required for Development and Pathogenicity by High-Throughput Gene Knockout in the Rice Blast Fungus. (prelekara.sk)
2007) Mnh6, a nonhistone protein, is required for fungal development and pathogenicity of Magnaporthe grisea. (prelekara.sk)

The principle aim of this project is to isolate TFs genes WRKY, AP2, MYP etc. that specifically regulate the expression of taxol biosynthetic rate limiting gene promoters using transient RNAi. (europa.eu)
A way to achieve this would be knowledge-based strain design by deleting and/or over-expressing transcription factors that specifically regulate xylanase gene expression. (biomedcentral.com)

One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)
Genes that encode the B-regulatory subunit (Cdc55) and the three catalytic subunits (Pph21, Pph22, and Pph3) of phosphatase 2A (PP2A) were isolated. (fsu.edu)
Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)

The data indicate that potential developmental roles for XP-related genes can be profitably studied in this system. (nih.gov)

While the number of identified lncRNAs is growing, our understanding of how lncRNAs themselves regulate other genes is quite limited. (umassmed.edu)

The repE gene maps to chromosome 4 and it is the first gene identified in Dictyostelium that is homologous to those involved in nucleotide excision repair and their related XP diseases in humans. (nih.gov)

Overall, the numbers of differentially expressed genes (DEGs) were higher in the resistant tomato line PI 114490 than in the susceptible line OH 88119, and the numbers of DEGs were higher at 6 DPI than at 6 HPI. (frontiersin.org)

Biological processes over-represented in the down-regulated genes include those belonging to central metabolic pathways, translation and transcription. (tu-berlin.de)

High temporal resolution (2-h) sampling over 48 h using RNA sequencing (RNA-Seq) identified circadianly expressed genes in Neurospora, revealing that from ∼10% to as much 40% of the transcriptome can be expressed under circadian control. (dartmouth.edu)

Gene regulatory network inference and gene module regulating virulence in Fusarium oxysporum. (openwetware.org)

Indeed, the isolation of clock-controlled genes (ccgs) was pioneered in Neurospora where circadian output begins with binding of the core circadian transcription factor WCC to a subset of ccg promoters, including those of many transcription factors. (dartmouth.edu)

The impact of constitutive HacA activity during exponential growth was explored in bioreactor controlled cultures using transcriptomic analysis to identify affected genes and processes. (tu-berlin.de)
In the present study, histochemical methods and quantification of the expression levels of the programmed cell death (PCD) and DNA repair processes related genes (MCA, TAT-D, RAD51, KU80, and LIG) were used to investigate the physiological events occurring in the megagametophyte tissue during embryo development. (scite.ai)
Aging of biological systems is controlled by various processes which have a potential impact on gene expression. (uni-frankfurt.de)

This data not only reveals novel photobiology and metabolic regulation, it also allows derivation of constitutive and regulated gene expression parts. (biorxiv.org)
We then define a modular cloning system, including antibiotic selections, integration sites, and reporter genes, and use the transcriptomics to derive strong constitutive and regulated promoters. (biorxiv.org)

Inactivation of E2f6 leads to a failure to deposit CpG island DNA methylation at these genes during implantation. (cnrs.fr)
In euchromatin, methylation of histone H3K4, H3K36 and H3K27me3 were shown to be associated with gene regulations including transcriptional activation and gene silencing13. (achrinhibitor.com)

In addition, the expression of ERG2, ERG24 and ERG11 genes and the ergosterol content had no differences between wild type and the mutant. (ncl.edu.tw)

It is the only mushroom-forming fungus for which genes have been inactivated by homologous recombination. (nature.com)
However, there is no high-throughput gene knockout system constructed, and little is known about most of the genes in this fungus. (prelekara.sk)
LncRNA RZE1 regulates zinc finger transcription factor ZNF2 and affects the yeast-to-hypha transition in the human pathogenic fungus Cryptococcus neoformans [ 22 ]. (biomedcentral.com)
Construction and Analysis of Gene Co-Expression Network in the Pathogenic Fungus Ustilago maydis. (openwetware.org)

When Arabidopsis plants were exposed to cold temperature, H3K27me3 was significantly reduced in the area of chromatin containing COR15A (Cold-regulated15A) and ATGOLS3 (Galactinol Synthase 3) 17, which are cold stress response genes. (achrinhibitor.com)
After epidermal injury, barrier repair requires activation of many wound response genes in epidermal cells surrounding wound sites. (sdbonline.org)

However, the gene expression and activity of antioxidative enzymes had no differences between wild type and the zcf29zcf29 mutant. (ncl.edu.tw)
Comparison of the deletion, the over-expression, and the parent strain demonstrated that Xpp1 regulates gene expression of xylanolytic enzymes at later cultivation stages. (biomedcentral.com)
The transactivator Xyr1 (Xylanase regulator 1) is essential for gene expression of most cellulolytic and xylanolytic enzymes [ 10 ]. (biomedcentral.com)

Common bunt, caused by two fungal species, Tilletia caries and Tilletia laevis , is one of the most potentially destructive diseases of wheat. (mdpi.com)
Structure of Co-expression Networks of Bifidobacterium species in Response to Human Milk Oligosaccharides. (openwetware.org)

It is required for the successful transcription of nearly all class II gene promoters in yeast. (wikipedia.org)

Here, we demonstrate that the transcription factor E2F6, a member of the polycomb repressive complex 1.6 (PRC1.6), is critical to target and initiate epigenetic silencing at germline genes in early embryogenesis. (cnrs.fr)
role of a plant ING2 gene in development, flowering, and gene expression, which likely involves an epigenetic mechanism. (nsf.gov)

The expression of efflux transporters is regulate and handle distinct stages of your detoxification method by modifications in particcontrolled mostly by fungal zinc group transcription variables (TF [Zn2Cys6]) [127]. (hsvinhibitor.com)

Here we show that deletion of PaClpP, encoding the CLP protease proteolytic subunit CLPP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina. (uni-frankfurt.de)
This phenotype can be reverted by expression of human ClpP in the fungal deletion background, demonstrating functional conservation of human and fungal CLPP. (uni-frankfurt.de)

2023. The gene regulatory network of Staphylococcus aureus ST239-SCCmecIII strain Bmb9393 and assessment of genes associated with the biofilm in diverse backgrounds. (openwetware.org)

RNA-seq data showed that FLK regulates expression abundance of some major defense- and development-related genes as well as alternative splicing of a number of genes. (nsf.gov)

Notably, cellulases seem to be regulated in a different manner by Xyr1 than xylanases. (biomedcentral.com)

This is evident at the subfamily level comparisons since Ciona GPCR sequences are significantly analogous to vertebrate GPCR subfamilies even while exhibiting Ciona specific genes. (biomedcentral.com)

Therefore, although circadian activation is critical to ccg rhythmicity, posttranscriptional regulation plays a major role in determining rhythmicity at the mRNA level. (dartmouth.edu)

Ambient pH signal transduction involves the products of the pal genes and the transcription factor PacC in A. nidulans, and the corresponding RIM homologs in S. cerevisiae. (ucm.es)

In recent years, the world has experienced an increase in mycotoxin contamination of grains due to climatic and agronomic changes that encourage fungal growth during cultivation. (usda.gov)

In rice, the OsWAK gene family is significantly amplified compared to Arabidopsis. (biomedcentral.com)

We have cloned and characterized the Dictyostelium discoideum repE gene, a homolog of the human xeroderma pigmentosum (XP) group E gene which encodes a UV-damaged DNA binding protein. (nih.gov)

Anatomy7

Organisms4

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes49

Disciplines and Occupations2

Information Science6

Health Care2

Pathway25

Pathogen14

Target genes5

Proteins6

Molecular7

Transcriptional regulation6

Negatively regulates2

Genome9

Fungi2

Protein-codin1

Intracellular3

Mutants8

Mutations6

Bacterial6

Resistance10

Eukaryotic3

Biosynthesis2

Kinase4

Cellulase2

Mechanisms5

Infections4

Genetic5

Pathogenesis4

Albicans3

Genetics1

Metabolism4

Cellular6

Infection4

Positively1

Regulators1

Conclusions1

Interactions1

Pathogenicity3

Specifically regulate2

Encode3

Developmental1

LncRNAs1

Humans1

Differentially expressed1

Pathways1

Transcriptome1

Fusarium1

Transcription factors1

Processes3

Constitutive2

Methylation2

ERG21

Fungus4

Response genes2

Enzymes3

Species2

Promoters1

Epigenetic2

Zn2Cys61

Deletion2

Regulatory1

Abundance1

Xylanases1

Specific genes1

Circadian1

Signal transduction1

Growth1

Significantly1

Homolog1