• Figure 2: Agrin delays neonatal cardiomyocyte maturation and is required for P1 cardiac regeneration following surgical resection. (nature.com)
  • Chromatin immunoprecipitation with sequencing demonstrates that Meis1 and Hoxb13 act cooperatively to regulate cardiomyocyte maturation and cell cycle . (bvsalud.org)
  • These results demonstrate that Meis1 and Hoxb13 act cooperatively to regulate cardiomyocyte maturation and proliferation and provide mechanistic insights into the link between hyperplastic and hypertrophic growth of cardiomyocytes . (bvsalud.org)
  • It was previously demonstrated that targeting of a Na + -Ca 2+ exchanger by miR-132 was able to prevent apoptosis of cardiomyocytes under hypoxic conditions ( 11 ). (spandidos-publications.com)
  • Here we show that changes in the composition of the extracellular matrix during this week can affect cardiomyocyte growth and differentiation in mice. (nature.com)
  • We take advantage of zebrafish models to address whether factors that regulate fiber-type differentiation enhance or suppress the zebrafish dmd muscle degeneration phenotype. (seattlechildrens.org)
  • They also found that without Braveheart, MesP1, the master gene that regulates heart-cell differentiation in vertebrate animals, doesn't work . (medicalnewstoday.com)
  • Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. (springer.com)
  • Elucidating the molecular mechanisms of cardiomyocyte apoptosis would be of great importance for tackling apoptosis related heart disease. (molcells.org)
  • In vivo , a single administration of agrin promotes cardiac regeneration in adult mice after myocardial infarction, although the degree of cardiomyocyte proliferation observed in this model suggests that there are additional therapeutic mechanisms. (nature.com)
  • Dendrites serve critical roles in establishing neuronal circuits and integration of synaptic signals, so mechanisms that regulate their arborization have significant impact on brain function. (jneurosci.org)
  • Overall, these findings not only reveal how the heart senses and adaptively responds to environmental changes due to cardiac injury, but also provide insight into how flow-mediated mechanisms may regulate cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)
  • However, while myocardial reperfusion is well established, the process itself can trigger myocardial reperfusion injury by causing further cardiomyocyte death through multiple pathophysiological mechanisms [ 3 - 5 ]. (hindawi.com)
  • It is important to understand how these mechanisms are dynamically regulated by pivotal molecular targets and potentially reversed in the context of cardioprotection [ 6 ]. (hindawi.com)
  • For instance, some studies have suggested that in addition to antioxidant enzymes, nitric oxide synthases (NOSs), and other traditional enzymes, novel molecular targets such as mitochondria-targeting hydrogen sulfide (H 2 S) donor AP39 and its auxiliary targets have recently been identified as critical participants in H 2 S synthesis for modulating the postischemic cardiomyocyte survival in a manner independent of classical cytosolic signaling mechanisms [ 7 , 8 ]. (hindawi.com)
  • Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
  • However, it is unclear how cerebral ischemic stroke regulates cardiac function, what are the direct effects of stroke on cardiac function, and what are the underlying molecular mechanisms. (justia.com)
  • Figure 1: Identification of agrin in a screen for mouse cardiac ECM-mediated cardiomyocyte proliferation. (nature.com)
  • Figure 4: Agrin promotes cardiomyocyte proliferation through Dag1, ERK and Yap signalling. (nature.com)
  • We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three amino acid loop extension (TALE) family homeodomain transcription factor , translocates to cardiomyocyte nuclei shortly after birth and mediates postnatal cell cycle arrest3. (bvsalud.org)
  • Cardiomyocyte -specific deletion of Hoxb13 can extend the postnatal window of cardiomyocyte proliferation and reactivate the cardiomyocyte cell cycle in the adult heart . (bvsalud.org)
  • Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. (ox.ac.uk)
  • To determine the relationships between myosin conformations, sarcomere function, and cell biology we assessed contractility, relaxation, and cardiomyocyte morphology and metabolism, with and without an allosteric modulator of myosin ATPase activity. (ox.ac.uk)
  • Research in the past 20 years revealed that non-glandular organs such as adipose tissue, liver and skeletal muscle can secrete hormones that regulate whole-body metabolism. (upenn.edu)
  • For instance, neurons rely on glycolysis and ensuing OxPhos but not FAO, while cardiomyocytes use OxPhos and FAO to generate most energy for cardiac contraction. (upenn.edu)
  • Here we report that Hoxb13 acts as a cofactor of Meis1 in postnatal cardiomyocytes . (bvsalud.org)
  • By profiling the transcriptome of ~24,000 nuclei, we identified major and rare cardiac cell types and revealed significant heterogeneity of cardiomyocytes, fibroblasts, and endothelial cells in postnatal developing hearts. (upenn.edu)
  • Beta Alanine Suffocates Cardiomyocytes, Taurine Lets Them Breath Again: Taurine Regulates Mitochondrial Protein Synthesis and Protects Mitochondria Against Superoxide Generation. (blogspot.com)
  • Congratulations to Ju Youn Beak, a postdoctoral fellow in Dr. Jensen's Lab, for publishing paper, titled "The nuclear receptor ROR-alpha preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy", in the journal JBC. (unc.edu)
  • Class IIa histone deacetylases (HDACs) regulate a variety of cellular processes, including cardiac growth, bone development, and specification of skeletal muscle fiber type. (jci.org)
  • Calcium homeostasis is vital to a number of day-to-day cellular activities and is regulated primarily by mitochondria. (sciencedaily.com)
  • Sirtuin 1 (SIRT1), a member of the sirtuin family, regulates the cellular ageing process, participates in metabolic diseases, such as diabetes, and is related to cancer development ( 13 ). (spandidos-publications.com)
  • Confirming this, 4 beta-phorbol 12-monoacetate and 4 alpha-phorbol had no effect on cellular eicosanoid formation, while the PMA-induced response was fully abolished both in the presence of the PKC inhibitors staurosporine and CGP 41251 and in PKC-down-regulated cells. (unige.ch)
  • Calcium ions are important for many cellular functions, including regulating the electrical activity of cells, cell-to-cell communication, the tensing of muscle fibers (muscle contraction), and the regulation of certain genes, particularly those involved in the development of the brain and bones before birth. (medlineplus.gov)
  • MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate several gene expressions, pathways, and complex biological networks at the cellular level acting either exclusively or together with other miRNAs. (justia.com)
  • MiRNAs are characterized by binding the 3 - UTR of special mRNA to regulate the expression of the related proteins [ 10 , 11 ]. (hindawi.com)
  • MiRNAs regulate both transcriptional and post-transcriptional gene expression as well as regulate several circuits involved in tissue repair, inflammation, hypoxia-response, and angiogenesis. (justia.com)
  • Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
  • The amount of calcium that mitochondria take up is regulated by various components of this channel. (sciencedaily.com)
  • Alpha-adrenergic receptor stimulation produces a cascade of second messenger systems that subsequently regulate calcium channels and in turn elicit increases in cytosolic calcium. (medscape.com)
  • Hibernation increased SRX conformations while pathogenic variants destabilized these and increased the proportion of DRX myosins, which enhanced cardiomyocyte contractility but impaired relaxation, and evoked hypertrophic remodeling with increased energetic stress. (ox.ac.uk)
  • In cardiomyocytes, CaMKII phosphorylation of HDAC4 results in hypertrophic growth, which can be blocked by a signal-resistant HDAC4 mutant. (jci.org)
  • We have previously reported that the cardiomyocyte circadian clock regulates transcriptional responsiveness of the heart to acute increases in fatty acid availability (e.g., short-term fasting). (nih.gov)
  • Fatty acid availability was increased in cardiomyocyte-specific CLOCK mutant (CCM) and wild-type (WT) littermate mice for 9weeks in time-of-day-independent (streptozotocin (STZ) induced diabetes) and dependent (high fat diet meal feeding) manners. (nih.gov)
  • Importantly, cardiomyocyte-specific inducible overexpression of Xbp1s partially ameliorated diastolic dysfunction, exercise intolerance and pulmonary congestion in HFpEF mice. (unina.it)
  • In this study, we demonstrate that miR-23a participates in the regulation of cardiomyocyte apoptosis in vitro and in vivo . (molcells.org)
  • In vitro , recombinant agrin promotes the division of cardiomyocytes that are derived from mouse and human induced pluripotent stem cells through a mechanism that involves the disassembly of the dystrophin-glycoprotein complex, and Yap- and ERK-mediated signalling. (nature.com)
  • Neonatal rat cardiomyocytes were also used to evaluate the protective effect of GRh2 on hypoxia/reoxygenation (H/R)‑induced myocardial injury in vitro. (spandidos-publications.com)
  • In their study they show how mouse embryonic stem cells that don't have enough Braveheart lncRNA fail to develop any of the three major types of cell of the cardiovascular system: cardiomyocytes (which make cardiac muscle), smooth muscle cells and endothelial cells. (medicalnewstoday.com)
  • MicroRNA-126 (miR-126) is endothelial cell (EC) specific and plays a key role in regulating EC function, controlling angiogenesis, and maintaining vascular integrity. (justia.com)
  • Here, we utilize in vivo biophysical and genetic fate mapping zebrafish studies to reveal that altered hemodynamic forces due to cardiac injury activate a sequential endocardial-myocardial signaling cascade to direct cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)
  • Consequently, Klf2a then activates endocardial Notch signaling which results in the non-cell autonomous initiation of myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)
  • This endocardial Notch signaling can in turn non-cell autonomously initiate myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration, whereas its inhibition through either using tissue-specific genetic-based strategies or altering blood flow impairs this reparative event. (elifesciences.org)
  • In this study, we demonstrate that MnSOD is down-regulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury. (molcells.org)
  • In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)
  • Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
  • Lower vertebrate and neonatal mammalian hearts exhibit the remarkable capacity to regenerate through the reprogramming of pre-existing cardiomyocytes. (elifesciences.org)
  • Molecular mechanism of apoptosis-inducing factor regulated by FBXO22 and its role in cancer cell apoptosis [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(4): 427-433. (shsmu.edu.cn)
  • The heart failure phenotype was only observed under combined treatment with HFD and L-NAME and was associated with molecular changes within the cardiomyocytes. (unina.it)
  • During injury stimulation, the major effects on the cardiac function may be those involving mitochondria-dominated events along with potential nucleus-governed genetic/epigenetic alternations within the cardiomyocytes as well as the macrophage-led inflammation and T-cell-led immune responses underlying the myocardium-vessel interactive cascade. (hindawi.com)
  • Critical role of insulin?like growth factor binding protein?5 in methamphetamine?induced apoptosis in cardiomyocytes. (genscript.com)
  • Specifically, the spliced form of X-box binding protein 1 (Xbp1s), a downstream effector of the unfolded protein response (UPR), exhibited a significant reduction in the HFpEF model hearts and cardiomyocytes. (unina.it)
  • These results demonstrate the essential role of protein homeostasis dysregulation in HFpEF cardiomyocytes and suggest that inhibiting iNOS activity may be a viable therapeutic strategy in this condition. (unina.it)
  • The expression of protein kinase C (PKC) isoenzymes and the effects of PKC activation on myocardial phospholipase A2 (PLA2) activity, platelet-activating factor (PAF) generation and eicosanoid release were studied in spontaneously beating cultured rat cardiomyocytes. (unige.ch)
  • We are also working to identify new epigenetic factors that regulate muscle fiber type. (seattlechildrens.org)
  • We have developed a novel preclinical model of HFpEF, unveiling iNOS-driven dysregulation of Xbp1s as a crucial mechanism of cardiomyocyte dysfunction. (unina.it)
  • The purpose of the present study was to investigate whether the cardiomyocyte circadian clock plays a role in adaptation of the heart to chronic elevations in fatty acid availability. (nih.gov)
  • These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of δ-catenin. (jneurosci.org)
  • PKC alpha, delta and/or zeta therefore appear to play an important role in the PMA-mediated activation of cardiomyocyte PLA2, an event leading to subsequent production of PGI2, PGE2, 15-HETE, lyso-PC and PAF in this tissue. (unige.ch)
  • Well, firstly it can distribute the beta alanine over millions of brain and muscle cells (something that obviously could not happen in the petri-dish with isolated cardiomyocytes the scientists used in this experiment), where it will ideally bind to histidine and form the potent intracellular buffer and anti-oxidant carnosine. (blogspot.com)
  • implying that this complex has functional roles that extend beyond its ability to regulate cell adhesion. (jneurosci.org)
  • Like a partial agonist, beta alanine also interferes with the actions of taurine by inhibiting reactions that involve the former, so that the cardiomyocytes Jong and his colleagues from the Universities of South Alabama, USA, and Kobe, Japan, incubated with 5mM beta alanine for 48h induced a 45% decrease in taurine content in the neonatal rat cardiomyocytes. (blogspot.com)
  • Our study reveals a novel model regulating cardiomyocyte apoptosis which is composed of miR-23a and MnSOD. (molcells.org)
  • Further, we show that miR-23a directly regulates the expression of MnSOD. (molcells.org)
  • miR-23a regulates cardiomyocyte apoptosis by suppressing the expression of MnSOD. (molcells.org)
  • IGFBP5 expression was up-regulated in the striatum of methamphetamine exposed male Sprague-Dawley rats. (genscript.com)
  • miR‑132 directly targeted SIRT1 and negatively regulated the expression of SIRT1. (spandidos-publications.com)
  • A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes. (bvsalud.org)
  • GDF15 is a heart-derived hormone that regulates body growth. (upenn.edu)