TyrosineAntibodiesCD47PathogensTightly regulatedMoleculesAndrogen receptorProteinTumorProto-oncogeneGenesComplexesBindsDifferentiationAdaptive immune rMembrane receptorProteinsGlycoproteinExtracellularInhibitorHER2Complement activationClinicalAntibodyGeneMiceInteractsDendritic cellsDeficiencySurfaceViralIdentificationRoleMolecularCellDiscoveryExpressionHumanSystemFunctionsPatientsFactorHostBloodMajorResponsePartner
Tyrosine4
- discoidin domain receptor tyrosine kin. (gsea-msigdb.org)
- Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
- The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. (iiab.me)
- Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (iiab.me)
Antibodies1
- Additionally, C3b molecules can attach to the Fc regions of antigen-bound antibodies leading to phagocytosis or movement to the liver, where the C3b-tagged immune complex is then destroyed. (wikipedia.org)
CD477
- Our cell cultures were strongly positive for CD46, CD47, CD56 and CD63 and were also strongly positive for some markers never described before in mesothelioma cell lines, including CD55, CD90 and CD99. (biomedcentral.com)
- CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain , five transmembrane domains , and a short C-terminal intracellular tail. (wikidoc.org)
- CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
- CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells . (wikidoc.org)
- Antigens, CD47" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
- This graph shows the total number of publications written about "Antigens, CD47" by people in this website by year, and whether "Antigens, CD47" was a major or minor topic of these publications. (rush.edu)
- Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)
Pathogens7
- C3b is potent in opsonization: tagging pathogens, immune complexes (antigen-antibody), and apoptotic cells for phagocytosis. (wikipedia.org)
- The key to the success of the complement system in clearing antigens is regulating the effects of C3b to pathogens alone and not healthy, host cells. (wikipedia.org)
- Recently we have shown the dual function of an autophagic receptor which, in addition to target pathogens towards the autophagic machinery, also regulates the maturation of autophagosome to efficiently degrade the substrates. (cfatg.org)
- Antigen presentation by molecules of the major histocompatibility complex (MHC) is an essential step to initiate an adaptive immune response to efficiently fight pathogens. (cfatg.org)
- Since numerous antigens which are presented by MHC molecules traffic via the lysosomes, autophagy is an important reservoir for the production of antigenic peptides derived from the degradation of intracellular pathogens. (cfatg.org)
- We seek to understand the molecular connections between autophagy and antigen presentation and to measure their impact on the diversity of the presentation, especially in the context of self antigens (those of the cell), and non-self antigens (those from pathogens). (cfatg.org)
- 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
Tightly regulated4
- The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. (jrheum.org)
- The complement system is a tightly regulated, cascading protein network that performs multiple roles in homeostasis and disease prevention and is a key component of both the innate and the humoral immune systems. (jrheum.org)
- The complement system is tightly regulated by inactivators that accelerate the decay of intermediates and certain cell surface receptors. (uams.edu)
- In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (iiab.me)
Molecules2
- The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
- In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)
Androgen receptor1
- The team has developed two prostate cancer vaccines, which activate the immune system against two prostate cancer associated proteins - the androgen receptor (AR), and prostatic acid phosphatase (PAP). (pcf.org)
Protein7
- Factor I, with cofactors including membrane cofactor protein (CD46), inactivates C3b and C4b. (msdmanuals.com)
- Searching for more direct proof to implicate thymic myoid and/or epithelial cells in the response, we now have looked for symptoms of go with attack in it and for appearance from the complement-regulatory protein CD46, Compact disc55, and Compact disc59. (kentlandsinitiative.org)
- Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
- The protein has no known natural ligand [4] and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikidoc.org)
- PAS-2 ' ) plays a functionally important role in maintaining erythrocyte shape and regulating membrane material properties, possibly through its interaction with protein 4.1. (wikidoc.org)
- GPC appears to be synthesized in excess in the erythrocyte and that the membrane content is regulated by band 4.1 (protein 4.1). (wikidoc.org)
- The JUN protein is a transcription factor that plays a crucial role in regulating gene expression in response to a variety of signals, including growth factors, cytokines, and stress. (cusabio.com)
Tumor3
- The LG.3A10 antibody reacts with CD27, a 45 - 55 kDa member of the tumor necrosis factor receptor superfamily. (stemcell.com)
- On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)
- A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)
Proto-oncogene1
- ABL proto-oncogene 1, non-receptor tyr. (gsea-msigdb.org)
Genes3
- The affected patients' genetic backgrounds revealed significant genetic heterogeneity in several genes involved in complement regulation, including the complement factor H, complement factor H-related proteins, complement factor I, complement factor B, complement component 3, and CD46 genes in the alternative complement pathway. (ekjt.org)
- Genes down-regulated in comparison of macrophages versus macrophages exposed to L.donovani. (gsea-msigdb.org)
- JUN-regulated genes are involved in a wide range of biological processes, including cell proliferation, differentiation, apoptosis, and inflammation. (cusabio.com)
Complexes2
- Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
- The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
Binds1
- Furthermore, host cells express p33 (globular C1q receptor) on the surface, which binds C1q, and prevents it from initiating complement activation. (wikipedia.org)
Differentiation1
- We show that NAD + regulates CD4 + T-cell differentiation through tryptophan hydroxylase-1 ( Tph1 ), independently of well-established transcription factors. (nature.com)
Adaptive immune r1
- CD4 + T helper (Th) cells play a central role in regulating the adaptive immune response associated with pathogen invasion. (nature.com)
Membrane receptor1
- This study aimed to investigate the role of LTα in MOG 35-55 -induced EAE using mice deficient in LTα or its membrane receptor, LTβR. (rusimmun.ru)
Proteins5
- Given the C3 is constantly being turned over in the alternative pathway and its ability to rapidly amplify a signal, these proteins are important in regulating the temporal and spatial effects of C3b to infected tissues. (wikipedia.org)
- Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
- Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
- Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
- Serum proteins that negatively regulate the cascade process of COMPLEMENT ACTIVATION. (uams.edu)
Glycoprotein1
- Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. (cusabio.com)
Extracellular1
- These variants encoded truncated GP130 receptors, with intact extracellular and transmembrane domains, but lacking the intracellular recycling motif and the four STAT3-binding residues, resulting in an inability to recycle and activate STAT3. (bvsalud.org)
Inhibitor2
- This pathway is regulated by C1 inhibitor (C1-INH). (msdmanuals.com)
- Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy. (edu.pl)
HER25
- Moreover, HSV engineered in gH of a scFv targeting the cancer-specific HER2 receptor, scFv-HER2-gH chimera, can enter, replicate and kill cancer cells efficiently [ 14 ]. (biomedcentral.com)
- It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
- HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (iiab.me)
- HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. (iiab.me)
- [10] [11] HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. (iiab.me)
Complement activation1
- CR1 also regulates complement activation by acting as a cofactor for factor I in the cleavage and degradation of bound C3b and C4b to its inactive forms. (medscape.com)
Clinical2
- Patients will be evaluated for safety, clinical responses, immune system responses against the vaccine antigens (PAP and AR), as well as immune system changes that correlate with clinical responses. (pcf.org)
- Evaluation of CD46 re-targeted adenoviral vectors for clinical ovarian cancer intraperitoneal therapy. (cardiff.ac.uk)
Antibody1
- Antibody FMC7 ( F linder M edical C entre) appears to recognise a conformational variant of CD20 [10] [11] also known as the FMC7 antigen. (wikidoc.org)
Gene2
- The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
- In melanocytic cells Glycophorin C gene expression may be regulated by MITF . (wikidoc.org)
Mice3
- Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
- CD27 is found on peripheral T cells, memory B cells, and NK cells and in mice has been found on most thymocytes, except CD46-CD8- precursors. (stemcell.com)
- Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
Interacts1
- In both cases C3b interacts with the C3b receptor, complement receptor 1 on phagocytic cells, such as macrophages and neutrophils, allowing for engulfment of the pathogen. (wikipedia.org)
Dendritic cells1
- This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
Deficiency1
- Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)
Surface2
- Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)
- B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
Viral1
- However, as TRIM7 is not immune regulated and has restricted tissue expression, its natural function may not be as a viral restriction factor. (mdpi.com)
Identification1
- Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications. (cardiff.ac.uk)
Role1
- CD46), which is ubiquitously expressed and plays a critical role in protecting host cells from damage by the C3b. (wikipedia.org)
Molecular2
- Thus, we have described a molecular link between CD46 and autophagy, which is engaged upon measles virus infection. (cfatg.org)
- These studies will tell us on how autophagy per se is regulated at the molecular level and inform us about the pathways of possible diversion targeted by infectious agents. (cfatg.org)
Cell5
- [ 2 ] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
- The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
- Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
- CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)
- attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. (cusabio.com)
Discovery1
- Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. (cardiff.ac.uk)
Expression4
- Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
- Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
- data indicated that miR-139-5p was down-regulated in the hearts of Hypertrophic cardiomyopathy patients and that it inhibited cardiac hypertrophy by targetting c-Jun expression. (cusabio.com)
- Furthermore, diverse structural alterations have been identified that cause ligand-independent firing of this receptor, doing so in the absence of receptor over-expression. (iiab.me)
Human2
- In 1993, the team of Prof. Chantal Rabourdin-Combe (1952-2011) identified the first human receptor for this virus, CD46. (cfatg.org)
- The human interferon-gamma receptor. (wikidoc.org)
System2
- [1] The following year a new but related antigen was discovered in a Mrs Yus for whom an antigen in this system is also named. (wikidoc.org)
- In 1972 a numerical system for the antigens in this blood group was introduced. (wikidoc.org)
Functions1
- More recently, comprehensive studies related to the functions of this receptor has established the basis of the projects of the current team, putting autophagy at the center of our research projects. (cfatg.org)
Patients1
- The antigen is named after one of the patients - a Mrs Gerbich. (wikidoc.org)
Factor2
- This pathway is regulated by properdin, factor H, and decay-accelerating factor (CD55). (msdmanuals.com)
- colony stimulating factor 2 receptor s. (gsea-msigdb.org)
Host1
- May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity. (cusabio.com)
Blood1
- Glycophorin A and glycophorin B carry the blood group MN and Ss antigens respectively. (wikidoc.org)
Major1
- CR1/CD35 and CR2/CD21 are major receptors for activated fragments of C3. (medscape.com)
Response1
- The antigen was discovered in 1960 when three women who lacked the antigen made anti-Gea in response to pregnancy. (wikidoc.org)
Partner1
- IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)