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  • mechanism
  • We propose that this unique mechanism of muscle stem cell development is a legacy of the evolutionary history of the chordate head mesoderm. (frontiersin.org)
  • neuronal
  • To study the biological function of the tumor suppressor BRCA1, we deleted BRCA1 in nestin positive neuronal stem cells in the brain and showed that the animals displayed severe neuro-developmental deficits. (aacrjournals.org)
  • In the absence of BRCA1, the number of heterochromatic centers is severely reduced in mouse neuronal cells. (aacrjournals.org)
  • Most NF1 sufferers ( 90%) develop tumors inside the peripheral ganglia, peripheral and/or cranial nerves neurofibromas known as, made up of cell types including neuronal axons, fibroblasts, perineurial cells, Schwann cells, and mast cells (7). (movd2016.org)
  • Those Schwann cells connected with neuronal cell physiques form satellite television cells that communicate either S100 or GFAP. (movd2016.org)
  • transcription
  • The changes in satellite cell properties coincided with the inactivation of Notch signaling and the activation of Wnt signaling and likely involve modulation by transcription factors of the Sox family. (hindawi.com)
  • In the past, we have reported aberrant regulation of several cell signaling pathways and transcription factors in skeletal muscle of dystrophin-deficient mdx mice. (louisville.edu)
  • Gene expression analysis showed reduced expression of the Forkhead box class O transcription factor 1 (FoxO1) gene in Ppardelta-cKO muscles under both quiescent and regenerating conditions, suggesting that PPARdelta acts through FoxO1 in regulating muscle progenitor cells. (umassmed.edu)
  • HP1 proteins are destabilized, and more importantly, the transcription of satellite DNA is derepressed in mouse neural progenitor cells, mouse fibroblasts, and human cancer cells, including a BRCA1 deficient breast cancer cell line. (aacrjournals.org)
  • These experiments showed that the E3 ligase activity of BRCA1 is required for repression of satellite DNA transcription. (aacrjournals.org)
  • Given that mutants in the RING domains are the same as in women who have pathological diseases, we hypothesize that deregulation of satellite DNA transcription can be explored as an early detection marker for breast cancer progression in BRCA1 patients. (aacrjournals.org)
  • The activation of this pathway appears to depend on the translocation of β-catenin from the cytoplasm to the nucleus and on interactions with transcription factors of the Lef1/Tcf family, which eventually regulate the transcription of target genes. (medsci.org)
  • vitro
  • In Vitro Cell. (nii.ac.jp)
  • Because BRCA1 contains an E3 ubiquitin ligase activity which is enhanced by BARD1 and the complex ubiquitinate histone H2A in vitro , we examined the heterochromatin silencing in cells with different BRCA1 mutants. (aacrjournals.org)
  • In particular, it has been shown that in vitro mouse satellite cells can directly differentiate into adipocytes ( 11 - 13 ). (diabetesjournals.org)
  • Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem cells may be the most promising route toward the therapy of muscle diseases such as muscular dystrophies. (frontiersin.org)
  • cellular
  • The effects of the reaction oxidative species (ROS) are dose-dependent, and low ROS concentration is necessary to guarantee cellular homeostasis while high ROS dose exerts toxic effects on the cells and may contribute to cellular dysfunction. (hindawi.com)
  • Inhibition of Notch signaling induces myotube hypertrophy by recruiting a subpopulation of reserve cells," Journal of Cellular Physiology , vol. 208, no. 3, pp. 538-548, 2006. (hindawi.com)
  • Pharmacological inhibition of RAS attenuated cellular priming, suggesting that RAS inhibition may be potentially useful for converting human cells into ground state and for efficient somatic cellular reprogramming. (utahcordbank.com)
  • mRNA
  • For instance, we previously showed that the endoribonuclease L (RNase L) and its inhibitor (RLI) regulates MyoD mRNA stability and consequently muscle differentiation.We now performed global gene expression analysis by SAGE to identify genes that were down-regulated upon activation of RNase L in C2C12 myogenic cells, a model of satellite cells. (jove.com)
  • We found that RNase L regulates mRNA stability of factors implicated in the control of pluripotency and cell differentiation. (jove.com)
  • The protein and mRNA levels of MyoG, MyHC, Sirt1 and FoxO1 in the satellite and C 2 C 12 cells with an H19 silencing or overexpression vector were respectively detected using western blot and real-time qPCR. (biomedcentral.com)
  • myotubes
  • By purifying the different muscle cell types and by testing them in pairwise combinations we have shown that myotubes negatively control FAP differentiation by activating the NOTCH pathway. (tu-dresden.de)
  • maturation
  • We find in mice that deletion of lysyl oxidase (Lox), an extracellular enzyme regulating collagen maturation and organization, uncouples the balance between the amount of myofibers and that of muscle connective tissue (MCT). (biologists.org)
  • mitochondrial
  • By disrupting M-cadherin-dependent cell-cell adhesion by knocking down M-cadherin expression using RNA interference, we demonstrated that M-cadherin-mediated signaling is important for maintaining mitochondrial integrity. (biologists.org)