Regulates progenitor cell proliferation and differentiation. Medical search. Frequent questions

In particular, the CHD8 protein and the genes it regulates likely help control the development of neural progenitor cells, which give rise to nerve cells (neurons), and the growth and division (proliferation) and maturation (differentiation) of neurons. (medlineplus.gov)
Without Hes genes such as Hes1 , however, progenitor cells prematurely differentiate into certain types of neurons only, and are depleted before they have proliferated sufficiently and generated all neuronal and glial cell types. (biologists.com)
We demonstrate that neural stem/progenitor cell (NSPC) self-renewal and spatiotemporal generation of neurons and other cell types are severely impacted by the loss of Ythdf2 in embryonic neocortex. (biomedcentral.com)
Cell proliferation ceased, and differentiation into electrophysiologically active neurons and other CNS cell types in vivo ensued upon transplantation into rats, both during development and after adult injury--with functional improvement and without neoplasia, overgrowth, deformation, emergence of non-neural cell types, phenotypic or genomic instability, or need for immunosuppression. (nih.gov)
Human antigen R-regulated mRNA metabolism promotes the cell motility of migrating mouse neurons. (ucas.ac.cn)
Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. (ucas.ac.cn)
The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. (jci.org)
This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. (jneurosci.org)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
We provide detailed protocols for the generation of lentiviral vectors, the transduction of hES-cells, and their differentia- tion into neurons. (lu.se)

Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
Wu, Y. and Zhao, R.C. (2012) The Role of Chemokines in Mesenchymal Stem Cell Homing to the Myocardium. (scirp.org)
Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
Fehrer, C. and Lepperdinger, G. (2005) Mesenchymal Stem Cell Aging. (scirp.org)
Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
Deletion of the glucocorticoid receptor gene (Nr3c1) from fetal pulmonary mesenchymal cells phenocopied defects caused by global Nr3c1 deletion, while lung epithelial- or endothelial-specific Nr3c1 deletion did not impair lung function at birth. (stanford.edu)
GR enhanced differentiation of a newly defined proliferative mesenchymal progenitor cell (PMP) into matrix fibroblasts (MFBs), in part by directly activating extracellular matrix-associated target genes, including Fn1, Col16a4, and Eln and by modulating VEGF, JAK-STAT, and WNT signaling. (stanford.edu)
Loss of mesenchymal GR signaling blocked fibroblast progenitor differentiation into mature MFBs, which in turn increased proliferation of SOX9+ alveolar epithelial progenitor cells and inhibited differentiation of mature alveolar type II (AT2) and AT1 cells. (stanford.edu)
GR signaling controls genes required for differentiation of a subset of proliferative mesenchymal progenitors into matrix fibroblasts, in turn, regulating signals controlling AT2/AT1 progenitor cell proliferation and differentiation and identifying cells and processes by which glucocorticoid signaling regulates fetal lung maturation. (stanford.edu)
The aim of this study is to investigate if CDK6 is required for mesenchymal stem cell proliferation and adipocyte differentiation. (bvsalud.org)
Profibrogenesis cytokine, transforming growth factor- (TGF-) β 1, induces hepatic progenitors experiencing epithelial to mesenchymal transition (EMT) to matrix synthesis cells, even tumor initiating cells. (hindawi.com)
Although hepatic progenitors, also called hepatic oval cells in rat, are less sensitive to TGF- β 1 than mature hepatocytes [ 7 ], TGF- β 1 could cause hepatic progenitors obtaining myofibroblast cells phenotype and expressing collagen I through epithelial-mesenchymal transition in vitro [ 8 ]. (hindawi.com)
Our previous results show that EGF is a specific cytokine which could suppress TGF- β 1-induced EMT initiation and drives mesenchymal-epithelial transition (MET) in the cells that have experienced EMT [ 13 ], revealing the plasticity of progenitor cells. (hindawi.com)
Demyelinating conditions are difficult to treat and stem cell therapy using bone marrow mesenchymal stem cells (BMSCs) is a promising novel strategy. (biomedcentral.com)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. (medlineplus.gov)
The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. (biologists.com)
In many organs, cell proliferation and differentiation are antagonistically regulated by multiple basic helix-loop-helix (bHLH) activator and repressor genes. (biologists.com)
In particular,the Hes bHLH repressor genes play an essential role in the development of many organs by maintaining progenitor cells and by regulating binary cell fate decisions. (biologists.com)
In these processes, Hes genes function as effectors of Notch signaling, which coordinates cellular events via cell-cell interactions. (biologists.com)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
Usage of the powerful oncogenes and in the era of induced pluripotent stem cells (iPSCs) limitations their translational tool STF 118804 1 2 Presently elimination of the genes during individual iPSC reprogramming needs suppression of p53 activity 2-16 which leads to the deposition of hereditary mutations in the causing iPSCs 8. (healthy-nutrition-plan.com)
By systematically analyzing the global properties of the miRNA-disease network, we found that only a small number of miRNAs regulated genes involved in various diseases, genes associated with neurological diseases were preferentially regulated by miRNAs and some immunological diseases were associated with several specific miRNAs. (biomedcentral.com)
Results: Our data showed that the lack of MKP-2 caused a significant down-regulation of colony-stimulating factor-2 (Csf2) and monocyte to macrophage-associated differentiation (Mmd) genes, suggesting a role of MKP-2 in macrophage development. (strath.ac.uk)
In adult mice, IL-7/IL-7R signaling up regulates expression of early B cell factor (EBF), and EBF in turn regulates expression of B cell-specific genes required for the transition from lymphoid progenitor to pro-B cells. (biolegend.com)

In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
Combining in vivo and in vitro assays, we show that the proliferation and differentiation capabilities of NSPCs decrease significantly in Ythdf2 −/− embryos. (biomedcentral.com)
We previously identified Macrophage Migration Inhibitory Factor (MIF) as a novel factor that can support the proliferation and/or survival of NSPCs based on in vitro functional cloning strategy and revealed that MIF can support the proliferation of human brain tumor-initiating cells (BTICs). (elsevierpure.com)
Furthermore, gene silencing of TPT1 caused defects in neuronal differentiation in the NSPCs in vitro. (elsevierpure.com)
We speculated that this could be induced in a regulatable manner such that cells proliferate only in vitro and differentiate in vivo without the need for promoting pluripotence or specifying lineage identity. (nih.gov)
were used in the development of a human immunocompetent Organ-on-Chip - a human cell-based in vitro model of the choroid layer of the eye integrating melanocytes and microvascular endothelial cells, covered by a layer of retinal pigmented epithelial cells. (ilexlife.com)
were used to establish a 3D organotypic in vitro model containing microtumor spheroids, macrophages, neutrophils, fibroblasts and endothelial cells, allowing for the analysis of tumor-stroma interactions in a controlled and modifiable environment. (ilexlife.com)
Moreover, JNK1 KO and WT D-JNKI-1 treated OLs, while not showing overt alterations of differentiation in vitro, display a reduced surface compared to controls. (nature.com)
In vitro cultured OPCs showed more differentiation after incubation with BMSC-CM. Hes1 expression was found to be significantly increased by HD and decreased by BMSC or BMSC-CM. The change of Hes1 was found, however, independent of Notch1 activation, but dependent on TNFα/RelB signaling. (biomedcentral.com)
Using pharmacological approaches along with in vitro and in vivo experiments, we found that Nogo-A/NgR1 signaling regulates the pace of neuronal neogeneration by reducing NSC proliferation. (jneurosci.org)
Our findings were subsequently tested by in vitro experiments, where putative early and later-stage DN1 progenitors from the thymus were purified and their progression into DN2 was measured. (lu.se)

All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
suggesting that progenitor cells in the embryonic and adult brain may share similar molecular phenotypes. (jneurosci.org)
Using gene manipulation (over or downregulation of TPT1) techniques including CRISPR/Cas9-mediated heterozygous gene disruption showed that TPT1 contributed to the regulation of cell proliferation/survival in mouse NSPCs, human embryonic stem cell (hESC) derived-NSPCs, human-induced pluripotent stem cells (hiPSCs) derived-NSPCs and BTICs. (elsevierpure.com)
We show that both embryonic and adult rat hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids could act on CB1 receptors to regulate neurogenesis. (jci.org)
This hypothesis is supported by further findings that HU210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal NS/PCs likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. (jci.org)
In keeping with their suggested mechanisms of actions these chemical substances generally function in mobile intermediates that occur past due in reprogramming catalyzing their last transformation into iPSCs 19 22 It really is presently unclear whether known chemical substances are enough for producing iPSCs from adult individual cells which are consistently more difficult to reprogram than mouse embryonic fibroblasts 23. (healthy-nutrition-plan.com)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)

Stem cells have two fundamental properties: self-renewal and multipotency. (wisc.edu)
WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
Precursor/progenitor cells from the organ of therapeutic concern typically lack only one critical attribute--the capacity for sustained self-renewal. (nih.gov)
we conditionally induced self-renewal efficiently within neural progenitors solely by introducing v-myc tightly regulated by a tetracycline (Tet)-on gene expression system. (nih.gov)
This strategy of inducing self-renewal might be applied to progenitors from other organs and may prove to be a safe, effective, efficient, and practical method for optimizing insights gained from the ability to reprogram cells. (nih.gov)
Myelin alterations are accompanied by higher OPC density and proliferation during the first weeks of life, consistent with a transient alteration of mechanisms regulating OPC self-renewal and differentiation. (nature.com)
we present that inhibition of Notch considerably improves the performance of iPSC era from mouse and individual keratinocytes by suppressing p21 within a p53-unbiased manner and thus enriching for undifferentiated cells with the capacity of long-term self-renewal. (healthy-nutrition-plan.com)
A broader interest of our laboratory is to understand the molecular regulation of HSCs both from the perspectives of self-renewal and differentiation, and how these features become altered upon disease-causing or disease-associated perturbations. (lu.se)

The medulloblastoma has been defined by the World Health Organization (WHO) as a "malignant, invasive embryonal tumor of the cerebellum with preferential manifestation in children , predominantly neuronal differentiation, and inherent tendency to metastasize via CSF [cerebrospinal fluid] pathways. (medscape.com)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)

PAK2 kinase activity is stimulated by transforming growth factor β in fibroblasts, by proteinase inhibitor alpha2-macroglobulin binding to GRP78 in prostate cancer cells, by its phosphorylation by AMP-activated protein kinase in stem and cancer cells and eryptosis. (wikipedia.org)
Insulin stimulation of neuronal cells also antagonizes PAK2 kinase activity, leading to an increased glucose uptake. (wikipedia.org)
RAF Kinase Activity Regulates Neuroepithelial Cell Proliferation and Neuronal Progenitor Cell Differentiation during Early Inner Ear Development. (mpg.de)
A-RAF kinase functions in ARF6 regulated endocytic membrane traffic. (mpg.de)
Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH 2 -terminal kinase) or the Ca 2+ -dependent (NLK and nuclear factor of activated T cells) signaling cascades. (aacrjournals.org)
A variety of extrinsic cues converge on the extracellular signal-regulated kinase/mitogen activated protein kinase (ERK/MAPK) pathway. (nature.com)
UTD2 also reduced the phosphorylation of Akt, which is an important signaling kinase regulating the cell survival through Rac1. (kjpp.net)
In addition, IL-7 controls T-cell size and metabolism through the activation of PI3 kinase-dependent pathways and regulation of glucose metabolism. (biolegend.com)

Stem Cell Reviews, 8, 243-250. (scirp.org)
Acute alveolar injury rapidly expands the AT2 stem cell pool by transiently inducing Wnt signaling activity in "bulk" AT2 cells, facilitating rapid epithelial repair. (stanford.edu)
Here, we review alveolar renewal and repair with a focus on the niches, rather than the stem cells, highlighting what is known about the cellular and molecular mechanisms by which they control stem cell activity in vivo. (stanford.edu)
Breakage of the stem cell signaling network leads to carcinogenesis. (aacrjournals.org)
This observation has led to the 'cancer stem cell' (CSCs) hypothesis, stating that a subpopulation of cancer cells survive therapy and lead to tumor relapse. (mdpi.com)
One of the key areas in stem cell research is the identification of factors capable of promoting the expansion of Neural Stem Cell/Progenitor Cells (NSPCs) and understanding their molecular mechanisms for future use in clinical settings. (elsevierpure.com)
Hiroyuki Koike is an Associate Professor in the Department of Medical Biochemistry, Tokyo Medical and Dental University, specializing in stem cell biology and developmental biology. (tmd.ac.jp)
L-arginine homeostasis governs adult neural stem cell activation by modulating energy metabolism in vivo. (ucas.ac.cn)
Neural Stem Cell Niche and Adult Neurogenesis. (ucas.ac.cn)
Among all the potential new therapies, stem cell-based treatments hold great promise for treating many obesity-related metabolic diseases. (bvsalud.org)
We consequently hypothesized that chemically traveling somatic cells into a more potent "stem cell" state might improve their reprogramming. (healthy-nutrition-plan.com)
The Notch signaling pathway is definitely highly conserved and regulates the proliferation and differentiation of many unique progenitor cell and stem cell types 27. (healthy-nutrition-plan.com)
In pores and skin Notch promotes differentiation by directly activating expression which in turn blocks proliferation and induces the differentiation of keratinocyte stem cell populations 29 30 We consequently hypothesized that inhibition STF 118804 of Notch in keratinocytes might enhance iPSC generation by inhibiting differentiation and enriching more easily reprogrammed STF 118804 progenitor cells. (healthy-nutrition-plan.com)
Red cell development is initially regulated by stem cell factor (SCF), which commits hematopoietic stem cells to develop into erythroid progenitors. (medscape.com)
We have established an influence of both compromised genomic maintenance (nuclear and mitochondrial), and alterations in external growth control to these processes, which also have direct relevance for the stability and potential reversibility of the aging stem cell state. (lu.se)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

Therefore, understanding the basic processes regulating OL cell number is key for the advancement in neurobiology. (hwupdate.org)
Embryogenesis involves orchestrated processes of cell proliferation and differentiation. (biologists.com)
In this primer, we describe the key features of Hes factors and detail their roles in some representative processes of embryogenesis: namely, in the development of the nervous and digestive systems, two well-characterized processes, where Hes1 (and Hes3 and Hes5 in the nervous system) regulates cell proliferation and differentiation, and in the process of somite segmentation, where Hes7 functions as a biological clock. (biologists.com)
N 6 -methyladenosine (m 6 A) modification in mRNAs was recently shown to be dynamically regulated, indicating a pivotal role in multiple developmental processes. (biomedcentral.com)
However, all developmental processes originate from pluripotent precursor cell types. (amegroups.org)
The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
How developmental trajectories are encoded in the genome and how the interplay between intrinsic and extrinsic processes regulates development is one of the major questions in developmental biology. (amegroups.org)
In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)
The nature of these processes was not clearly defined, but co-immunolabeling with GFAP suggested that they were principally in activated Müller cells from the third day after the laser impacts. (molvis.org)
After any retinal injury in experimental conditions, glial cells are activated and undergo reactive gliosis with increased an expression level of glial fibrillary acid protein (GFAP), which leads to overgrowth of outer Müller glial cell processes. (molvis.org)
Mast cells play an important role in a variety of biological processes and actively participate in the inflammatory response. (bvsalud.org)
Mast cells play an important role in a variety of biological processes including allergic reactions, atherosclerosis and inflammation 7,8 . (bvsalud.org)
YT modulate processes such as proliferation, differentiation, and organ size and are regulated by the Hippo pathway. (lu.se)
We have developed and applied FACS-based high-resolution cell fractionation procedures to map the differentiation processes from HSCs. (lu.se)
A sub line of our research deals with how proliferation dynamics, at defined cellular stages, associate with these processes. (lu.se)

The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. (wikipedia.org)
Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
MicroRNAs (MiRNAs) are important regulators that can strongly affect cellular functions including proliferation, differentiation, and apoptosis through post-transcriptional negative regulation of target gene expression [ 1 ]. (biomedcentral.com)

PRMT5 pharmacological inhibition, CRISPR/cas9 targeting, or genetic ablation decrease p53-dependent survival and impair differentiation without affecting proliferation. (hwupdate.org)
Conditional ablation of in progenitors results in hypomyelination, reduced survival and differentiation. (hwupdate.org)
Their number is tightly regulated and dependent on differentiation, survival, and proliferation of oligodendrocyte progenitor cells (OPCs). (hwupdate.org)
G-CSF stimulates production and mobilization of neutrophils and regulates survival, proliferation, and differentiation of various cells of the neutrophil lineage. (q2labsolutions.com)
This study investigated the effects of UTD2 on the actin cytoskeleton and its critical regulators, and the signaling pathways which are essential for cell motility, growth and survival in MCF-7 breast cancer cells. (kjpp.net)
In this fashion, IL-7 induces cell activation, survival, and proliferation of T lymphocytes. (biolegend.com)

The research in our laboratory focuses on understanding the molecular mechanisms that regulate neural stem cells and neurodevelopment with the goal of applying this knowledge in the treatment of neurological disorders and injuries. (wisc.edu)
My laboratory is investigating the mechanisms governing the behaviors and functions of neural stem cells in both healthy conditions and in neurological diseases. (wisc.edu)
Using neural stem cells as model systems, we are investigating the molecular mechanisms that regulate neuronal development during postnatal period and their implications in human neurodevelopmental disorders such as Rett Syndrome, Autism, and Fragile X syndrome. (wisc.edu)
We and others have previously contributed to elucidating the molecular mechanisms governing proliferation and differentiation of OPC2C4. (hwupdate.org)
Here, the role of GCC in regulating normal enterocyte dynamics along the crypt-villus axis and the corruption of those mechanisms in tumorigenesis were explored. (jefferson.edu)
In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
Currently, little is known about molecular mechanisms that regulate proliferation and differentiation in the SGZ. (jneurosci.org)
We integrated genome-wide gene expression profiling, ATAC-seq, and single cell RNA-seq data in mice in which GR was deleted or activated to identify the cellular and molecular mechanisms by which glucocorticoids control prenatal lung maturation. (stanford.edu)
However, the mechanisms regulating adipocyte stem cells/progenitors (precursors) are unknown. (bvsalud.org)
We also observed that most diseases in the same co-regulated module tended to belong to the same disease category, indicating that these diseases might share similar miRNA regulatory mechanisms. (biomedcentral.com)

Erythropoietin (EPO) a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. (rndsystems.com)
Red cell development, or erythropoiesis, is a carefully ordered sequence of events. (medscape.com)
Normal erythropoiesis begins with multipotent hematopoietic stem cells, which differentiate into erythroid progenitors, eventually to develop into the mature red blood cells. (medscape.com)
Erythropoiesis is carefully regulated with negative feedback inhibition from increased oxygen delivery, which down-regulates Epo production. (medscape.com)
The principal hormone that regulates erythropoiesis is EPO. (medscape.com)

However, details regarding the regulation of MSC/MPC proliferation and differentiation status are still unclear and it is likely that regulation involves both biological and mechanical influences in the different environments. (scirp.org)
Previous studies in neural stem cells underlined the importance of PRMT5 in the regulation of pre-mRNA splicing34. (hwupdate.org)
Based on this cumulative evidence, we reasoned that a thorough characterization of PRMT5 in the OL lineage is timely and may shed some light on a better understanding of the regulation of OL cell number in the brain. (hwupdate.org)
Regulation of the timing of cell differentiation and cell fate choice are key issues for making organs of the right size, shape and cell composition. (biologists.com)
Our results unveil a novel player in the complex regulation of OPC biology, on the one hand showing that JNK1 ablation cell-autonomously determines alterations of OPC proliferation and branching architecture and, on the other hand, suggesting that JNK1 signaling in OLs participates in myelination in vivo. (nature.com)
Both a cell-intrinsic program and environmental factors participate in the regulation of OPC architecture, proliferation and oligodendro-/myelino-genesis. (nature.com)
the expression of CD115, which is a receptor for M-CSF, and CD34, a stem/progenitor cell marker, suggesting global regulation of gene expression by MKP-2. (strath.ac.uk)
The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
Aberrant regulation of blood cell formation underlies a wide range of hematological disorders, including leukemia. (lu.se)

However, it remains unclear whether the formation of the crypt is related to the maturation of Paneth cells. (researchsquare.com)
The morphological and functional maturation of Paneth cells occurred in the first 2 weeks and was accompanied by histone H3 lysine 27 (H3K27) trimethylation. (researchsquare.com)
Inhibition of H3K27 trimethylation suppressed crypt formation and Paneth cell maturation on organoids derived from ileum of early second postnatal mouse. (researchsquare.com)
Overall, our data show that post-transcriptional modification of histones, particularly H3K27 trimethylation, leads to the structural and functional maturation of Paneth cells during postnatal development. (researchsquare.com)
2009). However, the relation between the localization of Paneth cells at the bottom of the crypt and their maturation remains to be elucidated. (researchsquare.com)

Signal pathway analysis revealed that TGF- β 1 impaired the pathways of cell cycle and cytochrome P450 detoxification, and EGF reverted TGF- β 1 effects through activating MAPK and PI3K-Akt pathway. (hindawi.com)
Our findings also suggest that the signaling pathways regulated by Rac1 may be evaluated as biomarkers for the response to therapy in clinical trials of epothilones. (kjpp.net)

Hepatic progenitors are responsive to many growth and differentiation factors [ 5 ], and the behavior of hepatic progenitors, either regenerating the liver or promoting fibrogenesis, is regulated and determined by the microenvironment in the injured liver [ 1 , 2 ]. (hindawi.com)

Polycythemia is categorized as primary or secondary due to intrinsic or extrinsic changes, respectively, to erythroid progenitors and RBCs. (medscape.com)

Our research focuses on how hematopoietic stem cells (HSCs) and their immediate offspring are regulated in situations such as infections, stress, aging and leukemia. (lu.se)

Neurogenesis in the adult hippocampus is a highly regulated process that originates from multipotent progenitors in the subgranular zone (SGZ). (jneurosci.org)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells. (geneticsmr.com)
The G-CSF receptor (G-CSFR) is expressed on myeloid progenitors and endothelial cells. (q2labsolutions.com)
Polycythemia vera, also known as polycythemia rubra vera, is a myeloproliferative disorder characterized by clonal proliferation of myeloid cells. (medscape.com)

CD4 T cell lymphopenia increases the expression of circulating IL-7, and TGFb induces IL-7 downregulation. (biolegend.com)

During Central Nervous System ontogenesis, myelinating oligodendrocytes (OLs) arise from highly ramified and proliferative precursors called oligodendrocyte progenitor cells (OPCs). (nature.com)
Myelinating OLs originate from parenchymal precursors expressing the neuron-glia antigen 2 (NG2) chondroitin sulphate proteoglycan and the platelet derived growth factor receptor alpha (PDGFRα), commonly referred to as oligodendrocyte progenitor cells (OPCs) 4 . (nature.com)
Primary polycythemias are due to factors intrinsic to red cell precursors caused by acquired or inherited mutations. (medscape.com)

In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)

In recent years, he has been studying cell-cell interaction by single-cell analysis to clarify the factors that disrupt tissue homeostasis. (tmd.ac.jp)
Lactate Homeostasis Regulated by Brain Endothelial Cells is Critical for Adult Hippocampal Neurogenesis. (ucas.ac.cn)
IL-7 is essential for normal murine B cell development, and plays a key role in regulating the homeostasis and function of the T-cells. (biolegend.com)
IL-7 also controls T cell-dendritic cell interactions that are essential for both T-cell homeostasis and activation in vivo . (biolegend.com)
Bone-marrow-derived progenitors must continually enter the thymus of an adult mouse to sustain T-cell homeostasis, yet only a few input cells per day are sufficient to support a yield of 5 ⋅ 10 7 immature T-cells per day and an eventual output of 1-2 ⋅ 10 6 mature cells per day. (lu.se)

Notably, the Tbr2+ IPCs formed cellular clusters, the average size of which (Tbr2+ cells per cluster) likewise more than doubled in runners. (jneurosci.org)
Our goal is to understand, at cellular and molecular levels, what controls HSCs and the fate of other immature blood cells. (lu.se)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

Its activity is thought to negatively regulate gene expression due to methylation of multiple arginine residues on nucleosomal histone tails20C22. (hwupdate.org)

Neural stem cells in the postnatal brain have significant roles in both normal brain functions, such as learning and memory and the brain's response to injuries. (wisc.edu)
Functional heterogeneity of Wnt-responsive and Hedgehog-responsive neural stem cells in the murine adult hippocampus. (ucas.ac.cn)

Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
Two non-AT2 "reserve" cell populations residing in the distal airways also contribute to alveolar repair, but only after widespread epithelial injury, when they rapidly proliferate, migrate, and differentiate into airway and alveolar lineages. (stanford.edu)
Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)

Myc Is a Metastasis Gene for Non-Small-Cell Lung Cancer. (mpg.de)
The CHD8 gene provides instructions for making a protein that regulates gene activity (expression) by a process known as chromatin remodeling. (medlineplus.gov)
Chromatin remodeling is one way gene expression is regulated during development. (medlineplus.gov)
During aging, a subset of AT2 cells expressing the canonical Wnt target gene, Axin2, function as stem cells, renewing themselves while generating new AT1 and AT2 cells. (stanford.edu)
This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes. (geneticsmr.com)
Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein-Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development. (who.int)

Granulocyte-colony stimulating factor (G-CSF) is a growth factor produced by endothelial cells, macrophages, fibroblast, bone marrow stromal cells and other immune cells. (q2labsolutions.com)

Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
Importantly, G-CSF can also mobilize CD34+ stem cells from bone marrow to peripheral blood. (q2labsolutions.com)
Mouse IL-7 was initially described as a pre B-cell grow factor expressed in bone marrow stromal cells. (biolegend.com)
This process initially occurs in fetal liver cells and subsequently takes place in the bone marrow of children and adults. (medscape.com)

Nestin is an intermediate filament protein known to play several roles, including as a marker of neural progenitor and proliferating endothelial cells. (molvis.org)
Our results confirmed the presence of nestin in glial (e.g., astrocytes), reactive Müller, and endothelial cells. (molvis.org)

The maintenance of their "stemness" state and commitment to differentiation are tightly controlled by both intrinsic genetic and epigenetic programs and extrinsic stimuli. (wisc.edu)
AT2 cell "stemness" is thus tightly regulated by access to Wnts, supplied by a specialized single-cell fibroblast niche during maintenance and by AT2 cells themselves during injury repair. (stanford.edu)

Immunophenotypic characterization of these mice was performed by conducting confocal analysis of brain sections, stained with antibodies specific for the pan-OL lineage marker OLIG2, for OPC-specific surface receptor (e.g., platelet-derived growth factor receptor- (PDGFR)) and for differentiation markers (e.g. (hwupdate.org)
1997). Within 14 days of postnatal development, Paneth cells mature and express cryptdin proteins as a specific marker (Bry, et al. (researchsquare.com)
However, the co-immunoreactivity of nestin and GS, a marker of mature functional Müller cells, could be observable only from the seventh day. (molvis.org)
During TGF- β 1-induced transition and EGF-induced reversion, hepatic oval cells sustained their progenitor cell marker expression, including α -fetoprotein, albumin, and cytokeratin-19. (hindawi.com)
Therefore, the aim of the present study is to determine the progenitor cell marker expression, proliferation capacity, and differentiation potential of hepatic progenitors in TGF- β 1-induced EMT transition and EGF-induced reversion. (hindawi.com)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

Conditional Expression of Oncogenic C-RAF in Mouse Pulmonary Epithelial Cells Reveals Differential Tumorigenesis and Induction of Autophagy Leading to Tumor Regression. (mpg.de)
Cultured oligodendrocyte progenitor cells (OPCs) were incubated with HD ± BMSC-derived conditional medium (BMSC-CM). OPC differentiation was studied by immunostaining and morphometric analysis. (biomedcentral.com)

The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. (frontiersin.org)
However, experimental evidence suggests these cells are important for thymus function by either directly influencing T-cell development, or by indirectly regulating TEC development and/or function. (frontiersin.org)
Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)
In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
IL-7 is necessary to specify CD8 lineage differentiation during CD4/CD8 cell fate choice in the thymus by inducing expression of the transcription factor Runx3. (biolegend.com)

Specific antibody-receptor interactions trigger InlAB-independent uptake of listeria monocytogenes into tumor cell lines. (mpg.de)
This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
In addition, Paneth cells provide a niche for leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing stem cells in crypts (Sato, et al. (researchsquare.com)
Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
It is secreted by activated keratinocytes and monocytes, and signals through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. (watson-int.cn)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

PAK2 activity negatively regulates the function and expression of c-Myc: PAK2 phosphorylation of c-Myc at T358-S373-T400 inhibits its transactivation function and PAK2 depletion stimulates c-Myc expression during granulocyte-monocyte lineage. (wikipedia.org)
The origins and basis for these fat deposits are largely unknown, but there is a possibility that the altered mechanical and biological environments lead to dysregulation of MSC/MPC and progression to preferential differentiation towards the adipocyte lineage. (scirp.org)
Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
In this study, we adopted several strategies to address this key question including: a detailed characterization of mice with cell-lineage-specific ablation of in immature oligodendrocyte progenitors or in oligodendrocytes, the use of CRISPR/Cas9 and pharmacological inhibitors to interfere with PRMT5 function in primary OPC cultures, transcriptomic analyses, and biochemical assays using synthetic proteins and modified histone peptides. (hwupdate.org)
Crypt expansion reflected hyperplasia of the proliferating compartment with reciprocal increases in rapidly cycling progenitor cells and reductions in differentiated cells of the secretory lineage, including Paneth and goblet, but not enteroendocrine, cells. (jefferson.edu)
While substantial progress has been made to delineate the developmental pathway of T-cell lineage commitment, still little is known about the relationship between differentiation competence and the remarkable expansion of the earliest (DN1 stage) T-cell progenitors. (lu.se)

Together, these results identify PRMT5 as critical for oligodendrocyte differentiation and developmental myelination by modulating the cross-talk between histone arginine methylation and lysine acetylation. (hwupdate.org)
We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)

Thus restricting the introduction of somatic cells by changing intercellular communication allows the creation of safer individual iPSCs. (healthy-nutrition-plan.com)
Given the likely need for additional reprogramming chemicals and the knowledge that most known compounds take action STF 118804 late in this process we reasoned it would be valuable to identify small molecules that improve reprogramming by acting early perhaps within the somatic cells themselves. (healthy-nutrition-plan.com)
We reasoned that one approach towards this goal would be to determine chemicals that could modulate transmission transduction cascades in somatic cell populations to enrich for those cells with an enhanced capacity for reprogramming. (healthy-nutrition-plan.com)

The aim of this study is to determine the characteristic changes of hepatic progenitors after TGF- β 1-induced transition and EGF-induced reversion. (hindawi.com)
Hepatic oval cells, rat hepatic progenitors, were isolated from rats fed a choline-deficient diet supplemented with ethionine. (hindawi.com)
EGF reverses the characteristics impaired by TGF- β 1 in hepatic oval cells, serving as a protective cytokine to hepatic progenitors. (hindawi.com)
Hepatic stem cells that resided in the canal of Hering represent a small population of the cells comprising a healthy liver. (hindawi.com)
Only under certain pathophysiology conditions, when the proliferation capacity of mature hepatocytes is compromised, are quiescent hepatic stem cells activated and changed into hepatic progenitors to assist in liver restoration [ 1 , 2 ]. (hindawi.com)
The number of hepatic progenitors is correlated with the degree of chronic hepatitis and the stage of liver fibrosis [ 3 , 4 ]. (hindawi.com)
These facts propose that it is difficult for hepatic progenitors to regenerate the liver in microenvironment of severe liver fibrosis except control and clearance of the underlying causative etiology. (hindawi.com)
It has been shown that mouse experimental liver fibrosis [ 11 , 12 ] and hepatic stellate cell activation could be alleviated by heparin-binding EGF-like growth factor [ 11 ]. (hindawi.com)
Hepatic progenitors obtain the myofibroblast phenotype after EMT and lose this phenotype after MET, yet the variation of progenitor cell characteristics is still not clear during the EMT/MET process. (hindawi.com)

PAK2-mediated phosphorylation of merlin at S518 modulates its tumor suppressor activity, c-Jun phosphorylation at T2, T8, T89, T93 and T286 contributes to the growth of growth factor-stimulated melanoma cells, Caspase-7 phosphorylation at S30, T173 and S239 inhibits apoptotic activity in breast cancer cells, Paxillin phosphorylation at S272 and S274 activates ADAM10 protease, and STAT5 phosphorylation at S779 modulates BCL-ABL-mediated leukemogenesis. (wikipedia.org)
Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part. (mpg.de)
On the signalling level, M-CSF stimulation induced extracellular signal-regulated kinases (ERK) phosphorylation, which was significantly enhanced in the absence of MKP-2. (strath.ac.uk)

Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
Paneth cell dysfunction has been reported to correlate with Crohn's disease-like inflammation, showing narrow crypts or loss of crypt architecture in mice. (researchsquare.com)
In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
IL-20 has functions of regulating proliferation and differentiation of keratinocytes during inflammation, and causing cell expansion of multipotential hematopoietic progenitor cells. (watson-int.cn)

Niche Cells and Signals that Regulate Lung Alveolar Stem Cells In Vivo. (stanford.edu)
Most clinical trials which utilize ADSCs for OA treatment have been based on the autologous cells from the stromal vascular fraction, as have most of the in vivo studies ( 6 , 7 ). (spandidos-publications.com)
In addition there is a lack of information regarding the presence of mast cells in dental pulp of rats, which are animals used to study important aspects of the pathophysiology of dental pulp in vivo 6 . (bvsalud.org)

In the adult, stem cells exist in many tissues throughout life and may play critical roles in physiological functions and tissue regeneration. (wisc.edu)
Our previous study showed that the absorptive cells of the jejunum and ileum change rapidly and dramatically from suckling to adult type during the weaning period (Fujita, et al. (researchsquare.com)
In adult mouse hippocampus, Tbr2 protein and Tbr2-GFP (green fluorescent protein) transgene expression were specifically localized to intermediate-stage progenitor cells (IPCs), a type of transit amplifying cells. (jneurosci.org)
Adult hippocampal neurogenesis is a constitutive but highly regulated process that occurs in a neurogenic niche, the subgranular zone (SGZ) of the dentate gyrus (DG). (jneurosci.org)
The present experiments were designed to determine whether aspects of this TF cascade are conserved in the adult DG and to examine the identity of Tbr2+ cells in the SGZ. (jneurosci.org)
Experiments were also conducted to assess the responses of Tbr2+ cells to neurogenic stimuli, with the goal of understanding how Tbr2+ IPCs contribute to neuron production in the adult DG. (jneurosci.org)
These cells initially amplify and colonize the entire CNS and maintain the proliferating ability even during adult life 5 . (nature.com)
Effects of HU210 treatment on cell proliferation in the dentate gyrus in adult rats ( n = 5-7 rats in each group). (jci.org)
To satisfy differentiation kinetics and overall cell yield data, our models require that adult DN1 cells divide multiple times before becoming competent to progress into DN2 stage. (lu.se)

A main focus of my lab research is to understand the epigenetic basis of cell fate specification and neurodevelopment. (wisc.edu)
WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. (aacrjournals.org)
In the field of induced potency and fate reprogramming, it remains unclear what the best starting cell might be and to what extent a cell need be transported back to a more primitive state for translational purposes. (nih.gov)

Among the latter, we reported decreased acetylation of lysine residues on histone tails as an essential event for the differentiation of OPCs into OL2,5C9. (hwupdate.org)
This assures the achievement of a "grid-like" homogenous cell distribution, where individual OPCs occupy non-overlapping domains. (nature.com)

Novel human renal proximal tubular cell line for the production of complex proteins. (rndsystems.com)
We first developed a method to simultaneously isolate proximal and distal lung progenitor cells from an individual mouse with the aid of a 3D printed surgical guide and found that the precision of dissecting the lung lobes affects the purity of the isolated distal progenitors and how they behave in organoid assays. (lu.se)

We also experienced that keratinocytes were a stylish model for STF 118804 screening our hypothesis because if Notch inhibition did have an effect it could be immediately translated to the production of patient-specific iPSCs 31 32 Here we display that Notch inhibition significantly improves the effectiveness of iPSC generation from mouse and human being keratinocytes by suppressing p21 and therefore enriching undifferentiated cells with increased reprogramming potential. (healthy-nutrition-plan.com)

A ) Representative microphotographs of the dentate gyrus show BrdU-positive cells clustered or aggregated in the SGZ in rats receiving an acute injection of vehicle or 100 μg/kg of HU210. (jci.org)
B ) There was no significant difference in the average number of BrdU-stained cells in the dentate gyrus per section following 1 dose of acute vehicle, 100 and 25 μg/kg of HU210, and 3 mg/kg of AM281. (jci.org)
C ) Representative microphotographs of the dentate gyrus show that twice-daily injections of 100 μg/kg of HU210 for 10 days apparently increased the density of BrdU-positive cells in the SGZ relative to chronic vehicle injection. (jci.org)
D ) Relative to vehicle injection, there was a significant increase in the number of BrdU-immunoreactive cells in the dentate gyrus following chronic treatment with 100 μg/kg of HU210, but not 25 μg/kg of HU210 or 3 mg/kg of AM281. (jci.org)

While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)

Moreover, UTD2 inhibited the activity and mRNA expression of MMP-2, which plays a key role in cell motility. (kjpp.net)
When treated with macrophage colony stimulating factor (M-CSF), Mmd and Csf2 mRNA levels increased but significantly reduced in ko cells in comparison to wt counterparts. (strath.ac.uk)

In agreement with the function of Ythdf2, delayed degradation of neuron differentiation-related m 6 A-containing mRNAs is seen in Ythdf2 −/− NSPCs. (biomedcentral.com)
We also identified the MIF-CHD7-TPT1-SMO signaling axis in regulating hESC-NSPCs and BTICs proliferation. (elsevierpure.com)

Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
The distal lung is a honeycomb-like collection of delicate gas exchange sacs called alveoli lined by two interspersed epithelial cell types: the cuboidal, surfactant-producing alveolar type II (AT2) and the flat, gas-exchanging alveolar type I (AT1) cell. (stanford.edu)

These experiments showed that the two DN1 sub-populations divided with similar rates, but progressed to the DN2 stage with different rates, thus providing experimental evidence that DN1 cells increase their commitment probability in a cell-intrinsic manner as they undergo cell division. (lu.se)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)

and miR-23b and miR-137 inhibits PAK2 expression in tumor cells. (wikipedia.org)
Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer. (mpg.de)
Elimination of B-RAF in Oncogenic C-RAF-expressing Alveolar Epithelial Type II Cells Reduces MAPK Signal Intensity and Lung Tumor Growth. (mpg.de)
Many cancers re-emerge after treatment, despite the sensitivity of the bulk of tumor cells to treatments. (mdpi.com)
And chronic and constant TGF- β exposure to rat liver progenitor-like cell line, WB-F344, makes them obtain tumor initiating properties [ 9 ]. (hindawi.com)
Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)

For example, in the developing nervous system of mouse embryos,progenitor cells proliferate and sequentially give rise to different types of cells by changing their differentiation competency. (biologists.com)

During development, stem cells and resulting progenitor cells are responsible for generating all the tissues and cells of an organism. (wisc.edu)
Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
At the beginning of intestinal development, proliferating progenitors that express ISC markers are ubiquitously distributed throughout the epithelium. (researchsquare.com)
Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway. (ucas.ac.cn)
Conclusions: Transcriptome profiling reveals that MKP-2 regulates macrophage development showing candidate targets from monocyte-to-macrophage differentiation and macrophage proliferation. (strath.ac.uk)
Subsequently, EPO continues to stimulate the development and terminal differentiation of these progenitors. (medscape.com)
By studying murine transgenic leukemia models developed in our laboratory, we are currently exploring the relationships between hematopoietic progenitor cell identities and the development and progression of acute leukemia. (lu.se)

CloneSeq - Single-cell clonal 3D culture and analysis protocol. (ilexlife.com)
3-D Life hydrogels and accessories are used in this CloneSeq protocol which combines clonal expansion inside 3D hydrogel spheres and droplet-based RNA sequencing to resolve the limited sensitivity of single-cell approaches. (ilexlife.com)

Another study in a glial cell line suggested this enzyme could affect OL differentiation by affecting transcription, although the mechanistic aspects were Fosphenytoin disodium not elucidated19. (hwupdate.org)

The expressional changes of Hes1, a transcription factor negatively regulating OPC-differentiation, were studied. (biomedcentral.com)

Anatomy64

Organisms12

Diseases5

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes58

Disciplines and Occupations1

Information Science3

Neurons10

Mesenchymal19

Genes12

Vitro11

Embryonic10

Self-renewal8

Neuronal differentiation2

Kinase8

Stem cell16

Processes15

Apoptosis3

Survival6

Mechanisms10

Erythropoiesis5

Regulation9

Maturation5

Pathways2

Growth and differentiation1

Erythroid progenitors1

Hematopoietic stem1

Multipotent2

Myeloid3

Induces1

Precursors3

Mammalian1

Homeostasis5

Cellular4

Negatively regulate gene expression1

Neural stem2

Differentiate3

Gene8

Macrophages1

Bone marrow6

Endothelial2

Tightly2

Marker6

Conditional2

Thymus6

Receptor6

Lineage6

Developmental2

Somatic3

Hepatic9

Phosphorylation3

Inflammation4

Vivo3

Adult9

Fate3

OPCs2

Proximal2

Hypothesis1

Dentate gyrus4

Lymphoid1

MRNA2

NSPCs2

Epithelial cell2

Populations3

Tumor6

Proliferate1

Development7

Clonal2

Glial cell1

Transcription1