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  • subsequently
  • Here, we have identified a novel heart- and muscle-specific microRNA, miR-92b, which is activated by Mef2 and subsequently downregulates Mef2 through binding to its 3′UTR, forming a negative regulatory circuit that fine-tunes the level of Mef2. (biologists.org)
  • mechanisms
  • Nevertheless, our knowledge about the molecular mechanisms linking environmental factors and type 2 diabetes still remains limited. (diabetesjournals.org)
  • CRC has to be considered a complex disease resulting from a combination of environmental factors, genetic/epigenetic predisposing variants and specific molecular mechanisms. (biomedcentral.com)
  • These analyses illustrate how a systems biology approach based on gene networks can yield insights into the molecular mechanisms of neural development and function, and provide clues as to the functional impact of the downstream effects of Ca 2+ signaling dysregulation on transcription. (biomedcentral.com)
  • This study thus provides novel insights into the signal transduction mechanisms that regulate microsclerotia formation and pathogenesis in this fungus. (frontiersin.org)
  • Within a cell, transcription of DNA packaged into chromatin is regulated by large multiprotein complexes that modify chromatin structure and gene accessibility through a variety of mechanisms. (stowers.org)
  • Because transcription factors such as p53 are perhaps the most deregulated control mechanisms in all of cancer [ 9 , 10 ], we first focused on changes in transcription factor responses of tumor cells exposed to RENCA macrobeads. (biomedcentral.com)
  • mechanism
  • Our lab identified and initially characterized schistosome Mef2 (SmMef2), however, the complex life cycle of schistosomes makes an in depth understanding of basic developmental mechanism challenging. (case.edu)
  • immunity
  • Some time back, we showed that two different TGF-betas regulate fly immunity, each inhibiting a specific arm of the immune response, and each being produced by only a subset of phagocytes. (openwetware.org)
  • anabolic
  • It appears that the disruption of anabolic kinase activity may be required to permit MEF2 to drive the antibacterial response. (openwetware.org)
  • epigenetic
  • Cis -regulatory elements characterized by the presence of transcription factors, RNA polymerase II occupancy and epigenetic marks, consistent with, but lacking, active transcription. (biologists.org)
  • Epigenetic factors include DNA methylations, histone modifications, and microRNAs, and they can help to explain how cells with identical DNA can differentiate into different cell types with different phenotypes. (diabetesjournals.org)
  • influx
  • TCR-induced calcium influx leads to the dissociation of MEF2 from Cabin1, as a result of competitive binding of activated calmodulin to Cabin1. (jhmi.edu)
  • Diabetes
  • Although obesity, reduced physical activity, and aging increase susceptibility to type 2 diabetes, many people exposed to these risk factors do not develop the disease. (diabetesjournals.org)
  • function
  • Examination of loss-of-function mutants also showed that some transcription factors supposedly binding to the modules are not required for their function. (biomedcentral.com)
  • Attribution of function to these sites and their cognate transcription factors may be incorrect even when modules are successfully identified. (biomedcentral.com)
  • Blocking miR-92b function using microRNA sponge techniques also increased Mef2 levels and caused muscle defects similar to those seen with the miR-92b deletion. (biologists.org)