Regulates growth factor. Medical search. Frequent questions

Ligands that activate the epidermal growth factor receptor (EGFR) are synthesized as membrane-anchored precursors that appear to be proteolytically released by members of the ADAM family of metalloproteases. (nih.gov)
The role of the cbl oncogene in regulating epidermal growth factor receptor-mediated signalling. (edu.au)
Here, we show higher levels of epidermal growth factor receptor (EGFR), but lower levels of miR-370 expression in most human lung cancer cells and non-tumor cells. (oncotarget.com)
Triple-negative breast cancer (TNBC), which lacks the expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), accounts for 10-15% of breast cancers [ 2 ]. (nature.com)
Epidermal growth factor receptor regulates lineage plasticity driving transformation to small cell lung cancer. (bvsalud.org)
Epidermal growth factor receptor (EGFR)-mutant non-small- cell lung cancer (NSCLC) is clinically and genetically heterogeneous, with concurrent RB1/TP53 mutations , indicating an increased risk of transformation into small cell lung cancer (SCLC). (bvsalud.org)
Mutations in the kinase domain of the epidermal growth factor receptor (EGFR) are found in a subset of patients with lung cancer and correlate with response to EGFR tyrosine kinase inhibitors (TKI). (elsevierpure.com)

These cells express both transforming growth factor alpha and amphiregulin and require autocrine signaling through the EGFR for proliferation and migration. (nih.gov)
Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. (uchicago.edu)
Both the overexpression of Met/HGFR, as well as its autocrine activation by co-expression of its hepatocyte growth factor ligand, have been implicated in oncogenesis. (wikipedia.org)
This study shows for the first time that PDGF autocrine signaling regulates DAB2 expression during megakaryocytic differentiation. (edu.hk)
Constitutive activation of the TSH receptor may generate autocrine factors that promote further growth, resulting in clonal proliferation. (medscape.com)

The results of this study may be helpful for further study of the function of PgGRF and PgGIF genes and lay a foundation for further study of their role in the growth and development of Panax ginseng . (biomedcentral.com)
The WRC domain can be combined with the cis-acting regions of downstream genes to regulate their expression. (biomedcentral.com)
Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), have been assigned to mouse chromosome 3 and human chromosome 1q22. (arizona.edu)
We have used the techniques of linkage analysis and pulsed field gel electrophoresis to determine the proximity of these two antithetically regulated genes in this conserved linkage group. (arizona.edu)
genes that encode for growth factors and/or cell cycle regulators (1.8 - 2.5-fold upregulated) and genes that encode for myoblast structural components (1.7 - 4.4-fold upregulated). (cdc.gov)
The expression of 3.2% of the genes was down regulated. (cdc.gov)
These include genes involved in energy production, intermediary metabolism and cell signaling/transcription factors (0.4 - 0.7 -fold down regulated). (cdc.gov)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
These genes produce proteins that regulate growth and alter cell division and other basic cell properties. (msdmanuals.com)
Oncogenes are mutated or amplified forms of genes that in their normal state regulate cell growth. (msdmanuals.com)
Tumor suppressor genes normally suppress the development of cancers by coding for proteins that repair damaged DNA or suppress the growth of cancerous cells. (msdmanuals.com)

Using yeast two-hybrid interaction cloning, we identified the HGF-regulated tyrosine kinase substrate (HRS) as a schwannomin interactor. (wustl.edu)

Losartan has protective effect on aortic wall of rats with aortic dissection, and the mechanism may be through inhibiting transforming growth factor-beta 1 pathway, which activates downstream phosphoinositide 3-kinase/protein kinase B pathway related proteins, and then inhibits the expansion and progression of aortic dissection. (ijpsonline.com)
Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are key elements in fetal growth. (ox.ac.uk)
Spred/Sprouty family proteins negatively regulate growth factor-induced ERK activation. (elsevierpure.com)
The three cap-binding proteins were immuno-detected in all tissues analysed and were coordinately regulated, with peak expression in anthers and pollen. (le.ac.uk)
Schwannomin, a member of the 4.1 family of proteins, which are known to link the cytoskeleton to the plasma membrane, has little known function other than its ability to suppress tumor growth. (wustl.edu)
In that regard recent studies in non-neural cells have suggested the living of functional relationships between Dlx proteins and Smad transcription factors which are essential mediators of transforming growth element-β (TGF-β) superfamily signaling pathways (Chiba et al. (bioinbrief.com)
Moreover we provide evidence that Dlx and R-Smad proteins are co-expressed literally interact and localize to Dlx-regulated enhancers/promoters in the developing subpallium. (bioinbrief.com)
The drug mediates interactions between these receptors, growth factors, and proteins within that pathway to reduce new abnormal bone formation. (medscape.com)
Early steps in this transition are complex, with at least 2 signaling pathways identified: 1 stops yeast growth and another, with a heat shock protein 70-type profile, initiates the assembly of proteins necessary for mycelial growth. (cdc.gov)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture. (sutterhealth.org)

Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis. (medsci.org)
To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
In addition, other studies demonstrated that AngII activated platelet-derived growth factor-A (PDGF-A), a novel contributor to cardiac remodelling, to result in atrial fibrosis in pressure-overloaded mouse model [ 13 ] . (medsci.org)
Platelet-derived growth factor (PDGF) is involved in megakaryocytopoiesis and is secreted into the culture medium during megakaryocytic differentiation of human leukemic cells. (edu.hk)

These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses. (nih.gov)

Hematoxylin and eosin staining was used to measure the thickness and diameter ratio of the aortic media of mice in each group, Masson staining was used to observe the content of collagen fibers in the aorta of mice in each group, elastic fibers in the aorta of mice in each group were stained, and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway protein expression. (ijpsonline.com)
Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)
Transforming growth factor-beta (TGF-beta) signaling in naive T cells induces expression of the transcription factor Foxp3, a 'master' regulator of regulatory T cells (T(reg) cells). (nih.gov)
Induction of miR-370 over-expression significantly reduced the levels of EGFR expression and the EGFR 3'untranslated region (UTR)-regulated luciferase activity in XWLC-05 and H157 cells, suggesting that miR-370 may bind to the 3'UTR of EGFR mRNA. (oncotarget.com)
Furthermore, miR-370 over-expression down-regulated the EGFR and hypoxia-inducible factor (HIF)-1α expression, and attenuated the extracellular single-regulated kinase (ERK)1/2 and AKT phosphorylation in XWLC-05 and H157 cells. (oncotarget.com)
Moreover, miR-370 over-expression significantly reduced the levels of EGFR and CD31 expression and inhibited the growth and lung metastasis of xenograft NSCLC tumors in mice. (oncotarget.com)
Our study indicates that miR-370 may bind to the 3'UTR of EGFR to inhibit EGFR expression and the growth, angiogenesis and metastasis of non-small cell lung cancer by down-regulating the ERK1/2 and AKT signaling. (oncotarget.com)
The role of vascular endothelial growth factor (VEGF) in differential vWF expression was investigated using cultured human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)
The higher mRNA and protein expression of vWF in GC tumor stroma may be regulated by the VEGF-VEGFR2 signaling pathway in vitro and may contribute to GC progression in vivo . (biomedcentral.com)
Research on the GC-hemostasis association has revealed that the increased expression of tissue factor (TF) promotes the pathogenic conditions of coagulation, tumor growth, and angiogenesis [ 7 ]. (biomedcentral.com)
There is an increased expression of epigenetic reprogramming factors like Sox2 and gene associated with neural development like NTRK in these EGFR knockout tumors . (bvsalud.org)
Although the expression of wild-type EGFR was also down-regulated by 17-AAG, its degradation required higher concentrations of drug and a longer duration of drug exposure. (elsevierpure.com)
Calcium-dependent signaling pathways and heat shock protein expression regulate dimorphism in Paracoccidioides brasiliensis and have broad implications for other pathogens. (cdc.gov)

It is a highly biocompatible hydrogel whose physical properties can potentially be tailored to direct 3D cell growth and differentiation both in vitro and in vivo 10 , 11 , 12 . (nature.com)
The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. (ox.ac.uk)
Our results therefore suggest that Brn-3b transcription factor contributes to proliferation of neuroblastoma cells in vivo and in vitro but may also influence progression and/or invasion during tumorigenesis. (ox.ac.uk)
Functional consequences of MSI2 depletion were explored for cell growth and response to EGFR-targeting drugs, in vitro and in vivo. (northwestern.edu)

To investigate the effect of losartan on vascular remodeling and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway. (ijpsonline.com)
Although vascular endothelial growth factor (VEGFA-165) is primarily known for its role in angiogenesis, it also plays important neurotrophic and neuroprotective roles for spinal motor neurons. (jneurosci.org)
The loss of myoferlin results in lack of proliferation, migration, and nitric oxide (NO) release in response to vascular endothelial growth factor (VEGF). (elsevierpure.com)
In cultured cells, the overexpression of Spred-1 or Spred-2 strongly suppressed vascular endothelial growth factor-C (VEGF-C)/VEGF receptor (VEGFR)-3-mediated ERK activation, while Spred-1/2-deficient cells were extremely sensitive to VEGFR-3 signaling. (elsevierpure.com)
The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. (lu.se)
ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
Vascular growth during implantation normal non-pregnant controls, 20 normal and placentation is critical for successful pregnant controls, 20 patients with mild gestation. (who.int)

Inadequate efficacy similarly halted the development of agents impinging on the activity of the activin receptor-like kinase (ALK)1, a member of the transforming growth factor-β superfamily. (lu.se)
Among these, the Transforming Growth Factor-β and the Janus kinase signaling cascades were validated as actionable targets to counteract the CAF-induced modulation of ER-α activity. (lu.se)

Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that modulation of alginate bioink mechanical properties represents a promising strategy to spatially regulate MSC fate within bioprinted tissues. (nature.com)
Growth factors enable the growth and repair of tissues throughout the body. (medlineplus.gov)

Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
PGs bind growth factors, regulate proteolytic activity and act as matrix receptors. (lu.se)
Taken orally, palovarotene selectively targets the gamma subtype of retinoic acid receptors that regulate skeletal development and ectopic bone in the retinoid signaling pathway. (medscape.com)

Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). (jneurosci.org)
The mechanism of OGF-OGFr action on DNA synthesis was related to the cyclin-dependent kinase inhibitory pathway because knockdown of p16 or p21 in OVCAR-3 cells, and p21 in SKOV-3 cells, eliminated OGF's inhibitory effect on growth. (nih.gov)

For example, RAD18 plays a vital role in regulating the DNA stability of embryonic stem cells and cellular homeostasis in highly prolific cells [ 6 ]. (nature.com)

These data suggest that Spreds play an important role in lymphatic vessel development by negatively regulating VEGF-C/VEGFR-3 signaling. (elsevierpure.com)
VEGF as an angiogenic growth factor and 20 weeks of pregnancy. (who.int)

Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. (wikipedia.org)
In addition, the data demonstrate that hypoxia up-regulates fetal hepatocyte IGFBP-1 mRNA steady-state levels and protein, with this being the major IGFBP derived from the fetal hepatocyte. (ox.ac.uk)
Trp53 R172HΔG/+ NSCLC cell lines identified EGFR as a MSI2-regulated protein. (northwestern.edu)

The process of myelination is controlled in part by cell extrinsic factors derived from the extracellular matrix (ECM). (jneurosci.org)

Additionally, RAD18 functions beyond DNA repair and may regulate many other key biological processes, such as chromatin strengthening, cell survival/death, stemness, and differentiation. (nature.com)
Nerve growth factor (NGF) is the classical inducer of neuronal differentiation. (en-journal.org)
We are particularly interested in studies illustrating intrinsic/extrinsic cellular and molecular factors regulating stemness, growth, and differentiation of tissue-specific MSCs as well as their potential implications for tissue engineering and regenerative medicine. (aibg.it)

Irbesartan or/and simvastatin can improve atrial fibrosis by regulating PDGF/Rac1/NF-κB axis. (medsci.org)

We found that metalloprotease inhibitors reduced cell proliferation in direct proportion to their effect on transforming growth factor alpha release. (nih.gov)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
Inhibition of YAP or TGF-β breaks this loop and suppresses cancer stemness and proliferation In nude mice, RAD18 promoted subcutaneous transplanted tumor growth and M2-type TAM recruitment. (nature.com)
In this study, we analyzed the effects of manipulating Brn-3b levels in the human neuroblastoma cell line, IMR-32 and showed that constitutive overexpression of Brn-3b consistently increased cellular growth and proliferation in monolayer as well as in an anchorage-independent manner compared with controls whereas stably decreasing Brn-3b can reduce the rate of growth of these cells. (ox.ac.uk)
It is possible that decreasing Brn-3b levels may reverse some effects on growth and proliferation of these cells. (ox.ac.uk)

With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)

The process involves several factors, such as hepatocyte growth factor (HGF), which restrains hepatic injury and facilitates reversibility of fibrotic reaction in response to an acute insult. (uni-regensburg.de)
Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the HGF receptor. (wikipedia.org)

Cells with high Brn-3b also fail to respond to growth inhibitory retinoic acid, as they continue to proliferate. (ox.ac.uk)

Metalloprotease inhibitors also reduced growth of EGF-responsive tumorigenic cell lines and were synergistic with the inhibitory effects of antagonistic EGFR antibodies. (nih.gov)
Further, depletion of MSI2 in combination with EGFR inhibitors such as erlotinib, afatinib, and osimertinib selectively reduced the growth of EGFR mut NSCLC cells and xenografts. (northwestern.edu)
17-AAG treatment, at its maximal tolerated dose, caused a significant delay in H3255 (L858R EGFR) xenograft growth but was less effective than the EGFR TKI gefitinib. (elsevierpure.com)
17-AAG alone delayed, but did not completely inhibit, the growth of H1650 and H1975 xenografts, two EGFR mutant models which show intermediate and high levels of gefitinib resistance. (elsevierpure.com)
These data suggest that p38 MAPK control of EGFR signaling activity may alter GSC cell cycle state by regulating quiescence and passage into transit amplifying state. (oncotarget.com)

abstract = "Disturbances in Insulin-like growth factor-I (IGF-I) and dysregulation in neonatal immune responses have been associated with typical neonatal diseases. (uni-luebeck.de)

Additionally, microfibrils regulate the activity of molecules called growth factors. (medlineplus.gov)

Notably, CAFs mediated estrogen-independent tumor growth by selectively regulating ER-α signaling. (lu.se)

PHEX stimulates fibroblast growth factor-23 (FGF-23), expressed in bone. (medscape.com)

Obesity has always been considered a significant risk factor in osteoarthritis (OA) progression, but the underlying mechanism of obesity-related inflammation in OA synovitis remains unclear. (elifesciences.org)

Moreover, Brn-3b levels significantly modified tumor growth in vivo with elevated Brn-3b resulting in faster tumor growth in xenograft models whereas decreasing Brn-3b resulted in slower growth compared with controls. (ox.ac.uk)

However, the role and molecular mechanisms of miR-370 in regulating the growth and metastasis of lung cancer have not been clarified. (oncotarget.com)
von Willebrand factor (vWF) is a potent regulator of angiogenesis, tumor growth, and metastasis. (biomedcentral.com)
Abnormal MET activation in cancer correlates with poor prognosis, where aberrantly active MET triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). (wikipedia.org)

Alginate is also commonly used for drug/growth factor delivery, where the degradation rate of the alginate can be tuned by altering the MW of the alginate 14 , 15 , which can in turn vary the release rate of the drug/growth factor encapsulated. (nature.com)

Eukaryotic initiation factor eIF4E plays a pivotal role in translation initiation. (le.ac.uk)
The antisense depletion of both NteIF4E and NteIFiso4E resulted in plants with a semi-dwarf phenotype and an overall reduction in polyribosome loading, demonstrating that both eIF4E and eIFiso4E support translation initiation in planta, which suggests their potential role in the regulation of plant growth. (le.ac.uk)

it was induced by GA3 (gibberellin) [ 3 ] and played an essential role in regulating stem elongation. (biomedcentral.com)

TE strategies typically incorporate cells, biomaterials and signals (e.g. growth factors), with the goal of developing a construct that once implanted will promote tissue regeneration. (nature.com)
We previously showed that the Brn-3b transcription factor is highly expressed in actively proliferating neuroblastoma cells but is significantly decreased when these cells are induced to differentiate. (ox.ac.uk)
Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells. (nih.gov)
Overview of Cancer A cancer is an abnormal growth of cells (usually derived from a single abnormal cell). (msdmanuals.com)
As human osteosarcoma cells are a source of additional growth they did not affect osteoinduction. (bvsalud.org)
Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)

Intracellular contents released by accumulated ACs further triggered an immune response and lead to a release of inflammatory factors, such as TNF-α, IL-1β, and IL-6, which induce chondrocyte homeostasis dysfunction in obese OA patients. (elifesciences.org)

Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). (springer.com)
Environmental factors-common to the family-may alter this genetic interaction and cause cancer. (msdmanuals.com)

We show that maximal growth is achieved when pathway activation is a more or less steeply graded function of the nutrient concentration. (lu.se)

Vulnerable workers - Different factors can make some workers more vulnerable than others to workplace illness or injury. (cdc.gov)

In recent years, studies have shown that GRF transcription factors play essential roles in plant growth development and defence responses to biological and abiotic stresses. (biomedcentral.com)
These two tyrosines engage various signal transducers, thus initiating a whole spectrum of biological activities driven by MET, collectively known as the invasive growth program. (wikipedia.org)

The E3 ubiquitin ligase Itch associated with and promoted conjugation of ubiquitin to the transcription factor TIEG1. (nih.gov)

Anatomy29

Organisms11

Diseases12

Chemicals and Drugs139

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes42

Disciplines and Occupations1

Information Science3

Epidermal growth f7

Autocrine5

Genes11

Tyrosine Kinase Substrate1

Proteins10

Substrate1

Platelet-derive4

Pathway that regulates1

Expression13

Vitro4

Vascular7

Transforming Gr2

Tissues2

Receptors3

Kinase2

Embryonic1

VEGF2

Protein3

Extracellular1

Differentiation3

PDGF1

Proliferation5

Metabolism1

Hepatocyte growth2

Retinoic acid1

EGFR5

Abstract1

Molecules1

Selectively1

Fibroblast1

Inflammation1

Tumor growth in vivo1

Metastasis3

Degradation1

Translation initiation2

Role1

Cells6

Immune response1

Interaction2

Activation1

Injury1

Biological2

Transcription factor1