Regulates gene expression regulation fungal. Medical search. Frequent questions

Our analysis of metabolic regulation shows that UV activates DNA repair, aromatic amino acid and carotenoid biosynthesis and represses central carbon metabolism and the fungal-like apoptotic pathway. (biorxiv.org)
The underlying principle is to identify the transcription factors that regulate the taxol pathway and establish a fungal engineering approach that can be implemented in industrial fermentation. (europa.eu)
Recent studies highlighted the importance of IMD pathway regulation as it is tightly controlled by numbers of negative regulators at multiple levels. (cnrs.fr)
Silencing of Velo led to constitutive expression of the IMD pathway dependent antimicrobial peptides (AMPs), and Escherichia coli stimulation further enhanced the AMP expression. (cnrs.fr)
Finally, our genetic and biochemical data suggest that PP2A regulates the phosphorylation of Tem1, which acts at the very top of MEN pathway. (fsu.edu)
Fungi 2021, 7,expression on the ERG1 gene (inside the ergosterol pathway) is regulated by each the PdsreA and PdsreB genes, while only PdsreA is involved in the expression of ERG2. (hsvinhibitor.com)
Regulation of gene expression by ambient pH in filamentous fungi and yeast is mediated by the pal/RIM signaling pathway and the transcription factor PacC/Rim101. (ucm.es)
The ambient pH signaling pathway is conserved in the fungal kingdom and has been mainly studied in the filamentous fungus Aspergillus nidulans and in the yeast Saccharomyces cerevisiae, although several studies have also been carried out in the yeasts Yarrowia lipolitica and Candida albicans 45. (ucm.es)
We found that major cellulase genes ( cel7a , cel7b , and cel3a ) exhibited concomitant decrease in IR rates and increase in their gene expression in T . reesei under cellulase-producing condition (cellulose and lactose) that was accompanied with a more active NMD pathway, as compared to non cellulase-producing condition (glucose). (researchsquare.com)
In the presence of the NMD pathway inhibitor that successfully repressed the NMD pathway, the mRNA levels of cellulase genes were sharply down-regulated, but the rates of IR in these genes were significantly up-regulated. (researchsquare.com)
In addition, the NMD pathway inhibitor caused the downregulated mRNA levels of two important genes of the target of rapamycin (TOR) pathway, trfkbp12 and trTOR1 . (researchsquare.com)
The absence of gene trfkbp12 made the cellulase production in T . reesei more sensitive to the NMD pathway inhibitor. (researchsquare.com)
All these findings suggest that the IR of cellulase genes regulates their own gene expression by coupling with the NMD pathway, which might involve the TOR pathway. (researchsquare.com)
He revealed a crucial role for MYC2, MYC3, and MYC4 as master regulators of defense gene expression in the JA pathway. (unil.ch)
In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges. (sdbonline.org)
Genetic epistasis and biochemical analyses revealed that Senju regulates the Toll signaling pathway at a step that converts Toll ligand Spatzle to its active form. (sdbonline.org)
While the defined roles of the c-Jun N-terminal kinase (JNK) pathway in regulating cell death have been well-established, additional factors that modulate JNK-mediated cell death have yet to be fully elucidated. (sdbonline.org)
This paper explores the involvement of the Toll/NF-kappaB pathway in the localized activation of wound repair genes around epidermal breaks. (sdbonline.org)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

We propose to biosynthesis de novo of fungal taxol® production by the regulation of transcription factors (TFs). (europa.eu)
The attractive features of this study, examining the elicitor-induced regulator of selected TFs genes to see whether their mRNA levels correlate with fungal taxol biosynthesis. (europa.eu)
Functional characterization showed the two genes (PdsreA and PdsreB) act as global controllers in a fantastic selection of biological functions, especially in elements that mediate ergosterol biosynthesis and resistance to fungicides. (hsvinhibitor.com)
As both genes regulate different elements, as has been shown with single and double mutations of your genes, it can be achievable that there are other transcription factors involved in ergosterol biosynthesis that could possibly be activated when both SREBPs are inhibited [126]. (hsvinhibitor.com)
In addition to the well known HacA targets such as the ER resident foldases and chaperones, GO enrichment analysis revealed up-regulation of genes involved in protein glycosylation, phospholipid biosynthesis, intracellular protein transport, exocytosis and protein complex assembly in the HacACA mutant. (tu-berlin.de)
Recently, the sterol regulatory element binding protein SrbA was found to be essential for adaptation to iron starvation, thereby linking regulation of iron metabolism, ergosterol biosynthesis, azole drug resistance, and hypoxia adaptation. (frontiersin.org)
RimR2 regulates the rimocidin biosynthesis by influencing the transcriptional levels of rim genes and binding to the promoter regions of rimA and rimC . (biomedcentral.com)
To date, the different types of regulators involved in polyene macrolide biosynthesis have been categorized as follows: (1) Streptomyces antibiotic regulatory protein (SARP) family regulator, such as ActII-orf4, which regulates actinorhodin biosynthesis, and CcaR, which regulates clavulanic biosynthesis. (biomedcentral.com)

Biofilms were stained with SYTO 9 ( green , live bacteria), FUN-1 (intracellular red , live fungal cells), calcofluor white ( blue , fungal cell wall). (asmblog.org)
CGD is a primary immunodeficiency that affects phagocytes of the innate immune system and leads to recurrent or persistent intracellular bacterial and fungal infections and to granuloma formation. (medscape.com)
In healthy cells and tissues, both intracellular and extracellular protease activity is well managed by regulation at the transcriptional and translational levels, as well as by inhibitory pro-domains, modulatory factors (such as pH), and antiproteases at the protein level. (encyclopedia.pub)
L-783,281, an antidiabetic fungal metabolite that has previously been shown to activate insulin signaling in CHO cells, was tested for its effect on intracellular Ca 2+ ([Ca 2+ ] i ) and insulin secretion in single mouse pancreatic β-cells. (diabetesjournals.org)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

Transcription Glycopeptide Inhibitor manufacturer Factors in Pd Fungicide Resistance Transcription things (TF) are involved in transcriptional regulation and play a relevant part in fungal interactions. (hsvinhibitor.com)
Proof around the transcriptional regulation of those target genes has emerged to explain the drug-resistant mechanisms of Pd. (hsvinhibitor.com)
Fungi are known to work with the transcriptional regulation of genes encoding efflux transporters to detoxify certain compounds. (hsvinhibitor.com)
The expression of efflux transporters isefflux Fungi are recognized to use the transcriptional regulation of genes encoding controlled mainly by fungal zinc group transcription elements (TF [Zn2Cys6]) [127]. (hsvinhibitor.com)
ADC gene expression and enzyme activity increased during embryogenesis, which suggests the involvement of transcriptional regulation in the expression of ADC. (scite.ai)
In addition, we show that the very early transcriptional regulation of the rice OsWAK genes is triggered by chitin and is partially under the control of the chitin receptor CEBiP. (biomedcentral.com)
Consequently, C. albicans maintains proper ROS levels via Set1-mediated transcriptional regulation, thus establishing a rapid defense against external ROS generated by the host. (korea.ac.kr)

Much of this work is carried out in the species Candida albicans, the most prevalent fungal pathogen of humans. (ucmerced.edu)
Within the citrus postharvest pathogen Pd, there is yet another SREBP homolog, PdsreB, which seems to become involved in fungicide resistance and within the control of CYP51 gene expression [126]. (hsvinhibitor.com)
The resulting data provide new insights into how Zn2Cys6 TF genes regulate important traits during the infection cycle of this rice blast pathogen. (prelekara.sk)
Fungal pathogenesis is a sophisticated process including infectious development of the pathogen and fungus-host interactions, which requires a fine-tuned regulation of gene expression dynamics. (biomedcentral.com)
Candida albicans is the most important opportunistic fungal pathogen of humans. (ncl.edu.tw)
Detection of pathogen through PRRs triggers PAMP-triggered immunity (PTI, also called basal defense) which is accompanied with rapid production of reactive oxygen species (ROS), activation of mitogen-activated protein kinases (MAPKs) and changes in expression of immune-related genes [ 2 ]. (biomedcentral.com)
Candida albicans is an opportunistic human fungal pathogen that exists in normal flora but can cause infection in immunocompromised individuals. (korea.ac.kr)
Aspergillus fumigatus is a ubiquitous saprophytic fungus, which has become the most common air-borne fungal pathogen of humans ( Tekaia and Latge, 2005 ). (frontiersin.org)

Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
Furthermore, gene overexpression is also frequently associated to antifungal resistance as well as an increase in the activity of proteins that reduce oxidative damage. (intechopen.com)
We speculated that the defect of protein synthesis attenuated expression of other exoglucanases or glucan synthesis-related proteins, and then induced release of Xog1p to the cell wall. (ncl.edu.tw)
Among CRE1 repressed transcripts, genes encoding unknown proteins and transport proteins were overrepresented. (biomedcentral.com)

Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae. (fsu.edu)
CNF1 is the first reported TF gene that strongly and negatively regulates asexual development in the rice blast fungus, and CCA1, CNF1, CNF2, CONx1, GPF1, GTA1, MoCOD1 and PCF1 are required for pathogenicity. (prelekara.sk)

Background: HacA/Xbp1 is a conserved bZIP transcription factor in eukaryotic cells which regulates gene expression in response to various forms of secretion stress and as part of secretory cell differentiation. (tu-berlin.de)
Histone-modifying enzymes, which regulate eukaryotic chromatin conformation and gene expression, are key epigenetic factors controlling fungal development, virulence, and secondary metabolism. (biomedcentral.com)
Eukaryotic fungal and animal clocks comprise transcription-translation-based feedback loops that control rhythmic transcription of a substantial fraction of these transcriptomes, yielding the changes in protein abundance that mediate circadian regulation of physiology and metabolism: Understanding circadian control of gene expression is key to understanding eukaryotic, including fungal, physiology. (dartmouth.edu)

Another example of structural variability is seen in vertebrates, in which 3 paralogues of subunits of the cyclin-dependent kinase module have evolved by 3 independent gene duplication events followed by sequence divergence. (wikipedia.org)
Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
The FLS2 protein belongs to the Receptor-like Kinase (RLK) gene family. (biomedcentral.com)

To identify more negative regulators of MEN, we carried out a genetic screen for genes that are toxic to cdc5-1 mutants when overexpressed. (fsu.edu)
We developed a high-throughput gene knockout system, and using this system, we obtained null mutants of 104 fungal-specific Zn2Cys6 transcription factor (TF) genes by screening 8741 primary transformants in M. oryzae. (prelekara.sk)
Moreover, the expression of an apple defense-related F-box protein was strongly induced by infection with Cfhos2 deletion mutants. (biomedcentral.com)
Here we show using rice ( Oryza sativa ) loss-of-function mutants of four selected OsWAK genes, that individual OsWAKs are required for quantitative resistance to the rice blast fungus, Magnaporthe oryz ae. (biomedcentral.com)
Using available Arabidopsis mutants lacking important defense signals, she studied gene expression changes with microarrays and tried to correlate transcript profiles with insect performance in order to assess the effect of plant defenses on insect growth. (unil.ch)

A remarkable transcriptional response in the HacACA strain was the down-regulation of the AmyR transcription factor and its target genes. (tu-berlin.de)
CreA/CRE1 binds to the promoters of the respective target genes via the consensus motif 5'-SYGGRG-3', whose function in vivo has been shown both in Aspergillus nidulans and Trichoderma reesei [ 9 - 12 ]. (biomedcentral.com)

Most studies on CCR in fungi have been made with gene model systems where CCR functions in the counteraction of gene induction [ 7 ]. (biomedcentral.com)

This renders the patients susceptible to severe, recurrent bacterial and fungal infections. (medscape.com)

It is required for the successful transcription of nearly all class II gene promoters in yeast. (wikipedia.org)
We then define a modular cloning system, including antibiotic selections, integration sites, and reporter genes, and use the transcriptomics to derive strong constitutive and regulated promoters. (biorxiv.org)
The principle aim of this project is to isolate TFs genes WRKY, AP2, MYP etc. that specifically regulate the expression of taxol biosynthetic rate limiting gene promoters using transient RNAi. (europa.eu)
This project offer de nova interactions between the TFs and the TB gene promoters, which results of DNA binding cis-elements. (europa.eu)
Indeed, the isolation of clock-controlled genes (ccgs) was pioneered in Neurospora where circadian output begins with binding of the core circadian transcription factor WCC to a subset of ccg promoters, including those of many transcription factors. (dartmouth.edu)

These stable associations have also been shown to regulate gene expression in vivo, and are prevented by mutations in MED12 that produce the human disease FG syndrome. (wikipedia.org)
Most patients (approximately 80%) are males, who have hemizygous mutations on the X-linked gene coding for gp91phox. (medscape.com)
SCID results from mutations in any of more than 15 known genes. (medscape.com)

One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)
Genes that encode the B-regulatory subunit (Cdc55) and the three catalytic subunits (Pph21, Pph22, and Pph3) of phosphatase 2A (PP2A) were isolated. (fsu.edu)
All of the virulence-associated genes are transcriptionally upregulated during iron starvation and encode functions that are important for survival during iron starvation, which emphasizes the crucial role of adaptation to iron starvation in virulence. (frontiersin.org)
Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)

Pathogenic fungal infection success depends on the ability to escape the immune response. (bvsalud.org)
Most strategies for fungal infection control are focused on the inhibition of virulence factors and increasing the effectiveness of antifungal drugs. (bvsalud.org)
RNA-seq based transcriptome analysis highlighted that Cfhos2 regulates secondary metabolism-related virulence genes during infection. (biomedcentral.com)
Climate induced physiological changes that occur in the host and influence mycotoxins and/or Fusarium infection will be useful as markers in plant breeding programs aimed at developing climate resilient fungal resistance strategies. (usda.gov)
Hence, our results provide evidence for the involvement of Ac and ceramide in controlling P. yoelii infection by regulating red blood cell development. (elifesciences.org)
WAK genes are often transcriptionally regulated during infection but the pathways involved in this regulation are not known. (biomedcentral.com)
Finally, we show that OsWAK91 is required for H 2 O 2 production and sufficient to enhance defense gene expression during infection. (biomedcentral.com)
Suppression of the degalactosylation by senju overexpression resulted in reduced induction of Toll-dependent expression of an antimicrobial peptide, Drosomycin , and increased susceptibility to infection with Gram-positive bacteria. (sdbonline.org)

The number of ADH enzymes, their metabolic roles, and their functions vary within fungal species. (bvsalud.org)
Therefore, this review aims to summarize the latest knowledge about the importance of ADH enzymes in the physiology and metabolism of fungal cells, as well as their structure, regulation, evolutionary relationships, and biotechnological potential. (bvsalud.org)
These responses can lead to changes in cell behavior, activation of enzymes, regulation of gene expression, and various other essential cellular processes. (marketsampler.com)
However, the gene expression and activity of antioxidative enzymes had no differences between wild type and the zcf29zcf29 mutant. (ncl.edu.tw)
Because histone-modifying enzymes can regulate gene expression, they are thought to control the virulence of C. albicans. (korea.ac.kr)
2022. Analysis of Carbohydrate-Active Enzymes and Sugar Transporters in Penicillium echinulatum: a Genome-wide Comparative Study of the Fungal Lignocellulolytic System. (openwetware.org)
Comparison of the deletion, the over-expression, and the parent strain demonstrated that Xpp1 regulates gene expression of xylanolytic enzymes at later cultivation stages. (biomedcentral.com)
The transactivator Xyr1 (Xylanase regulator 1) is essential for gene expression of most cellulolytic and xylanolytic enzymes [ 10 ]. (biomedcentral.com)
The up-regulation of xyr1 transcription goes hand in hand with the up-regulation of gene expression of cellulolytic enzymes, whereas the regulation of xylanases seems to depend on additional mechanisms and factors [ 11 ]. (biomedcentral.com)
This is usually achieved through inhibition of gene expression of enzymes involved in the catabolism of other carbon sources than the preferred ones. (biomedcentral.com)

PA metabolism was analyzed by fitting statistical regression models to the data of free and soluble conjugated PAs, to the enzyme activities of ADC and ornithine decarboxylase (ODC), as well as to the gene expression of ADC. (scite.ai)
Notably, Xpp1 has neither influence on the d -xylose metabolism nor on the expression of cellulases. (biomedcentral.com)
The identification and functional characterization of 24 genes that are involved in iron homeostasis in A. fumigatus and/or Aspergillus nidulans , respectively, revealed significant insights into iron metabolism and its regulation (Table 1 ). (frontiersin.org)
Re-expression of PLIN5 S155A in the liver of Plin5 liver-specific null mice reduced lipolysis compared with wild-type PLIN5 re-expression, but was not associated with other changes in hepatic lipid metabolism. (uci.edu)

Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. (dartmouth.edu)

Among them, the Wall-associated kinases (WAKs) have been shown to be positive regulators of fungal disease resistance in several plant species. (biomedcentral.com)
However, the same main regulators regulate gene expression of cellulases and xylanases in T. reesei . (biomedcentral.com)
In this study, using domain structure and amino acid alignment and phylogenetic tree construction, rimR 2, which located in the rimocidin biosynthetic gene cluster, was first found and identified as a larger ATP-binding regulators of the LuxR family (LAL) subfamily regulator. (biomedcentral.com)

This chapter summarizes the main molecular mechanisms to C. albicans antifungal drug resistance, besides offering an overview of new antifungal agents and new antifungal targets to combat fungal infections. (intechopen.com)
Our findings elucidate the mechanisms of epigenetic targeting of germline genes and provide a paradigm for how transient repression signals by DNA-binding factors in early embryonic cells are translated into long-term epigenetic silencing during mouse development. (cnrs.fr)
We further found via RNA-seq that GPF1 and CNF2 have similar mechanisms in gene expression regulation related to pathogenicity. (prelekara.sk)
Today, a plethora of genes have been shown to be under control of CreA or CRE1 (reviewed in [ 7 ]) but the mechanisms triggering regulation by CreA/CRE1 are less well understood. (biomedcentral.com)
Streptococcal pathogens continue to evade concerted efforts to decipher clear-cut virulence mechanisms, although numerous genes have been implicated in pathogenesis. (cdc.gov)

The lab is also beginning to study interspecies interactions between different fungal and bacterial species. (ucmerced.edu)
Common bunt, caused by two fungal species, Tilletia caries and Tilletia laevis , is one of the most potentially destructive diseases of wheat. (mdpi.com)
Thus, the rationale for this review to place focus on fungal catalases and their role in pathogenesis in addition to counteracting the effect of immune system reactive oxygen species. (bvsalud.org)
In particular, levels of cellular mitochondrial reactive oxygen species (ROS) were higher in Δset1 than in the wild-type due to the defect of those genes' expression. (korea.ac.kr)
Structure of Co-expression Networks of Bifidobacterium species in Response to Human Milk Oligosaccharides. (openwetware.org)

It is the only mushroom-forming fungus for which genes have been inactivated by homologous recombination. (nature.com)
However, there is no high-throughput gene knockout system constructed, and little is known about most of the genes in this fungus. (prelekara.sk)
Systematic Analysis of ZnCys Transcription Factors Required for Development and Pathogenicity by High-Throughput Gene Knockout in the Rice Blast Fungus. (prelekara.sk)
2007) Genome-wide functional analysis of pathogenicity genes in the rice blast fungus. (prelekara.sk)
Construction and Analysis of Gene Co-Expression Network in the Pathogenic Fungus Ustilago maydis. (openwetware.org)
Here, we deciphered the CRE1 regulatory range in the model cellulose and hemicellulose-degrading fungus Trichoderma reesei (anamorph of Hypocrea jecorina ) by profiling transcription in a wild-type and a delta- cre1 mutant strain on glucose at constant growth rates known to repress and de-repress CCR-affected genes. (biomedcentral.com)
Our study provides the first global insight into the molecular physiological response of a multicellular fungus to carbon catabolite regulation and identifies several not yet known targets in a growth-controlled environment. (biomedcentral.com)

In Pd, the SREBP protein SreA was initially identified and characterized, which plays an important function in prochloraz resistance and within the transcription of ergosterol synthesis genes [111]. (hsvinhibitor.com)
In addition, the expression of ERG2, ERG24 and ERG11 genes and the ergosterol content had no differences between wild type and the mutant. (ncl.edu.tw)
The primary target of PEM is the fungal cell membrane, which interacts with PEM via the ergosterol-forming channels present on it, causing loss of ions, imbalance of electrochemical gradients, and cell death [ 13 ]. (biomedcentral.com)

We found that 61 Zn2Cys6 TF genes play indispensable and diversified roles in fungal development and pathogenicity. (prelekara.sk)
2007) Mnh6, a nonhistone protein, is required for fungal development and pathogenicity of Magnaporthe grisea. (prelekara.sk)

A way to achieve this would be knowledge-based strain design by deleting and/or over-expressing transcription factors that specifically regulate xylanase gene expression. (biomedcentral.com)

The complementary expertise of Dr Kamal (Fungal biotechnology) and the supervisor Prof. Dr. Frank Kempken (FK) (Fungal genetic and molecular biology) offer the unique combination to realize the fungal taxol biosynthetic potential. (europa.eu)

2012) The Top 10 fungal pathogens in molecular plant pathology. (prelekara.sk)

Moreover, C. albicans Hom6p affects expression of the cell wall protein Xog1p which is a major exoglucanase and is found to be involved in cell adhesion. (ncl.edu.tw)
The transition to pathogenic C. albicans requires a change of various gene expressions. (korea.ac.kr)

The repE gene is not expressed by mitotically dividing cells, and repE mRNA is first detected during the aggregation phase of development when the cells have ceased dividing and replicating genomic DNA. (nih.gov)
Therefore, although circadian activation is critical to ccg rhythmicity, posttranscriptional regulation plays a major role in determining rhythmicity at the mRNA level. (dartmouth.edu)

The repE gene maps to chromosome 4 and it is the first gene identified in Dictyostelium that is homologous to those involved in nucleotide excision repair and their related XP diseases in humans. (nih.gov)

In addition, phosphorylation of a serine in a conserved short stretch within an acidic domain of T. reesei CRE1 has been demonstrated to regulate its DNA binding [ 13 ]. (biomedcentral.com)
Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation. (uci.edu)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

Fungal alcohol dehydrogenases (ADHs) participate in growth under aerobic or anaerobic conditions, morphogenetic processes, and pathogenesis of diverse fungal genera. (bvsalud.org)
The impact of constitutive HacA activity during exponential growth was explored in bioreactor controlled cultures using transcriptomic analysis to identify affected genes and processes. (tu-berlin.de)
Biological processes over-represented in the down-regulated genes include those belonging to central metabolic pathways, translation and transcription. (tu-berlin.de)
In the present study, histochemical methods and quantification of the expression levels of the programmed cell death (PCD) and DNA repair processes related genes (MCA, TAT-D, RAD51, KU80, and LIG) were used to investigate the physiological events occurring in the megagametophyte tissue during embryo development. (scite.ai)
As bioactive molecule, ceramide is involved in the regulation of many cellular processes. (elifesciences.org)
The findings are of interest in understanding molecular processes involved in regulating erythropoiesis, as well as the potential to develop host-directed therapies for malarial parasites that target human reticulocytes. (elifesciences.org)
A number of processes are essential to maintain effective MCC including regulation of ion channel activity, ciliary beat frequency (CBF), mucin expression and secretion and mucus viscosity [ 8 ] . (encyclopedia.pub)

Gene regulatory network inference and gene module regulating virulence in Fusarium oxysporum. (openwetware.org)

Xpp1 as regulator acting on the expression of xylanases, but not cellulases, is a highly promising candidate for knowledge-based strain design to improve the cellulases-to-xylanases ratio during industrial cellulase production. (biomedcentral.com)
In industrial applications, however, the co-secretion of xylanases is a disadvantage for cost-efficient cellulase production because T. reesei uses additional energy and nutrients for their expression. (biomedcentral.com)

Genetic manipulations allowed analysis of changes in gene expression underlying pheromone signaling, cell cycle control, and polarized morphogenesis. (nih.gov)
This programme of work will provide a new strategy for unlocking the full potential of fungal biotechnology at the interface with metabolic engineering and rDNA technology to establish of fungal fermentation through genetic engineering approaches. (europa.eu)
Enhancement of Genetic Molecular Expression by Mineral Ions in Microbial Cells, and its Effect at the Cellular Level. (raulcuero.com)
The extent to which environmental and secondary genetic factors influence phenotypic expression of disease is unknown. (medscape.com)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)

This data not only reveals novel photobiology and metabolic regulation, it also allows derivation of constitutive and regulated gene expression parts. (biorxiv.org)
Conclusions: The results indicate that the constitutive activation of the HacA leads to a coordinated regulation of the folding and secretion capacity of the cell, but with consequences on growth and fungal physiology to reduce secretion stress. (tu-berlin.de)

The expression of efflux transporters is regulate and handle distinct stages of your detoxification method by modifications in particcontrolled mostly by fungal zinc group transcription variables (TF [Zn2Cys6]) [127]. (hsvinhibitor.com)

The toes are prone to fungal infections because of the constant touching of skin to skin. (marketsampler.com)
And who wants to prevent fungal infections and bad odors? (marketsampler.com)

While OsWAK14, OsWAK91 and OsWAK92 positively regulate quantitative resistance, OsWAK112d is a negative regulator of blast resistance. (biomedcentral.com)
Here, we demonstrated that Set1 positively regulates the expression of mitochondrial protein genes by methylating H3K4. (korea.ac.kr)
Together, these findings suggest that Set1 is required to regulate proper cellular ROS production by positively regulating the expression of mitochondrial protein genes and subsequently sustaining mitochondrial membrane integrity. (korea.ac.kr)

2023. The gene regulatory network of Staphylococcus aureus ST239-SCCmecIII strain Bmb9393 and assessment of genes associated with the biofilm in diverse backgrounds. (openwetware.org)

Regulation of Fungicide Resistance 5.1. (hsvinhibitor.com)

Ambient pH signal transduction involves the products of the pal genes and the transcription factor PacC in A. nidulans, and the corresponding RIM homologs in S. cerevisiae. (ucm.es)

In our case, we isolated 11 tested Trichoderma fungal strains from samples collected both from the rhizosphere and roots from two endemic plants. (bvsalud.org)

Inactivation of 10 of the 19 A. fumigatus genes caused defects in virulence. (frontiersin.org)
However, defects in autosomal genes may also underlie the disease and cause CGD in both males and females. (medscape.com)

In recent years, the world has experienced an increase in mycotoxin contamination of grains due to climatic and agronomic changes that encourage fungal growth during cultivation. (usda.gov)

Indeed application of oral secretions to wounded leaves suppressed the induction of two defense-related genes. (unil.ch)

Overall, this research will lead to a comprehensive understanding of the key TFs that control elicitor induced metabolic changes to produce highest yield of fungal taxol and will provide intellectual property (IP), technology development, which lead to Dr. Kamal with new and cutting-edge research training. (europa.eu)

Analysis of genome-wide microarrays reveals 2.8% of transcripts whose expression was regulated in at least one of the four experimental conditions: 47.3% of which were repressed by CRE1, whereas 29.0% were actually induced by CRE1, and 17.2% only affected by the growth rate but CRE1 independent. (biomedcentral.com)
Here we chose to use chemostat cultures on D-glucose as a carbon source at two different growth rates (one repressing and one derepressing [ 16 ]) to investigate the genome-wide changes in gene expression in relation to CRE1 function, using a Δcre1 recombinant mutant strain of T. reesei and corresponding control strain. (biomedcentral.com)

Notably, we discover a novel promoter from a hypothetical gene that has 9-fold activation upon UV exposure. (biorxiv.org)
Notably, cellulases seem to be regulated in a different manner by Xyr1 than xylanases. (biomedcentral.com)

Here, we demonstrate that the transcription factor E2F6, a member of the polycomb repressive complex 1.6 (PRC1.6), is critical to target and initiate epigenetic silencing at germline genes in early embryogenesis. (cnrs.fr)
To dissect the epigenetic regulation of GLS pathogenesis, we characterized a histone deacetylase gene Cfhos2 in Colletotrichum fructicola , the causing agent of GLS. (biomedcentral.com)
Taken together, we demonstrate that Cfhos2 is a key epigenetic factor regulating appressorium development, virulence gene expression, and GLS pathogenesis in C. fructicola . (biomedcentral.com)

We conclude that the rice OsWAK genes studied are part of basal defense response, potentially mediated by chitin from fungal cell walls. (biomedcentral.com)
Beyond this protective role, Mrr can inflict chromosomal DNA damage that elicits the SOS response in the host cell upon heterologous expression of specific methyltransferases such as M.HhaII, or after exposure to high pressure (HP). (uci.edu)

Her lab is interested in investigating how transcriptional networks underlie the regulation of gene expression during biofilm development. (ucmerced.edu)

Studies carried out in A. nidulans showed that the proteolytical processing of the transcription factor regulates its nucleo-citoplasmic localization 31. (ucm.es)

E2F6 cooperates with MGA to silence a subgroup of germline genes in mouse embryonic stem cells and in embryos, a function that critically depends on the E2F6 marked box domain. (cnrs.fr)

Clearly, interspecies bacterial communication influences the regulation of gene expression. (asmblog.org)

However, the complete list of its gene targets is not known. (biomedcentral.com)

Anatomy23

Organisms16

Diseases4

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes99

Disciplines and Occupations4

Information Science8

Health Care3

Pathway19

Biosynthesis8

Intracellular5

Transcriptional regulation7

Pathogen8

Proteins4

Negatively regulates2

Eukaryotic3

Kinase3

Mutants5

Target genes2

Fungi1

Bacterial and fungal1

Promoters5

Mutations3

Encode4

Infection8

Enzymes10

Metabolism4

Genetics1

Regulators3

Mechanisms5

Species5

Fungus7

Ergosterol3

Pathogenicity2

Specifically regulate1

Biosynthetic1

Pathogens1

Albicans2

MRNA2

Humans1

Phosphorylation3

Processes7

Fusarium1

Cellulase2

Genetic5

Constitutive2

Zn2Cys61

Infections2

Positively3

Regulatory1

Resistance1

Signal transduction1

Trichoderma1

Defects2

Cultivation1

Defense-related1

Metabolic1

Genome-wide2

Notably2

Epigenetic3

Cell2

Biofilm1

Nidulans1

Embryonic1

Interspecies1

Targets1