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  • targets
  • El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D, van Obberghen E (2008) miR-375 targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. (springer.com)
  • cardiac
  • Cheng Y, Liu X, Zhang S, Lin Y, Yang J, Zhang C (2009) MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4. (springer.com)
  • tumor
  • Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). (jci.org)
  • RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. (jci.org)
  • The expression levels of miR-21 ( p = 0.027), miR-181b ( p = 0.002) and miR-146b ( p = 0.021) in tumor tissue and miR-21 ( p = 0.003) in noncancerous tissue were associated with overall survival of patients. (wiley.com)
  • Researchers at Purdue University have discovered a mechanism for delivering tumor-suppressing microRNAs that eliminates the need for toxic delivery vehicles. (healthcanal.com)
  • However, getting the microRNA to the tumor hasn't been easy. (healthcanal.com)
  • Even if the RNA is somehow toxic, they're delivering it at a much lower dose than what was used in the trial, and whatever isn't taken up by the tumor is cleared from the organism very fast. (healthcanal.com)
  • Novel
  • This review highlights the need to investigate the role of microRNAs in GVHD and hypothesizes that microRNAs may be one of the missing links in our understanding of GVHD, with the potential for novel therapeutics. (frontiersin.org)
  • The objective of the research project lead by Marko Kallio, Principal Scientist at VTT, was to identify novel microRNAs participating in the regulation of cell division among the over 1000 microRNAs found in human. (eurekalert.org)
  • We are exploring novel approaches using microRNAs to alter mitochondrial function for both acute and long-term therapies. (stanford.edu)
  • Our results demonstrate that P311 is a novel RNA-binding protein that by interacting with TGF-?s 5'UTRs and eIF3b stimulates the translation of TGF-?1, 2 and 3. (jove.com)
  • knockdown
  • We recently reported the cloning and expression of bovine NOBOX during early embryonic development and our gene knockdown studies indicate that NOBOX is a maternal effect gene essential for early embryonic development. (biomedcentral.com)
  • mechanism
  • A cellular mechanism that degrades unwanted RNAs in the cytoplasm but not in the nucleus. (slideserve.com)
  • Therefore, the molecular mechanism that regulates the progression of bladder cancer is of great significance for treatment of bladder cancer. (springer.com)
  • Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. (jci.org)
  • Here, we show that the CXC chemokine ligand 12 (CXCL12)-CXCR4-STAT3 axis regulates IL-10 production by CLL cells and their ability to suppress T-cell effector function through an IL-10 mediated mechanism. (frontiersin.org)
  • transcripts
  • This gene generates several known transcripts by alternative promoter and alternative splicing (OCT4A, OCT4B and OCT4B1). (openaccesspub.org)
  • This gene encodes at least three transcripts, designated as OCT4A, OCT4B and OCT4B1, by alternative splicing and alternative promoter mechanisms 5 , 6 , 7 , 8 . (openaccesspub.org)
  • Intriguingly, these RNA transcripts are detectable and stable in the blood of patients with cancer and cardiovascular disease. (jove.com)
  • After validating RNA integrity by Bioanalyzer, we will perform a medium throughput quantitative real time PCR (qPCR) to identify the exosomal miRNA using Taqman Low Density Array (TLDA) cards and gene expression studies for transcripts of interest. (jove.com)
  • cellular
  • MicroRNAs are about 21 nucleotides in length and have been implicated in many cellular processes such as development, differentiation, and stress response (1,2). (cellsignal.com)
  • The HIF pathway plays a central role in sensing and responding to changes in cellular oxygen levels, and, since increased expression of HIF-α is observed in many human cancers, understanding how HIF-α becomes deregulated in cancer could lead to new therapeutic strategies. (jci.org)
  • The cellular effects of type IV collagen were studied in pancreatic cancer cell lines by reducing type IV collagen expression through RNA interference and by functional receptor blocking of integrins and their binding-sites on the type IV collagen molecule. (diva-portal.org)
  • extracellular
  • Time-course analysis revealed that decreased expression of miR-1 and miR-133a commences at a pre-disease stage, and precedes upregulation of target genes causal of cardiac hypertrophy and extracellular matrix remodelling, suggesting a role for miR-1 and miR-133a in early disease development. (jove.com)
  • early embryonic development
  • Expression analysis of miR-196a in bovine oocytes and during early embryonic development indicated that it is expressed both in oocytes and embryos and tends to increase at the four-cell and eight-cell stages. (biomedcentral.com)
  • Chromatin immunoprecipitation experiments show that Sox2 and Oct-4 bind to thousands of gene regulatory sites, many of which regulate cell pluripotency and early embryonic development (4,5). (cellsignal.com)
  • pathways
  • This accomplishment highlights the importance of his research, which centers on the investigation of non-coding RNA pathways during the development of the Fabry disease and its appropriate disease modeling. (mh-hannover.de)
  • chromatin
  • In contrast, histone deacetylation promotes a 'closed' chromatin conformation and typically leads to repression of gene activity (4). (cellsignal.com)
  • ENCODE
  • Additional bioinformatics analysis of short RNA sequencing data from ENCODE cell lines showed that miR-1285 is expressed in different cancer cell lines and differentiated cells. (openaccesspub.org)
  • High conserved through evolution, in mammals three distinct genes encode for three different VDAC isoforms, namely VDAC1, VDAC2, and VDAC3. (frontiersin.org)
  • development
  • LIN28 genes are reported to be involved in primordial germ cell development and germ cell malignancy (5). (cellsignal.com)
  • Genetic mouse model and LNA-anti-miRNA technology were used to dissect the function of microRNAs in retinal vascular development and vascular retinopathy. (arvojournals.org)
  • thereby
  • Thereby, it is clear that a new genomic era has started, and we can name this as the "non-coding RNA (ncRNA) revolution. (frontiersin.org)
  • bind
  • The mature miRNA then becomes a part of the RNA-Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA (3). (cellsignal.com)
  • At the molecular level, HuR was found to bind the Lrp6 mRNA via its 3'-untranslated region and enhanced LRP6 expression by stabilizing Lrp6 mRNA and stimulating its translation. (jove.com)
  • long
  • April 2019 The long noncoding RNA LIPCAR was previously shown to be elevated in heart failure (HF) patients with reduced ejection fraction and associated with left ventricular remodeling. (mh-hannover.de)
  • Binding sites were mapped to the non-canonical RNA recognition motif (RRM) of eIF3b and a central 11 amino acid-long region of P311, here referred to as eIF3b binding motif (EBM). (jove.com)