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  • PIPKI
  • We show here that overexpression of PIPKIγ promoted focal adhesion formation, whereas cells expressing either PIPKIγ K188,200R or PIPKIγ D316K , two kinase-dead mutants, had much fewer focal adhesions than those expressing WT PIPKIγ in CHO-K1 cells and HCT116 colon cancer cells. (uky.edu)
  • Depletion of PIPKIγ by using shRNA strongly inhibited formation of focal adhesions in HCT116 cells. (uky.edu)
  • Overexpression of PIPKIγ K188,200R or depletion of PIPKIγ reduced the strength of HCT116 cell adhesion to fibronection and inhibited the invasive capacities of HCT116 cells. (uky.edu)
  • kinase gene
  • Here, we show that in vivo conditional ablation of the focal adhesion kinase gene (Fak) from mouse hippocampal pyramidal cells impairs axon outgrowth and growth cone morphology during development, which leads to functional defects in neuronal connectivity. (sigmaaldrich.com)
  • proteins
  • Although focal adhesions, podosomes, and invadopodia share common signaling proteins, they are distinct in cellular architecture and function (summarized in Table 1 ). (hindawi.com)
  • These protein platforms recruit adaptor proteins and lead to the activation of complex network of signaling cascades that regulate basic cellular functions [ 16 , 36 ]. (hindawi.com)
  • endothelial
  • It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting that IL-8 participated in regulating endothelial permeability in the developing processes of vascular disease. (ijbs.com)
  • The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. (semanticscholar.org)
  • Signaling
  • In summary, this report highlights the critical role of sFRP1 in regulating spermiation via its effects on the FAK signaling and retention of nectin-3 adhesion complex at the apical ES. (popcouncil.org)
  • Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion / N. L. Quach;S. Biressi;L. F. Reichardt;C. Keller;T. A. Rando. (unitn.it)
  • Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. (rupress.org)
  • This study has unveiled a novel function of Akt as an 'ignition kinase' of FAK in growth factor signaling and may shed light on the mechanism by which growth factors regulate integrin signaling. (biologists.org)
  • organization
  • While it is well-recognized that stimuli for osteogenesis of mesenchymal stem cells (MSCs) drive FA maturation, actin organization, and stress-fiber polarization, the extent to which FA-mediated signals regulated by the FA protein composition specifies MSC commitment remains largely unknown. (biologists.org)
  • In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. (hindawi.com)
  • The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion. (nih.gov)