Regulates drosophila proteins. Medical search. Frequent questions

Recently, these functions have been genetically dissected in the fruit fly Drosophila melanogaster , revealing a crucial role for cell-surface activation of the downstream effector kinase Akt in many of these processes. (silverchair.com)
Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. (nih.gov)
Studies carried out by scientists at IRIG, in collaboration with the University of Geneva, on the fruit fly model Drosophila melanogaster have revealed the role of Pcif1 in the control of gene expression, despite the fact that this protein has completely lost its RNA methyltransferase activity compared to its mammalian counterpart PCIF1. (cea.fr)
One species of Drosophila in particular, D. melanogaster , has been heavily used in research in genetics and is a common model organism in developmental biology . (wn.com)
The terms "fruit fly" and " Drosophila " are often used synonymously with D. melanogaster in modern biological literature. (wn.com)
Here we used electrophysiology and arousal-testing paradigms to show that the fruit fly, Drosophila melanogaster , transitions between deeper and lighter sleep within extended bouts of inactivity, with deeper sleep intensities after ∼15 and ∼30 min of inactivity. (jneurosci.org)
A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary. (oeaw.ac.at)
Yolk catabolism initiates at cellularization in Drosophila melanogaster embryos. (harvard.edu)
In recent years, the fruit fly, Drosophila melanogaster, has proven itself as an attractive model system in which to study the genes and pathways that modify acute and chronic behavioral responses to ethanol exposure. (escholarship.org)
2017. The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaster. . (ncbs.res.in)
The Long 3′UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster. (tcd.ie)
Chromosome 4 of Drosophila melanogaster is an atypical autosome, exhibiting several features characteristic of the X chromosome. (the-scientist.com)
The description of the new role of Notch, found in the fly Drosophila melanogaster , and the mechanism that regulates this function have been published in the journal Current Biology , which belongs to the Cell group. (sciencedaily.com)
Charles J.-P., Chihara C., Nejad S., Riddiford L.M. (1998) Identification of proteins and developmental expression of RNAs encoded by the 65A cuticle protein gene cluster in Drosophila melanogaster , Insect Biochem. (apidologie.org)
Masato Umeda's research team at Kyoto University was interested in understanding how the degradation of DESAT1 is regulated in the fruit fly Drosophila melanogaster in order to better understand thermal regulation in diverse organisms. (asbmb.org)
Anteroposterior patterning in Drosophila melanogaster is dependent on the sequence-specific RNA-binding protein Smaug, which binds to and regulates the translation of nanos (nos) mRNA. (embl.de)
Using mosaic analysis and RNAi in the model organism Drosophila melanogaster, we show that Dystroglycan is required cell-autonomously for cellular polarity in two different cell types, the epithelial cells (apicobasal polarity) and the oocyte (anteroposterior polarity). (lu.se)

Here we identify Drosophila RIM (Rab3 interacting molecule) and demonstrate that it localizes to active zones at the larval neuromuscular junction. (jneurosci.org)
To address our goals we use several model systems such as giant reticular spinal axon in lamprey, Drosophila neuromuscular junction, and mammalian neurons, in combination with molecular biology, genetics, cellular imaging techniques, and intracellular recordings. (ki.se)
An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction. (ki.se)
Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction. (neurotree.org)
The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. (neurotree.org)
At the Drosophila larval neuromuscular junction (NMJ) , the retrograde BMP pathway is part of the machinery that controls NMJ expansion concurrent with larval growth. (sdbonline.org)

In addition to regulating mRNA maturation of hundreds of genes MBNL1 (along with its paralogs MBNL2 & MBNL3) autoregulate alternative splicing of the MBNL1 pre-mRNA transcript. (wikipedia.org)
The work of the scientists shows that mutation of Pcif1 gene in Drosophila results in a deregulation of the expression of a set of genes, reduced body weight and a significant drop in fertility which indicates an important role for this protein in the physiology of the organism. (cea.fr)
Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. (nih.gov)
To study the role of these genes in ciliogenesis, I have developed an experimental platform in Drosophila and showed, using genetic tools, that a subgroup of these genes encodes components of a ciliary transport pathway unique to cilia. (utoledo.edu)
Found in the cell membrane, this protein activates a signalling pathway that regulates the expression of genes that make the cell divide, grow, migrate, specialise or die. (sciencedaily.com)
NF-κB activation by fluid flow, leading to expression of target genes such as E-selectin, ICAM-1, and VCAM-1, may regulate early monocyte recruitment and fatty streak formation. (rupress.org)
Apple R.T., Fristrom J.W. (1991) 20-hydroxyecdys-one is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes, Dev. (apidologie.org)
Dotson E.M., Cornel A.J., Willis J.H., Collins F.H. (1998) A family of pupal-specific cuticular protein genes in the mosquito Anopheles gambiae , Insect Biochem. (apidologie.org)
Surprisingly, 72% of known human neurological disease genes exist in Drosophila, including the Fragile X gene, so Drosophila has often been used to identify and understand genes that can cause human disease. (fraxa.org)
The impaired function of specific organelles indicates that the causative genes encode protein complexes that regulate vesicle trafficking in the endolysosomal system including AP-3, BLOC-1, BLOC-2, and BLOC-3. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
The SALL1 gene is part of a group of related genes that provide instructions for making proteins involved in the formation of tissues and organs before birth. (medlineplus.gov)
These proteins are transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes. (medlineplus.gov)
A shortage of functioning SALL1 protein, due to either type of mutation, likely impairs the regulation of genes that direct the development of many different organs and tissues before birth. (medlineplus.gov)
The impaired function of specific organelles indicates that the causative genes encode proteins operative in the formation of lysosomes and vesicles. (medscape.com)

Instead, the experiments suggest that Tao negatively regulates BMP signaling as reduction of Tao leads to an increase in pMad levels in motor neuron nuclei and an increase in BMP target gene expression. (sdbonline.org)

We report here the characterization of the Drosophila homolog of the onecut homeobox gene, which encodes a protein product with one cut domain and one homeodomain. (psu.edu)
This study shows that Schip1 , a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. (sdbonline.org)

Septins tune lipid kinase activity and PI(4,5)P turnover during G-protein-coupled PLC signalling in vivo. (ncbs.res.in)
Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP Turnover and Insulin Signaling. (ncbs.res.in)
Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide. (ncbs.res.in)
Neuronal loss of the serine-threonine protein kinase Tao , a regulator of the Hippo signaling pathway, results in supernumerary boutons, each of which contain a normal number of active zones. (sdbonline.org)
It has shown that miR-429 could inhibit the development of colorectal cancer via targeting in large tumor suppressor kinase (LATS2), and decreased miR-429 could promote the expression of SRY-box transcription factor 2 (SOX2) and B-cell lymphoma 2 (BCL2) to attenuate the neuronal injury induced by accumulation of amyloid β -protein [ 12 ]. (hindawi.com)

Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. (nih.gov)
Hartl, F. U. Molecular chaperones in cellular protein folding. (nature.com)
This question has become increasingly relevant since Drosophila became a model of choice for investigating molecular processes associated with sleep in health and disease ( van Alphen and van Swinderen, 2013 ). (jneurosci.org)
This project will incorporate a wide range of molecular and cell biology techniques, which will be applied by using the genetic model organism Drosophila and various cell culture models. (findaphd.com)
We study the molecular and biophysical mechanisms underlying and regulating vesicle trafficking in neurons and in particular in their axons and presynaptic nerve terminals. (ki.se)
We are aiming at characterizing the signaling mechanisms that regulate the liquid-liquid phase transitions in the synaptic vesicle cycle, mitochondrial functions, and degradation pathways at nerve terminals to clarify how do they become affected at the early stages of neurodegenerative diseases and which molecular steps lead to protein aggregate formation. (ki.se)
Molecular mechanisms of developmentally programmed crinophagy in Drosophila. (sdbonline.org)
In a study to better understand the neuroanatomical substrates and molecular pathways underlying ethanol sensitivity in Drosophila, we found that genetic manipulation of a small group of insulin producing cells results in a strong increase in sensitivity to ethanol-induced sedation. (escholarship.org)
Structural organization of RDGB (retinal degeneration B), a multi-domain lipid transfer protein: a molecular modelling and simulation based approach. (ncbs.res.in)
report the molecular cloning of Painting of fourth (Pof), which encodes a protein that specifically paints chromosome 4 (Proc Natl Acad Sci USA 2001, 98:6273-6278). (the-scientist.com)
and this study sets the stage for analyzing the Dystroglycan complex by using the power of Drosophila molecular genetics. (lu.se)

Akt is activated by increased levels of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)- P 3 ], a phospholipid signalling molecule produced by IIS-regulated class I PI3-kinases( Downward, 1998 ). (silverchair.com)

In agreement with these observations, the Pcif1 protein is distributed all along the polytene chromosomes at the level of active transcription sites and interferes with chromatin-dependent gene expression regulation. (cea.fr)
The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. (oeaw.ac.at)
This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. (nih.gov)
Pentapeptide insertion mutagenesis of the Hoxa1 protein: mapping of transcription activation and DNA-binding regulatory domains. (nih.gov)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)

The genetic makeup of the Drosophila piRNA pathway. (oeaw.ac.at)
We propose that the conserved Tor metabolic sensing pathway regulates yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome. (harvard.edu)
Marco Milán's group has now discovered that the presence of Notch proteins in the cell membrane is also required to inactivate the pathway. (sciencedaily.com)
In order for the Notch pathway to be activated, ligand-type proteins from neighbouring cells bind to the Notch receptor. (sciencedaily.com)
In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki) . (sdbonline.org)
Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway , regulate synaptic development in vertebrates and invertebrates. (sdbonline.org)
A signaling pathway that plays a key role in regulating tissue and organ growth. (bvsalud.org)

ELAV/Hu proteins are gene-specific regulators of alternative splicing of mRNAs, but can also affect other aspects of the maturation of an mRNA and its cytoplasmic expression into a protein. (findaphd.com)
Nakato H., Toriyama M., Izumi S., Tomino S. (1990) Structure and expression of mRNA for a pupal cuticle protein of the silkworm, Bombyx mori , Insect Biochem. (apidologie.org)
MiRNAs are characterized by binding the 3 - UTR of special mRNA to regulate the expression of the related proteins [ 10 , 11 ]. (hindawi.com)
Smaug, a protein that helps to establish a morphogen gradient in Drosophila embryos by repressing the translation of nanos (nos) mRNA, binds to the 3' untranslated region (UTR) of nos mRNA via two similar hairpin structures. (embl.de)
The Nanos protein gradient in Drosophila, required for proper abdominal segmentation, is generated in part via translational repression of its mRNA by Smaug. (embl.de)

By combining centrosome biochemistry with Drosophila genetics, we have found that Sas-4 forms several complexes of PCM proteins. (utoledo.edu)

Researchers at IRIG, in collaboration with the University of Geneva, focused on a RNA mammalian methyltransferase, the PCIF1 protein (homologous to the Drosophila Pcif1 protein), which adds an extra methyl group to m 6 A (m 6 adenosine) to form m 6 Am when the first transcribed nucleotide is an adenosine. (cea.fr)
These participate in transcriptional/translational feedback loops and many homologous clock-components in the fruit fly Drosophila are also expressed in mammalian clock tissues with circadian rhythms. (bioone.org)

D-Onecut appears to be a moderate transcriptional activator and functions as a nuclear protein in neuronal tissues of both the CNS and PNS during development and in the adult. (psu.edu)
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. (findaphd.com)
Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. (sdbonline.org)
We investigated combinatorial translational regulation by Drosophila Pumilio (Pum) and Nanos (Nos), which control development, fertility, and neuronal functions. (elifesciences.org)

But in the cellular environment, newly synthesized proteins are at great risk of aberrant folding and aggregation, potentially forming toxic species. (nature.com)
Skach, W. R. Cellular mechanisms of membrane protein folding. (nature.com)
Since ELAV/Hu proteins bind short U-rich motifs embedded in a highly degenerate sequence context, it is thought that multimerization of ELAV/Hu proteins is key to generate target specificity and that this step is highly regulated by cellular signaling. (findaphd.com)
The p53 interacting partner protein NUMB (homology of numb protein) preserves this intrinsic cellular asymmetry by preventing ubiquitin-mediated proteolysis of p53 catalyzed by the MDM2 E3 ubiquitin ligase 11 . (nature.com)
however, how these interactions are regulated and their basic cellular functions are poorly understood. (lu.se)
For example, some research indicates that the abnormally short SALL1 protein interferes with proteins that control the formation of cellular structures called cilia. (medlineplus.gov)
In cellular environment protein abundance and half-life are determined by ubiquitin-proteasomal system. (lu.se)

This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

The MBNL1 protein specifically binds to double stranded CUG RNA expansions. (wikipedia.org)
This protein binds to the phosphorylated form of serine 5 of RNA polymerase II ( Figure ) and may directly modulate its activity or promote the recruitment of chromatin components. (cea.fr)

The founding member of the human MBNL family of proteins was the Drosophila Muscleblind protein (PMID 9334280). (wikipedia.org)

Expression of these proteins is spatially and temporally regulated during embryonic development. (nih.gov)

In addition, larvae containing mutations in both RIM and rab3 have reduced Ca 2+ channel levels and a Brp distribution that is very similar to that of the rab3 single mutant, indicating that RIM functions to regulate Ca 2+ channel accumulation but is not a Rab3 effector for release machinery distribution across release sites. (jneurosci.org)
It is possible some of the other novel mutations we identify will also affect proteins that may have a connection to Fragile X, or we may be able to connect to dfxr in the future. (fraxa.org)
Most SALL1 gene mutations involved in this disorder lead to the production of an abnormally short version of the SALL1 protein that malfunctions within cells. (medlineplus.gov)
Some studies suggest that mutations that reduce the amount of SALL1 protein are responsible for milder cases of Townes-Brocks syndrome, and mutations that result in an abnormally short, malfunctioning SALL1 protein underlie the more severe cases of the condition. (medlineplus.gov)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)

The insulin/insulin-like growth factor signalling (IIS) cascade performs a broad range of evolutionarily conserved functions, including the regulation of growth, developmental timing and lifespan, and the control of sugar, protein and lipid metabolism. (silverchair.com)
However, the mechanisms regulating lipid metabolism and the storage of lipid during development are less well characterized. (silverchair.com)
Our work therefore reveals a signalling mechanism by which the effect of insulin on lipid metabolism could be regulated independently of some of its other functions during development and adulthood. (silverchair.com)
IP3R mediated Ca(2+) release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress. (ncbs.res.in)

Immunofluorescence analysis with anti-Pcif1 antibodies revealed the presence of the Pcif1 protein (in green) along the chromosome at transcriptionally active euchromatin sites ( i.e. excluded from DAPI dense staining, in red). (cea.fr)
POF protein decorates chromosome 4 by spreading out from an initiation site in the proximal region of the chromosome. (the-scientist.com)
In the related fruitfly species Drosophila busckii , POF paints the whole X chromosome, exclusively in males. (the-scientist.com)
POF complexes may function like the Male Lethal Specific proteins, which regulate dosage-compensation of the X chromosome. (the-scientist.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

The lack of catalytic activity of Pcif1 in Drosophila reveals a new mechanism of gene expression regulation. (cea.fr)
Intriguingly, human Hu proteins can substitute for ELAV in a Drosophila model for alternative splicing regulation. (findaphd.com)
Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in the Drosophila Antennal Lobe. (tcd.ie)
A Genetic Screen in Drosophila To Identify Novel Regulation of Cell Growth by Phosphoinositide Signaling. (ncbs.res.in)

Identification and functional characterization of muscle satellite cells in Drosophila. (ncbs.res.in)
2017. Identification and structural characterization of the precursor conformation of the prion protein which directly initiates misfolding and oligomerization. . (ncbs.res.in)
Identification and structural characterization of interneurons of the Drosophila brain by monoclonal antibodies of the Würzburg hybridoma library. (tcd.ie)
Lampe D.J., Willis J.H. (1994) Characterization of a cDNA and gene encoding a cuticular protein from rigid cuticles of the giant silkmoth, Hyalophora cecropia , Insect Biochem. (apidologie.org)

Heterogeneity in synaptic transmission along a Drosophila larval motor axon. (neurotree.org)
Erratum: Heterogeneity in synaptic transmission along a Drosophila larval motor axon Nature Neuroscience . (neurotree.org)
Long H , Sabatier C, Ma L , Plump A, Yuan W , Ornitz DM , Tamada A , Murakami F , Goodman CS , Tessier-Lavigne M . Conserved roles for Slit and Robo proteins in midline commissural axon guidance. (neurotree.org)

These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)
Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. (findaphd.com)

article{5f173e96-c6fe-4b5f-8f37-b070076bc387, abstract = {{The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)

In Drosophila RIM mutants, there is a large decrease in evoked synaptic transmission because of a significant reduction in both the clustering of Ca 2+ channels and the size of the readily releasable pool of synaptic vesicles at active zones. (jneurosci.org)
We conducted a genetic screen in Drosophila using a locomotor video tracking system to identify mutants with altered ethanol sensitivity. (escholarship.org)
Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders. (ncbs.res.in)

Ochieng V.O., Osir E.O., Ochanda J.O., Olembo N.K. (1993) Temporal synthesis of cuticle proteins during larval development in Glossina morsitans , Comp. (apidologie.org)
To gain insight this study quantitatively investigated synaptic growth and connectivity in the Drosophila nociceptive network during larval development. (sdbonline.org)

We highlight common and distinctive functional features of these expression groups and identify a coupling between downregulation of transcript levels and targeted protein degradation. (nih.gov)
Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed and contributes to p53 degradation in TICs. (nature.com)

The POU-domain protein Pdm3 regulates axonal targeting of R neurons in the Drosophila ellipsoid body. (sinica.edu.tw)
For Aim 1, we analyzed both over-expression and loss of function for dfxr in sensory neurons in Drosophila. (fraxa.org)

In the fruit fly Drosophila, it has been suggested that nearly equal numbers of two subtypes of EEs (Allatostatin A: AstA and Diuretic hormone 31 : Dh31) are alternately produced from the intestinal stem cells in the posterior midgut. (bioone.org)
With a $35,000 grant from FRAXA Research Foundation in 2003, Dr. Jay Brenman and his team at the University of North Carolina utilized the fruit fly (Drosophila) to model disease and examined the fly model of Fragile X in an effort to understand the basic mechanisms of disease. (fraxa.org)

Our results show that sleep is not homogenous in insects, and suggest that waking behavior and the associated synaptic plasticity mechanisms determine the timing and intensity of deep sleep stages in Drosophila . (jneurosci.org)
Social communication of predator-induced changes in Drosophila behavior and germline physiology. (tcd.ie)
Absence of the Fragile X gene function in both humans and Drosophila results in abnormal behavior and neuroanatomical defects. (fraxa.org)

Synaptic vesicle exocytosis occurs at specialized regions of the presynaptic membrane, termed active zones, in which presynaptic release machinery proteins cluster opposite postsynaptic neurotransmitter receptors. (jneurosci.org)

As they are synthesized, mRNAs undergo chemical modifications that ensure their stability, their delivery to ribosomes and eventually their translation into proteins. (cea.fr)
Nos shifts the recognition sequence and promotes repression complex formation on mRNAs that are not stably bound by Pum alone, explaining the preponderance of sub-optimal Pum sites regulated in vivo . (elifesciences.org)

From initial studies on human Hu proteins, we anticipate that altering phosphorylation will impact dramatically on ELAV function and will generate neurological phenotypes. (findaphd.com)
We aim to dissect how ELAV activity is regulated by phosphorylation in Drosophila genetic and cell culture cell models for neurodegeneration. (findaphd.com)
Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila. (tcd.ie)

Two molecules linked to synaptic plasticity regulate the intensity of the first deep sleep stage. (jneurosci.org)

Whereas Atg1 was required for a burst of spatially regulated autophagy during late cellularization, autophagy was not required for initiating yolk catabolism. (harvard.edu)

We present evidence that D-Onecut can bind to similar DNA sequences with high specificity and affinity as other Onecut proteins through the highly conserved cut domain and homeodomain. (psu.edu)

In living organisms, gene expression is a complex process that results in the production of proteins from the genome in a time- and space-regulated manner. (cea.fr)
Here, we review ADAR gene expression, splice forms, posttranslational modifications, subcellular localizations and functions of ADAR protein isoforms. (muni.cz)

Widespread domain in signalling and nuclear proteins. (embl.de)

How signaling proteins generate a multitude of information to organize tissue patterns is critical to understanding morphogenesis. (biorxiv.org)

The researchers quantified 5,117 proteins from this profiling strategy and found that 182 of them changed significantly in response to vessel maturation and plaque development. (asbmb.org)

In Drosophila neuroblasts, asymmetric division and spindle orientation is dependent on Pins/LGN recruitment to the apical cortex. (elifesciences.org)

Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2, the fly homologue of the vertebrate lipid-storage protein perilipin. (silverchair.com)
Release efficacy is regulated by the many proteins that comprise the presynaptic release apparatus, including Ca 2+ channels and proteins that influence Ca 2+ channel accumulation at release sites. (jneurosci.org)

Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. (sdbonline.org)

Drosophila ADAR, an orthologue of vertebrate ADAR2, also regulates let-7 miRNA levels and Adar mutant flies have a circadian mutant phenotype. (muni.cz)

Binger L.C., Willis J.H. (1994) Identification of the cDNA, gene and promoter for a major protein from flexible cuticles of the giant silkmoth Hyalophora cecropia , Insect Biochem. (apidologie.org)

Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation. (tcd.ie)

Employing the Drosophila lymph gland, which harbors differentiated blood cells , and stem -like progenitor cells and their niche, we demonstrate how a systemic signal interacts and harmonizes with local factor/s to achieve cell type-specific tissue homeostasis . (bvsalud.org)

Highwire regulates presynaptic BMP signaling essential for synaptic growth. (neurotree.org)

A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)

This expression is strictly dependent on the synthesis of messenger RNAs transcripts from the DNA molecule and their subsequent translation into proteins by the ribosomes. (cea.fr)
Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity. (neurotree.org)
Nakato H., Izumi S., Tomino S. (1992) Structure and expression of gene coding for a pupal cuticle protein of Bombyx mori , Biochim. (apidologie.org)
Izumi S., Tomino S. (1994) Structure and developmental expression of a larval cuticle protein gene of the silkworm, Bombyx mori , Biochim. (apidologie.org)
DESAT1 in fruit flies is transcribed at a constant rate, but the rate at which the protein degrades determines its overall expression level. (asbmb.org)
A very small portion is responsible for expression of the protein. (asbmb.org)

In Drosophila , FGF produced in wing-disc cells regulates the development of the disc-associated air-sac-primordium (ASP). (biorxiv.org)
A PI4KIIIα protein complex is required for cell viability during Drosophila wing development. (ncbs.res.in)
Santos A.E., Bitondi M.M.G., Simões Z.L.P. (2001) Hormone-dependent protein patterns in integument and cuticular pigmentation in Apis mellifera during pharate adult development, J. Insect Physiol. (apidologie.org)
1. Testing the genetic requirements of dfxr (Drosophila Fragile X related gene) in dendritic filopodia development. (fraxa.org)
We are developing a genetic model for analyzing dendrite and dendritic spine development utilizing Drosophila, or fruit flies. (fraxa.org)
By controlling gene activity, the SALL1 protein plays an important role in development of the hands (particularly the thumbs), ears, anus, kidneys, and other parts of the body before birth. (medlineplus.gov)

The researchers have discovered the self-repression mechanism of Notch in Drosophila and it should be checked now whether this also operates in mice and humans. (sciencedaily.com)

This study demonstrates the importance to not restrict the function of enzymes to their sole catalytic role in the living world and the interest of thoroughly examining the evolution of proteins in eukaryotes in order to discover unsuspected or hidden mechanisms of action. (cea.fr)
Optogenetic upregulation of cyclic adenosine monophosphate during the day increases sleep intensity at night, whereas loss of function of a molecule involved in synaptic pruning, the fragile-X mental retardation protein, increases sleep intensity during the day. (jneurosci.org)
Hence, RIM may have a similar function in Drosophila . (jneurosci.org)
Intersectin associates with synapsin and regulates its nanoscale localization and function. (ki.se)
The Ataxin-2 protein is required for miRNA function and synapse-specific, long-term olfactory habituation. (tcd.ie)
Extended synaptotagmin regulates membrane contact site structure and lipid transfer function in vivo. (ncbs.res.in)
Phospholipid transport protein function at organelle contact sites. (ncbs.res.in)
We then showed that Tubulin, the building block of microtubules, functions as a switch like regulatory subunit that regulates the formation of the PCM complexes, and centrosome function. (utoledo.edu)
Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. (neurotree.org)
Scientists reveal a surprising new function of Notch protein that contrasts with the one known to date. (sciencedaily.com)
Scientists headed by ICREA researcher Marco Milán, at the Institute for Research in Biomedicine (IRB Barcelona), reveal a surprising new function of Notch protein that contrasts with the one known to date. (sciencedaily.com)
This represents a new function for the SAM domain family, which is well characterized for mediating protein-protein interactions. (embl.de)
Residues that compose the RNA-binding surface are conserved in a subgroup of SAM domain-containing proteins, suggesting that the function of the domain is conserved from yeast to humans. (embl.de)
Our genetic analyses uncovered a novel function of Lar, a receptor protein tyrosine phosphatase . (bvsalud.org)
The malfunctioning protein may also interact with other proteins, disrupting their function. (medlineplus.gov)

Collaboration among the multitude of RNA-binding proteins (RBPs) is ubiquitous, yet our understanding of these key regulatory complexes has been limited to single RBPs. (elifesciences.org)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. (oeaw.ac.at)
My second line of investigation in centrosome assembly involves studying centrosome biogenesis in Drosophila using biochemistry. (utoledo.edu)

Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex. (oeaw.ac.at)
In the last decades, HOX proteins have been extensively studied due to their pivotal role in transcriptional events. (mdpi.com)

Recent advances suggest that an age-related decline in proteostasis capacity allows the manifestation of various protein-aggregation diseases, including Alzheimer's disease and Parkinson's disease. (nature.com)
In humans, ELAV/Hu proteins have been associated with schizophrenia, Alzheimer's and Parkinson's disease. (findaphd.com)

Indeed, ELAV/Hu proteins have numerous sites for post-translational modifications. (findaphd.com)

Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche. (bvsalud.org)

Anatomy37

Organisms5

Diseases1

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology4

Phenomena and Processes65

Disciplines and Occupations1

Information Science4

Melanogaster17

Neuromuscular junction6

Genes16

Negatively1

Homolog2

Kinase5

Molecular11

Signalling molecule1

Transcription8

Pathway7

MRNA5

Genetics1

Mammalian2

Neuronal4

Cellular7

Encodes a protein1

Binds2

PMID1

Embryonic Development1

Mutations5

Metabolism4

Chromosome5

Regulation4

Characterization4

Axon3

Pathways2

Abstract1

Mutants3

Larval development2

Degradation2

Neurons2

Fruit fly2

Behavior3

Receptors1

MRNAs2

Phosphorylation3

Synaptic plasticity1

Spatially1

Highly conserved1

Gene expression2

Nuclear Proteins1

Morphogenesis1

Maturation1

Asymmetric division1

Accumulation2

Autophagy1

Vertebrate1

Identification1

Differentiation1

Interacts1

Presynaptic1

Neurodegeneration1

Expression6

Development6

Mechanism1

Function15

Complexes2

Biogenesis2

Transcriptional2

Alzheimer's2

Translational1

Organ1