• Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
  • An example of highly conserved signaling pathways in eukaryotes are the mitogen-activated protein kinase (MAPK) pathways. (ku.edu)
  • In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
  • Many projects in the lab apply phage display to evolve peptides and proteins to bind cancer and diabetes-associated biomarkers. (uci.edu)
  • Cytokine" is a general term used for a diverse group of soluble proteins and peptides which act as regulators under both normal and pathological conditions to modulate the functional activities of individual cells and tissues. (sigmaaldrich.com)
  • The leader peptides regulate the expression of the downstream resistance gene in response to the presence of the drug. (uni-muenchen.de)
  • It is located in the 5′ untranslated regions of mRNAs encoding ribosomal proteins L10 and L12 (rplJ-rplL). (wikipedia.org)
  • Lin28/LIN-28 also bind and regulate many mRNAs in diverse cell types. (stanford.edu)
  • Background: MicroRNAs (miRNA) are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition. (usda.gov)
  • Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
  • Moreover, modulation of the proteins involved in cellular metal homeostasis may help in the regulation of metabolism, adaptability to a diverse range of environmental conditions, and biofortification. (frontiersin.org)
  • Here, we review progress in the understanding of different subcellular metal transport components in plants and discuss the prospects of regulating cellular metabolism and strategies to develop biofortified crop plants. (frontiersin.org)
  • Diverse signal recognition receptors and signal transduction pathways were defined which regulate cellular functions, metabolism and development. (mdpi.com)
  • It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. (thermofisher.com)
  • p53 can control diverse transcriptional programs to regulate senescence and cell death programs as well as cellular metabolism (2). (novusbio.com)
  • MiRNAs are known to control diverse processes including animal development and growth, cell differentiation, signal transduction, cancer disease, virus-induced immune defense, programmed cell death, insulin secretion and metabolism. (usda.gov)
  • Insulin , secreted by the islet cells of the pancreas, affects the processing (metabolism) of glucose, protein, and fat throughout the body. (msdmanuals.com)
  • However, the principles that determine if a gene is regulated by miRNAs are poorly understood. (frontiersin.org)
  • While most membranous and disease related proteins are regulated by miRNAs, the G-protein coupled receptor (GPCR) family is an exception, being mostly unregulated by miRNAs. (frontiersin.org)
  • MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
  • About 30% of the human protein-coding genes are negatively regulated by miRNAs which suggests that they have a major role in regulating gene expression. (usda.gov)
  • that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
  • As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)
  • Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
  • Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli. (wikipedia.org)
  • Iron (Fe), zinc (Zn), manganese (Mn), and copper (Cu) are essential micronutrient mineral elements for living organisms, as they regulate essential cellular processes, such as chlorophyll synthesis and photosynthesis (Fe, Cu, and Mn), respiration (Fe and Cu), and transcription (Zn). (frontiersin.org)
  • The COMMD3 protein regulated melanin synthesis by controlling the acidity of melanosomes. (ou.edu)
  • Erythromycin targets bacterial ribosomes - the nanomachine responsible for the translation of messenger RNA (mRNA) sequences into protein - thus preventing synthesis of the proteins required for continued growth and survival. (uni-muenchen.de)
  • When the drug is present, it binds within the tunnel of the ribosome and interacts with the translating leader peptide to stall protein synthesis. (uni-muenchen.de)
  • Glucocorticoid synthesis and release is strictly regulated by the pituitary and hypothalamus by negative feedback and, to a lesser extent, by catecholamines from the adrenal medulla and neural inputs from the autonomic system. (medscape.com)
  • Evidence exists for telomerase dysfunction, ribosome deficiency, and protein synthesis dysfunction in this disorder. (medscape.com)
  • We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
  • In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
  • Protein kinase C epsilon, or PKCε, a crucial signaling molecule within cells, plays a significant role in transmitting signals and influences various cellular functions. (asbmb.org)
  • By removing ubiquitin, BAP1 helps regulate diverse cellular processes. (medlineplus.gov)
  • Therefore, the understanding of the diverse signalling molecules, signal recognition mechanisms and signal transduction pathways is fundamental for the insight into physiological and pathophysiological processes. (mdpi.com)
  • The scope of the special issue is to summarize and enlarge the knowledge in signalling processes and networks in diverse cells and tissues. (mdpi.com)
  • Cell flow responses regulate diverse processes such as blood pressure, bone density, and neural growth. (aps.org)
  • Well-known processes such as capping, splicing and polyadenylation, as well as the recently discovered and ever-expanding list of diverse chemical modifications and editing, significantly alter the properties and fates of a given RNA during the course of its lifetime. (uci.edu)
  • GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. (bmj.com)
  • In fungi, MAPK pathways have been shown to regulate a diverse array of biological processes, such as asexual and sexual development, stress responses and the production of secondary metabolites (SMs). (ku.edu)
  • The technological processes developed and used by the research team could also be applied to identify genes that regulate melanin production in fungi and bacteria. (ou.edu)
  • The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. (embl-heidelberg.de)
  • These proteins also mediate direct interactions between cells and regulate processes taking place in the extracellular environment. (sigmaaldrich.com)
  • Ultimately, hormones control the function of entire organs, affecting such diverse processes as growth and development, reproduction, and nutrient metabolisms. (msdmanuals.com)
  • Although it is unclear exactly how loss of BAP1 function leads to BAP1 tumor predisposition syndrome, researchers speculate that altered activity of proteins normally regulated by BAP1 deubiquitination may promote cell proliferation or survival, resulting in tumor formation. (medlineplus.gov)
  • from the coding potential of DNA through to the regulated activity of proteins and large protein complexes. (umu.se)
  • The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl-heidelberg.de)
  • RNA sequencing revealed that genes involved in G protein-coupled receptor (GPCR) signaling were significantly up-regulated in the high-erythroid output donors. (lu.se)
  • The glucocorticoid receptor is an intracellular protein that, in its ligand-bound form, acts as a nuclear transcription factor to regulate the expression of a diverse array of genes in many areas of the body. (medscape.com)
  • In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
  • We conclude that duplicated paralogous genes that often changed their function, also diverse in their tendency to be miRNA regulated. (frontiersin.org)
  • We conclude that protein function is informative across species in predicting post-transcriptional miRNA regulation in living cells. (frontiersin.org)
  • Aberrant activation of the Wnt signaling pathway is an important step in the initiation and progression of tumor development in diverse cancers. (nih.gov)
  • In addition to its role as a transcription factor, p53 functions in the cytoplasm to regulate the activity of apoptotic pathway proteins such as BAX, BAK , and BCL-2 (2). (novusbio.com)
  • Here, we report that C. elegans LIN-28 represses the expression of LIN-46, a downstream protein in the heterochronic pathway. (stanford.edu)
  • In the model fungus Aspergillus nidulans, a MAPK pathway known as the pheromone module is utilized to regulate both development and SM production. (ku.edu)
  • Diverse organization of genes of the β-ketoadipate pathway in members of the marine Roseobacter lineage. (microbiologyresearch.org)
  • Its function is to remove molecules called ubiquitin from certain proteins (deubiquitination), which can affect the activity of the protein and its interactions with other proteins. (medlineplus.gov)
  • Homer proteins are components of postsynaptic density (PSD) and play a crucial role in coupling diverse target molecules. (jneurosci.org)
  • Scientists discovered a protein that plays a crucial role in regulating fatty acids, the molecules that make up body fat. (rockefeller.edu)
  • Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. (thermofisher.com)
  • Lysine methyltransferase, or KMT, enzymes help with the transfer of methyl groups from S-adenosyl methionine molecules to proteins. (asbmb.org)
  • This group of G protein-coupled receptors share lipid mediators as ligands. (rndsystems.com)
  • Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl-heidelberg.de)
  • Our structural and functional assays demonstrate the different binding modes of chemically distinct agonists of S1PRs, reveal the mechanical switch that activates these receptors, and provide a framework for understanding ligand selectivity and G protein coupling. (rcsb.org)
  • Evidence presented suggests that little diversities, neuronal receptors, trans- lyssavirus (family Rhabdoviridae , genomic variation in New World West port, and cellular protein-virus inter- genus Lyssavirus ), also a neurotrope. (cdc.gov)
  • BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. (nih.gov)
  • The applications of p53 antibodies range from assessing protein levels and post-translational modifications to examining interactions with binding partners or occupancy at a gene locus. (novusbio.com)
  • These proteins regulate diverse cellular functions through interactions with PDGF R alpha and R beta (1, 2). (rndsystems.com)
  • However, we lack information on the lateral movement of extracellular membrane proteins located at the cell-fluid interface. (aps.org)
  • Furthermore, these pathways are essential for cellular dynamics and build a highly regulated cellular signalling network. (mdpi.com)
  • Prostaglandins are associated with diverse physiological and pathological pathways. (rndsystems.com)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • In order for eukaryotes to efficiently detect and respond to environmental stimuli, a myriad of protein signaling pathways are utilized. (ku.edu)
  • RA is a critical signaling molecule that regulates gene transcription and the cell cycle. (nih.gov)
  • Previous reports have suggested that protein kinases play important roles in the regulation of circadian clocks ( Reischl and Kramer, 2011 ). (elifesciences.org)
  • We identified both new and previously known genes that play important roles in regulating melanin production in humans. (ou.edu)
  • The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
  • Synergistic transcriptional activation by one regulatory protein in response to two metabolites. (microbiologyresearch.org)
  • Caveolin interacts with and regulates heterotrimeric G-proteins. (thermofisher.com)
  • Herein, we present five cryo-electron microscopy structures of S1PRs bound to diverse drug agonists and the heterotrimeric Gi protein. (rcsb.org)
  • Molecular markers for allelic variation of the genes that regulate nitrogen can be used in breeding programmes aimed at improving NUE and yield in novel wheat cultivars. (landinstitute.org)
  • CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. (nih.gov)
  • This allows p53 to bind DNA and regulate the expression of various genes (2). (novusbio.com)
  • These structures can be recognized by antiviral cellular RNA-binding proteins, including DExD-box (DDX) helicases, that bind viral RNAs to control infection. (bvsalud.org)
  • Together, these findings suggested that Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity. (jneurosci.org)
  • These results suggest that the phosphorylation may regulate postsynaptic molecular architecture and Ca 2+ signaling of Purkinje cells in response to synaptic activity. (jneurosci.org)
  • To better understand the molecular mechanisms of osteoclast function, we first screened Rab proteins especially induced during osteoclast formation in mouse. (scienceblog.com)
  • Molecular Biology is an extensive and diverse field of endeavour. (umu.se)
  • The study , published in Molecular & Cellular Proteomics , presents a list of proteins that could be potential targets for developing drugs to reduce alcohol consumption and anxiety in humans. (asbmb.org)
  • C. Elegans LIN-28 Controls Temporal Cell Fate Progression by Regulating LIN-46 Expression via the 5' UTR of Lin-46 MRNA. (stanford.edu)
  • pubMedId':'34496246','pubMedUrl':'https://www.ncbi.nlm.nih.gov/pubmed/34496246','publicationId':'826388','title':'C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA. (stanford.edu)
  • GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. (bmj.com)
  • Expression levels of PER2, a clock protein, were elevated in Sik3 -knockdown cells but down-regulated in Sik3 -overexpressing cells, which could be attributed to a phosphorylation-dependent decrease in PER2 protein stability. (elifesciences.org)
  • Here, we show the association of Dbl with G protein betagamma subunits (Gbetagamma) in transient co-expression and cell-free systems. (embl-heidelberg.de)
  • DESAT1 in fruit flies is transcribed at a constant rate, but the rate at which the protein degrades determines its overall expression level. (asbmb.org)
  • A very small portion is responsible for expression of the protein. (asbmb.org)
  • In this work, we show that PcaQ also regulates the expression of the S. meliloti smb20568-smb20787-smb20786-smb20785-smb20784 gene cluster, which is predicted to encode an ABC transport system. (microbiologyresearch.org)
  • The LIN-14 transcription factor likely directly represses dma-1 gene expression through a transcriptional means, whereas the LIN-41 tripartite motif protein likely indirectly promotes dma-1 gene expression through a posttranscriptional means. (stanford.edu)
  • These findings support the notion that the depression risk variants contribute to AD via regulating expression of their corresponding transcripts in the brain," the investigators write. (medscape.com)
  • Moreover, endosomal sorting complex required for transport (ESCRT)-related proteins and their transcripts are most abundant at early and mid-development. (nature.com)
  • The transcripts of both TaVRN-A1 and TaANR1 were down-regulated by nitrogen. (landinstitute.org)
  • In addition, the investigators identified 75 brain transcripts (messenger RNA) and 28 brain proteins regulated by the depression-predisposing genetic variants. (medscape.com)
  • Of these, 46 brain transcripts and seven proteins were significantly associated with at least one AD feature ― for example, beta-amyloid, tau tangles, and cognitive trajectory. (medscape.com)
  • This study revealed proteins involved in oxidative stress are able to inhibit p53 degradation (4). (novusbio.com)
  • Masato Umeda's research team at Kyoto University was interested in understanding how the degradation of DESAT1 is regulated in the fruit fly Drosophila melanogaster in order to better understand thermal regulation in diverse organisms. (asbmb.org)
  • benK encodes a hydrophobic permease-like protein involved in benzoate degradation by Acinetobacter sp. (microbiologyresearch.org)
  • Here we find that in Caenorhabditis elegans, mouse, rat and human neurons, dendritically and axonally polarized transmembrane proteins are recognized by endocytic machinery in the AIS, robustly endocytosed and targeted to late endosomes for degradation. (stanford.edu)
  • Now researchers report that microbiota regulate the ability of lung dendritic cells to generate immune responses. (sciencedaily.com)
  • Microbiota--the trillions of bacteria that co-exist in the body--regulate the ability of lung dendritic cells to generate immune responses, according to a study led by researchers from the Icahn School of Medicine at Mount Sinai, published online in the Journal of Experimental Medicine . (sciencedaily.com)
  • A protein that guides the early development of creatures as diverse as fruit flies and humans also plays a role in regulating fat and bone formation in adult organisms, researchers at UT Southwestern Medical Center have discovered. (news-medical.net)
  • In studies published in scientific journals J Biol Chem and Cell Struct Funct , researchers led by Osaka University revealed proteins named Rab32 and Rab38 play pivotal roles in bone resorption in osteoclast, cell specialized in the process. (scienceblog.com)
  • Additionally, the researchers observed that cKMT1 modifies a crucial protein called ferredoxin-NADP(+) oxidoreductase and influences its activity, indicating its role in regulating energy transfer in Synechocystis. (asbmb.org)
  • The researchers found 169 functionally diverse genes that impacted melanin production. (ou.edu)
  • The researchers quantified 5,117 proteins from this profiling strategy and found that 182 of them changed significantly in response to vessel maturation and plaque development. (asbmb.org)
  • CYP26B1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. (nih.gov)
  • Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. (embl-heidelberg.de)
  • It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. (embl-heidelberg.de)
  • An amino-terminal portion conserved among a subset of Dbl family proteins is sufficient for the binding of Gbetagamma. (embl-heidelberg.de)
  • The storage and distribution of these minerals in various cellular organelles is strictly regulated to ensure optimal metabolic rates. (frontiersin.org)
  • Together our data identified promising targets to be genetically engineered to modulate seed storage protein accumulation that have a growing role in health and nutritional issues. (nature.com)
  • p53 has a crucial but complex role in regulating ferroptosis. (nature.com)
  • It plays an important role in regulating cell junction configuration. (nih.gov)
  • This protein is known to play a role in regulating transcription, however, the precise mechanism remains unknown. (dkfz.de)
  • Becky uses various tools to delete SRSF2 to better determine its role and diverse functions. (dkfz.de)
  • p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. (novusbio.com)
  • This widespread role in tumorigenesis has made p53 one of the most highly studied proteins and a target for anti-cancer therapeutics. (novusbio.com)
  • These techniques are essential for understanding p53's complex role in regulating cell behavior. (novusbio.com)
  • This reversible modification may play a role in regulating photosynthesis in both cyanobacteria and plants. (asbmb.org)
  • The DNA-binding protein KLF6 led to a loss of melanin production in humans and animals, confirming the role KLF6 plays in melanin production in other species as well. (ou.edu)
  • Another gene implicated in DKC, TINF2 , encodes a key component of the protein shelterin, which plays a role in telomere homeostasis. (medscape.com)
  • He also showed that double-stranded (ds)RNA- and ZDNA binding proteins had a role in poxvirus pathogenesis. (cdc.gov)
  • The central effector of canonical Wnt signaling, β-catenin (CTNNB1), is a multifunctional protein, and has been extensively studied with respect to its roles in cell-cell adhesion and in regulation of Wnt-driven transcription. (nih.gov)
  • The Rho family of GTP-binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton-dependent morphological change. (embl-heidelberg.de)
  • Proteins of this family carry out essential cellular functions, and emerging literature is revealing additional roles in immune defense. (bvsalud.org)
  • We will discuss the diverse roles that members of the DEAD-box helicase family play during viral infections. (bvsalud.org)
  • Through genetic screening, we found that the conserved RNA binding protein DDX56 is antiviral against chikungunya virus in insects and humans. (bvsalud.org)
  • Although the mechanisms are still unclear, p53 is thought to regulate these apoptotic proteins through direct interaction (2). (novusbio.com)
  • Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. (thermofisher.com)
  • The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. (embl-heidelberg.de)
  • To investigate this transport system further, we generated a pcaM deletion mutant (predicted to encode the substrate-binding protein) and introduced a polar insertion mutation into pcaN , a gene that is predicted to encode a permease. (microbiologyresearch.org)
  • all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)
  • Abstract: RNA transcribed from the genome in the nucleus bears little resemblance to the RNA polymer it will ultimately become in the cytoplasm where it is translated into protein. (uci.edu)
  • p class=\'abstract\'>Lin28/LIN-28 is a conserved RNA-binding protein that promotes proliferation and pluripotency and can be oncogenic in mammals. (stanford.edu)
  • This signaling cascade consists of the three kinases SteC, MkkB, and MpkB, as well as the SteD adaptor protein and the HamE scaffold. (ku.edu)
  • E.coli-derived human Caveolin-2 recombinant protein (Position: M1-D162). (thermofisher.com)
  • Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. (lu.se)
  • Methods for detecting infec- tinuous genetic variation may lead to of various proteins in virus infections, tions caused by neurotropic viruses partial protection and escape mutants, neuronal involvement, and apoptosis and for detecting viruses or their which could provide a "pump" that are being recognized. (cdc.gov)
  • During development, protein trafficking and storage require an extensive reorganization of the endomembrane system. (nature.com)
  • Consequently, endomembrane-modifying proteins will influence the final grain quality and yield. (nature.com)
  • Based on proteome annotation and a homology search, 94 proteins associated with the endomembrane system were identified that exhibited significant changes in abundance during grain development. (nature.com)
  • The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root bending in Arabidopsis thaliana seedlings. (portlandpress.com)
  • Here, a novel mass spectrometry-based proteomics technique in colorectal cancer cells expressing stabilized β-catenin, was used to identify a protein-protein interaction between β-catenin and DNA methyltransferase I (Dnmt1) protein, the primary regulator of DNA methylation patterns in mammalian cells. (nih.gov)
  • Over 50 Rab proteins are known in mammalian cells including human and mouse, and they are thought to be specifically involved in the traffic between each specific organelle, thereby reliable logistics between them are guaranteed. (scienceblog.com)
  • In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-β-catenin protein complex and perturbation of the Dnmt1-β-catenin interaction altered DNA methylation. (nih.gov)
  • Lysine methylation, a specific PTM involving the addition of a methyl group to a protein's amino acid, has diverse functions in organisms. (asbmb.org)
  • Gaoxiang Cao and a team at the Chinese Academy of Sciences in Wuhan recently analyzed the proteins in Synechocystis that have lysine methylation and found many proteins involved in photosynthesis that can be modified in this way. (asbmb.org)
  • BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. (nih.gov)
  • Conversely, the Dnmt1 regulates the levels of nuclear β-catenin and β-catenin/TCF-driven transcription. (nih.gov)
  • In summary, a functional protein-protein interaction was identified between two critically important oncoproteins, in turn revealing a link between Wnt signaling and downstream nuclear functions mediated by Dnmt1. (nih.gov)
  • Acetylases are now known to modify a variety of proteins, including transcription factors, nuclear import factors and alpha-tubulin. (embl-heidelberg.de)
  • Different subcellular compartments are suggested to be linked through complex retrograde signaling networks to regulate cellular metal homeostasis. (frontiersin.org)
  • Rab is a group of small proteins that regulate the logistics between diverse compartments inside the cells called organelle. (scienceblog.com)
  • Recent research has highlighted the significance of posttranslational modifications, or PTMs, in regulating photosynthesis in both cyanobacteria and plants. (asbmb.org)
  • PDGF-DD is secreted as a100 kDa latent homodimer which is activated by proteolysis to release a 35 kDa bioactive protein containing the PDGF/VEGF homology domain (3,4,6,7). (rndsystems.com)
  • The recent identification of enzymes that regulate histone acetylation has revealed a broader use of this modification than was suspected previously. (embl-heidelberg.de)
  • Cereal endosperm is a short-lived tissue adapted for nutrient storage, containing specialized organelles, such as protein bodies (PBs) and protein storage vacuoles (PSVs), for the accumulation of storage proteins. (nature.com)
  • The BAP1 protein acts as a tumor suppressor, which means it helps prevent cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
  • Investigation of p53 activation has revealed protein stability in an important aspect of p53 activity. (novusbio.com)
  • Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalysed by guanine nucleotide exchange factors (GEFs) in the Dbl family. (embl-heidelberg.de)
  • Fundamental physics of flow-mediated membrane protein transport. (aps.org)
  • In a novel, automated machine learning framework, we use sequence as well as diverse functional annotations to train models on multiple organisms using experimentally validated data. (frontiersin.org)
  • B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
  • DyNamin Binding Protein (DNMBP), also called Tuba, is a Cdc42-specific Guanine nucleotide Exchange Factor (GEF) that binds dynamin and various actin regulatory proteins. (nih.gov)
  • Known as commensal bacteria, they exist in a mutually beneficial, symbiotic relationship with their human hosts, helping with a diverse range of functions that are only beginning to be understood. (sciencedaily.com)
  • Acetylation regulates many diverse functions, including DNA recognition, protein-protein interaction and protein stability. (embl-heidelberg.de)
  • Endocrine Glands The endocrine system consists of a group of glands and organs that regulate and control various body functions by producing and secreting hormones. (msdmanuals.com)
  • affects cells throughout the body and is involved in such important functions as regulating growth of cells, controlling the heart rate, and affecting the speed at which calories are burned. (msdmanuals.com)
  • To control endocrine functions, the secretion of each hormone must be regulated within precise limits. (msdmanuals.com)