Regulates differentiation. Medical search. Frequent questions

Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. (ca.gov)
Thus, our work revealed a novel role for Dnmt3a in regulating both the timing of neural cell differentiation and the cell proliferation in the paradigm of mESC-derived-NSCs. (ca.gov)
MSCs isolated from MSCKO mice showed reduced differentiation towards osteoblasts and chondrocytes in vitro, but no difference in proliferation or apoptosis. (harvard.edu)
Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Human tonsil and lymph node-derived FRCs constrained the proliferation of both naïve and pre-activated T cells, skewing their differentiation away from a central memory T cell phenotype. (birmingham.ac.uk)
Here, we show that microbial polyamines reinforce colonic epithelial proliferation and regulate macrophage differentiation. (elsevierpure.com)
The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. (omicsdi.org)
The expression of REG3A by keratinocytes is induced by interleukin-17 (IL-17) via activation of keratinocyte-encoded IL-17 receptor A (IL-17RA) and feeds back on keratinocytes to inhibit terminal differentiation and increase cell proliferation by binding to exostosin-like 3 (EXTL3) followed by activation of phosphatidylinositol 3 kinase (PI3K) and the kinase AKT. (omicsdi.org)
In most biological systems the down-regulation of proliferation is necessary for initiation of key steps in the differentiation process. (elsevierpure.com)
miR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis[J]. Biomed Pharmacother, 2019, 109:1112-1119. (magtechjournal.com)
CTGF is a cysteine-rich secretory protein and belongs to a six member family who are known to be involved in fundamental biological processes such as cell proliferation, attachment, migration, differentiation, wound healing and angiogenesis as well as in the development of several pathologic conditions including fibrosis and tumorigenesis. (cdc.gov)
Hematopoiesis, in particular the genetic control of hematopoietic cell proliferation and differentiation is also studied in human cell cultures and transgenic mouse model systems. (lu.se)
A leading hypothesis proposes that tubular cell proliferation and differentiation are linked to flow rate and that ciliary dysfunction may thus lead to cystic transformation. (msdmanuals.com)

Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
We conclude that SIRT1 deacetylates β-catenin to promote its accumulation in the nucleus leading to transcription of genes for MSC differentiation. (harvard.edu)
Finally, we found that transcription factors Jun , Fos , Atf3 , and Egr1 were upregulated in protective cells, especially Egr1 was predicted to be involved in the regulation of genes related to antioxidant stress and angiogenesis, suggesting a role in promoting differentiation into this cell phenotype. (hindawi.com)
N. van Belzen, W. N. Dinjens, B. H. Eussen and F. T. Bosman, "Expression of Differentiation-Related Genes in Colorectal Cancer: Possible Implications for Prognosis," Histology and Histopathology, Vol. 13, No. 4, 1998, pp. 1233-1242. (scirp.org)
Mechanistically, specificity protein 1 (Sp1), a major transcription factor that controls expression of lens-specific genes such as β-crystallins, was positively regulated by SUMO1 but negatively regulated by SUMO2. (nebraska.edu)
A variety of genes become up- or downregulated upon differentiation, giving rise to both neuron-specific proteins and ribonucleic acids (RNAs), including circular RNAs (circRNAs). (savesome.green)
To further characterize the molecular mechanisms responsible for this effect, we investigated the expression of epidermal differentiation-related genes after AEA treatment. (univaq.it)
In fact, the modulation of DNA methylation by endocannabinoids may affect the expression of a number of genes that regulate many cell functions in response to these substances. (univaq.it)
Glis1 is a highly promiscuous transcription factor, regulating the expression of numerous genes, either positively or negatively. (wikipedia.org)
This means the genes that are required for differentiation to other types of cell are packaged within chromatin structures, so that they are not expressed. (wikipedia.org)
We have examined regulatory mechanisms controlling expression of the cell cycle-dependent histone genes, which are functionally coupled with DNA synthesis, in proliferating cells and during the onset of differentiation in several phenotypes including adipocytes. (elsevierpure.com)
In proliferating cells transcription of the histone genes is up-regulated at the onset of S phase. (elsevierpure.com)
In the present study, we assessed the hypothesis that miR-214 and its target genes play an important role in VSMCs differentiation. (oncotarget.com)
We further demonstrated that QKI down-regulated the expression of SRF, MEF2C and Myocd through transcriptional repression and direct binding to promoters of the SRF, MEF2c and Myocd genes. (oncotarget.com)
Corticosteroids are also believed to perinatology wards as well as routine and regulate several genes associated with the intensive neonatal care. (who.int)
RNA sequencing revealed that genes involved in G protein-coupled receptor (GPCR) signaling were significantly up-regulated in the high-erythroid output donors. (lu.se)

Here we examined whether deficiency of a de novo DNA methyltransferase, Dnmt3a, affects in vitro differentiation of mouse embryonic stem cells (mESCs) to neuronal and glial cell lineages. (ca.gov)
The team, led by Associate Professor Tomohide Takaya from the Department of Agricultural and Life Sciences at Shinshu University, recently discovered that an anti-nucleolin aptamer, myogenetic oligodeoxynucleotide iSN04, induced myocardial differentiation in embryonic stem cells (ESCs). (shinshu-u.ac.jp)
We investigate the role of Zeb2 in skeletal muscle differentiation using genetic tools and transgenic mouse embryonic stem cells, together with single-cell RNA-sequencing and in vivo muscle engraftment capability. (unipv.it)
MicroRNA-214(miR-214) has been recently reported to regulate angiogenesis and embryonic stem cells (ESCs) differentiation. (oncotarget.com)

Our findings unravel a new pathway orchestrating CD4 + T-cell differentiation and demonstrate that NAD + may serve as a powerful therapeutic agent for the treatment of autoimmune and other diseases. (nature.com)
These data provide evidence that p75 can modulate signal transduction through Trk in a neuronal progenitor cell context and that such modulation has functional consequences for the neuronal differentiation pathway induced by NGF. (caltech.edu)
These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)
Second, it results in the modulation of the Wnt signaling pathway that governs cell differentiation. (shinshu-u.ac.jp)
Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis. (escholarship.org)
Through acetylation modification of ZBTB16, GCN5 regulated the Wnt/β-catenin signaling pathway and further mediated PDLF osteogenic differentiation. (harvard.edu)

Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4 + T effector cell subsets. (jci.org)
In the current study, we investigated the effect of prenatal exposure to DES on thymocyte differentiation involving apoptotic pathways. (aspetjournals.org)
The 5-HT neurotransmitter regulates important pathways of mammalian metabolism and is synthesized from the phenylalanine, tyrosine and tryptophan amino acids 5 . (bvsalud.org)

Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
ZBTB16 interference hindered PDLF osteogenic differentiation and decreased Wnt and β-catenin levels. (harvard.edu)

DNA methylation is known to regulate cell differentiation and neuronal function in vivo. (ca.gov)
We have examined NGF-induced signal transduction events and neuronal differentiation in MAH cells, a neuronal progenitor cell line, in which the expression of the two NGF receptors, p140^(trk) (Trk) and p75^(LNGFR) (p75), has been independently manipulated. (caltech.edu)
In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly "taps the brake" on neurogenesis. (savesome.green)
Correct timing and delicate control of neuronal differentiation is essential for development of a functional nervous system. (savesome.green)

We show that NAD + regulates CD4 + T-cell differentiation through tryptophan hydroxylase-1 ( Tph1 ), independently of well-established transcription factors. (nature.com)
The presence of 'stem cell-like' cells has previously been postulated based on sphere-forming capacity and differentiation in vitro 1 and evidence for the presence of label-retaining cells in the distal fallopian tube 2 . (nature.com)
Recently, single cell RNA sequencing (scRNA-seq) analysis has been used to examine cellular fate and function during cellular differentiation and has contributed to elucidating the mechanisms of various diseases. (hindawi.com)
Analysis of dynamic gene expression revealed that Gpx3 was significantly upregulated during cell differentiation into protective cells. (hindawi.com)
I found that rRNA transcription was downregulated during hematopoietic differentiation in both human leukemia cell line and mouse hematopoietic stem cells. (nii.ac.jp)
A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
Together, the current study demonstrates that prenatal exposure to DES triggers significant alterations in apoptotic molecules expressed on thymocytes, which may affect T-cell differentiation and cause long-term effects on the immune functions. (aspetjournals.org)
Aptamers are single-stranded pieces of DNA that bind to target proteins and are able to modulate signaling cascades during cell differentiation when a stem cell commits to a specific functional role or phenotype. (shinshu-u.ac.jp)
Ultimately, terminal cell differentiation commits to the cardiomyocyte lineage. (shinshu-u.ac.jp)
We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic differentiation through Insulin-like receptor (InR) activation. (ucl.ac.uk)
Thus, we show that somatic cell differentiation is controlled by PI3K/Tor signaling downstream of InR and that the local production of positive and negative InR signals regulates the differentiation niche. (ucl.ac.uk)
These results support a model in which leaving the stem cell niche and initiating differentiation are actively induced by signaling. (ucl.ac.uk)
Collectively, we define a four-part molecular mechanism by which FRCs regulate the T cell response to strongly activating events in secondary lymphoid organs, while permitting activated and CAR T cells to utilise effector functions. (birmingham.ac.uk)
The mammalian small ubiquitin-like modifiers (SUMOs) are actively involved in regulating differentiation of different cell types. (nebraska.edu)
Indeed, overexpression of SUMO2/3, but not SUMO1, inhibited basic (b) FGF-induced cell differentiation. (nebraska.edu)
Together, our results establish distinct roles of different SUMO isoforms and demonstrate for the first time, to our knowledge, that Sp1 acts as a major transcription factor target for SUMO control of cell differentiation. (nebraska.edu)
Plant growth and development requires a continuous balance between cell division and differentiation. (upm.es)
In this work, a functional screening of transcription factors, using the Spanish collection TRANSPLANTA, identifies Arabidopsis OBP4 as a novel regulator of root growth by reducing cell elongation and cell differentiation. (upm.es)
Our findings indicate that BATF crucially mediates CIA by regulating Th cell differentiation without directly affecting the functions of FLS. (biomedcentral.com)
We investigated the role of crotonylation in hESC differentiation by introduce crotonate into the culture medium of GFP tagged LTR7 primed H9 cell and extended pluripotent stem cell lines. (bioinfor.com)
Finally, we used knocked-down hESCs by shRNA, wild GAPDH and GAPDH mutants to explore potential role of GAPDH crotonylation in regulating human embryonic stem cell differentiation and metabolic switch. (bioinfor.com)
The Insulinoma-associated protein 1 ( Insm1 ), which encodes a protein containing one SNAG domain and five zinc fingers, plays essential roles in pancreatic endocrine cell differentiation and in mature beta-cell function. (figshare.com)
Our study has identified a novel function of the SNAG domain of Insm1 in the regulation of pancreatic endocrine cells differentiation, particularly in the repression of beta- to delta-cell transdifferentiation. (figshare.com)
We show that PEs in serine-arginine-rich (SR) proteins, a family of 14 essential SFs, are differentially spliced during induced pluripotent stem cell (iPSC) differentiation and in tumors versus normal tissues. (mendeley.com)
Regulating T cell differentiation through the polyamine spermidine. (ox.ac.uk)
OBJECTIVE: We aimed to characterize the polyamine SPMD as a modulator of T cell differentiation and function. (ox.ac.uk)
METHODS: Naïve T cells were isolated from wild type (WT) mice or cord blood from healthy donors, and submitted to polarizing cytokines, with and without SPMD treatment, in order to evaluate T cell differentiation in vitro. (ox.ac.uk)
RESULTS: SPMD modulates CD4+ T cell differentiation in vitro, preferentially committing naïve T cells to a regulatory phenotype. (ox.ac.uk)
Furthermore, dietary supplementation with SPMD promotes homeostatic differentiation of Tregs within the gut and reduces pathology in a model of T cell transfer colitis. (ox.ac.uk)
We showed that CPT induced GSC loss and retarded two- cell cysts differentiation in a niche- or apoptosis -independent manner. (bvsalud.org)
In addition, CPT compromised two- cell cysts differentiation by decreasing the expression of Bam and inducing cell arrest at G1/ S phase via cyclin A , eventually resulting in two- cell accumulation. (bvsalud.org)
Is the Subject Area "Cell differentiation" applicable to this article? (plos.org)
M2 Microglia Extracellular Vesicle miR-124 Regulates Neural Stem Cell Differentiation in Ischemic Stroke via AAK1/NOTCH. (medscape.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)
Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generation of specific cell types, especially RBC. (lu.se)
Red cell development is initially regulated by stem cell factor (SCF), which commits hematopoietic stem cells to develop into erythroid progenitors. (medscape.com)
Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. (bvsalud.org)

Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase signaling cascades. (nih.gov)

However, successive passaging to passage 6 (P6), when wild-type NSCs become gliogenic, revealed a robust phenotype of precocious astrocyte and oligodendrocyte differentiation in Dnmt3a(-/-) NSCs, consistent with our previous findings in the more severely hypomethylated Dnmt1(-/-) NSCs. (ca.gov)

Expression of β-catenin targets important for differentiation was reduced in MSCKO cells. (harvard.edu)
It is thought that the developmental program of gene expression at the locus is regulated by specific changes in chromatin structure (Williams et al. (bl.uk)
This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
Here, we report that expression of the mouse homolog of Drosophila tumor suppressor Lethal giant larvae 1 (Lgl1) is induced during OL differentiation. (escholarship.org)
These results indicate that Dlx3 is a novel target of ER-α, and that ER-α regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3. (molcells.org)
We show that Zeb2 over-expression has a positive impact on skeletal muscle differentiation in pluripotent stem cells and adult myogenic progenitors. (unipv.it)
OTM increased the expression of Zinc finger and BTB domain-containing 16 (ZBTB16), which is implicated in osteogenic differentiation. (harvard.edu)
SUMO2 also interfered with the interaction between Sp1 and the coactivator, p300, and recruited a repressor, Sp3 to β-crystallin gene promoters, to negatively regulate their expression. (nebraska.edu)
Glis1 also up-regulates expression of the protein LIN28 which binds the let-7 microRNA precursor, preventing production of active let-7. (wikipedia.org)
Equally important for developmental transcriptional control, histone gene expression is repressed when differentiation is initiated. (elsevierpure.com)
Mechanistically, our data showed that miR-214 regulated VSMCs gene expression during VSMCs differentiation from ESCs through suppression of QKI. (oncotarget.com)
Conclusions Over-expression of miR-217 can inhibit the expression of EZH2 and promote the osteogenic differentiation of BM-MSCs in OP mice, which could provide a new strategy for clinical prevention and treatment of OP. (magtechjournal.com)
The RNA isoform repertoire is regulated by splicing factor (SF) expression, and alterations in SF levels are associated with disease. (mendeley.com)
We define sequences that regulate PE inclusion and protein expression of the oncogenic SF TRA2β using an RNA-targeting CRISPR screen. (mendeley.com)
Instead, CPT induced ectopic expression of a differentiation factor, bag of marbles (Bam), and regulated the expression of cyclin A , which contributed to GSC loss. (bvsalud.org)

Using the ocular lens as a model system, we demonstrate that different SUMOs display distinct functions in regulating differentiation of epithelial cells into fiber cells. (nebraska.edu)

Deletion analysis indicates that proximal Site II mediates the differentiation response of H4 gene transcription in adipocytes. (elsevierpure.com)

In response to the inhibition of rRNA transcription, nucleolar protein MYBBP1A was translocated from the nucleolus to the nucleoplasm and interacted with c-Myc, which is one of the master regulator of hematopoietic differentiation. (nii.ac.jp)
The results provide an interesting example of co-evolution of a circRNA, and its host-encoded protein product, that regulate each other's function, to directly impact the fundamental process of neurogenesis. (savesome.green)
We recently demonstrated that BATF, a member of the activator protein-1 (AP-1) family, regulates osteoarthritic cartilage destruction. (biomedcentral.com)

An anti-nucleolin DNA aptamer, iSN04, regulates cardiomyogenesis of murine pluripotent stem cells. (shinshu-u.ac.jp)
We had previously found that iSN04 promoted myogenic precursor cells (myoblasts) to differentiate into skeletal muscle cells and had hypothesized that the aptamer also enhanced differentiation of pluripotent stem cells. (shinshu-u.ac.jp)

BATF is known to regulate OA cartilage destruction, and we previously showed that BATF overexpression in joint tissues causes synovial inflammation [ 4 ] suggesting that BATF could contribute to inflammatory arthritis. (biomedcentral.com)
Importantly, miR-214 overexpression in ESCs promoted VSMCs differentiation in vivo . (oncotarget.com)

The adeno-associated virus-shZBTB16 injection also proved to inhibit osteogenic differentiation and reduce tooth movement distance in in vivo tests. (harvard.edu)

We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) are adult stem cells with the capability of self-renewal and multilineage differentiation into skeletal and/or mesodermal tissues, including bone, fat, cartilage, and muscle tissues. (aibg.it)
Objective To explore the effect of microRNA-217 (miR-217) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) in osteoporosis (OP) mouse model and potential regulatory mechanism. (magtechjournal.com)
miR-217 inhibits osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells by binding to Runx2[J]. Mol Med Rep, 2017, 15:3271-3277. (magtechjournal.com)

CD4 + T helper (Th) cells play a central role in regulating the adaptive immune response associated with pathogen invasion. (nature.com)
Although differentiation of naïve CD4 + T cells has been considered to be an irreversible process, accumulating evidence suggests that T cells are much more flexible than initially believed with the ability to interchange between helper phenotypes 15 . (nature.com)
Early-passage neural stem cells (NSCs) derived from Dnmt3a-deficient ESCs exhibited a moderate phenotype in precocious glial differentiation compared with wild-type counterparts. (ca.gov)
ASK1 thus appears to mediate signals leading to both differentiation and survival of PC12 cells. (nih.gov)
However, mutating K49R or K345R in β-catenin to mimic deacetylation restored nuclear localization and differentiation potential in MSCKO cells. (harvard.edu)
These results suggest that the downregulation of rRNA transcription accelerates cellular differentiation at least in hematopoietic cells. (nii.ac.jp)
This raises a pertinent question: Can regulating the fate of stem cells in clinical settings and at scale be made more economical? (shinshu-u.ac.jp)
Stem cells reside in niches that provide signals to maintain self-renewal, and differentiation is viewed as a passive process that depends on loss of access to these signals. (ucl.ac.uk)
Here, we demonstrate that the differentiation of somatic cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. (ucl.ac.uk)
In response to DNA damage, myeloid leukemia cells activate a poorly understood terminal differentiation process. (psu.edu)
However, no direct evidence has shown that microbial polyamines are incorporated into host cells to regulate cellular responses. (elsevierpure.com)
Batf knockout inhibited the differentiation of T helper (Th)17 cells and the conversion of CD4 + Foxp3 + cells to CD4 + IL-17 + cells. (biomedcentral.com)
In the present study, we compared the differentiation of pancreatic endocrine cells between Insm1 null and Insm1 SNAG domain mutants (Insm1delSNAG) to explore the specific function of the SNAG domain of Insm1. (figshare.com)
However, very little is known about its functional role in vascular smooth muscle cells (VSMCs) differentiation from ESCs. (oncotarget.com)
erythroid cells after in vitro differentiation, despite having similar frequencies of phenotypic HSC initially. (lu.se)

MYBBP1A attenuated transcriptional activity of c-Myc and promoted megakaryocytic differentiation. (nii.ac.jp)

miR-214 was significantly upregulated during VSMCs differentiation. (oncotarget.com)

In this study, I have tried to address the role of the nucleolus in cellular differentiation. (nii.ac.jp)
N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
We are particularly interested in studies illustrating intrinsic/extrinsic cellular and molecular factors regulating stemness, growth, and differentiation of tissue-specific MSCs as well as their potential implications for tissue engineering and regenerative medicine. (aibg.it)

Neuroendocrine mechanisms, particularly those related to 5-HT, are associated with the differentiation and activation of osteoblasts and osteoclasts. (bvsalud.org)

The Epidermal Differentiation Complex (EDC) is a co-ordinately regulated locus that is evolutionarily conserved within mammals. (bl.uk)

Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling. (biocytogen.com)

Murine ESCs were seeded on collagen-coated flasks and cultured in differentiation medium for 2 to 8 days to allow VSMCs differentiation. (oncotarget.com)

An effect of AEA on DNA methylation because of CB1R-mediated increase of methyltransferase activity is described here for the first time, and we believe that the importance of this effect clearly extends beyond the regulation of skin differentiation. (univaq.it)

Loss of pro-mitotic proteoglycan and OPC marker NG2 in the OL progeny is the earliest immunophenotypic change of unknown mechanism that indicates differentiation commitment. (escholarship.org)
Our goal was to investigate the mechanism of PDLF osteogenic differentiation mediated by ZBTB16. (harvard.edu)

Dlx3 is essential for the skeletal development and plays an important role in osteoblast differentiation. (molcells.org)
Skeletal muscle differentiation is triggered by a unique family of myogenic basic helix-loop-helix transcription factors, including MyoD, MRF-4, Myf-5, and Myogenin. (unipv.it)

The allocation and specification of pancreatic endocrine lineages are tightly regulated by transcription factors. (figshare.com)

Quaking (QKI) was predicted as one of the major targets of miR-214, which was negatively regulated by miR-214. (oncotarget.com)

Subsequently, EPO continues to stimulate the development and terminal differentiation of these progenitors. (medscape.com)

Taken together, we have uncovered a central role of miR-214 in ESC-VSMC differentiation, and successfully identified QKI as a functional modulating target in miR-214 mediated VSMCs differentiation. (oncotarget.com)

Interferons also help regulate inflammation, which is another part of the body's innate immune response. (medlineplus.gov)

The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)

however, the molecular mechanisms of renewal and differentiation remain obscure in many cases, including the fallopian tube, a central organ of human reproduction. (nature.com)
Although myocardial fibrosis is a common pathophysiological process associated with many heart diseases, the molecular mechanisms regulating the development of fibrosis have not been fully determined. (hindawi.com)
However, the molecular mechanisms by which ER-α regulates osteoblast differentiation remain to be elucidated. (molcells.org)

Disturbances in differentiation of these lineages contribute to the development of various metabolic diseases, including diabetes. (figshare.com)

an anti-nucleolin DNA aptamer, iSN04, can determine a cell's lineage during differentiation. (shinshu-u.ac.jp)

Recently we have shown that AEA inhibits differentiation of human keratinocytes, by binding to type-1 cannabinoid receptors (CB1R). (univaq.it)

IRF6, a member of interferon regulatory factor family, has a role in development and differentiation of the epidermis, downstream of Notch signaling. (iyte.edu.tr)

Collectively, our results indicate that ER-α-induced Dlx3 activity may induce the osteoblast differentiation in a ligand independent manner. (molcells.org)

Lgl1 conditional knockout OPC progeny retain NG2 and show reduced OL differentiation, while undergoing more symmetric self-renewing divisions at the expense of asymmetric divisions. (escholarship.org)

Camptothecin Effectively Regulates Germline Differentiation through Bam-Cyclin A Axis in Drosophila melanogaster . (bvsalud.org)

These data establish Lgl1 as a suppressor of gliomagenesis and positive regulator of asymmetric division and differentiation in the healthy and demyelinated murine brain. (escholarship.org)
Therefore, we investigated the regulation of Dlx3 and found that ER-α is a positive regulator of Dlx3 transcription in BMP2-induced osteoblast differentiation. (molcells.org)

Anatomy65

Organisms8

Diseases8

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes57

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Proliferation15

Genes16

Embryonic stem4

Pathway7

Pathways3

Osteogenic differentiation and decreased2

Neuronal4

Cell38

Apoptosis1

Oligodendrocyte differentiation1

Expression17

Epithelial cells1

Mediates1

Protein3

Pluripotent2

Overexpression2

Vivo1

Mesenchymal4

Cells15

Transcriptional activity1

Significantly upregulated1

Cellular3

Osteoblasts1

Epidermal1

Bone1

ESCs1

Methylation1

Mechanism2

Skeletal2

Transcription factors1

Negatively1

Terminal1

Functional1

Inflammation1

MSCs1

Molecular mechanisms3

Lineages1

Lineage1

Inhibits1

Downstream1

Induce1

Knockout1

Drosophila1

Regulator2