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AnaphaseAnaphase-Promoting Complex-CyclosomeUbiquitin-Protein Ligase ComplexesCdc20 ProteinsCdh1 ProteinsMitosisApc3 Subunit, Anaphase-Promoting Complex-CyclosomeCell Cycle ProteinsApc1 Subunit, Anaphase-Promoting Complex-CyclosomeSpindle ApparatusSecurinCyclin BF-Box ProteinsGenes, APCMetaphaseLigasesM Phase Cell Cycle CheckpointsCyclin A2Apc5 Subunit, Anaphase-Promoting Complex-CyclosomeMad2 ProteinsCyclin B1Chromosome SegregationUbiquitin-Protein LigasesCell CyclePrometaphaseCDC2 Protein KinaseHeLa CellsMeiosisUbiquitinationGemininSchizosaccharomyces pombe ProteinsApc2 Subunit, Anaphase-Promoting Complex-CyclosomeCyclin ASaccharomyces cerevisiae ProteinsProtein-Serine-Threonine KinasesMolecular Sequence DataSchizosaccharomycesApc8 Subunit, Anaphase-Promoting Complex-CyclosomeSeparaseAmino Acid SequenceFungal ProteinsNocodazoleMutationNuclear ProteinsTelophaseAurora KinasesChromatidsProto-Oncogene Proteins c-mosXenopus ProteinsG1 PhaseGenes, cdcProtein BindingOocytesProtein SubunitsMicrotubulesUbiquitinUbiquitin-Conjugating EnzymesXenopusApc6 Subunit, Anaphase-Promoting Complex-CyclosomeSKP Cullin F-Box Protein LigasesSaccharomyces cerevisiaeUbiquitinsKinetochoresProteasome Endopeptidase ComplexPhosphorylationRNA InterferenceChromosomesRecombinant Fusion ProteinsS PhaseAmino Acid MotifsCytokinesisCalcium-Binding ProteinsDrosophila ProteinsModels, BiologicalG2 PhaseProtein KinasesSubstrate SpecificityCentromereApc11 Subunit, Anaphase-Promoting Complex-CyclosomeCarrier ProteinsRepressor ProteinsAdenomatous Polyposis Coli ProteinCadherinsProtein Processing, Post-TranslationalCyclinsDrosophilaRNA, Small InterferingProtein StabilityCell LineChromosomal Proteins, Non-HistoneMacromolecular SubstancesApc7 Subunit, Anaphase-Promoting Complex-CyclosomeCyclin-Dependent KinasesBase SequenceMicrotubule-Associated ProteinsSequence Homology, Amino AcidKinesinProphaseBivalviaEndoreduplication

Multi-subunitUbiquitin ligasesCullinSubstrateCdc16MitosisCdc27ProteinsCdh1Cell cycleAssemblyUbiquitin ligaseStructurallyUpregulationCELL CYCLE PRProteinInteractionRegulatoryFunctionExpressionDomain

Multi-subunit1

• The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. (embl-heidelberg.de)

Ubiquitin ligases1

• The anaphase promoting complex or cyclosome (APC2) is an E3 ubiquitin ligase which is part of the SCF family of ubiquitin ligases. (embl-heidelberg.de)

Cullin4

• We analyzedthe architecture of the APC using a recently constructed budding yeaststrain that is viable in the absence of normally essential APC subunits.We found that the largest subunit, Apc1, serves as a scaffold thatassociates independently with two separable subcomplexes, one thatcontains Apc2 (Cullin), Apc11 (RING), and Doc1/Apc10, and another thatcontains the three TPR subunits (Cdc27, Cdc16, and Cdc23). (embl-heidelberg.de)
• Apc4,Apc5, Cdc23, and Apc1 associate interdependently, such that loss of anyone subunit greatly reduces binding between the remaining three.Intriguingly, the cullin and TPR subunits both contribute to the bindingof Cdh1 to the APC. (embl-heidelberg.de)
• The human genome contains eight cullin genes CUL1, part of SCF complex CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box) CUL3, part of CUL3-BTB complex CUL4A CUL4B CUL5 CUL7 CUL9, also known as PARC There is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex. (wikipedia.org)
• Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae (Baker's yeast), and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. (wikipedia.org)

Substrate2

• Our structure explains how this TPR sub-complex, together with additional scaffolding subunits (Apc1, Apc4 and Apc5), coordinate the juxtaposition of the catalytic and substrate recognition module (Apc2, Apc11 and Apc10 (also known as Doc1)), and TPR-phosphorylation sites, relative to co-activator, regulatory proteins and substrates. (ox.ac.uk)
• Cdh1 is an activator of the anaphase-promoting complex-cyclosome, and is involved in substrate recognition. (jefferson.edu)

Cdc162

• We found thatthe three TPR subunits display a sequential binding dependency, with Cdc27the most peripheral, Cdc23 the most internal, and Cdc16 between. (embl-heidelberg.de)
• Three conserved tetratricopeptide repeat (TPR) subunits (Cdc16, Cdc23 and Cdc27) share related superhelical homo-dimeric architectures that assemble to generate a quasi-symmetrical structure. (ox.ac.uk)

Mitosis1

• It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication. (jefferson.edu)

Cdc271

• Enzymatic assays performed with APC purified fromstrains lacking each of the essential subunits revealed that onlycdc27Delta complexes retain detectable activity in the presence of Cdh1.This residual activity depends on the C-box domain of Cdh1, but not on theC-terminal IR domain, suggesting that the C-box mediates a productiveinteraction with an APC subunit other than Cdc27. (embl-heidelberg.de)

Proteins6

• There are 1082 APC2 domains in 1081 proteins in SMART's nrdb database. (embl-heidelberg.de)
• Taxonomic distribution of proteins containing APC2 domain. (embl-heidelberg.de)
• The complete taxonomic breakdown of all proteins with APC2 domain is also avaliable . (embl-heidelberg.de)
• Click on the protein counts, or double click on taxonomic names to display all proteins containing APC2 domain in the selected taxonomic class. (embl-heidelberg.de)
• The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
• The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)

Cdh11

• The anaphase-promoting complex or cyclosome (APC) is an unusuallycomplicated ubiquitin ligase, composed of 13 core subunits and either oftwo loosely associated regulatory subunits, Cdc20 and Cdh1. (embl-heidelberg.de)

Cell cycle2

• During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
• The anaphase-promoting complex or cyclosome (APC/C) is an unusually large E3 ubiquitin ligase responsible for regulating defined cell cycle transitions. (ox.ac.uk)

Assembly1

• Structural basis for the subunit assembly of the anaphase-promoting complex. (ox.ac.uk)

Ubiquitin ligase3

• 5. The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2. (nih.gov)
• HN - 2014 FX - Ammonia MH - Anaphase-Promoting Complex-Cyclosome UI - D064173 MN - D8.811.464.938.750.92 MN - D12.776.167.24 MS - An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. (nih.gov)
• An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS . (bvsalud.org)

Structurally1

• 11. Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster. (nih.gov)

Upregulation1

• 14. Upregulation of anaphase promoting complex (APC) 7 as a prognostic marker for esophageal squamous cell carcinoma: A hospital based study. (nih.gov)

CELL CYCLE PR1

• In eukaryotes, the anaphase-promoting complex (APC/C, also known as the cyclosome) regulates the ubiquitin-dependent proteolysis of specific cell-cycle proteins to coordinate chromosome segregation in mitosis and entry into the G1 phase. (rcsb.org)

Protein3

• We now provide evidence that inversin interacts with the anaphase promoting complex protein Apc2. (nih.gov)
• Here, we report that the HIV-1 p6 protein suppresses HIV-1-stimulated expression of IFN-I and promotes immune evasion. (bvsalud.org)
• protein_coding" "Cz01g02060.t1","No alias","Chromochloris zofingiensis","Nascent polypeptide-associated complex NAC domain [Interproscan]. (ntu.edu.sg)

Interaction1

• As expected of an Apc2 target, inversin possesses D-boxes and site-directed mutagenesis of the well-conserved D-box residues abrogates inversin-Apc2 interaction. (nih.gov)

Regulatory1

• Efficient phosphorylation of the auto-inhibitory segment, and thus relief of auto-inhibition, requires the recruitment of Cdk-cyclin in complex with a Cdk regulatory subunit (Cks) to a hyperphosphorylated loop of Apc3. (rcsb.org)

Function2

• as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. (wikipedia.org)
• 20. The anaphase promoting complex is required for memory function in mice. (nih.gov)

Expression1

• 1. The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients. (nih.gov)

Domain1

• 19. Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. (nih.gov)