Regulated regulates gene expression micro rna that regulates. Medical search. Frequent questions

Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. (en-journal.org)
Together, our results provide new insights into the potential role of miR-1908-5p in the pathogenesis of BD and also propose a hypothesis that neuronal synapses could be a key converging pathway of some BD-associated protein-coding genes and miRNAs. (en-journal.org)
These miRNAs are around 22 nucleotides in size that are central and negative regulators of gene expression. (mbpinc.net)
Moreover, the block expression at the post-transcriptional levels and transcriptional levels, on the basis of perfect or imperfect match in sequences among miRNAs and target genes is also there. (mbpinc.net)
These miRNAs are known to be the "epigenetic controllers" since they impact gene expression without brining any changes in the genomic sequence. (mbpinc.net)
Changed and manipulated expression of miRNAs is commonly seen in several pathological conditions like cancer. (mbpinc.net)
Just like the protein coding genes, miRNAs are also influenced to epigenetic changes and regulation by DNA methylation in their respective promoter regions. (mbpinc.net)
The DNA methylation of miRNAs has an indirect impact on the regulation of the miRNA target genes. (mbpinc.net)
That being said, the DNA methylation of miRNAs also is a big factor that leads to overexpression in the target genes. (mbpinc.net)
Also, miRNAs have the ability to influence the expression of several targets. (mbpinc.net)
As a result, the gene targets can be regulated with the help of a plethora of different miRNAs, simultaneously. (mbpinc.net)
This creates a great network of miRNAs-targets that greatly enhances the complexity of gene regulation. (mbpinc.net)
Scientists further worked showed that despite of the differences between cell lines in the gene expression level, the miRNAs-gene network is very slightly influenced or disrupted in these pathways. (mbpinc.net)
This also showed that there is an inverse correlation between methylation statuses of the above mentioned miRNAs along with the expression of their gene targets. (mbpinc.net)
All in all, the data shows a very complex, multi-level interaction of all the epigenetically changed and influenced miRNAs that weren't able to completely regulate the cell cycle. (mbpinc.net)
On the other hand, the miRNAs examined in this study can also be used to target other genes and pathways. (mbpinc.net)
Moreover, other literature and studies have demonstrated that many genes are directly silenced by methylation, and not by miRNAs. (mbpinc.net)
A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
Furthermore, the miRNAs correlated negatively with the immunohistochemical expression of NRF1 and NRF2 but positively with their respective mRNA. (hindawi.com)
MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by imperfect matching of mRNA [ 6 ]. (hindawi.com)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
MicroRNAs (miRNAs) are short (21-24 nucleotides) sequences of RNA that reduce gene expression by promoting the breakdown of messenger RNAs (mRNAs) and by repressing translation of mRNAs into proteins. (freethoughtblogs.com)
We show that, similar to metazoan steady-state systems, endogenous miRNAs in Chlamydomonas can regulate gene expression both by destabilization of the mRNA and by translational repression. (freethoughtblogs.com)
MicroRNAs (miRNAs) are a category of small nonencoding RNAs of 22 nucleotides in length. (hindawi.com)
Here, microRNA-127 (miR-127) is one of the miRNAs that focuses on lung diseases [ 31 - 33 ]. (hindawi.com)
MicroRNAs (miRNAs) are small non-coding RNAs that bind complementary messenger RNAs (mRNAs) to repress gene expression and regulate essentially all cellular processes 19 . (nature.com)
MicroRNAs (miRNAs) are well-recognized for their abilities to regulate gene expression post-transcriptionally in plants and animals. (frontiersin.org)
The expressions of candidate miRNAs and mRNAs were determined by real-time quantitative PCR(RT-qPCR) in MC3T3-E1 cells. (frontiersin.org)
We aimed to evaluate the selected miRNAs expression based on bioinformatic analysis and their changes before and after an ultramar. (researchgate.net)
Objective: To identify miRNAs that regulate angiogenesis. (ca.gov)
DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)
From the list of genes that were targeted by the 73 diagnostic miRNAs, DGKE and WDR47 had significant associations with responses to both systemic therapies and radiotherapy in lung cancer. (cdc.gov)
This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)

The differentially expressed genes (DEGs) in AD were screened in GSE48350 dataset. (nature.com)
The OA subchondral bone dataset GSE51588 was downloaded from the GEO database, and the differentially expressed genes (DEGs) were screened. (spandidos-publications.com)
Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
Conclusion and Clinical Relevance: Examination of the pulmonary genetic profiles revealed differentially expressed genes and microRNAs following subchronic inhalation exposure to A. fumigatus. (cdc.gov)

miRNA binding downregulates the expression of target mRNAs either by decreasing their stability or by inhibiting translation. (en-journal.org)
RNA extraction kits are used to enable the total RNA extraction from tissues and other places.They apply their abilities and functions with the help of base-pairing using 3'UTR if mRNAs. (mbpinc.net)
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
mRNAs corresponding to several regulatory genes that mediate auxin responses contain short stretches of sequence that are complementary to microRNAs, and therefore have been considered potential targets of microRNA-mediated regulation. (sciencedaily.com)
The plants showed increased accumulation of ARF17 mRNA and altered levels of mRNAs corresponding to several genes that may be regulated by ARF17. (sciencedaily.com)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

As a result, the functionalities of DNA methylation are highly dependent on context and therefore have a completely opposite impact on gene expression, especially if it happens in the promoter of a coding gene or a miRNA. (mbpinc.net)
Here, we provide a comprehensive global analysis of the evolutionarily distant unicellular green alga Chlamydomonas reinhardtii to quantify the effects of miRNA on protein synthesis and RNA abundance. (freethoughtblogs.com)
We find that the core microRNA (miRNA) biogenesis and targeting machinery maintains the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity. (nature.com)
Expression of each miRNA machinery component strongly correlates with intratumoral T cell infiltration in nearly all human cancer types. (nature.com)
Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
The miRNA-mRNA interactions were verified by dual-luciferase reporter gene assays and experiments using mimics miRNA or their inhibitors. (frontiersin.org)
Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

MicroRNAs are tiny ribonucleic acid (RNA) molecules (~22 nucleotides long) that recently have been found to play important roles in regulating gene expression in eukaryotic organisms, including plants and animals. (sciencedaily.com)

Investigation of hub genes for the development of potential therapeutic targets and candidate biomarkers is warranted. (nature.com)
Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
Furthermore, altered microRNAs may serve as potential biomarkers to evaluate fungal exposure. (cdc.gov)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

Notably, some of the proteins expressed from BD-associated genes function in neuronal synapses, suggesting that abnormalities in synaptic function could be one of the key pathogenic mechanisms of BD. (en-journal.org)
It is a main inductor of genes of antioxidant proteins and phase II detoxifying enzymes [ 1 ]. (hindawi.com)
Immunohistochemical staining was performed to confirm the expression of related proteins in OA and non‑OA tissue samples. (spandidos-publications.com)
Research reported in The Plant Cell shows that microRNAs control the accumulation of transcription factor proteins that regulate the expression of genes in the auxin response pathway. (sciencedaily.com)
Messenger RNA (mRNA) molecules are encoded by genes and are themselves templates for the proteins that carry the main metabolic functions in a cell. (sciencedaily.com)
There are many AGO1-like proteins in animals and other eukaryotes as well, indicating that the RNA-induced silencing complex is of ancient evolutionary origin, and that microRNA-mediated regulation of gene expression is shared among many eukaryotes. (sciencedaily.com)
Degradation of cellular proteins in the ubiquitin-proteasome system regulates various biological processes. (helsinki.fi)
Regulatory non-coding RNAs and RNA-binding proteins (RBPs) are important research areas in gene regulation and RNA biology. (rochester.edu)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)

Although they are structurally similar, plant and animal microRNAs repress gene expression through very different mechanisms. (freethoughtblogs.com)
One of these targets is the transcription factor AUXIN RESPONSE FACTOR17 (ARF17), which is thought to repress the expression of a number of other genes involved in auxin responses. (sciencedaily.com)

We have only known that microRNAs even existed since the early 1990's, and their importance in gene regulation and development wasn't appreciated until the 2000's. (freethoughtblogs.com)
These changes were correlated with dramatic development defects in leaves, roots, and flowers, showing that microRNA-mediated regulation of ARF17 is essential for normal plant development. (sciencedaily.com)
Arabidopsis ago1 mutants lacking the AGO1 protein have numerous severe developmental defects, supporting the notion that regulation by microRNAs is critical for normal plant growth. (sciencedaily.com)
Dr. Bellini and her colleagues found that the mutant plants over-accumulate ARF17 mRNA within the hypocotyl, pointing to ARF17 as a major regulator of adventitious rooting and microRNA-mediated regulation as a major regulator of ARF17. (sciencedaily.com)
Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in c. (rochester.edu)
The objective of this study is to identify microRNAs-small, non-coding RNAs that help control gene expression-that contribute to the regulation of new blood vessel formation. (ca.gov)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

The differentially expressed oxidative stress genes (DEOSGs) were analyzed by intersection of DEGs and oxidative stress-related genes. (nature.com)
A total of 1160 DEGs (259 up-regulated and 901 down-regulated) were screened in GSE48350. (nature.com)

Objective: The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia. (cdc.gov)

In cancer, they act as tumor suppressor genes and sometimes as oncogenes. (mbpinc.net)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Twenty-two of the pairs, chromosome numbers 1 to 22, the autosomes, are normally homologous (identical in size, shape, and position and number of genes). (msdmanuals.com)
the smaller Y chromosome carries genes that initiate male sex differentiation, as well as a few other genes. (msdmanuals.com)
The genes that occupy the same locus on each chromosome of a pair (one inherited from the mother and one from the father) are called alleles. (msdmanuals.com)
A chromosome contains many genes. (msdmanuals.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
It regulates Sp7 protein expression and induces expression of major bone matrix protein genes, such as Col1a1, Spp1, Ibsp, Bglap2, and Fn1 ( 7 , 8 ). (frontiersin.org)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

Functional enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and then Gene Set Enrichment Analysis (GSEA) was used to formulate the molecular functions and pathways based on the results of GO and KEGG analyses. (spandidos-publications.com)
In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)

It is generally hypothesized to be related to aging, trauma, inflammation, obesity, metabolism and genetics, and may also be related to genetic factors, chromosomal abnormalities and gene fusion ( 5 , 6 ). (spandidos-publications.com)
Genetic experiments in zebrafish revealed that miR-10 functions, in part, by directly regulating the level of a protein called FLT1, which inhibits the behavior of endothelial cells that promotes new blood vessel growth. (ca.gov)

Our study identified 9 key genes associated with oxidative stress and immune reaction in AD pathogenesis. (nature.com)
Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)
Similar to NRF2, it is responsive to oxidative stress and activates antioxidant responsive element- (ARE-) driven genes [ 4 ]. (hindawi.com)

We characterized the immunohistochemical expression of NRF1 and NRF2 in 99 naevi, 88 primary skin melanomas, and 67 lymph node metastases. (hindawi.com)

The immune-related DEOSGs and hub genes were identified by weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, respectively. (nature.com)
We obtained 66 immune-related DEOSGs by intersecting turquoise module with the DEOSGs and identified 15 hub genes through PPI analysis. (nature.com)
The other approach is to screen CRISPR-Cas9-based guide RNA (gRNA) libraries that target either the whole genome using cancer cell and immune cell co-culture systems 9 , 10 , or focused gene sets using immunocompetent murine tumors 11 , 12 . (nature.com)
MicroRNAs regulating genes involved in the pulmonary immune responses were those with the greatest fold change. (cdc.gov)

Research conducted by three independent groups and reported in The Plant Cell shows that fundamental developmental processes controlled by the plant hormone auxin are regulated by microRNAs in the model plant Arabidopsis thaliana. (sciencedaily.com)

Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. (cdc.gov)

I am molecular and cellular biologist with expertise in virus and microRNAs. (researchgate.net)
He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)

The mRNA expression of diagnostic genes was determined by qRT-PCR analysis. (nature.com)

Core genes were expressed differentially between OA subchondral bone and normal tissue samples. (spandidos-publications.com)

Within the complex, microRNAs are thought to bind to mRNA molecules containing a complementary stretch of RNA sequence. (sciencedaily.com)

Genes are contained in chromosomes in the cell nucleus and mitochondria. (msdmanuals.com)
The 23rd pair, the sex chromosomes (X and Y), determines a person's sex as well as containing other functional genes. (msdmanuals.com)
Genes are arranged linearly along the DNA of chromosomes. (msdmanuals.com)
Each gene has a specific location (locus), which is typically the same on each of the 2 homologous chromosomes. (msdmanuals.com)
Some genes occur in multiple copies that may be next to each other or in different locations in the same or different chromosomes. (msdmanuals.com)

Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
Of note, recent study identified that miR-127 expression was aberrant in the inflammation-related pulmonary disorders [ 36 ] and further revealed that enhanced expression of miR-127 could promote the development of inflammatory macrophages and contribute to the exaggerated lung inflammation and injury [ 37 ]. (hindawi.com)

Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)

Dual-luciferase reporter gene assays demonstrated Arhgap11a as the target of miR-211-5p. (frontiersin.org)

Analysis from the Gene Expression Omnibus datasets supported the mRNA findings. (hindawi.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)

The mRNA levels in a cell are fine tuned by different mechanisms, one of which is driven by microRNA molecules. (sciencedaily.com)
They regulate gene expression through different mechanisms [ 10 ] and play a diverse role in many cellular processes [ 11 - 14 ]. (hindawi.com)
During his post-doctoral training under Dr. Paul Fox at Lerner Research Institute of Cleveland Clinic, he made contributions in understanding the translational control mechanisms regulating VEGFA (vascular endothelial growth factor-A) expression in human monocytes. (rochester.edu)

Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tissues at specific stages during the plant life cycle - e.g. for leaves, roots, and floral organs to develop in the correct patterns and correct time sequence. (sciencedaily.com)
In this study, we sought to determine the expressions of miR-127 in the lung tissues of sodium taurocholate-induced AP models in rats and that in plasma of AP patients and to preliminarily explore the association of miR-217 levels and LI. (hindawi.com)

Formation and remodeling of blood vessels during development and disease involves a precisely regulated network of attractants and repellants that is similar across species. (ca.gov)
Rationale: Formation and remodeling of the vasculature during development and disease involves a highly conserved and precisely regulated network of attractants and repellants. (ca.gov)

Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury? (hindawi.com)
The aim of this study was to determine the expression of microRNA-127 (miR-127) in both rat models and patients of acute pancreatitis (AP) with lung injury (LI). (hindawi.com)
Total RNA was isolated from whole lung 24 and 48 hours post final exposure and was further processed for gene expression and microRNA array analysis. (cdc.gov)

Results: Comparison of datasets revealed increased Il4, Il13, and Il33 expression in mice exposed to viable versus heat-inactivated conidia. (cdc.gov)

Enrichment analysis was performed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. (nature.com)

Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)

The subsequent huge changes in morphology were more often due to changes in when and where those genes were expressed than to changes in the coding sequences of the genes themselves. (freethoughtblogs.com)

A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)

Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)

Moreover, bioinformatic analyses of human brain expression profiles revealed that the expression levels of miR-1908-5p and its synaptic target genes show an inverse-correlation in many brain regions. (en-journal.org)

In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)

A total of 25 important modules were generated, and two core gene clusters and seven core genes were obtained (COL6A2, COL5A2, COL12A1, COL5A1, COL6A1, LUM and COL3A1). (spandidos-publications.com)
While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)
While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
The ability to regulate blood vessel growth is important for treating many diseases, including cancer. (ca.gov)

As a consequence, both factors are transported to the nucleus to induce the expression of their target genes. (hindawi.com)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

The diagnostic value of hub genes was assessed by receiver operating characteristic analysis and validated in GSE1297. (nature.com)
Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)

Comparative Toxicogenomics Database and TargetScan were used to identify the hub‑gene‑related diseases and the microRNAs that regulated the central hub genes. (spandidos-publications.com)

Altered expression of circular RNAs (circRNAs) has previously been investigated in breast cancer. (researchgate.net)

This reveals that DNA methylation regulates gene expression on a rich profusion of levels, and regulates cell homeostasis along with cancer progression. (mbpinc.net)

Weighted gene co‑expression network analysis was performed, and a protein‑protein interaction network was constructed and further analyzed using Cytoscape and STRING. (spandidos-publications.com)

Our aim was to investigate these redox transcription factors in conjunction with redox-related microRNAs in naevi and melanoma. (hindawi.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)

Search miRCancer for miR-107 associations with cancer and associated genes. (cancerindex.org)

The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
Osterix (OSX) is a transcription factor in the SP family, which is essential for osteoblast differentiation, and its expression is closely related to Runx2 ( 9 ). (frontiersin.org)

If DNA methylation is present at the gene promoter, this can result in the downregulation of the gene. (mbpinc.net)
Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)

In our preliminary experiments, the expression of miR-1908-5p was increased after chronic treatment with valproate but not lithium in control human neural progenitor cells. (en-journal.org)

Anatomy7

Organisms2

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes40

Disciplines and Occupations1

Information Science3

Health Care1

MiRNAs40

Differentially expressed genes4

MRNAs6

MiRNA8

Nucleotides1

Biomarkers4

Proteins9

Repress2

Regulation10

DEGs2

Messenger RNA1

Tumor suppr5

Chromosome5

Protein expression3

Play important roles1

Pathways2

Genetic2

Oxidative stress3

Immunohistochemical1

Immune4

Developmental processes1

Murine1

Molecular3

MRNA expression1

Tissue1

Complementary1

Chromosomes5

Inflammation2

Tumors1

Assays1

Omnibus3

Mechanisms3

Tissues2

Remodeling2

Lung3

Datasets1

Ontology1

Oncogenic1

Sequences1

Functional2

Regulators1

Profiles revealed1

Significantly1

Important4

Target2

Diagnostic3

Diseases1

Breast Cancer1

Progression1

Analysis was performed1

Transcription factors3

Cancer1

Differentiation2

Downregulation2

Control1