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  • analysis of miRNA
  • Clustering and comparative analysis of miRNA read frequencies showed that normal breast samples were separated from most noninvasive ductal carcinoma in situ and invasive carcinomas by increased miR-21 (the most abundant miRNA in carcinomas) and multiple decreased miRNA families (including miR-98/let-7), with most miRNA changes apparent already in the noninvasive carcinomas. (aacrjournals.org)
  • assays
  • and bEnd.3 and HeLa cells transfected with control or anti-miR-320 oligonucleotides ( D ), as measured by TaqMan miRNA assays and qRT-PCR, respectively, and normalized to GAPDH levels. (pnas.org)
  • Cell viability, invasion and wound healing assays were carried out for functional analysis after miRNA transfection. (spandidos-publications.com)
  • proteins
  • To fine-tune the production of miRNAs, plants deploy a combination of proteins that act as cofactors of the miRNA-processing machinery. (pnas.org)
  • RCF3 interacts with the phosphatases C-TERMINAL DOMAIN PHOSPHATASE-LIKE1 and 2 (CPL1 and CPL2), ultimately affecting the phosphorylation of one of the main DICER-LIKE1 (DCL1) accessory proteins, HYPONASTIC LEAVES1 (HYL1), with a concomitant effect on miRNA production. (pnas.org)
  • Furthermore
  • Furthermore, expression of many miRNAs is dynamically regulated during neurogenesis and its dysregulation may play a role in the process of cerebral corticogenesis leading to malformations of cortical development (MCD), which represent one of the major causes of drug-resistant epilepsy. (frontiersin.org)
  • therapeutic
  • In addition, knocking-down specific miRNAs in these animals have demonstrated that this may consist in a promising therapeutic intervention. (frontiersin.org)
  • Scientists from the Institute of Molecular and Translational Therapeutic Strategies (IMTTS) are screening genetic material for RNAs that play a role in regulating the cardiovascular system and thereby might be putative targets for an improved treatment of cardiovascular diseases. (mh-hannover.de)
  • potentially
  • To gain insight into potentially relevant miRNAs in vivo, we investigated 2 models with differential 11β-HSD2 activity linked with salt-sensitive hypertension. (ahajournals.org)
  • distinct
  • Bioinformatic analyses showed a distinct clustering for cortical collecting ducts and proximal convoluted tubules with 53 of 375 miRNAs, where 13 were predicted to bind to the rat HSD11B2 3′-untranslated region. (ahajournals.org)